Garuda - Garba Rujukan Digital

DRUG RELATED PROBLEMS PAOA PENATALAKSANAAN PASIEN STROKE 01 INSTALASI RAWAT INAP RSAL OR RAMELAN SURABAYA PERIOOE 1 SEPTEMBER m 31 OKTOBER 2006 Bangunawati Rahajeng; Widyati Widyati; Zullies Ikawati
Jurnal Ilmiah Farmasi Vol. 8 No. 2 (2011)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Stroke merupakan penyakit yang memerlukan perawatan jangka panjang sehingga untuk mendapatkan therapeutic outcome yang baik perlu kerjasama antara dokter, perawat, apoteker, pasien, dan keluarga pasien. Kejadian drug related problems sangat umum terjadi pada pasien rawat inap yang berisiko meningkatkan kesakitan, kematian, dan biaya. Penelitian ini bertujuan untuk menelusuri kejadian DRPs pada pasien stroke rawat inap dan untuk mengetahui apakah terjadi DRPs pada penatalaksanaan pasien stroke rawat inap di RSAL Dr Ramelan Surabaya periode 1 September - 31 Oktober 2006. Penelitian dilakukan dengan rancangan studi cross sectional yang dikerjakan secara prospektif terhadap suatu populasi terbatas, yaitu seluruh pasien stroke rawat inap di RSAL Dr. Ramelan Surabaya periode 1 September - 31 Oktober 2006. Data pasien stroke rawat inap didapat dari poli saraf dan UGo, kemudian dilakukan pencatatan status pasien dari rekam medik di bangsal rawat inap. Kekurangan rekam medik dilengkapi dengan melihat catatan perawat, melihat kondisi pasien langsung dengan mengikuti visite dokter, dan wawancara pasien atau keluarga pasien. Data yang diperoleh dilakukan kajian DRPs dengan acuan guidelines stroke yang ada, dihitung persentasenya. Sebanyak 102 dari 109 pasien memenuhi kriteria inklusi. Pad a 102 pasien didapat 67 pasien mengalami DRPs (65,69 %) dan 35 pasien tidak mengalami DRPs (34,31 %). Jenis DRPs yang terjadi adalah drug needed 27 pasien (22,50 %), wrong drug/innappropriate drug 32 pasien (26,67 %), wrong dose 26 pasien (21,67 %), adverse drug reaction 16 pasien (13,33 %), drug interaction 19 pasien (15,83 %). Kata kunci: drug related problems, stroke

Kontrol Glikemik dan Prevalensi Gagal Ginjal Kronik pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Wilayah Provinsi DIY Tahun 2015 Vitarani D. A. Ningrum; Zullies Ikawati; Ahmad H. Sadewa; Mohammad R. Ikhsan
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Universitas Padjadjaran

