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FORMULASI DAN UJI EFEKTIVITAS SEDIAAN GEL ANTISEPTIK EKSTRAK DAUN CABE RAWIT (Capsicumfrutescens L) DENGAN METODE REPLIKA Suci Muslikah Fatmawati; Iwan Setiawan; Dwi Saryanti
Jurnal Ilmiah Pharmacy Vol 6, No 1 (2019)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v6i1.16

Daun cabe rawit (Capsicum ftutescens L) memiliki kandungan senyawa flavonoid yang dapat menghambat pertumbuhan bakteri sehingga perlu dibuat sediaan yang lebih praktis dalam bentuk gel. Penelitian ini bertujuan untuk mengetahui pengaruh perbedaan konsentrasi gelling agent carbopol 940 terhadap stabilitas fisik sediaan gel ekstrak daun cabe rawit, mengetahui konsentrasi gellingagent carbopol 940 yang baik untuk gel ekstrak daun cabe rawit dan untukmengetahui pengaruh sediaan gel ekstrak daun cabe rawit terhadap penurunan jumlah koloni bakteri sebelum dan setelah menggunakan gel antiseptik ekstrak daun cabe rawit dengan metode replika. Ekstrak daun cabe rawit diperoleh melalui proses ekstraksi maserasi menggunakan etanol 96% selama 5 hari. Gel dibuat menggunakan gelling agent carbopol 940 dengan konsentrasi 0,5%, 1,5% dan 2%. Uji efektivitas, stabilitas fisik dan aseptabilitas dilakukan pada hari ke 0, 7, 14, 21 dan 28. Metode replika digunakan untuk mengetahui efektivitas gel antiseptik. Uji stabilitas fisik meliputi organoleptis (warna, bentuk, bau, rasa), homogenitas, viskositas, pH, daya lekat, daya sebar dan kemampuan proteksi. Aseptabilitas dilakukan dengan parameter uji meliputi gel lembut di kulit, gel tidak mengiritasi kulit, gel nyaman digunakan, gel mudah digunakan, dan gel terasa dingin di kulit. Berdasarkan hasil yang diperoleh, gel antiseptik ekstrak daun cabe rawit dengan konsentrasi carbopol 1,5% menghasilkan efektivitas, stabilitas fisik dan aseptabilitas paling baik.

OPTIMALISASI BUDIDAYA TOGA DENGAN PEMBUATAN PESTISIDA ALAMI DAN PEMANFAATAN TANAMAN REFUGIA Prashinta Nita Damayanti; Nastiti Utami; Iwan Setiawan; Nur Rasmi Safitri; Renatha Audya Larasati; Winda Vionia Seviana; Elen Arditawati; Mutiara Kartika Sari
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 5, No 1 (2021): Desember
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v5i1.5835

