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All Journal Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology
ARIYANTI SUHITA DEWI
Research and Development Center for Marine and Fisheries Product Processing and Biotechnology, Jalan KS Tubun, Petamburan 6, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology

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STUDY ON THE EFFECT OF POLLUTANTS ON THE PRODUCTION OF AAPTAMINES AND THE CYTOTOXICITY OF CRUDE EXTRACT FROM Aaptos suberitoides Dewi, Ariyanti Suhita; Hadi, Tri Aryono; Januar, Hedi Indra; Pratitis, Asri; Chasanah, Ekowati
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 7, No 3 (2012): December 2012
Publisher : Research and Development Center for Marine and Fisheries Product Processing and Biotechnol

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.v7i3.4

Abstract

This experiment was conducted to study the effects of anthropogenic stressor on the spatialvariability of secondary metabolites from marine sponge Aaptos suberitoides. Samplings wereconducted at 7 sites in Marine National Park of Thousand Islands that are extended within 30 kmoff Jakarta bay on late February 2011. Sponges were collected and quantified by means of liquidchromatography coupled with photo-diode array detection, whereas, cytotoxicity of sponges extractswas determined against T47D (breast) cancer cell lines. Results showed that the spatialproduction of aaptamine and isoaaptamine did not correlate with the quality of their surroundinghabitat, despite nitrite and nitrate levels significantly affected the bioactivity of crude extracts.
Stress response in sponges and their potential applications to biomonitor stressors in coral reef ecosystem Dewi, Ariyanti Suhita
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 5, No 3 (2010): December 2010
Publisher : Research and Development Center for Marine and Fisheries Product Processing and Biotechnol

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.v5i3.52

Abstract

Sponges are sessile invertebrates that belong to the class of primitive and simple metazoans.Slow mobility causing sponges to develop a high adaptability toward environmental changes. Asfilter feeder, sponges bioaccumulate pollutants from their surroundings. Therefore, they can beused as tools to detect heavy metals pollutions and non-biodegradable chemical wastes.Ecologically, every sponge species demonstrates different level of resiliency toward disturbances.Observation on their community structures, including species diversity, richness and abundance,provides information on the biological integrity of their inhabited ecosystem. Detection ofenvironmental stress also can be conducted by measuring the expression of stress indicatorprotein such as Heat Shock Protein (HSP) 70 as biomarker in sponges. These sensitive anddiverse stress responses make sponges as potential bioindicators for biomonitoring program ofcoral reef ecosystem.
PENGEMBANGAN DRUG DISCOVERY DARI BAHAN ALAMI LAUT UNTUK IMUNOTERAPI KANKER Dewi, Ariyanti Suhita
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 4, No 3 (2009): December 2009
Publisher : Research and Development Center for Marine and Fisheries Product Processing and Biotechnol

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.v4i3.152

Abstract

Penyakit kanker adalah permasalahan kesehatan global yang mengancam setiap individu baik di negara maju maupun di negara berkembang. Penanganan kanker sejauh ini dilakukan berdasarkan metode konvensional yang cenderung menurunkan kualitas hidup para penderitanya. Pendekatan imunoterapi kanker adalah suatu metode pengobatan kanker dengan cara menstimulasi sistem kekebalan hidup pasien untuk melawan tumor melalui regulasi enzim-enzim yang berperan penting pada jalur molekuler tertentu dengan tujuan untuk meminimalisasi terjadinya efek samping yang tidak diinginkan yang umumnya terjadi pada terapi konvensional. Beberapa target molekuler telah dikembangkan saat ini, diantaranya adalah penghambatan enzim Indoleamine-2,3-dioxygenase  (IDO)  dan  pengaktifan  enzim  SHIP (SH2-containing-inositol-5-phosphatase). Senyawa-senyawa bioaktif dari bahan alam laut yang telah dilaporkan sebagai regulator kedua enzim di atas akan dijabarkan.
Co-Authors Ekowati Chasanah HEDI INDRA JANUAR Pratitis, Asri Tri Aryono Hadi