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Alfian Nur Firdaus
Pharmacy Study Program, STIKES Banyuwangi, Jl. Letkol Istiqlah No. 109, Banyuwangi, 68422, Indonesia
Chemistry

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Ceftriaxone Degradation by Titanium Dioxide (TiO2) Nanoparticles: Toxicity and Degradation Mechanism Mohammad Rofik Usman; Azmi Prasasti; Sovia Islamiah; Alfian Nur Firdaus; Ayu Wanda Marita; Syamsiyatul Fajriyah; Eka Fitri Yanti
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1049.934 KB) | DOI: 10.15408/jkv.v6i1.12475

Abstract

Ceftriaxone is a third generation of cephalosporin antibiotics that commonly used in patients with ulcers. Ceftriaxone residues in the environment are degraded using Titanium dioxide (TiO2) nanoparticles. Degradation of ceftriaxone using TiO2 nanoparticles was influenced by environmental conditions, such as light sources, pH of the solution, the mass of TiO2 nanoparticles, and the length of radiation. The remained ceftriaxone was analyzed by using a spectrophotometer UV-visible. The toxicity of the solution after the degradation process was tested on Escherichia coli and the type of products resulted was analyzed using Liquid Chromatography-Mass Spectrophotometry (LC-MS). The optimum conditions in degrading 50 mL 250 ppm ceftriaxone was radiation under a mercury UV lamp (white), pH 8, and 100 mg of TiO2 nanoparticles for 9 hours. The degradation degree of ceftriaxone obtained was 96.52%, producing simpler compounds that not toxic to E. Coli.
Co-Authors Ayu Wanda Marita Azmi Prasasti Eka Fitri Yanti Mohammad Rofik Usman Sovia Islamiah Syamsiyatul Fajriyah