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All Journal Majalah Kedokteran Bandung Althea Medical Journal Jurnal Sistem Kesehatan Journal of Medicine and Health Oto Rhino Laryngologica Indonesiana Majalah Anestesia dan Critical Care International Journal of Nasopharyngeal Carcinoma
Yussy Afriani Dewi
Department of Otorhinolaringology-Head and Neck Surgery Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Karakteristik Gangguan Dengar Sensorineural Kongenital pada Anak yang Dideteksi dengan Brainstem Evoked Response Audiometry Dewi, Yussy Afriani; Agustian, Ratna Anggraeni
Majalah Kedokteran Bandung Vol 43, No 2
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Gangguan dengar merupakan salah satu kelainan yang sering timbul sejak lahir (kongenital), sehingga deteksi dan rehabilitasi dini yang tepat dapat meningkatkan perkembangan bicara dan berbahasa. Penelitian ini dilakukan untuk mengetahui berbagai aspek gangguan dengar kongenital dari segi klinik maupun sosiologik. Subjek penelitian adalah anak yang dilakukan brainstem evoked response audiometry (BERA) di Rumah Sakit Dr. Hasan Sadikin dengan gangguan dengar sensorineural bilateral kongenital selama periode April 2002–April 2005. Penelitian dilakukan secara deskriptif retrospektif. Sebanyak 286 anak termasuk dalam penelitian terdiri atas 149 (52,1%) laki-laki dan 137 (47,9%) perempuan. Sebanyak 58,7% terdeteksi pada usia >1–3 tahun. Usia anak saat dicurigai menderita gangguan dengar mulai dari usia 5 bulan sampai 14 tahun. Tenggang waktu antara usia pada saat mulai dicurigai adanya gangguan dengar dan dilakukan BERA adalah 82 (28,7%) <6 bulan, 72 (25,2%) antara >6 bulan sampai <1 tahun, dan 70 (24,4%) antara >1 sampai< 2 tahun. Penderita lebih banyak berasal dari daerah perkotaan, yaitu 149 (52,1%) anak dan sebagian besar dirujuk oleh spesialis THT sebanyak 129 (45,1%). Derajat gangguan dengar terbanyak adalah berat 181 (63,3%) dan sangat berat 96 (33,6%), sebagian besar bersifat simetris (71%). Faktor risiko terbanyak tidak teridentifikasi (51,1%), prematur/BBLR (13,6%), asfiksia (13,3%), hiperbilirubinemia (8,7%), dan rubela (7,3%). Simpulan, usia curiga pada saat anak dideteksi mengalami gangguan dengar masih tinggi. Agar deteksi dapat lebih dini, perlu peningkatan pengetahuan tenaga kesehatan dan masyarakat serta upaya pencegahan terhadap faktor risiko. [MKB. 2011;43(2):77–82].Kata kunci: Anak, brainstem evoked response audiometry (BERA), gangguan dengar sensorineural bilateral kongenital Characteristic of Congenital Bilateral Sensorineural Hearing Loss inChildren Diagnosed by Brain Evoked Response AudiometryHearing loss is one of the most common congenital anomalies, therefore early detection and rehabilitation might enhance speech ability. The purpose of this study was to explore the clinical and sociological characteristics of congenital bilateral sensorineural hearing loss. Subjects were children who suffered from congenital bilateral sensorineural hearing loss diagnosed by brainstem evoked response audiometry (BERA) in Dr. Hasan Sadikin Hospital from period of April 2002–April 2005. Data obtained retrospectively from patient’s record and presented descriptively. There were 286 children included in the study consisted of 149 (52.1%) males and 137 (47.9%) females. More (58.8%) children were detected by BERA at age of >1–3 years. Children’s age that first suspected to have hearing disorder was between 5 months and 14 years old. The delay between suspected and diagnosis was 82 (28.7%) <6 months, 72 (25.2%) between >6 months–<1 year, 70 (24.4%) between >1–<2 years. There were 52.1% (149) subjects came from urban area and 45.1% (129) of them were referred by otolaryngology-head and neck surgery specialists. The degrees of hearing loss were severe 181 (63,3%) and profound 96 (33.6%). Most cases (71%) were symmetrical. The cause of hearing loss in 51.1% of children couldn’t be determined, 13.6% were premature/low birth weight, 13.6% asphyxia, 8.7% hyperbilirubinemia, and 7.3% rubella. Conclusions, age of children when suspected to have hearing disorder is still high. Early detection needs knowledge from health provider officer, society, and prevention of the risk factors. [MKB. 2011;43(2):77–82].Key words: Brainstem evoked response audiometry (BERA), child, congenital bilateral sensorineural hearing loss DOI: http://dx.doi.org/10.15395/mkb.v43n2.47