ABSTRAKKelompok tani dan masyarakat pedesaan berperan dalam kemandirian kesehatan melalui pengembangan TOGA (Tanaman Obat Keluarga). Namun ada beberapa kendala dalam budidaya TOGA, salah satunya adalah hama tanaman sehingga perlunya dilakukan penanganan hama dengan tepat dan aman dengan pembuatan pestisida alami dan pemanfaatan tanaman refugia. Kegiatan ini bertujuan untuk meningkatkan pengetahuan masyarakat Desa Laban, Mojolaban, Sukoharjo dalam pembuatan pestisida alami dari daun pepaya dan pemanfaatan tanaman refugia dalam rangka optimalisasi budidaya toga. Metode yang digunakan adalah ceramah dan diskusi. Penyuluhan dilaksanakan melalui whatsapp group. Evaluasi keberhasilan dilaksanakan dengan pemberian pretest dan postest sebelum dan sesudah penyampaian materi serta survei kepuasan mengenai tema dan kegiatan pengabdian melalui pengisian kuesioner. Hasil pengabdian menunjukkan adanya peningkatan pengetahuan masyarakat tentang optimalisasi budidaya TOGA dengan cara pembuatan pestisida alami serta penanaman tanaman refugia sebagai pengendali hama, hal tersebut dapat dilihat dari nilai rata-rata pretest dan posttest yang semula 53,71 menjadi 84,00. Hasil evaluasi kepuasan peserta terhadap tema dan kegiatan pengabdian menunjukkan bahwa dari 35 peserta, 42,9% peserta menyatakan sangat puas, 48,6% peserta menyatakan puas, dan 8,6% peserta menyatakan cukup puas dengan kegiatan dan tema pengabdian masyarakat ini. Kata kunci: budidaya; toga; pestisida; refugia. ABSTRACTFarmer groups and rural communities have a role in health independence through the development of medicinal plants. However, there are several detrimental factors in medicinal plants cultivation, such as plant pests, so we need an proper pest management by making natural pesticides and using refugia plants. This community service program aims to increase the knowledge of the people of Laban Village in context of manufacture of natural pesticides from papaya leaves and the use of refugia plants in order to optimize the cultivation of medicinal plants. The methods used are counceling and discussions via whatsapp group. Evaluation of program was carried out by giving a pretest and posttest and survey of satisfaction through filling out questionnaires. The results of the programs show that there is an increase in participants knowledge about optimizing medicinal plants cultivation by making natural pesticides and planting refugia plants as pest control, as indicated by an increase value of the pretest and posttest from 53.71 to 84.00. The results of the evaluation of participants satisfaction with program showed that 42.9% of the participants said it was very good, 48.6% of the participants said good, and 8.6% of the participants said it was good enough. Keywords: cultivation; medicinal plants; pesticides; refuge.

Peningkatan Pengetahuan Tentang Jamu Pada Siswa-Siswi di Sekolah Dasar Negeri 1 Boyolali Iwan Setiawan; Suharyanto Suharyanto; Ryan Dianto
Jurnal Surya Masyarakat Vol 1, No 1 (2018): November 2018
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.1.1.2018.54-58

Jamu dibuat dari bahan-bahan alami, berupa bagian tumbuhan seperti rimpang (akar-akaran), daun-daunan, kulit dan batang serta buah. Sebagai suatu bentuk pengobatan tradisional, jamu memegang peranan penting dalam pengobatan penduduk negara berkembang. Litbang Depkes menginformasikan bahwa 50% penduduk Indonesia menggunakan jamu baik untuk menjaga kesehatan maupun untuk pengobatan karena sakit. Jamu telah diterima oleh masyarakat Indonesia sebagai bagian dari pengobatan tradisional. Usia 6-12 tahun anak sudah memiliki dunia sekolah yang lebih serius walaupun ia tetap seorang anak dengan dunia yang khas, masa ini ditandai dengan perubahan dalam kemampuan dan perilaku. Pertumbuhan dan perkembangan anak membuatnya lebih siap untuk belajar dibanding sebelumnya, anak juga mengembangkan keinginan untuk melakukan berbagai hal dengan baik. Tujuan dari program pengabdian ini adalah memperkenalkan profesi ahli farmasi, memberikan pengetahuan tentang resiko mengkonsumsi minuman kesehatan dan memberikan pengetahuan tentang khasiat jamu dan obat tradisional bagi siswN 1 Boyolali Metode pengabdian dibuatm enarik dengan kegiatan minum jamu bersama, mengumpulkan dan menguji pengetahuan siswa terhadap beraneka ragam tanaman obat tradisional dan penyuluhan mengenai resiko mengkonsumsi minuman kesehatan, pengetahuan tentang khasiat jamu dan obat tradisional. Pengabdian masyarakat ini diterima baik oleh pihak sekolah sehingga ditambahkan pada jadwal mingguan ada kegiatan minum susu bersama dan minum jamu bersama serta bagi anak usia dini akan sangat bermanfaat dan mampu menanamkan kecintaan anak-anak pada tanaman obat tradisional indonesia.Kata kunci: siswa, jamu, obat tradisionalAbstractHerbs are made of natural ingredients, such as parts of plants such as rhizomes (roots), leaves, skin and stems and fruit. As a kind of traditional medicine, herbs play an important role in curing people in developing countries. Research and Development division of the Ministry of Health states that 50% of Indonesian people drink herbs either to keep them healthy or to recover from illness. Herbs have been accepted by Indonesian people as a part of traditional medicine. Children at the age of 6-12 years old has had more serious schooling world though their world is still distinctive. This period is signified by chances of abilities and behaviors. Growth and development of a child makes him or her more ready to learn the he or she has been in the previous stages. He or she also develop will to do things better. The program was aimed at promoting the profession of pharmacist, sharing knowledge the risk of consuming on healthy drink and informing the benefits of drinking herbs and traditional medicine for students of Public Elementary School 1 of Boyolali. The method of the service was made interesting with drinking herbs together, collecting various kinds of traditional medicinal plants, and testing their knowledge on them and socializing the risk of consuming healthy drinks, knowledge on the benefits of drinking herbs and traditional medicine. This community service was positively received by the school so that in the weekly schedule, drinking milk and herbs together for young children were added. And for the young children, it was really useful and able to instill the children’s love to Indonesian traditional medicinal plants.

