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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Sainteks Pharmacon JURNAL PHARMASCIENCE INDONESIAN JOURNAL OF PHARMACY Pharmascience
Oktavia Indrati, Oktavia
Jurusan Farmasi, Fakultas MIPA, Universitas Islam Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology

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Journal : EKSAKTA: Journal of Sciences and Data Analysis

 1 
Formulation and Evaluation of Kaptopril Tablets Using Threaded Amylum Tubes and HPMC as Fillers and Binders of the Direct Method Ahmad Sastra Kelana; Aris Perdana Kusuma; Oktavia Indrati
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 18, ISSUE 1, February 2018
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/eksakta.vol18.iss1.art2

Abstract

Indonesia is a tropical country which has many potential plants as excipients, likestarches and tubers. Amylum of taro tuber (Colocasia esculenta) has the potential to be developed into excipient but its use is limited. The purpose of this study was to optimize the formulation and to evaluate the characteristics of captopril tablets by using amylum of taro tuber and HPMC modified as filler and binder on direct compression method. Amylum of taro tuber was obtained by extraction process, then combined with HPMC by partial pregelatination and co-process method. Variation of the starch was divided into five formulation. The main test included friability test, hardness test, dissolution test, and assay. The data analysis was done by theoretical approach between the evaluation result and the literature to observe the result of the modification formulation. It indicated that the combination of equal amount of taro amylum and microcrystalline cellulose (MCC) pH 102 (50% : 50%) has the best result among others. Friability percentage was 0.17 ± 0.07%, disintegration time was 12.09 ± 0.52 minutes, assay was 97.88 ± 1.71% and dissolution test results was 90.65 ± 4.81%.
Effervescent Tablet Formulation Melinjo Seed Extract (Gnetum gnemon L.) Using PEG 6000 As Lubricant and Citric Acid - Tartaric Acids As Acid Sources Puput Andi Apsari; Dewi Nur Eka Sari; Aris Perdana Kusuma; Oktavia Indrati
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 18, ISSUE 1, February 2018
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/Eksakta.vol18.iss1.art4

Abstract

Melinjo seeds (Gnetum gnemon L.) have antioxidant properties one of which is from phenol compounds. However, there is no pharmaceutical dosage form of melinjo seeds especially effervescent tablet. The purpose of this research was to determine the best variation of citric-tartaric acid and PEG 6000 from effervescent tablet of melinjo seed extract. The effervescent tablet of melinjo seed extract were formulated with variation of citric-tartaric acid 25%:75%, 65%:35%, 50%:50%, 20%:80% and PEG 6000 0%, 2%, 3%, up to 5%. The effervescent tablet were made by melting parts of acids and bases, added with extract and other ingredients. The evaluation included flow and powder tapping, tablet hardness, weight variation, friability, and tablet solubility test. The data were analyzed by comparing approaches based on the requirements of Pharmacopeia Indonesia V andUnited States of Pharmacopeia 36.Variations of equal amount of citric-tartaric acid produced hard effervescent tablets with small friability. The unbalanced acid concentration resulted in higher friability. The greater the concentration of citric acid resulted in the longer solubility of the tablet. The addition of PEG 6000 made the flow time of granules quicker, while higher concentrations would increase the hardness of tablets and accelerate the soluble time. Excessively high concentrations resulted in a high degree of friability. Variation of citric-tartaric acid and PEG 6000 influenced physical properties of granule and effervescent tablet extract of melinjo seeds, such as flowability, hardness, friability, and solubility of the tablet.
Co-Authors Ahmad Sastra Kelana Akhmad Kharis Nugroho Ari Wibowo Aris Perdana Kusuma, Aris Perdana Bambang Hernawan Nugroho Citrariana, Shesanthi Dewi Nur Eka Sari Ita Nurma Sari Lailiana Garna Nurhidayati Lutfi Chabib, Lutfi Martien, Ronny Muhammad Ikhwan Rizki Puput Andi Apsari Puspa Dwi Pratiwi Rohman, Abdul