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Peningkatan Pengetahuan Masyarakat Tentang Penyakit Diabetes Melitus Dwi Saryanti; Dian Nugraheni
JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) VOL. 3 NOMOR 1 MARET 2019 JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat)
Publisher : Lembaga Publikasi Ilmiah dan Penerbitan (LPIP)

Prevalensi penyakit Diabetes melitus (DM) cukup tinggi di Desa Mancasan, Kecamatan Baki Kabupaten Sukoharjo dan pengetahuan masyarakat terhadap penyakit ini masih rendah sehingga perlu adanya peningkatan pengetahuan tentang penyakit DM. Penyakit DM yang tidak terkontrol dapat mempengaruhi ginjal, mata, sistem saraf dan organ lain dalam tubuh. Kegiatan ini bertujuan untuk memberikan edukasi tentang penyakit DM dan cara pengatasannya, serta memberikan pelatihan pembuatan teh celup herbal yang dapat digunakan untuk menunjang pengobatan penyakit DM. Kegiatan dilakukan dengan memberikan edukasi kepada masyarakat tentang penyakit DM dan cara pengatasannya dan pelatihan pembuatan teh celup herbal dengan memanfaatkan biji mahoni yang merupakan bahan alam yang tersedia berlimpah disekitar lingkungan. Metode yang digunakan yaitu dengan memberikan penyuluhan dan pelatihan. Sebelum dan setelah penyuluhan dan pelatihan dilakukan diberikan pretes dan post tes untuk menilai pemahaman masyarakat tentang diabetes melitus dan sebagai indikator keberhasilan dari kegiatan. Hasil penyuluhan menunjukkan adanya peningkatan pemahaman masyarakat mengenai diabetes melitus yaitu dari 67,83% menjadi 90,43%. Berdasarkan hasil ini diharapkan masyarakat dapat lebih bijak dalam menggunakan obat diabetes melitus dan dapat memanfaatkan teh herbal dari bahan alam.

Uji Cemaran Mikroba dan Kapang Khamir Ekstrak Air Daun Muntingia calabura L. (Kersen) Aulia Nur Rahmawati; Dwi Saryanti; Fryda Nurita Sari; Irma Yovita Turnip
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.18304

Kersen (Mutingia calabura L.) is a plant that can be used as a raw material for medicine because it has many medicinal benefits. Kersen as a medicinal raw material must pass a quality parameter testing process to be safe to use. One of the extract quality parameters is the total plate count for microbial (ALT) and yeast contamination (AKK). This study aims to evaluate the suitability of microbial and yeast contamination in the water extract of Kersen leaves to the applicable regulations. Extraction of Kersen leaves used maceration method with water solvent for 3 days with a ratio of 1:10. The results obtained from the water extract of Kersen leaves are organoleptically in the form of thick extract, dark brown in color, sour taste, bitter, and has a distinctive odor. The ALT value in the aqueous extract of cherry leaves was 8.4 x 10⁴ colonies/g. The AKK value in the aqueous extract of cherry leaves was 102 colonies/g which was reported as an approximate AKK value. The ALT and AKK values in the water extract of Kersen leaves meet the safety and quality requirements of traditional medicine.

Optimization of Selfnanoemulsifying Drug Delivery System (SNEDDS) Formulation of Ethil Acetate Fraction Soursop Leaf as Antioxidant Dwi Saryanti; Iwan Setiawan
Indonesian Journal of Global Health Research Vol 4 No 3 (2022): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Soursop leaves have acetogenin compounds that can be used to fight cancer in the presence of adenosine triphosphate (ATP) inhibition. Acetogenin is a long-chain fatty acid derivative (C23 or C34) which is very difficult to dissolve in water so that it will cause low oral bioavailability. The use of Selfnanoemulsifying Drug Delivery System (SNEDDS) as a drug delivery system can increase bioavailability and increase the solubility of a drug. Optimization of the use of VCO as the oil phase, tween 80 as surfactant and propylene glycol as co-surfactant in the SNEDDS formula using the Simplex Lattice Design method. The responses used in the optimization are % transmittance and emulsification time. Verification of the optimal SNEDDS formula obtained with one sample t-test. The optimal formula of SNEDDS ethyl acetate fraction of soursop leaves was tested for particle size with Partcle Size Analyzer, zeta potential with zeta sizer and antioxidant activity using ABTS. The optimal formula was obtained at the concentration of the components of VCO oil (0.56 ml), Surfactant (3.50 ml), and Propylene glycol (0.93 ml) with a desirability value of 0.769. The results of the verification of the optimal formula show that there is no significant difference between the prediction and the actual, which means that the Simplex Lattice Design method is valid and can describe the % transmittance response and emulsification time of SNEDDS ethyl acetate fraction of soursop leaves. The optimal formula for SNEDDS has an emulsification time of 53±1.527 seconds, transmittance value of % 96.3±0.360%. The particle size results obtained from the optimal formula were 13.83 nm ± 0.650, the polydispersity index was 0.143 ± 0.128. The zeta potential test results obtained were -0.23 mV ± 0.057. The optimal formula for the ethyl acetate fraction of soursop leaf SNEDDS has a very strong antioxidant activity with an IC50 value of 16.89 ppm.