Pengendalian glikemik yang baik pada diabetes melitus tipe 2 (DMT2) terbukti dapat mencegah penyakit komplikasi akibat DMT2. Puskesmas sebagai sarana pelayanan kesehatan primer merupakan garda terdepan yang diharapkan dapat memberikan pelayanan pengelolaan DMT2 dengan baik untuk mencegah penyakit komplikasi seperti penyakit gagal ginjal kronik (GGK). Kejadian GGK yang seringkali tanpa gejala spesifik serta keterbatasan pemeriksaan diagnostik di puskesmas menyebabkan keterlambatan diagnosis GGK maupun pengelolaan terapi yang sub-optimal. Penelitian ini bertujuan menganalisis kontrol glikemik dan kejadian GGK pada pasien DMT2 di puskesmas serta faktor pasien yang memengaruhi kontrol glikemik dan kejadian GGK. Penelitian potong-lintang pada 6 puskesmas di Yogyakarta tahun 2015 ini melibatkan pasien DMT2 dewasa tanpa riwayat gagal hati kronik. Parameter kontrol glikemik menggunakan Glukosa-Darah-Puasa (GDP), Glycated-Albumin (GA), atau hemoglobin terglikasi (HbA1C), sedangkan nilai eLFG digunakan sebagai dasar klasifikasi GGK. Sebanyak 101 pasien dengan rata-rata usia 50,75±6,73 tahun terlibat dalam penelitian. Kontrol glikemik kategori baik ditemukan hanya pada 13,86% pasien, sedangkan 12,87% pasien mengalami GGK. Tidak ada faktor pasien yang memengaruhi kontrol glikemik. Sementara itu, usia dan durasi DMT2 berkorelasi dengan kejadian GGK (p<0,01). Berdasarkan penelitian ini, kontrol glikemik yang buruk dapat meningkatkan kemungkinan kejadian GGK sebesar 63,64%. Oleh karena itu, diperlukan strategi pengelolaan DMT2 maupun pencegahan GGK yang lebih baik termasuk penyediaan fasilitas pemeriksaan yang memadai untuk meminimalkan kejadian clinical inertia di puskesmas.Kata kunci: Faktor-pasien, gagal ginjal kronik, kontrol glikemik, puskesmas Glycemic Control and Prevalence of Chronic Kidney Disease in Type-2 Diabetes Mellitus Patients at Primary Healthcare Centers in Yogyakarta Province 2015AbstractGood glycemic control in type-2 diabetes mellitus (T2DM) has proven to be able to prevent complications. Primary healthcare is at the forefront being expected to provide good services in T2DM management for preventing such complication as chronic kidney disease (CKD). The incidence of CKD that often shows no specific symptoms and the limitations in diagnostic examinations at primary healthcare centers has caused delay in diagnosis and suboptimal therapy management. This study aimed to determine glycemic controls and prevalence of CKD in patients with T2DM in primary healthcare centers as well as to assess patient’s factors related to the glycemic controls and prevalence of CKD. This cross-sectional study in six primary healthcare centers in Yogyakarta in 2015 involved adult T2DM patients without a history of chronic liver disease. The glycemic control parameters comprised of Fasting-Blood-Glucose (FBG), Glycated-Albumin (GA), or glycated-hemoglobin (HbA1C), while the estimated Glomerular-Filtration-Rate (eGFR) was used as the basis for CKD classification. A total of 101 patients with an average age of 50.75±6.73 years old engaged in the research. Good glycemic control was found in only 13.86% patients, while 12.87% of them had CKD. No patient factors affected the glycemic control. Meanwhile, age and T2DM duration are correlated with the prevalence of CKD (p<0.01). The research found that poor glycemic control was likely to increase the occurrence of CKD amounting to 63.64%. Therefore, better strategies for T2DM management as well as CKD prevention were required, including the provision of adequate examination facilities to minimize the incidence of clinical inertia in primary healthcare centers.Keywords: Chronic kidney disease, glycemic control, patient factors, primary healthcare centers

FAKTOR PASIEN YANG MEMPENGARUHI RESPONGLIKEMIK PENGGUNAAN MONOTERAPI METFORMIN PADA DIABETES MELITUS TIPE 2 Vitarani Dwi Ananda Ningrum; Zullies Ikawati; Ahmad Hamim Sadewa; M. Robikhul Ikhsan; Yunilistiaingsih Yunilistiaingsih
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 6, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.355

Metformin sebagai obat antidiabetik oral terpilih pada terapi diabetes melitus tipe 2 (DMT2) menunjukkan ketidaktercapaian target glikemik pada 35 – 40% pasien. Penelitian ini bertujuan menganalisis faktor pasien yang berpengaruh terhadap respon glikemik penggunaan metformin tunggal pada pasien DMT2. Penelitian kohort prospektif dilakukan pada 5 Puskesmas periode Januari-Oktober 2015 dengan melibatkan pasien DMT2 dewasa tanpa riwayat disfungsi tiroid dan gagal hati kronik. Parameter respon glikemik menggunakan glukosa darah puasa (GDP) dan glycated albumin (GA). Sebanyak 35 pasien dengan rata-rata usia, indeks masa tubuh (IMT), serta eLFG masing-masing yaitu 50,48±6,67 tahun, 25,99±4,79 kg/m2, dan 96,49±18,17 mL/mnt terlibat dalam penelitian. Penelitian menunjukkan selain indeks glikemik awal, faktor demografi pasien tidak berkorelasi baik dengan nilai GDP, GA maupun perubahan nilai keduanya setelah penggunaan rutin monoterapi metformin. Sementara itu, lama terapi metformin sebelumnya mempengaruhi nilai GDP akhir dan perubahan nilai GDP (P<0,05), namun tidak dengan nilai GA setelah penggunaan monoterapi metformin. Penelitian ini merekomendasikan durasi penggunaan rutin metformin sebelumnya perlu dipertimbangkan untuk penentuan waktu pemantauan ketercapaian target glikemik penggunaan metformin dalam implikasinya terhadap penyesuaian besaran dosis pada pasien DMT2.

