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All Journal VALENSI Bulletin of Chemical Reaction Engineering & Catalysis Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Akademika Kimia Jurnal Pengabdian Pada Masyarakat Bulletin of Chemical Reaction Engineering & Catalysis
Mohammad Rofik Usman
Bachelor In Pharmacy Program, Faculty Of Health Science, Universitas Dr. Soebandi, Jember, Jawa Timur
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Ceftriaxone Degradation by Titanium Dioxide (TiO2) Nanoparticles: Toxicity and Degradation Mechanism Mohammad Rofik Usman; Azmi Prasasti; Sovia Islamiah; Alfian Nur Firdaus; Ayu Wanda Marita; Syamsiyatul Fajriyah; Eka Fitri Yanti
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1049.934 KB) | DOI: 10.15408/jkv.v6i1.12475

Abstract

Ceftriaxone is a third generation of cephalosporin antibiotics that commonly used in patients with ulcers. Ceftriaxone residues in the environment are degraded using Titanium dioxide (TiO2) nanoparticles. Degradation of ceftriaxone using TiO2 nanoparticles was influenced by environmental conditions, such as light sources, pH of the solution, the mass of TiO2 nanoparticles, and the length of radiation. The remained ceftriaxone was analyzed by using a spectrophotometer UV-visible. The toxicity of the solution after the degradation process was tested on Escherichia coli and the type of products resulted was analyzed using Liquid Chromatography-Mass Spectrophotometry (LC-MS). The optimum conditions in degrading 50 mL 250 ppm ceftriaxone was radiation under a mercury UV lamp (white), pH 8, and 100 mg of TiO2 nanoparticles for 9 hours. The degradation degree of ceftriaxone obtained was 96.52%, producing simpler compounds that not toxic to E. Coli.
Degradation of Ciprofloxacin by Titanium Dioxide (TiO2) Nanoparticles: Optimization of Conditions, Toxicity, and Degradation Pathway Mohammad Rofik Usman; Azmi Prasasti; Sovia Islamiah; Alfian Nur Firdaus; Ayu Wanda Marita; Syamsiyatul Fajriyah; Atiek Rostika Noviyanti; Diana Rakhmawaty Eddy
Bulletin of Chemical Reaction Engineering & Catalysis 2021: BCREC Volume 16 Issue 4 Year 2021 (December 2021)
Publisher : Department of Chemical Engineering - Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.9767/bcrec.16.4.11355.752-762

Abstract

The popular use of ciprofloxacin is often irrational, so it causes environmental pollution such as resistance. The solution to overcome environmental pollution due to ciprofloxacin is degradation by using TiO2 nanoparticles. TiO2 nanoparticles performance is influenced by environment such as light source, pH solvent, duration of lighting and TiO2 nanoparticles mass. The residual levels determination of ciprofloxacin was carried out by using a UV-Vis spectrophotometer. Toxicity test of ciprofloxacin degradation products with TiO2 nanoparticles used Escherichia coli bacteria. Liquid Chromatography Mass Spectrometry (LCMS) was used to determine the type of ciprofloxacin degradation product with TiO2 nanoparticles. The optimum condition for the ciprofloxacin degradation with TiO2 nanoparticles is lighting for 5 hours by using a white mercury UV lamp and 50 mg TiO2 nanoparticles with pH solvent of 5.5. The toxicity of ciprofloxacin degradation product with TiO2 nanoparticles was low. The smallest degradation product identified with m/z was p-fluoraniline (m/z 111). Copyright © 2021 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0). 
Ekstraksi Kalsium dari Cangkang Kerang Hijau (Perna viridis L.) dan Kerang Batik (Paphia undulata B.) dengan Metode Kalsinasi sebagai Sediaan Effervescent Mohammad Rofik Usman; Rifka Nabila; Lutfiah Nurul Hakiki
Indonesian Journal of Chemical Research Vol 8 No 2 (2020): Edisi Bulan September (Edition for September)
Publisher : Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2020.8-mru

