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All Journal Jurnal Insan Farmasi Indonesia Proceeding of Mulawarman Pharmaceuticals Conferences Medical Sains : Jurnal Ilmiah Kefarmasian Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian
cikra ikhda Nur Hamidah safitri
Akademi Farmasi Mitra Sehat Mandiri Sidoarjo
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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Formulasi dan Uji Mutu Fisik Sediaan Pasta Gigi Herbal Ekstrak Temu Kunci (Boesenbergia pandurata Roxb) : Formulation and Physical Quality of Temu Kunci (Boesenbergia pandurata Roxb) as Toothpaste Reza Alfian Ardianto; Cikra Ikhda Nur Hamida Safitri
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.939 KB) | DOI: 10.25026/mpc.v13i1.471

Abstract

Dental caries is one of the oral and dental problems in Indonesia. One of the causes of dental caries is the accumulation of dental plaque which is caused by food residue that sticks to the teeth and undergoes fermentation by the bacteria Streptococcus mutans. Temu Kunci (Boesenbergia pandurata Roxb) is one of Indonesia's native plants which contains flavonoids, tannins and saponins which can inhibit bacterial growth. The purpose of this study was to formulate the extract of temu Kunci (Boesenbergia pandurata Roxb) into a toothpaste preparation and the physical quality of these preparations. The key extract was obtained by maceration method using 96% ethanol as a solvent. Divided into several toothpaste preparations made with the concentration of extract of temu Kunci (Boesenbergia pandurata Roxb) FI 2%, FII 4%, FIII 6% with uniform toothpaste. Evaluation of dental preparations including homogeneity, organoleptic, pH, dispersibility and foam height tests. The test results of the three formulations of dental preparations showed that the three formulations were homogeneous, there was no organoleptic change, the pH range of toothpaste from 6.5 to 8.0 which fulfilled the pH requirements of toothpaste according to SNI 12-3524-1995 were 4.5 - 10, 5, the spreadability test of 6.5 to 8.0 cm, and the test of the height range of the foam from 6.6 to 8.3 cm.
Formulasi dan Uji Mutu Fisik Sediaan Pasta Gigi Ekstrak Biji Jintan Hitam (Nigella sativa): Formulation and Physical Quality Test of Toothpaste from Black Cumin Seeds (Nigella sativa) Vika Novia Agustyani; Cikra Ikhda Nur Hamida Safitri
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.782 KB) | DOI: 10.25026/mpc.v13i1.472

Abstract

Black Cumin seeds (Nigella sativa) have antibacterial activity because they contain thymoquinones, tannins, saponanins, and flavonoids. According to (Sinaga, 2018) black cumin seeds can inhibit the Streptococcous mutans bacteria that causes dental caries. The research conducted was experimental. The thick extract of black cumin seeds (Nigella sativa) is formulated into toothpaste by varying the concentration of the viscous extract of black cumin seeds (Nigella sativa). The concentration of the active substance used was 0% in the control formula, 2% in formula I, 4% in formula II, 6% in formulation III. Then performed a physical stability test of the toothpaste preparation consisting of homogeneity, pH, high foam, dispersibility, color, odor, and taste. The test was carried out for 28 days of storage. During 28 days of storage all formulations were stable, homogeneity, pH and high foam preparation were stable and met the standards. The particles are evenly distributed so that the preparation has a stable color, smell and taste. The thick extract of black cumin seeds (Nigella sativa) can be formulated into a toothpaste preparation that is stable and meets the requirements. The most stable formulation is formulation I with a concentration of 2% viscous black cumin seed (Nigella sativa) extract.
Formulasi dan Uji Mutu Fisik Sabun Padat Ekstrak Kulit Nanas (Ananas comosus L.): Formulation and Physical Quality Test of Pineapple Peel Extract (Ananas comosus L.) Solid Soap Milani Agustina Putri; Elly Purwati; Cikra Ikhda Nur Hamidah Safitri
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.941 KB) | DOI: 10.25026/mpc.v13i1.479

Abstract

Nanas (Ananas comosus L.) merupakan salah satu tanaman di indonesia yang sangat berpotensi untuk dikembangkan karena mempunyai banyak manfaat. Nanas mengandung banyak vitamin B12, vitamin C, vitamin E dan enzim bromelin. Sedangkan kulit nanas yang hanya dianggap sampah yang tidak memiliki manfaat, padahal kulit nanas mengandung enzim bromelin, karotenoid, vitamin C dan flavonoid yang baik bagi kesehatan. Kandungan flavonoid dalam kulit nanas dapat dimanfaatkan sebagai antioksidan, anti alergi, anti inflamasi, dan anti bakteri. Antioksidan kulit nanas dapat dimanfaatkan sebagai pelindung kulit karena dapat mencegah terjadinya radikal bebas dan dapat diaplikasikan dalam bentuk sediaan sabun padat. Penelitian ini bertujuan untuk menghasilkan sabun padat ekstak kulit nanas dan menguji mutu fisik sesuai Standar Nasional Indonesia (SNI). Metode penelitian ini bersifat eksperimental yang terdiri dari pembuatan simplisia dan ekstraksi menggunakan metode maserasi dengan pelarut etanol 70%. Formulasi menggunakan ekstrak kulit nanas dengan konsentrasi 0% (basis), 1% (F1), 3% (F2). Evaluasi karakteristik fisik sabun padat meliputi pengamatan organoleptis, pengujian homogenitas, uji pH, uji daya busa. Sediaan di evaluasi selama 4 minggu, data dianalisis secara deksriptif. Hasil penelitian ini menunjukkan ke tiga formula menghasilkan sabun padat yang homogen, bertekstur padat dan halus, beraroma wangi, Basis (berwarna putih pekat kekuningan), F1 (berwarna putih pekat kekuningan), F2 (berwarna putih pekat kekuningan). Nilai pH pada basis, F1, F2 adalah 9,52 ,9,35, 9,45. Hasil organoleptis pada sediaan sabun padat basis, F1, F2 tidak mengalami perubahan. Nilai homogenitas pada sabun padat basis, F1, F2 tidak mengalami perubahan. Nilai uji daya busa sabun padat basis, F1, F2 tetap stabil. Kesimpulan pada penelitian ini yaitu mutu fisik sediaan sabun padat ekstrak kulit nanas memenuhi syarat SNI dan stabil selama penyimpanan 4 minggu.
Aktivitas Sedatif Nutrasetikal Jelly Drink Kombinasi Ekstrak Putri Malu (Mimosa Pudica Linn.) dan Ekstrak Secang (Caesalpinia Sappan L.) Sebagai Pencegah Mental Illness Cikra Ikhda Nur Hamida Safitri; Vania Angel
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 2 (2024): March : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i2.326

