Garuda - Garba Rujukan Digital

Quantitative structure-cytotoxic activity relationship of phenylthiourea derivatives from ChemBL database on sirtuin-1 receptor by in silico Nasyanka, Anindi Lupita
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 1 (2019): April
Publisher : University of Muhammadiyah Malang

Rational drug design becomes a necessity amid the development of drugs that are inefficient and time-consuming. Hansch's QSAR helps reduce these shortcomings supported by the role of biocomputation. Some of the roles of biocomputation that can be used include in silico testing and the availability of databases for new drug-receptor and ligand candidates. This study aims to determine the QSAR through the search for the best equations analyzed by ANOVA statistics between cytotoxic activity in silico (Log 1/c) anticancer compounds derived from phenylthiourea stored in the ChemBL database with lipophilic parameters (ALPP and AlogP) , electronic (ACDpKa), and its sterics (PMW). The best equation is obtained Log 1/c = -46,194 - 0,152 PMW- 3,769 ALogP - 1,336 ACDpKa with a value of N = 28; F = 20,866; r = 0,850;Â P = 0,000; SE = 5.82160. In the future, this equation can be used to find other new phenylthiourea derivatives that have better cytotoxic activity.

Profil Kesesuaian Penulisan Resep Pada Pasien Umum Eawat Inap Dengan Formularium Di Rumah Sakit Bedah Mitra Sehat Lamongan Nasyanka, Anindi Lupita; Maesaroh, Dewi; Arizka, Hawwin Elina
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 1 No 02 (2020): HERCLIPS VOL 01 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v1i02.1414

The hospital minimum service standard becomes the minimum reference for assessing the services provided by the hospital. One important point is the suitability of prescribing to patients based on hospital formulary. In this study aims to determine the suitability profile of inpatient prescribing in Rumah Sakit Bedah Mitra Sehat Lamongan with hospital formulary. The research method used was cross-sectional with accidental sampling as many as 614 prescriptions from May until June 2019. The results showed that the percentage of compliance with the average prescribing in May-June did not reach the minimum service standards (100%). therefore, a periodic evaluation of the formulary and outreach is needed to all doctors who write prescriptions for inpatients Keyword : prescribing, hospital formulary, inpatient

Identifikasi Glikosida dan Evaluasi Fisik Formula Pemanis Rendah Kalori Tanaman Stevia (Stevia rebaudiana Bentoni) Pada Minuman Fungsional Bir Pletok indahsari, dita dwi; Nasyanka, Anindi Lupita; Na'imah, Janatun
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 2 No 1 (2020): Herclips vol.2 no.1
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v2i1.2209

Instant drinks, which are often consumed by the public, are mostly sweetened drinks that contain high calories and artificialsweeteners and can cause various diseases, such as obesity, cancer, diabetes and others. This can be controlled and prevented by consuminglow-calorie sweeteners. Stevia is a plant that has a sweetness of 300 times that of sucrose, so it can be used as a low-calorie sweetener, suchas in the functional drink Pletok beer. This study aims to identify glycosides and to evaluate the physical evaluation of the low-caloriesweetener formula for Stevia (Stevia rebaudiana B.) in the functional beverage of Bir Pletok. Physical evaluation and hedonism test werecarried out on 20 panelists and 1 expert panelist, then analyzed descriptively. In this study, several tests of instant preparations were carriedout, namely organoleptic test, pH test, specific gravity test, movable volume test and hedonism test on 20 panelists and 1 expert panelist. Theresults of the research that have been done show that the leaves of Stevia (Stevia rebaudiana B.) contain diterpenoid glycosides and based onall test preparations the best formula of the three formulas is Formula II. Keywords: Sweeteners, Stevia, Functional Drinks, Bir Pletok, Glycosides.

Pembuatan Sabun Pembersih Wajah Dari Ekstrak Daun Jambu Biji Na'imah, Janatun; Nasyanka, Anindi Lupita
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 2 No 02 (2021): HERCLIPS VOL 02 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v2i02.2387

Sabun pembersih wajah umumnya mempunyai kemampuan daya bersih yang baik, khususnya pada kulit yang berjerawat. Salah satu bahan alam yang membantu pembersihan tersebut ialah daun jambu biji . Ekstrak daun jambu biji memiliki kandungan beberapa metabolit sekunder, seperti golongan tanin, triterpenoid, glikosida dan flavanoid, yang memiliki aktivitas antijerawat. Selain itu, pemilihan bentuk sediaan juga mempengaruhi daya bersih suatu sabun pembersih. Oleh karena itu, pada penelitian ini telah dilakukan pembuatan emulgel sabun pembersih yang berasal dari daun jambu biji serta dilakukan evaluasi fisik sesuai spesifikasi dan persyaratan yang ditentukan. Hasil penelitian menunjukkan emulgel sabun pembersih dengan kadar ekstrak 9,779% memenuhi spesifikasi evaluasi organoleptis, pH, viskositas, daya sebar, daya bersih, dan tinggi busa. Namun, uji homogenitas masih belum memenuhi persyaratan sehingga diperlukan optimasi terkait pemilihan teknik pembuatan.

