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All Journal Jurnal Kedokteran Diponegoro Sari Pediatri Paediatrica Indonesiana Medica Hospitalia Diponegoro International Medical Journal (DIMJ) eJournal Kedokteran Indonesia

Anindita Soetadji

Department Of Child Health, Diponegoro Univetsity Medical School/Dr. Kariadi Hospital, Semarang, Central Java

Author-ID : 2666945

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 9 Documents Claim Missing Document

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Articles

Hubungan Pengetahuan dengan Perilaku Kesehatannya pada Orangtua Anak dengan Penyakit Jantung Bawaan Nisa Alifia Rahmi; Anindita Soetadji
Medica Hospitalia : Journal of Clinical Medicine Vol. 1 No. 3 (2013): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar belakang : Setiap tahun di Indonesia diperkirakan akan lahir 40.000 bayi dengan Penyakit Jantung Bawaan (PJB). Jumlah tindakan bedah dan intervensi non bedah yang dilakukan pada anak PJB menunjukkan kenaikan, namun angka kematian masih tetap tinggi. Orangtua sebagai bagian yang paling dekat dengan anak diharapkan mempunyai pengetahuan yang cukup serta sikap yang mendukung sehingga akan terbentuk perilaku kesehatan yang menunjang perawatan anak dengan PJB. Tujuan penelitian ini adalah untuk mengetahui hubungan antara pengetahuan dan perilaku orangtua terhadap anak dengan penyakit jantung bawaan Metode : Penelitian observasional dengan pendekatan cross sectional. Subyek penelitian adalah orangtua yang mempunyai anak dengan PJB yang datang ke Poliklinik RSUP Dr. Kariadi Semarang bulan Maret–Juni 2010. Pengambilan data dilakukan dengan pengisian kuesioner terpimpin yang telah diujicobakan. Data dianalisis dengan uji korelasi Spearman menggunakan SPSS ver 15 for Windows dengan nilai p<0,05. Hasil : Jumlah responden pada penelitian ini sebanyak 30, terbanyak usia 31–40 tahun (53,33%). Pendidikan terbanyak SD (37%), pekerjaan ibu terbanyak adalah ibu rumah tangga (83%). Sumber biaya kesehatan yang banyak digunakan adalah asuransi (jamkesmas dan jamsostek) sebesar 93%. Sebanyak 86,7% responden mempunyai tingkat pengetahuan sedang dan 76,7% responden berperilaku baik. Tidak ada hubungan bermakna antara pengetahuan dengan perilaku orangtua terhadap anak dengan PJB, didapatkan r=0,216. Simpulan : Pengetahuan tidak berhubungan bermakna dengan perilaku orangtua terhadap anak dengan PJB. Ada faktor-faktor lain yang lebih mempengaruhi perilaku orangtua sehingga diperlukan penelitian lebih lanjut mengenai faktor-faktor ini. Kata kunci : Pengetahuan, perilaku, penyakit jantung bawaan

The difference of physical fitness of short stature children with and without Channa striata extract (CSE) supplementation Arif Faiza; Mohammad Syarofil Anam; Anindita Soetadji; Maria Mexitalia
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Background: Physical fitness affected by aortic elasticity which is increased appropriately with insuline growth factor-1 (IGF-1). Channa striata extract (CSE) supplementation increased arginine serum level and further lead to increase of IGF-1, endothelial dysfunction remodeling, and physical fitness. The current study aimed to explore the difference of physical fitness of short stature children with and without CSE supplementation. Method: This cross sectional study conducted to 100 short stature children (male 58; female 42; CSE 50; placebo 50) aged 8-12 years in Brebes, Central Java Indonesia. Short stature was defined as the height/age Z score between -2 and -3 based on WHO 2007 growth chart standard. Physical fitness was measured by modified Harvard step test as stated as VO2max, physical activity by physical activity record and stated as physical activity level (PAL). Data was analyzed by independent t-test and Pearson correlation. Results: VO2max level was higher in CSE 41.67 ± 6.967 ml/kg/minutes and placebo 41.16 ± 5.238 mL/kg/minutes, p=0.682. Hemoglobin level was higher in CSE than placebo (13.12 ± 0.932; 12.99 ± 0.878) g/dL; p=0.5020. All children revealed active category on PAL. The results showed a significant relationship between PAL and physical fitness, hemoglobin and PAL on CSE (p<0.05), however there was no correlation between hemoglobin level and physical fitness. Conclusion: Physical fitness in short stature children with CSE supplementation or placebo was good category. There was no differences between hemoglobin level and PAL in both of groups. There was no difference between physical fitness in short stature children with CSE supplementation or placebo. Keywords: physical fitness, short stature, physical activity, hemoglobin level

BARRIERS TO THE IMPLEMENTATION OF ISONIAZID PREVENTIVE THERAPY AMONG CHILDREN UNDER FIVE YEARS OLD IN CLOSE CONTACT WITH SPUTUM SMEAR-POSITIVE TB PATIENTS Tirsa Hizkia Saverina Nugroho; Anindita Soetadji; Dea Amarilisa Adespin; Stefani Candra Firmanti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29456

