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Maria Ulfa
Departemen Dermatologi Dan Kelamin Fakultas Kedokteran Universitas Nahdlatul Ulama Surabaya
Health Professions Nursing Social Sciences

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NEUROPROTECTIVE ACTIVITY OF EXTRACT OF CELERY (APIUM GRAVEOLENS) IN INSILICO STUDY Reza Mahendra; Ainul Rofik; Hotimah Masdan Salim; Maria Ulfa; Evy Silvia Awwaliyah
Jurnal Ilmu Kesehatan dan Kesehatan Vol 5 No 2 (2021): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v5i2.2362

Abstract

Backround: Celery (Apium graveolens L., Apiaceae) is one of the medicinal plants with secondary metabolite components that have pharmacological effects such as vitamin (choline) content. This study aims to evaluate the mechanism and interaction of choline contained in celery on its effectiveness as a neuroprotective. Methods: This research is an experimental research using the in silico study. Results: The insilico search found that the choline content in celery binds to Slc5a7, Chat and Ache. Which has a function in the process of neurotransmitter biosynthesis, neurotransmitter metabolic processes and neurotransmitter secretion processes Conclusion: The celery (Apium graveolens L., Apiaceae)  have pharmacological activity as neuroprotective through the interaction of Slc5a7, Chat and Ache
Effect Of Water Clover (Marsilea Crenata) Leaf Extract On Estrogen Receptors-Β In Skin Aging winawati eka putri wina; maria ulfa maria
Jurnal Ilmiah Kesehatan Vol 14 No 1 (2021): Jurnal Ilmu Kesehatan (Journal of Health Sciences)
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (582.667 KB) | DOI: 10.33086/jhs.v14i1.1811

Abstract

Extrinsic and intrinsic factors influence skin aging. Hormonal changes, especially estrogen, significantly affect intrinsic skin aging. Decreased circulating estrogen levels reduce skin collagen content and skin elasticity. Isoflavones in Marsilea crenata (MC) leaf are active substances containing compounds that mimic estrogen. This study aims to analyze MC leaf extract against the estrogen receptor (ER)-β. The sample for this research was female Wistar Rats (Rattus norwegicus). All of them were 12 months old, with their weight was between 350 to 550 grams divided into five groups. P1 P2 and P3 were grouping with MC leaf extract administration in sequential doses 20 mg/kg BW, 30 mg/kg BW, and 40 mg/kg BW. At the same time, P4 was a positive control group, and P5 was a negative control group. The independent variable was M.crenata leaf extract. The dependent variables were (ER)-β expression and dermal thickness. The data analysis utilized the one-way analysis of variance (ANOVA) showed significant differences (p< 0.05). Each group showed significant results, and group P2 showed the highest expression of (ER)-β and dermal thickness. The result showed that there were significant correlations between both variables (P<0.05). This research has proved that water clover extract could become an alternative treatment in the future for skin aging. However, further research should find a proper dose for human consumption.
Co-Authors Ainul Rofik Evy Silvia Awwaliyah Putri, Winawati Eka Reza Mahendra Salim, Hotimah Masdan