Peningkatan Pengetahuan Tentang Jamu Pada Siswa-Siswi di Sekolah Dasar Negeri 1 Boyolali Iwan Setiawan; Suharyanto Suharyanto; Ryan Dianto
Jurnal Surya Masyarakat Vol 1, No 1 (2018): November 2018
Publisher : Universitas Muhammadiyah Semarang

Jamu dibuat dari bahan-bahan alami, berupa bagian tumbuhan seperti rimpang (akar-akaran), daun-daunan, kulit dan batang serta buah. Sebagai suatu bentuk pengobatan tradisional, jamu memegang peranan penting dalam pengobatan penduduk negara berkembang. Litbang Depkes menginformasikan bahwa 50% penduduk Indonesia menggunakan jamu baik untuk menjaga kesehatan maupun untuk pengobatan karena sakit. Jamu telah diterima oleh masyarakat Indonesia sebagai bagian dari pengobatan tradisional. Usia 6-12 tahun anak sudah memiliki dunia sekolah yang lebih serius walaupun ia tetap seorang anak dengan dunia yang khas, masa ini ditandai dengan perubahan dalam kemampuan dan perilaku. Pertumbuhan dan perkembangan anak membuatnya lebih siap untuk belajar dibanding sebelumnya, anak juga mengembangkan keinginan untuk melakukan berbagai hal dengan baik. Tujuan dari program pengabdian ini adalah memperkenalkan profesi ahli farmasi, memberikan pengetahuan tentang resiko mengkonsumsi minuman kesehatan dan memberikan pengetahuan tentang khasiat jamu dan obat tradisional bagi siswN 1 Boyolali Metode pengabdian dibuatm enarik dengan kegiatan minum jamu bersama, mengumpulkan dan menguji pengetahuan siswa terhadap beraneka ragam tanaman obat tradisional dan penyuluhan mengenai resiko mengkonsumsi minuman kesehatan, pengetahuan tentang khasiat jamu dan obat tradisional. Pengabdian masyarakat ini diterima baik oleh pihak sekolah sehingga ditambahkan pada jadwal mingguan ada kegiatan minum susu bersama dan minum jamu bersama serta bagi anak usia dini akan sangat bermanfaat dan mampu menanamkan kecintaan anak-anak pada tanaman obat tradisional indonesia.Kata kunci: siswa, jamu, obat tradisionalAbstractHerbs are made of natural ingredients, such as parts of plants such as rhizomes (roots), leaves, skin and stems and fruit. As a kind of traditional medicine, herbs play an important role in curing people in developing countries. Research and Development division of the Ministry of Health states that 50% of Indonesian people drink herbs either to keep them healthy or to recover from illness. Herbs have been accepted by Indonesian people as a part of traditional medicine. Children at the age of 6-12 years old has had more serious schooling world though their world is still distinctive. This period is signified by chances of abilities and behaviors. Growth and development of a child makes him or her more ready to learn the he or she has been in the previous stages. He or she also develop will to do things better. The program was aimed at promoting the profession of pharmacist, sharing knowledge the risk of consuming on healthy drink and informing the benefits of drinking herbs and traditional medicine for students of Public Elementary School 1 of Boyolali. The method of the service was made interesting with drinking herbs together, collecting various kinds of traditional medicinal plants, and testing their knowledge on them and socializing the risk of consuming healthy drinks, knowledge on the benefits of drinking herbs and traditional medicine. This community service was positively received by the school so that in the weekly schedule, drinking milk and herbs together for young children were added. And for the young children, it was really useful and able to instill the children’s love to Indonesian traditional medicinal plants.