THE COMPARISON BETWEEN MONOTHERAPY AND POLYTHERAPY IN EPILEPSY IDIOPATHIC GENERALISED TONIC CLONIC Ratna Wijayatri; Zullies Ikawati; Abdul Ghofir
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 3, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.106

The prevalence of epilepsy in the world reachs 5-20 per 1000 population. In Indonesia, the prevalence of epilepsy is approximately at 0.5-1.2%. Antiepilepsy drug has an important role in the epilepsy treatment. This study was aimed to know the effectiveness and safety of monotherapy treatment compared to polytherapy in terms of seizure frequency, seizure-free duration, and adverse drug reaction. This study was the observational research. The data were collected prospectively using instruments i.e.: seizure diaries and APS (Adverse Drug Reaction Probability Scale). Subject of this study were epileptic patient with idiopathic generalized tonic clonic who receive either polytherapy or monotherapy in neurological clinic of Dr. Sardjito Hospital on May-June 2012 period, which fulfilled the inclusion criteria. The data from monotherapy and polytherapy group was analysed in term of seizure frequency, seizure-free duration and adverse drug reaction. Result showed that monotherapy treatment more effective in controlling seizure (reduce the frequency of seizure) compared to polytherapy (<0.05). Percentage of seizure free was 83% in monotherapy compared to 48% in polytherapy. The prevalence of adverse drug reaction was about 20% in monotherapy and 14% in polytherapy. Based on the interview, although monotherapy caused more adverse drug reaction than that in polytherapy, the drug adverse reaction in monotherapy was milder and did not annoy patient convenience.Keywords: Epilepsy, Idiopathic Generalised Tonic Clonic, Monotherapy, Polytherapy, Adverse Drug Reaction

DRUG RELATED PROBLEMS ON CHILDREN IN-PATIENTS WITH LOWER RESPIRATORY TRACT INFECTION AND ASTHMA IN PANTI RAPIH HOSPITAL YOGYAKARTA ON 1ST JANUARY – 30TH JUNE 2006 Dyah Anggraeni Budhi Pratiwi; Zullies Ikawati; Wara Kusharwanti
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 1, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.50

Drug related problems commonly happen to children. The treatment of these problems should be prioritizedbecause their physiologic factor have not perfect yet, so the drugs metabolism and absorption are different. Lowerrespiratory tract infection and astma were causes of children’s pain, and its also still become major problem in medicalfield. This research was generally aimed for investigating drug related problems happened to children with lower respiratory infection in Panti Rapih Hospital Yogyakarta on January until June 2006.This was a non-experiment research conducted in descriptive concept through retrospective data collecting from the medical record of children with lower respiratory tract infection and astma treated in Panti Rapih Hospital Yogyakarta on January until June 2006. These problems were analyzed from the medical record of the patients andthen analized percentage of drug related problems.There were 77 patients who fit the inclusion criteria in this research, number of children in patients with lowerrespiratory tract infection was 55 patients and 22 patients for asthma. The result of research to children in patients with lower respiratory tract infection showed that unnecessary drug therapy was 20%, Wrong drug was 12.72%,too low dosage was 7.27%, too high dosage was 21.81%, and drug interactions was 12.72%. The result of research tochildren in patients with asthma showed that unnecessary drug therapy was 18.18%, wrong drug was 4.54%, dosagetoo high was 13.63%, Drug interactions was 50% and uncompliance was 4.54%. Key words: Drug Related Problems, Lower Respiratory Tract Infection, Pediatric