Abstract

One of the solutions is the supplying of calcium effervescent powder as a source of calcium. The source of calcium that has not been processed maximally is the clam shell. Calcium from the clam shells will be extracted by calcination method at 900 °C for 4 hours. The extracted clam shells powder are tested using XRD and analyzed using the Rietveld method. The particle sizes of calcium are determined by the Scherer equation. The best calcium is formulated into 3 formulations with several variations in composition. Evaluation of calcium effervescent powder includes organoleptic test, water content and dispersion time. The extracted calcium crystal diffractogram shows the CaO compound with cubic structure and space group FM3M. The particle sizes of CaO nanoparticles from green shells and batik were 88.7597nm and 96.66566nm, respectively. The best CaO based on χ2 values ​​and particle sizes are CaO from green clamshells. The organoleptic test of the three formulations produced the same data as yellow, granular shape, and citrus aroma. Formulation three is the best formulation based on the low water content and short dispersion time.
Synthesis of Pentapeptide FWKVV (Phe-Trp-Lys-Val-Val) and Its Activity as Antioxidants Eka Fitri Yanti; Eviyanti Nazareth; Yuana Dwi Agustin; Mohammad Rofik Usman
Indonesian Journal of Chemical Research Vol 9 No 1 (2021): Edition for May 2021
Publisher : Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2021.9-eka

Abstract

Antioxidant pentapeptides are pentapeptide compounds that have antioxidant activity. One of the pentapeptide compounds that have antioxidant activity is FWKVV. FWKVV is a linear pentapeptide with the amino acid sequence phenylalanine-tryptophan-lysine-valine-valine, which was first isolated to hydrolyzate the muscle protein of Miiuy croaker (Miichthysmiiuy). In addition to isolation, FWKVV compounds can be produced by the peptide synthesis method because this method requires a shorter time than the isolation method from natural materials. Synthesis methods commonly used are solution-phase peptide synthesis and solid-phase peptide synthesis (SPPS). However, the SPSS method is more efficient because it does not require purification in every process. The purpose of this study was to synthesize FWKVV compounds using the SPPS method and test their antioxidant activity. FWKVV has been synthesized using the SPPS method with HBTU/HOBt coupling reagent and Fmoc protective group. The FWKVV crud produced was 148.8 mg and had antioxidant activity against DPPH radicals with an IC50 value of 4.2 mg/mL.
Photocatalytic Degradation of Diazinon Using Titanium Oxide Synthesized by Alkaline Solvent Mohammad Rofik Usman; Atiek Rostika Noviyanti; Diana Rakhmawaty Eddy
Indonesian Journal of Chemistry Vol 17, No 1 (2017)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (639.362 KB) | DOI: 10.22146/ijc.23548

Abstract

Photoactivity of titanium dioxide (TiO2) can be improved by turning it into nanoparticles. Synthesis of TiO2 nanoparticles can be done by using hydrothermal method. Hydrothermal method is influenced by types of precursor, hydrothermal conditions, including time, temperature, type and concentration of reactants. The purpose of this study is to obtain a hydrothermal condition which produces crystals of TiO2 nanoparticles with high quality. The material used was titanium tetrachloride (TiCl4) as initial precursors and for the type of reactants was used aqudestilate, aquabidestilate, ethanol, t-butanol, sodium hydroxide (NaOH) and potassium hydroxide (KOH). The resulting diffractogram showed the crystal structure of TiO2 nanoparticles with anatase and rutile. Based on calculations using the scherrer equation, TiO2 crystal obtained had a crystal size below 50 nm in both anatase and rutile. The percentage of rutile and anatase composition was obtained by using rietveld method with the help of rietica software. Morphology of TiO2 anatase showed particles with shape of cubic, while rutile was flower-shaped.
Development and Validation of RP-HPLC Analysis Method for Determination of Total Alkaloid Content of Soursop (Annona muricata L.) Leaf Extract Lindawati Setyaningrum; Dyah Purwaningtyas; Ayik Rosita Puspaningtyas; Dyan Wigati; Mohammad Rofik Usman; Maasyitoh Sari Latifah
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 23 No. 03 (2022): Eksakta: Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1166.627 KB) | DOI: 10.24036/eksakta/vol23-iss03/325