OPTIMASI SINTESIS NATRIUM KARBOKSIMETIL SELULOSA DARI KULIT SINGKONG (Manihot utilissima) DAN PENGEMBANGANNYA SEBAGAI BAHAN GELLING AGENT Iwan Setiawan; Novena Yety Lindawati; Bevy Amalia
BORNEO JOURNAL OF PHARMASCIENTECH Vol 1 No 2 (2017): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

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OPTIMASI SINTESIS NATRIUM KARBOKSIMETIL SELULOSA DARI KULIT SINGKONG (Manihot utilissima) DAN PENGEMBANGANNYA SEBAGAI BAHAN GELLING AGENT OPTIMIZATION OF SODIUM CARBOKSIMETILSELULOSA FROM SKIN OF CASSAVA (Manihot utilissima) AND DEVELOPMENT AS GELLING AGENT Iwan Setiawan1, Novena Yety Lindawati2Bevy Amalia3 1Farmasetika dan Teknologi Farmasi Unit, Sekolah Tinggi Ilmu Kesehatan Nasional 2Kimia Analisis Unit, Sekolah Tinggi Ilmu Kesehatan Nasional 3Farmakologi Unit, Sekolah Tinggi Ilmu Kesehatan Nasional Email : iwan.setiawan02@gmail.com ABSTRAK Singkong, dikenal dengan nama lain ketela pohon, ubi kayu (Manihot esculenta) merupakan tanaman yang kaya karbohidrat. Kulit singkong mengandung selulosa yang dapat dikembangkan dalam pembuatan sodium karboksimetil selulosa. Aplikasinya dalam bidang pangan dan industri digunakan sebagai stabilizer, thickener, adhesive, dan emulsifier. Pada penelitian ini Na CMC yang isolasi dari kulit singkong dengan Proses Alkalisasi dan karboksimetilasi dan proses netralisasi. Natrium karboksimetilselulosa yang diperoleh dianalisis dan digunakan sebagai gelling agent pada sediaan hidrogel. Berdasarkan hasil penelitian Na CMC memiliki potensi untuk diperoleh dari kulit singkong. Na CMC dari kulit singkong memiliki derajat subsitusi 0,47, viskositas < 10 dpas dan kemurnian yang rendah 76,6 % memiliki kecenderungan konsistensi yang sangat encer. Uji stabilitas fisik terhadap sediaan hidrogel dengan kandungan CMC Na dari kulit singkong menghasilkan sediaan yang tidak homogen dengan viskositas yang rendah dan memiliki daya sebar dan daya lekat yang kurang baik. Kata Kunci : Natrium karboksimetil selulosa, Kulit Singkong Borneo Journal of Pharmascientech, Vol 01, No. 02, Tahun 2017 ISSN- Print. 2541 – 3651 ISSN- Online. 2548 – 3897 Research Article ABSTRACT Cassava (Manihot esculenta) is a plant rich in carbohydrates. Cassava skin contains cellulose which can be developed in the manufacture of sodium carboxymethyl cellulose. Its application in the field of food and industry is used as stabilizer, thickener, adhesive, and emulsifier. In this study Sodium CMC is isolated from cassava leaf with alkalization process, carboxymethylation and neutralization process. The obtained carboxymethylcellulose sodium was analyzed and used as a gelling agent in the hydrogel preparation. Based on the results of research, Sodium CMC has the potential to be obtained from cassava skin. Sodium CMC from cassava leaf has a degree of substitution of 0.47, a viscosity of