Abstract

Insomnia is a sleep disorder that often occurs in teenagers. Insomnia can be treated using sedative hypnotic drugs but this can cause dangerous effects. Therefore, alternative natural ingredients are needed, such as Putri Malu and Secang, which are formulated in the form of jelly drinks as nutrasetikals. This research used 20 female mice as test animals which were divided randomly into 5 grups. The method used was the Traction Test and the data collected was the length of time the mice turned and the time the mice fell. In the positive control grup, Diazepam, distilled water and agar, the average time for mice to fall was 62.5 seconds and the time to turn around was 62.9 seconds. In the negative control grup, Jelly Drink combination of Putri Malu and Secang 0.68 g/kgBW, showed that the time for mice to fall was 106.6 seconds and the time to turn around was 128.5 seconds. In conclusion, the Jelly drink combination of Putri Malu and Secang has a sedative effect and has the potential to prevent insomnia as seen by the need for mice in the Jelly drink grup who had less time to fall and turn around.
PEGARUH VARIASI KONSETRASI BAHAN PENGIKAT PVP (Polyvinyl Pyrrolidone) TERHADAP MUTU FISIK TABLET KUNYIT (Curcuma domestica Val.) cikra ikhda safitri; Yeyen Dwi Aprilia
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 4 No 2 (2020)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v4i2.130

Abstract

Diabetes Melitus (DM) adalah suatu penyakit kronis dan Indonesia merupakan peringkat ke-6 di dunia. Kunyit (Curcuma domestica Val.) mengandung 75% curcumin yang memiliki aktivitas sebagai antidiabetes. Penelitian ini bertujuan untuk memformulasikan tablet kunyit menggunakan metode granulasi basah dengan varian konsentrasi bahan pengikat 2,5% (F1) dan 5% (F2). Penelitian ini terdiri dari pembuatan simplisia, pembuatan ekstrak, pembuatan granul dengan variasi konsentrasi bahan pengikat 2,5% dan 5%, pencetakan tablet dengan cetak tablet single punch serta uji mutu fisik tablet. Tablet yang dihasilkan dilakukan pegujian mutu fisik yang meliputi uji keseragaman bobot, uji keseragaman ukuran, uji kekerasan tablet, uji waktu hancur tablet dan uji kerapuhan tablet. Analisis hasil menggunakan bantuan software SPSS dengan uji statistik non-parametric 2-independent sample atau mann whiteney U. Hasil uji mutu fisik tablet yang meliputi uji keseragaman bobot dengan hasil rata-rata F1 dan F2 adalah 320,75±3,56 dan 307,80±0,98. Uji keseragaman ukuran dengan rata-rata diameter F1 dan F2 adalah 1,00±0,00 dan 1,10±0,00, sedangkan rata-rata tebal F1 dan F2 adalah 0,31±0,00 dan 0,28±0,00. Uji kekerasan tablet dengan hasil rata-rata F1 dan F2 adalah 1,00±0,00. Uji waktu hancur tablet dengan hasil rata-rata F1 dan F2 adalah 840 detik dan 816 detik dan uji kerapuhan tablet dengan hasil rata-rata F1 dan F2 adalah 0,10±0,02 dan 0,26±0,00. Hasil uji statistik menunjukkan bahwa ada perbedaan yang signifikan diakibatkan karena adanya pengaruh dari perbedaan variasi konsentrasi bahan pengikat pada mutu fisik tablet berupa keseragaman bobot tablet dan waktu hancur tablet (sig <0,05).                                                                                           Kata kunci : Kunyit, diabetes melitus, tablet, Polyvinyl pyrrolidone (PVP)
Co-Authors Adelya Youan Nurdiana Angelica Olsa Okta Rizky Chelsie Onesya Prolapita Chyntia Maharani Deva Rahayu Nurindah Kusuma Wardani Dewinta Hesti Dwi Nurani Elly Purwati Elly Purwati Luluk Jubaidah Milani Agustina Putri Panji Ratih Suci Reza Alfian Ardianto Sintya Zagita Sukma Dewi Ayu Anggraini Vania Angel Vika Novia Agustyani Yeyen Dwi Aprilia