Gambaran Peresepan Antibiotik Golongan Fluorokuinon Pada Pasien Rawat Jalan di RUmah Sakit Ibnu Sina Gresik shofiyah, lailatus; Nasyanka, Anindi Lupita; Na'imah, Janatun
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 2 No 1 (2020): Herclips vol.2 no.1
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v2i1.2174

One of the indicators used in assessing the success of drug use is prescription. Fluoroquinolone antibiotiks are one of the most frequently prescribed drugs. if the use is too high it will cause antibiotik resistance. The purpose of this study was to determine the overview of fluoroquinolone antibiotik prescription in outpatients at Rumah Sakit Ibnu Sina Gresik with a descriptive observational study design that carried out retrospective secondary data collection. This study used a population of all outpatient prescriptions who received fluoroquinolone class antibiotik therapy on February 1, 2020 - February 29, 2020 at the Outpatient Pharmacy Installation of Rumah Sakit Ibnu Sina Gresik with a sample size of 311 sheets of prescriptions taken by total sampling technique. It can produce the highest prescription profile from each of the analysis variables, namely 1 antibiotik item of 88.75%, lung clinic 21.87%, capsule preparation 58.80%, over 55 years of age 47.91%, generik fluoroquinolones 81.67% BPJS patients were 67.52% and fluoroquinolone second generation 69.77%. These results can be seen from the overview of outpatient prescriptions at Rumah Sakit Ibnu Sina Gresik on February 1 - February 29, 2020. Keywords: Prescribing, Antibiotik, Fluoroquinolone

Quantitative structure-cytotoxic activity relationship of phenylthiourea derivatives from ChemBL database on sirtuin-1 receptor by in silico Anindi Lupita Nasyanka
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 4 No. 1 (2019)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i1.7745

Rational drug design becomes a necessity amid the development of drugs that are inefficient and time-consuming. Hansch's QSAR helps reduce these shortcomings supported by the role of biocomputation. Some of the roles of biocomputation that can be used include in silico testing and the availability of databases for new drug-receptor and ligand candidates. This study aims to determine the QSAR through the search for the best equations analyzed by ANOVA statistics between cytotoxic activity in silico (Log 1/c) anticancer compounds derived from phenylthiourea stored in the ChemBL database with lipophilic parameters (ALPP and AlogP) , electronic (ACDpKa), and its sterics (PMW). The best equation is obtained Log 1/c = -46,194 - 0,152 PMW- 3,769 ALogP - 1,336 ACDpKa with a value of N = 28; F = 20,866; r = 0,850; P = 0,000; SE = 5.82160. In the future, this equation can be used to find other new phenylthiourea derivatives that have better cytotoxic activity.

Penyuluhan Masyarakat Mojogede Pada Pemanfaatan Minuman Fungsional Kombinasi Jahe dan Serai Janatun Na'imah; Heru Baskoro; Anindi Lupita Nasyanka
Jurnal Gema Ngabdi Vol. 2 No. 3 (2020): Jurnal Gema Ngabdi
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jgn.v2i3.90

Coronavirus Disease 2019 (Covid-19) is a new type of disease that has never been identified before in humans. The virus that causes Covid-19 is called Sars-CoV-2. This research was conducted to educate the public about the use of ginger and lemongrass functional drinks to improve immunity. The method of implementing Community Service is carried out interactively with a video conversion application ZOOM on 25 youth cadets in the village of Mojogede, Balongpanggang Gresik on June 14, 2020. Before starting the event the participants were given a face shield that must be used during the event as an effort to implement health protocols. Furthermore, pre-test is given first, then material exposure is carried out and continued filling in post-test with the same problem. Based on the results of the pre-test and post-test obtained an increase in public knowledge which was 79.09% to 89.23%.