Pengaruh Gel Kombinasi Ekstrak Kulit Semangka ( Citrullus Lanatus( Thunb.)) Dan Ekstrak Kulit Manggis (GarciniaMangostana L.) Terhadap Penyembuhan Luka Bakar Pada Kelinci Yosephine Vania Prima Aryati; Iwan Setiawan; Nofi Risa Ariani; Diah Dwi Hastuti - Sekolah Tinggi Ilmu Kesehatan Nasional Surakarta
Indonesian Journal on Medical Science Vol 6 No 1 (2019): IJMS 2019
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

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Abstract : Burns caused by damage or loss of tissue due to contact with heat sources. Treatment of burns is done by restoring the function and shape of skin tissue back. The use of herbal plants as an alternative treatment of burns increased due to the lack of side effects caused. Watermelon skin (Citrullus lanatus (Thunb.)) Has an alkaloid content of sitrulin that plays a role in the healing process of wound and mangosteen skin (Garcinia mangostana L.) contains xanton flavonoids that have anti-inflammatory effect by triggering the formation of collagen which plays an important role in the maintenance of structures and wound healing. The aim of this research is to know the effect of gel combination of skin watermelon extract and mangosteen skin which has anti-inflammatory effect on burn on rabbit's back and quality control of gel preparation. Testing of physical quality of gels made include organoleptic test, pH, homogeneity, viscosity, adhesion, dispersion, protection and acceptability at 0 days storage until the 28th day. The gel activity test was performed on 7 rabbits divided into 7 treatment groups consisting of negative control, positive control, KS (100), KM (100), KSKM (25:75), KSKM (50:50), KSKM (75 : 25). Each rabbit is burned using a hot metal plate 2 cm in diameter. Wound diameter was measured for 14 days. The results showed that gel combination of watermelon extract and mangosteen skin can decrease burn diameter. The effective formula is the 75:25 KSKM formula with an average diameter of 1.29 cm.Keywords : Burns, Citrullus lanatus, Garcinia mangostana, GelÂ Abstrak : Luka bakar disebabkan karena kerusakan atau kehilangan jaringan akibat kontak dengan sumber panas. Pengobatan luka bakar dilakukan dengan mengembalikan fungsi dan bentuk jaringan kulit kembali. Penggunaan tanaman herbal sebagai alternatif pengobatan luka bakar meningkat karena minimnya efek samping yang ditimbulkan. Kulit semangka (Citrullus lanatus (Thunb.)) mempunyai kandungan alkaloid berupa sitrulin yang berperan dalam proses penyembuhan luka serta kulit manggis (Garcinia mangostana L.) memiliki kandungan flavonoidberupa xantonÂ yang memiliki efek anti inflamasi dengan memicu pembentukan kolagen yang berperan penting dalam pemeliharaan struktur dan penyembuhan luka. Penelitian ini bertujuan mengetahui pengaruh gel kombinasi ekstrak kulit semangka dan kulit manggis yang memiliki efek antiinflamasi pada luka bakar yang terdapat pada punggung kelinci serta kontrol kualitas sediaan gel yang dibuat. Pengujian mutu fisik gel yang dilakukan meliputi uji organoleptik, pH, homogenitas, viskositas, daya lekat, daya sebar, daya proteksi dan aseptabilitas pada penyimpanan hari ke-0 sampai hari ke-28. Uji aktivitas gel dilakukan pada 7 ekor kelinci yang dibagi dalam 7 kelompok perlakuan yang terdiri dari kontrol negatif, kontrol positif, KS (100), KM (100), KSKM(25:75), KSKM (50:50), KSKM (75:25). Setiap kelinci dibuat luka bakar menggunakan lempeng logam panas berdiameter 2 cm. Pengukuran diameter luka dilakukan selama 14 hari. Hasil penelitian menunjukkan bahwa gel kombinasi ekstrak kulit semangka dan kulit manggis dapat menurunkan diameter luka bakar. Formula efektif yaitu formula KSKM 75:25 dengan rata-rata diameter 1,29 cm.Kata kunci : Luka bakar, Citrullus lanatus, Garcinia mangostana, Gel