Perbandingan Akurasi Berbagai Formula untuk Mengestimasi Laju Filtrasi Glomerulus pada Penderita Karsinoma Nasofaring Stadium Lanjut Sebelum Mendapat Kemoterapi Cisplatin Nissa, Camelia Khairun; Oehadian, Amaylia; Martakusumah, Abdul Hadi; Dewi, Yussy Afriani
Majalah Kedokteran Bandung Vol 47, No 1 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Cisplatin adalah obat sitotoksik dengan efektivitas tinggi dan digunakan secara luas, termasuk pada karsinoma nasofaring (KNF). Salah satu keterbatasan penggunaan cisplatin adalah nefrotoksisitas, terutama pada tubulus ginjal. Formula HARUS 15-30-60 dan HADI merupakan formula baru dalam menilai laju filtrasi glomerulus (LFG) dengan memperhitungkan  fungsi tubulus. Penelitian ini bertujuan mengetahui perbandingan akurasi formula Cockroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), HARUS 15-30-60, dan HADI dengan klirens kreatinin dalam menilai LFG pada penderita KNF stadium lanjut. Dilakukan penelitian analitik komparatif dengan rancangan potong lintang. Data diambil dari rekam medik penderita KNF yang akan mendapat kemoterapi cisplatin di Departemen Ilmu Penyakit Dalam Rumah Sakit Dr. Hasan Sadikin Bandung mulai Agustus 2012 sampai Agustus 2013. Data dianalisis menggunakan ANOVA dan uji concordance correlation coefficient (CCC). Subjek penelitian terdiri atas 70 subjek, 28 perempuan (40%) dan 42 laki-laki (60%), dengan usia rata-rata 42±12,3 tahun. Estimasi LFG berdasarkan MDRD, CG, dan HADI berbeda dengan klirens kreatinin (p<0,05), sedangkan estimasi LFG berdasarkan HARUS 15-30-60 tidak berbeda (p>0,05). Formula HARUS 15-30-60 memiliki CCC 0,401, lebih besar daripada CG (CCC=0,387), HADI (CCC=0,258), dan MDRD (0,136). Simpulan, formula HARUS 15-30-60 lebih akurat dibanding dengan formula CG, HADI, dan MDRD dalam menilai LFG pada penderita KNF stadium lanjut. [MKB. 2015;47(1):42–8]Kata kunci: Cockroft-Gault, formula HADI dan HARUS 15-30-60, klirens kreatinin, laju filtrasi glomerulus,  modification of diet in renal diseaseAccuracy Comparison of Various Formulas for Estimating Glomerular Filtration Rate in Advanced Nasopharyngeal Carcinoma Patients before Cisplatin AdministrationCisplatin is a widely used and highly effective cytotoxic agent, including for nasopharyngeal carcinoma (NPC). One of the side effects of cisplatin is nephrotoxicity, especially in tubulus. HARUS 15-30-60 and HADI are new formulas for estimating glomerular filtration rate (GFR) which also calculate tubular function. The aim of this study was to compare the accuracy of Cockroft–Gault (CG), modification of diet in renal disease (MDRD), HARUS 15-30-60 and HADI formula with creatinine clearance in assessing GFR. This was a cross-sectional study with comparative design in patients with advanced NPC before administration of cisplatin in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Data were collected from August 2012 to August 2013 and analyzed using ANOVA and concordance correlation coefficient test (CCC). There were 70 patients, consisted of 28 (40%) females and 42 (60%) males with the mean age of 42±12.3 years. LFG estimations based on MDRD, CG, and HADI were different from the creatinine clearance  (p<0.05), whereas no difference was found between HARUS 15-30-60 and creatinine clearance (p>0.05). HARUS 15-30-60 with creatinine clearance had CCC 0.401 was greater than CG (CCC=0.387), HADI (CCC=0.258), and MDRD (CCC=0.136). In conclusion, HARUS 15-30-60 formula is more accurate than CG, HADI, and MDRD formula in assessing renal function (GFR) in patients with advanced NPC. [MKB. 2015;47(1):42–8]Key words: Cockroft-Gault, creatinine clearance, estimated glomerular filtration rate, HADI and HARUS 15-30-60 formula, modification of diet in renal disease DOI: 10.15395/mkb.v47n1.396   
Co-Authors - Wijana Abdul Hadi Martakusumah Agung Dinasti Permana Alex Syamsuddin Amaylia Oehadian Attaufany, Fahmi Bambang Purwanto Cahyadi, Ismi Camelia Khairun Nissa Eman Sulaiman, Eman Inez Aulia Rakhmawulan, Inez Aulia Kirana, Intan Datya Lesmono, Bayu Lina Lasminingrum Nur Akbar Aroeman Nursiah Nasution, Nursiah Pandu Putra Harsarapama, Pandu Putra Ratna Anggraeni Agustian Ratna Anggraeni Agustian rikha fatmawati, rikha Sally Mahdiani Samiadi, Dindi Sinta Sari Ratunanda Titing Nurhayati