Optimization of Selfnanoemulsifying Drug Delivery System (SNEDDS) Formulation of Ethil Acetate Fraction Soursop Leaf as Antioxidant Dwi Saryanti; Iwan Setiawan
Indonesian Journal of Global Health Research Vol 4 No 3 (2022): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Soursop leaves have acetogenin compounds that can be used to fight cancer in the presence of adenosine triphosphate (ATP) inhibition. Acetogenin is a long-chain fatty acid derivative (C23 or C34) which is very difficult to dissolve in water so that it will cause low oral bioavailability. The use of Selfnanoemulsifying Drug Delivery System (SNEDDS) as a drug delivery system can increase bioavailability and increase the solubility of a drug. Optimization of the use of VCO as the oil phase, tween 80 as surfactant and propylene glycol as co-surfactant in the SNEDDS formula using the Simplex Lattice Design method. The responses used in the optimization are % transmittance and emulsification time. Verification of the optimal SNEDDS formula obtained with one sample t-test. The optimal formula of SNEDDS ethyl acetate fraction of soursop leaves was tested for particle size with Partcle Size Analyzer, zeta potential with zeta sizer and antioxidant activity using ABTS. The optimal formula was obtained at the concentration of the components of VCO oil (0.56 ml), Surfactant (3.50 ml), and Propylene glycol (0.93 ml) with a desirability value of 0.769. The results of the verification of the optimal formula show that there is no significant difference between the prediction and the actual, which means that the Simplex Lattice Design method is valid and can describe the % transmittance response and emulsification time of SNEDDS ethyl acetate fraction of soursop leaves. The optimal formula for SNEDDS has an emulsification time of 53±1.527 seconds, transmittance value of % 96.3±0.360%. The particle size results obtained from the optimal formula were 13.83 nm ± 0.650, the polydispersity index was 0.143 ± 0.128. The zeta potential test results obtained were -0.23 mV ± 0.057. The optimal formula for the ethyl acetate fraction of soursop leaf SNEDDS has a very strong antioxidant activity with an IC50 value of 16.89 ppm.

PENETAPAN KADAR FLAVONOID EKSTRAK AIR BUAH JAMBU BIJI MERAH (Psidium guajava Linn) Aulia Nur Rahmawati; Eka Wisnu Kusuma; Dwi Saryanti
Parapemikir : Jurnal Ilmiah Farmasi Vol 12, No 3 (2023): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v12i3.5746

Buah jambu biji merah (Psidium guajava Linn) memiliki kandungan metabolit sekunder yang melimpah, namun penentuan parameter ekstrak dengan pelarut air masih belum dilaksanakan. Penelitian ini bertujuan untuk mengetahui kadar flavonoid total dari ekstrak air buah jambu biji merah sebagai bagian kecil dari proses standarisasi ekstrak air buah jambu biji merah. Metode yang digunakan adalah metode Wilstater “cyanidin” untuk pengujian flavonoid secara kualitatif dan metode kolorimetri alumunium klorida (AlCl3) untuk pengujian secara kuantitatif. Penentuan panjang gelombang maksimal, operating time, kurva baku kuersetin dan penetapan kadar flavonoid sampel dilaksanakan menggunakan spektrofotometer Uv-Vis. Hasil pengujian kualitatif menunjukkan terjadinya perubahan warna menjadi oranye kekuningan, sementara hasil pengujian kuantitatif menunjukkan bahwa kadar flavonoid ekstrak air buah jambu biji merah dapat diukur menggunakan kurva baku quercetin dengan panjang gelombang 350-500 dan operating time selama 30 menit Kesimpulan dari penelitian ini adalah ekstrak air buah jambu biji merah terdeteksi mengandung flavonoid dengan kadar sebesar 3,293±0,155 mgQE/g.

Pemanfaatan Tanaman Lokal Serai (Cymbopogon Nardus) sebagai Spray Anti Nyamuk oleh Kader Pkk Kelurahan Pucang Sawit Muhammad Sa'ad; Dwi Saryanti
Jurnal Abdimas Kesehatan (JAK) Vol 5, No 3 (2023): November
Publisher : Sekolah Tinggi Ilmu Kesehatan Baiturrahim Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jak.v5i3.589

One of the diseases that is still a health problem in Central Java Province is Dengue Hemorrhagic Fever (DHF). Surakarta is the city with the highest death rate (CFR) due to dengue fever in Central Java Province at 14.6%. Lack of knowledge and awareness of dengue fever is one of the causes of the high number of dengue fever cases. This service activity was carried out as an effort to prevent dengue fever by increasing community knowledge through Family Welfare Development (PKK) cadres regarding dengue fever and the use of herbal plants in the environment to prevent dengue fever. Community service was carried out in Pucang Sawit Village, Jebres, Surakarta which was attended by representatives from each Neighborhood Association (RT). Starting with counseling about dengue fever and the use of natural ingredients for dengue fever, especially the lemongrass plant, then continued with the practice of making repellent spray products from the lemongrass plant. Evaluation of the service implementation process is carried out by carrying out pre-tests and post-tests by service participants to determine the level of participants' knowledge of dengue fever and the use of Serai as a repellant, before and after service activities. The average pre-test and post-test scores obtained were 80.31 and 89.69 respectively. This value shows an increase in community knowledge before and after the extension activities were carried out.

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