Optimization of Selfnanoemulsifying Drug Delivery System (SNEDDS) Formulation of Ethil Acetate Fraction Soursop Leaf as Antioxidant Dwi Saryanti; Iwan Setiawan
Indonesian Journal of Global Health Research Vol 4 No 3 (2022): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Soursop leaves have acetogenin compounds that can be used to fight cancer in the presence of adenosine triphosphate (ATP) inhibition. Acetogenin is a long-chain fatty acid derivative (C23 or C34) which is very difficult to dissolve in water so that it will cause low oral bioavailability. The use of Selfnanoemulsifying Drug Delivery System (SNEDDS) as a drug delivery system can increase bioavailability and increase the solubility of a drug. Optimization of the use of VCO as the oil phase, tween 80 as surfactant and propylene glycol as co-surfactant in the SNEDDS formula using the Simplex Lattice Design method. The responses used in the optimization are % transmittance and emulsification time. Verification of the optimal SNEDDS formula obtained with one sample t-test. The optimal formula of SNEDDS ethyl acetate fraction of soursop leaves was tested for particle size with Partcle Size Analyzer, zeta potential with zeta sizer and antioxidant activity using ABTS. The optimal formula was obtained at the concentration of the components of VCO oil (0.56 ml), Surfactant (3.50 ml), and Propylene glycol (0.93 ml) with a desirability value of 0.769. The results of the verification of the optimal formula show that there is no significant difference between the prediction and the actual, which means that the Simplex Lattice Design method is valid and can describe the % transmittance response and emulsification time of SNEDDS ethyl acetate fraction of soursop leaves. The optimal formula for SNEDDS has an emulsification time of 53±1.527 seconds, transmittance value of % 96.3±0.360%. The particle size results obtained from the optimal formula were 13.83 nm ± 0.650, the polydispersity index was 0.143 ± 0.128. The zeta potential test results obtained were -0.23 mV ± 0.057. The optimal formula for the ethyl acetate fraction of soursop leaf SNEDDS has a very strong antioxidant activity with an IC50 value of 16.89 ppm.

Formulasi Tablet Effervescent Ekstrak Sirih Cina (Peperomia pellucida L.) Dan Uji Aktivitas Terhadap Antibakteri Staphylococcus aureus Vinsensia Ivana Widjayanti; Iwan Setiawan
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 2 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i2.18338

Chinese Betel herb (Peperomia pellucida L.) has flavonoid and saponin content compounds that can inhibit bacterial growth. The innovation of effervescent tablets used as disinfectants is not widely known in the Indonesian market. This preparation has the advantage of being easy to manufacture as a disinfectant. Chinese betel herb extract is formulated into an effervescent tablet preparation. This study aims to determine the influence on variations in the levels of binders and fillers in the physical properties of effervescent tablet preparations and determine the activity in the effervescent tablet formula of Chinese betel extract (Peperomia pellucida L.) in inhibiting the growth of Staphylococcus aureus bacteria. Chinese betel herb extract is obtained through a maceration extraction process using methanol solvent for 5 days. The preparation of effervescent tablets is made 3 formulas, namely the concentration of binding substances 10%, 13%, 15%. Physical tests of tablet preparations include organoleptic tests, tablet hardness tests, tablet soluble time tests, size uniformity tests, weight uniformity tests,, fragility tests and antibacterial activity tests against Staphylococcus aureus with disc paper diffusion methods.The best formula tablets are formula I (PEG 10%) with uniformity of weight 525±17,014, tablet hardness 3,452±1,172, tablet fragility 0.264%, soluble time 1 minute 6 seconds, uniformity size 3.33±0.06. The results of antibacterial activity tests showed weak inhibitory power with an average formula value of 4.51±0.02.