Abstract

Soursop leaves contain alkaloids that have pharmacological effects. This study aims determine the total alkaloid content of soursop leaf ethanol extract using a validated HPLC method. Extraction was carried out by soxhletation followed by liquid-liquid extraction using chloroform. Optimizing HPLC conditions on the mobile phase, flow rate, concentration, and wavelength, further testing the validation of the analytical method. Optimizing HPLC conditions obtained optimal results at concentration of 500 ppm with a flow rate of 1.0 mL/min using acetonitrile: methanol: water (80:5:15) at wavelength of 272 nm. These results have met the validation requirements of analytical methods including System Suitability Test (UKS), selectivity, linearity with y = 2.01914x –219,97226, correlation coefficient value (r) = 0.9995, and Vx0 value 0.11201%. The limit of detection and quantization were 8,78525 ppm and 29,28418 ppm, respectively. The RSD percentage of the precision test is 1.0453%, and the accuracy test is obtained from the recovery of 98-102%. The result of determining the total alkaloid content  sample was 0.0862 ± 0.004 % (%w/w) of the entire alkaloid content (TALC) triple replication. This research concludes that the analytical method using the HPLC system for determining the total alkaloid content of the ethanolic extract of soursop leaves is validate
Calcium Extract Characterization from Rajungan Crab Shell (Portunus pelagicus) and Bakau Crab Shell (Scylla serrata) using Calcination as Effervescent Mohammad R. Usman; Muhamad D. Permana; Aditya F. Ardinsyah; Mega T. Wulandari; Aliyah Purwanti; Lindawati Setyaningrum; Ima F. Lestari; Stephanie D. Artemisia
Jurnal Akademika Kimia Vol. 11 No. 2 (2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2022.v11.i2.pp122-128

Abstract

One of the prevention of osteoporosis is by taking calcium supplements. Crab shells are calcium sources that can be processed into supplements. Calcium extraction used the calcinations method at 900°C temperature for 4 hours. After calcining the crab shell powder, it was analyzed by using XRD and processed with the Highscore Plus application by using Rietveld method. The best calcium crystals will be used as raw material for effervescent powder. The results showed that calcium crystals from rajungan crab shells contained 0.4% CaCO3 with a crystallite size of 25.9001 nm and 99.6% CaO with a crystallite size of 82.7183 nm with a GoF value of 1.69979. Calcium crystals produced from bakau crab shells were 100% CaO with a crystallite size of 77.3397 nm with a GoF value of 1.90266. Calcium crystals from bakau crab shells were used as effervescent raw materials with 2 different formulations. The results of the organoleptic test from both effervescents showed the same results, namely in the form of a pale yellow powder with a orange scent and sour taste The results of the dispersion time test showed that the 2 formulations had met the requirements with the dispersion time of formula 1 being 31.67 seconds and formula 2 being 32.33 seconds. The results of the water content test of the two formulas met the requirements with the water content of formula 1 being 0.071% and formula 2 being 0.067%.
Peningkatan Kesadaran Masyarakat Terhadap Lingkungan Melalui Penyuluhan Pupuk Organik di desa Sumberbulus, kecamatan Ledokombo-Jember Ade Nisa’ Kartika Azzahra; Dwiki Yudistira; Ikfira Agustina Putri; Reno Kurnia Ramadhan; Rosita Dina Dwi Ayunliana; Fathor Rosi; Frida Oktavia Putri Hermanto; Reza Zarkasih Adytia; Ridho Anil Shohibul Falah; Haikal Alhamdi Sirojul Alam; Mohammad Rofik Usman
Jurnal Pengabdian Pada Masyarakat Vol 7 No 4 (2022): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.604 KB) | DOI: 10.30653/002.202274.207

Abstract

INCREASING PUBLIC AWARENESS OF THE ENVIRONMENT THROUGH ORGANIC FERTILIZER COUNSELING İN SUMBERBULUS VİLLAGE, DİSTRİCT OF LEDOKOMBO-JEMBER. Sumberbulus Village is a village where most of the residents work as farmers. The farmers in this village are very dependent on the results of their agricultural production on inorganic fertilizers, because it can speed up the harvest period. But the continuous use of inorganic fertilizers can pollute the environment. The counseling was carried out at the Sumberbulus Village Hall, district of Ledokombo-Jember Regency on August 9, 2022. The implementation of this activity was with the lecture method accompanied by questions and answers and the practice of making organic fertilizer. Participants consisted of 50 farmers in Sumberbulus Village. Organic fertilizer is an environmentally friendly technology. How to make organic fertilizer using materials that are quite easy to find and household waste. This activity has an impact in increasing the insight and understanding of farmers regarding sustainable agricultural management so that the resulting agricultural production has a long-term effect, and is safe for the environment.
Antioxidant Activity of Red Dragon Fruit Teabag (Hylocereus polyrhizus) Peels with the Addition of Ginger (Zingiber officinale var. amarum) and Cinnamon (Cinnamomum zeylanicum, BI) Wima Anggitasari; Lindawati Setyaningrum; Muhammad Rofik Usman; Dyan Wigati
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 02 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol24-iss02/377

