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All Journal Indonesian Journal of Tropical and Infectious Disease Medical Laboratory Technology Journal Jurnal Surya Kencana Dua: Dinamika Masalah Hukum & Keadilan
Rika Yuliwulandari
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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The Use of High Resolution Melting (HRM) Method to Detect rs1800629 of Tumor Necrosis Factor-alpha (TNF-alpha) Gene among Tuberculosis Patients Kinasih Prayuni; Intan Razari; Silviatun Nihayah; Rika Yuliwulandari
Medical Laboratory Technology Journal Vol. 7 No. 1 (2021): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.767 KB) | DOI: 10.31964/mltj.v7i1.362

Abstract

The rs1800629 polymorphism plays a crucial role in the pathogenesis of infectious and autoimmune diseases. Meanwhile, tuberculosis (TB) remains a health primary infectious disease in Indonesia. The purpose of this study is to evaluate the HRM method in detecting the rs1800629 genotype, in the TNF-α gene’s promoter region, within TB patients. The benefit of this study is to accelerate the detection of rs1800629 with a simple, rapid, and cost-effective method for genotyping and mutation screening that does not include the use of a fluorescent probe. In this experimental study, the rs1800629 genotyped in a total of 25 tuberculosis patients using KAPA HRM kit in MyGo Mini PCR, and all amplified PCR products subsequently dispatched for direct DNA sequencing to Macrogen Inc, South Korea. Based on the results, a 100% concordance find in the genotyping of rs1800629 between HRM and sequencing. The authors provided evidence to use HRM in detecting rs1800629 within the TNF-α promotor region. This application as a genotyping assay in tuberculosis patients is a low-cost, rapid, and accurate detection. However, further studies using the HRM method in case-control samples of tuberculosis are required to evaluate the method’s effectiveness and to obtain more information regarding the genotype’s susceptibility to tuberculosis and its adverse effect treatment, including anti-tuberculosis drug, induced liver injury (AT-DILI), and multidrug-resistant TB (MDR-TB), within the Indonesian population.
THE RISK FACTORS FOR DRUG INDUCED HEPATITIS IN PULMONARY TUBERCULOSIS PATIENTS IN DR. SOETOMO HOSPITAL Soedarsono Soedarsono; Sari Mandayani; Kinasih Prayuni; Rika Yuliwulandari
Indonesian Journal of Tropical and Infectious Disease Vol. 7 No. 3 (2018)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.097 KB) | DOI: 10.20473/ijtid.v7i3.8689

Abstract

Tuberculosis (TB) is still a major public health problem in Indonesia. Anti-tuberculosis drug-induced hepatotoxicity (DIH) is common side effect leading to changes in treatment regimens, and the less effective second-line treatments. Several risk factors such as age, sex, body mass index (BMI) and acetylization status for hepatotoxicity were suggested in previous studies but in the fact, those are often not related to DIH incidence after receiving standard TB treatment regimen. The aim of this study was to asses the role of risk factors in the DIH incidence in pulmonary TB patients receiving standard TB treatment regimen in Dr. Soetomo Hospital, Surabaya. Study design was analytic observational with case control. The subjects were 30 TB DIH patients and 31 TB non-DIH patients receiving standard national TB program therapy. DIH severity was divided based on International DIH Expert Working Group. Demographic data and BMI status were taken from medical records. The age classification are ≥35 years old and <35 years old as one of the risk factors studied. DNA sequencing was used to assess single-nucleotide polymorphisms in NAT2 coding region to evaluate acetylator status from blood samples. The risk factors were evaluated using chi-square test and Mantel-Haenszel test. Significant association between low BMI and DIH in general was identified (OR=3.017; 95% CI=1.029-8.845) and more significant association between low BMI and moderate DIH (OR=15.833; 95% CI=1.792-139.922). Age, sex, and acetylization status has no significant correlation with DIH incidence in general. Significant association between slow acetylator phenotype and incidence of moderate DIH was identified (OR=7.125; 95% CI= 1.309-38.711). In conclusion, some risk factors were correlated to DIH incidence in pulmonary TB patientsreceiving standart TB treatment regimen.
PENGEMBANGAN DAN PERLINDUNGAN OBAT/JAMU TRADISIONAL MENUJU INDUSTRI OBAT HERBAL DI JAWA TENGAH DAN JAWA TIMUR Endang Purwaningsih; Rika Yuliwulandari; Soenyono Soenyono; Jarot Tri Bowo Santoso
Jurnal Surya Kencana Dua : Dinamika Masalah Hukum dan Keadilan Vol 6, No 1 (2019): Jurnal Surya Kencana Dua: Dinamika Masalah Hukum & Keadilan
Publisher : Universitas Pamulang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (714.39 KB) | DOI: 10.32493/SKD.v6i1.y2019.3038

Abstract

Abstrak Pengrajin obat dan jamu tradisional harus diberdayakan dan produknya dilindungi. Tujuan penelitian ini untuk mengidentifikasi dan menganalisis potensi, prospek dan arah pengembangan industri jamu/obat tradisional menuju obat herbal. Metode yang digunakan dalam penelitian ini adalah pendekatan penelitian yang bersifat analisis deskriptif kualitatif dengan memanfaatkan pendekatan participatory (PRA), dan pendekatan sosiologis yuridis. Berdasarkan hasil penelitian disimpulkan bahwa  dewasa ini permasalahan pengusaha jamu/OT belum sampai pada seberapa besar kekuatan motivasi  menuju peningkatan ke herbal terstandar (OHT), namun masih berkutat pada masalah pemenuhan CPOTB demi  lolosnya ijin edar. Perlu uluran kepedulian berbagai pihak mengingat urgensi kepentingan ekonomi (kelanjutan produksi, modal, pemasaran/promosi, kerjasama/networking, manajemen), sosiologi humaniora (pemberdayaan), Kesehatan (higinitas dan uji lab, standarisasi CPOTB), Hukum (regulasi, kebijakan, merek, perlindungan konsumen) Perlu upaya serius untuk jembut bola (disertai pembenahan SDM), pelatihan dan pendampingan dari instansi terkait, yakni   Badan POM (dan Bala Besar POM), Dinas Perindag, Dinas Kesehatan, Dinas Koperasi &UMKM, Ditjen HKI (dan Kanwil), Dinas Pertanian, Kampus, dan peran aktif organisasi GP Jamu (model empowerment, promote and protect bisa diterapkan).Kata Kunci: Potensi, strategi,  jamu, tradisional, herbal
Co-Authors Endang Purwaningsih Intan Razari Jarot Tri Bowo Santoso Kinasih Prayuni Kinasih Prayuni S. Soedarsono Sari Mandayani Silviatun Nihayah Soenyono Soenyono