Optimization of Selfnanoemulsifying Drug Delivery System (SNEDDS) Formulation of Ethil Acetate Fraction Soursop Leaf as Antioxidant Dwi Saryanti; Iwan Setiawan
Indonesian Journal of Global Health Research Vol 4 No 3 (2022): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Soursop leaves have acetogenin compounds that can be used to fight cancer in the presence of adenosine triphosphate (ATP) inhibition. Acetogenin is a long-chain fatty acid derivative (C23 or C34) which is very difficult to dissolve in water so that it will cause low oral bioavailability. The use of Selfnanoemulsifying Drug Delivery System (SNEDDS) as a drug delivery system can increase bioavailability and increase the solubility of a drug. Optimization of the use of VCO as the oil phase, tween 80 as surfactant and propylene glycol as co-surfactant in the SNEDDS formula using the Simplex Lattice Design method. The responses used in the optimization are % transmittance and emulsification time. Verification of the optimal SNEDDS formula obtained with one sample t-test. The optimal formula of SNEDDS ethyl acetate fraction of soursop leaves was tested for particle size with Partcle Size Analyzer, zeta potential with zeta sizer and antioxidant activity using ABTS. The optimal formula was obtained at the concentration of the components of VCO oil (0.56 ml), Surfactant (3.50 ml), and Propylene glycol (0.93 ml) with a desirability value of 0.769. The results of the verification of the optimal formula show that there is no significant difference between the prediction and the actual, which means that the Simplex Lattice Design method is valid and can describe the % transmittance response and emulsification time of SNEDDS ethyl acetate fraction of soursop leaves. The optimal formula for SNEDDS has an emulsification time of 53±1.527 seconds, transmittance value of % 96.3±0.360%. The particle size results obtained from the optimal formula were 13.83 nm ± 0.650, the polydispersity index was 0.143 ± 0.128. The zeta potential test results obtained were -0.23 mV ± 0.057. The optimal formula for the ethyl acetate fraction of soursop leaf SNEDDS has a very strong antioxidant activity with an IC50 value of 16.89 ppm.

Inovasi Teknologi Kristalisasi Serbuk Instan Kombinasi Jahe dan Kencur guna Meningkatkan Pengetahuan dan Ketrampilan di Desa Wirun Retnowati Adiningsih; Iwan Setiawan; DZAKI FIKRI FIRDAUS BAKRI
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 4 No. 4 (2023): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN)
Publisher : Sistem Informasi dan Teknologi (Sisfokomtek)

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Cardiovasculer diseases are the main causes of death in the world with 32% of total deaths. Hypertension is one of the main risk factors for cardiovascular disease, so it needs special attention in society. Ginger (Zingiber officinale Rosc) and galangal (Kaempferia galanga) are medicinal plants and easy to found at home, so it can the best solutions for long term treatment of hypertension. Community service activities were carried out for the Kelompok Wanita Tani (KWT) in Wirun, Mojolaban, Sukoharjo. This research includes analysis of public knowledge regarding hypertension, education on the benefits of product as antihypertensives, education on making crystal powder from ginger and galangal and final evaluation. The results of the research show that this community service activity can produce crystal powder products from ginger and galangal that are easy, cheap and can help lower blood pressure in the people of Wirun Village. This crystal powder products from traditional plants can be a business opportunity for KWT from Wirun as a Produksi Industri Rumah Tangga (PIRT).

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