Abstract

Free radicals have very unstable and reactive molecules. Excessive free radicals can trigger oxidative stress and cause various diseases. The peel of red dragon fruit contains chemical compounds that shows potential as an antioxidants. This study aims to optimize the benefits of red dragon fruit peels as tea bags because its convenient and simple to use. Design of this study was a randomized block design (RBD) which consisted of two factors, the drying temperature of the red dragon fruit skin (T) and the teabag formulation (F). Ginger and cinnamon are added as flavoring ingredients to the formula. The result showed that the drying temperature of the peel red dragon fruit affects the antioxidant activity of the teabag, where T1 has the highest antioxidant activity. The formulation of teabags also affects the antioxidant activity of the teabag, where F1 has the highest antioxidant activity. T1F1 had the highest antioxidant activity, and the interaction between the two (T and F) had a significant effect on antioxidant activity (p < 0.05).
Degradation of Ciprofloxacin by Titanium Dioxide (TiO2) Nanoparticles: Optimization of Conditions, Toxicity, and Degradation Pathway Mohammad Rofik Usman; Azmi Prasasti; Sovia Islamiah; Alfian Nur Firdaus; Ayu Wanda Marita; Syamsiyatul Fajriyah; Atiek Rostika Noviyanti; Diana Rakhmawaty Eddy
Bulletin of Chemical Reaction Engineering & Catalysis 2021: BCREC Volume 16 Issue 4 Year 2021 (December 2021)
Publisher : Masyarakat Katalis Indonesia - Indonesian Catalyst Society (MKICS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.9767/bcrec.16.4.11355.752-762

Abstract

The popular use of ciprofloxacin is often irrational, so it causes environmental pollution such as resistance. The solution to overcome environmental pollution due to ciprofloxacin is degradation by using TiO2 nanoparticles. TiO2 nanoparticles performance is influenced by environment such as light source, pH solvent, duration of lighting and TiO2 nanoparticles mass. The residual levels determination of ciprofloxacin was carried out by using a UV-Vis spectrophotometer. Toxicity test of ciprofloxacin degradation products with TiO2 nanoparticles used Escherichia coli bacteria. Liquid Chromatography Mass Spectrometry (LCMS) was used to determine the type of ciprofloxacin degradation product with TiO2 nanoparticles. The optimum condition for the ciprofloxacin degradation with TiO2 nanoparticles is lighting for 5 hours by using a white mercury UV lamp and 50 mg TiO2 nanoparticles with pH solvent of 5.5. The toxicity of ciprofloxacin degradation product with TiO2 nanoparticles was low. The smallest degradation product identified with m/z was p-fluoraniline (m/z 111). Copyright © 2021 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0). 
Co-Authors Ade Nisa’ Kartika Azzahra Aditya F. Ardinsyah Alfian Nur Firdaus Alfian Nur Firdaus Aliyah Purwanti Atiek Rostika Noviyanti Ayik Rosita Puspaningtyas Ayu Wanda Marita Ayu Wanda Marita Azmi Prasasti Azmi Prasasti Diana Rakhmawaty Eddy Diana Rakhmawaty Eddy Dwiki Yudistira Dyah Purwaningtyas Dyan Wigati Eka Fitri Yanti Eka Fitri Yanti Eviyanti Nazareth Fathor Rosi Frida Oktavia Putri Hermanto Haikal Alhamdi Sirojul Alam Ikfira Agustina Putri Ima F. Lestari lindawati setyaningrum Lindawati Setyaningrum Lutfiah Nurul Hakiki Maasyitoh Sari Latifah Mega T. Wulandari Muhamad D. Permana Reno Kurnia Ramadhan Reza Zarkasih Adytia Ridho Anil Shohibul Falah Rifka Nabila Rosita Dina Dwi Ayunliana Sovia Islamiah Sovia Islamiah Stephanie D. Artemisia Syamsiyatul Fajriyah Syamsiyatul Fajriyah Yuana Dwi Agustin