EFFECT OF GIVING ANTIHYPERTENSIVE DRUG AGAINST REDUCTION OF BLOOD PRESSURE IN ACUTE ISCHEMIC STROKE PATIENTS WHO HOSPITALIZED IN RSUP DR. SARDJITO YOGYAKARTA Wahyu Sedjatiningsih; Zullies Ikawati; Abdul Gofir
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 2, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.85

Incidence of ischemic stroke 10 times more often than haemorrhagic stroke in the the west countries, but haemorrhagic stroke has a higher risk of mortality than ischemic stroke. One focus of acute stroke management is the management of hypertension. Blood pressure reduction in ischemic stroke patients could potentially reduce the risk of brain edema, the risk of hemorrhage, and prevent further vascular damage. However, an aggressive blood pressure reduction can cause a decrease in perfusion pressure to the ischemic area. Most hypertensive patients require two or more antihypertensive medications to achieve blood pressure targets. This study used observational study design with retrospective data collection on medical records of acute ischemic stroke patients and performed in RSUP Dr. Sardjito Yogyakarta period January 2010-December 2010. Data were analyzed with descriptive analysis and chi-square evaluative analysis on the relationship between the type of therapy with a reduction in blood pressure of acute ischemic stroke patients. Initial antihypertensive medication use in patients with acute ischemic stroke in RSUP Dr. Sardjito were 13 types of five classes of antihypertensive drugs. After getting a single antihypertensive medication, patients who experienced a decrease in systolic blood pressure on day-3 was 60%, while 17% fixed and 23% up and after getting a combination of antihypertensive medications, patients who experienced a decrease in systolic blood pressure on day-3 was 75%, while 10% fixed and 15% rise. Antihypertensive drug therapy alone or in combination had the same ability to lower systolic blood pressure (p = 0.260) and diastolic (p = 0.567) in patients with acute ischemic stroke in RSUP Dr. Sardjito Yogyakarta. Keywords: Hypertension, acute ischemic stroke, single antihypertensive drug, antihypertensive drug combinations, RSUP Dr.Sardjito Yogyakarta

Perbandingan Efektivitas Regimen Terapi Antipsikotik Pasien Schizophrenia di RSJ Dr. Ernaldi Bahar Palembang Saharuddin Saharuddin; Zullies Ikawati; Cecep Sugeng Kristanto
Majalah Farmaseutik Vol 17, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v17i2.58508

Penatalaksanaan schizophrenia menawarkan berbagai macam metode baik dengan terapi nonfarmakologi maupun farmakologi. Terapi farmakologi dengan antipsikotik merupakan terapi pokok dalam penatalaksanaan schizophrenia. Namun, efektivitas antara regimen antipsikotik masih menjadi perdebatan, sehingga penting untuk mengetahui efektivitas suatu regimen terapi pengobatan schizophrenia. Penelitian ini bertujuan untuk mengetahui perbandingan efektivitas regimen terapi antipsikotik pada pasien schizophrenia di RSJ dr. Ernaldi Bahar Palembang. Rancangan penelitian ini adalah Cohort Prospective pre – post test menggunakan alat bantu kuesioner penelitian The Positive and Negative Syndrome Scale (PANSS). Data diambil di Poliklinik Rawat Jalan RSJ dr. Ernaldi Bahar Palembang periode bulan Maret – April 2020. Uji chi-square digunakan untuk mengetahui perbandingan efektivitas regiman terapi antipsikotik. Sebanyak 451 pasien yang terdiagnosa schizophrenia ditelusuri pengobatannya dan diperoleh 35 jenis pola peresepan antipsikotik pada semua pasien. Dipilih tiga (3) regimen antipsikotik yang terbanyak digunakan untuk dianalisis efektivitasnya yaitu monoterapi risperidone (n=59), kombinasi risperidone dengan klorpomazine (n=59) dan kombinasi risperidone dengan clozapine (n=59). Hasil penelitian ini menemukan tidak adanya perbedaan efektivitas yang bermakna berdasarkan penurunan skala PANSS antara regimen terapi antipsikotik pada pasien schizophrenia di RSJ dr. Ernaldi Bahar Palembang dengan nilai signifikan p>0,05 (p=0,173).

Title

Found 7 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 7 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 7 Documents
Search