Monitoring Pengetahuan Tanya 5O dan Dagusibu Obat yang Benar pada Ibu PKK RT/RW 003/003 Desa Kedanyang, Kebomas, Gresik Janatun Na’imah; Anindi Lupita Nasyanka; Riskha Aulia
ACADEMICS IN ACTION Journal of Community Empowerment Vol 2, No 1 (2020)
Publisher : President University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33021/aia.v2i1.1102

At this time, community does not understand classes of drugs that can be purchase or stored at home. This can have two impacts, positive and negative. The positive impact is community become more responsive to health, while the negative impact is increasing use of drugs which raises problems related to how to get, use, store and dispose of drugs properly or commonly known as Dagusibu. This community service activity aims to educating housewives as "pharmacists" in the household regarding how to get, use, store, and dispose of drugs properly in Kedanyang Village RT/RW 003/003, Kebomas, Gresik. Method that we use in this community service is counseling and training using property and followed with monitoring. We use questionnaire for monitoring a month after counseling and training. Our method to counseling and training involve several variable, including Question of 5”O”, Get, Use, Save and Discard (Dagusibu). The result shows that this activity is effective with the percentage of correct answer for each variable are above 75%, including question about 5”O" as much as 97%, get 84.38%, use 87.14%, save 76%, and waste 93%. This proved that the method chosen in this community service is appropriate, where the community still remember and understand.

Edukasi Interaktif dan Aplikasi Media Komik Strip Vaksin COVID-19 Kepada Mahasiswa Sebagai Upaya Pemenuhan Cakupan Vaksinasi COVID-19 Tahap 3 Anindi Lupita Nasyanka; Janatun Na'imah; Diah Ratnasari
Jurnal Surya Masyarakat Vol 4, No 1 (2021): November 2021
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.4.1.2021.29-37

Covid-19 is still a health problem for the past two years. Various prevention strategies have begun to be implemented in Indonesia in fighting the COVID-19 pandemic, namely from Work From Home (WFH), 3M's motto, and vaccination. Immunization coverage in Indonesia is still relatively small, which is below 50% until the second stage of vaccination. Therefore, an effort is needed to increase the coverage of COVID-19 vaccination in the third stage, which is targeting students. Students are the millennial generation who like creativity and get bored easily in learning something. This service activity aims to increase student knowledge about Covid-19 vaccination so as to increase vaccination coverage. The method used in this activity werw interactive education for 59 students from two different universities through zoom and distributing comic strip media related to three materials, including an introduction to the immune system, the covid-19 vaccine in Indonesia, and facts and hoaxes about the Covid-19 vaccine. The increase in knowledge was measured using a googleform questionnaire in the form of post-test and pre-test. The results of the activity was showed an increase in knowledge up to 70.82%. In addition, participants who have not vaccinated were willing to immunize after this activity with a percentage of 80%. The distribution of comic strip media was expected to help students remember the information and transmit it to the surrounding community groups.

Edukasi Interaktif dan Aplikasi Media Komik Strip Vaksin COVID-19 Kepada Mahasiswa Sebagai Upaya Pemenuhan Cakupan Vaksinasi COVID-19 Tahap 3 Anindi Lupita Nasyanka; Janatun Na'imah; Diah Ratnasari
Jurnal Surya Masyarakat Vol 4, No 1 (2021): November 2021
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.4.1.2021.29-37

Covid-19 is still a health problem for the past two years. Various prevention strategies have begun to be implemented in Indonesia in fighting the COVID-19 pandemic, namely from Work From Home (WFH), 3M's motto, and vaccination. Immunization coverage in Indonesia is still relatively small, which is below 50% until the second stage of vaccination. Therefore, an effort is needed to increase the coverage of COVID-19 vaccination in the third stage, which is targeting students. Students are the millennial generation who like creativity and get bored easily in learning something. This service activity aims to increase student knowledge about Covid-19 vaccination so as to increase vaccination coverage. The method used in this activity werw interactive education for 59 students from two different universities through zoom and distributing comic strip media related to three materials, including an introduction to the immune system, the covid-19 vaccine in Indonesia, and facts and hoaxes about the Covid-19 vaccine. The increase in knowledge was measured using a googleform questionnaire in the form of post-test and pre-test. The results of the activity was showed an increase in knowledge up to 70.82%. In addition, participants who have not vaccinated were willing to immunize after this activity with a percentage of 80%. The distribution of comic strip media was expected to help students remember the information and transmit it to the surrounding community groups.

Title

Found 25 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 25 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 25 Documents
Search