Background: The implementation of isoniazid preventive therapy (IPT) among children under five years old in close contact with sputum smear-positive TB patients is still low. Only 21,7% of children implemented the IPT in Central Java in 2017. Assessment of the barriers to IPT implementation needs to be carried out in the control of child TB cases.Objective: To analyze the barriers to IPT implementation among children under five years old in close contact with sputum smear-positive TB patients.Methods: A cross-sectional study was conducted among children (age <5 years) in close contact with sputum smear-positive TB patients. Data were collected from KRMT Wongsonegoro Hospital, Dr. Adhyatma, MPH Hospital, Puskesmas Kedungmundu, and Puskesmas Bandarharjo. Structured questionnaires were used to obtain sociodemographic information and to identify associated barriers to IPT implementation. The data were analyzed using Fisher’s exact test.Results: The majority (93,3%) of the total subject (75) of this study did not implement the IPT. The results of the bivariate analysis showed that distance to health facilities (p=0.024), perceived barriers (p=0.016), and cues to action (p=0.001) had a significant association as barriers to IPT implementation. Meanwhile age (p=0.622), gender (p=2.121), education level (p=0.073), economic level (p=0.521), knowledge level (p=0.166), and perceived threats (p=0.316) had no significant association as barriers to IPT implementation.Conclusion: IPT implementation rate is low. The barriers were distance to health facilities, perceived barriers, and cues to action.

Dampak Penambahan Digoksin terhadap Kapasitas Fungsional Penyakit Jantung Bawaan Pirau Kiri ke Kanan yang Mengalami Gagal Jantung Dana Sumanti; Anindita Soetadji; Nanik Tri Mulyani
Sari Pediatri Vol 16, No 6 (2015)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Latar belakang. Efek penambahan digoksin terhadap kapasitas fungsional menunjukkan hasil yang berbeda.Beberapa penelitian menyebutkan bahwa digoksin dapat meningkatkan kapasitas fungsional, tetapi penelitianlain tidak. Uji jalan enam menit adalah uji yang mudah dilaksanakan untuk menilai kapasitas fungsionalindividu.Tujuan. Mengetahui manfaat penambahan digoksin selama satu bulan terhadap kapasitas fungsional pasienPJB pirau kiri ke kanan yang mengalami gagal jantung.Metode. Uji klinis dilaksanakan di Rumah Sakit Umum Pusat Dr Kariadi Semarang. Uji jalan enam menitdilakukan pada kedua kelompok penelitian sebelum dan sesudah perlakuan. Analisis statistik menggunakanuji â€“t berpasangan dan Mann-Whitney.Hasil. Tigapuluh empat subjek dapat menyelesaikan penelitian. Didapatkan perbedaan jarak tempuh uji jalan6 menit pada kelompok digoksin sebelum dan sesudah perlakuan (p=0,002). Tidak terdapat perbedaan jaraktempuh uji jalan 6 menit pada kelompok kontrol sebelum dan sesudah perlakuan (p=0,77). Perbandinganselisih jarak tempuh uji jalan 6 menit pada kelompok digoksin dan kontrol berbeda signifikan (p=0,019).Analisis kurva ROC (receiver operating curve) menunjukkan area di bawah kurva ROC untuk delta jaraktempuh sebelum dan sesudah perlakuan pada kedua kelompok 0,82. Delta jarak tempuh sebelum dansesudah perlakuan baik dengan cut of point 2,75 meter.Kesimpulan. Penambahan digoksin dapat meningkatkan kapasitas fungsional pada pasien PJB pirau kirike kanan yang mengalami gagal jantung

Kadar N-terminal Pro Brain Natriuretic Peptide Anak Penyakit Jantung Bawaan Pirau Kiri ke Kanan pada Sindrom Down Wardati Rahma; Anindita Soetadji
Sari Pediatri Vol 17, No 2 (2015)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Latar belakang. Faktor yang dapat memengaruhi kinerja jantung pada anak dengan sindrom Down kemungkinan dapat memengaruhikadar hormon N-Terminal Pro Brain Natriuretic Peptide (NT-proBNP) dalam darah. Kadar NT-proBNP lebih tinggi pada anaksindrom Down. Kadar NT-proBNP anak penderita PJB dengan gagal jantung akan sangat tinggi karena berhubungan dengan fungsiventrikel.Tujuan. Membuktikan adanya perbedaan kadar NT-proBNP anak penyakit jantung bawaan (PJB) pirau kiri ke kanan bukan sindromDown dan dengan sindrom Down menurut klasifikasi fungsional.Metode. Penelitian observasional analitik belah lintang di RSUP Dr. Kariadi. Perhitungan jumlah sampel ditentukan dengan rumusbesar sampel untuk uji beda dua kelompok tidak berpasangan. Metode sampling secara konsekutif. Kadar NT-proBNP ditentukandengan metode ELISA. Uji Mann-Whitney dilakukan untuk menganalisis perbedaan kadar NT-proBNP anak PJB pirau kiri ke kananbukan sindrom Down dan dengan sindrom Down.Hasil. Lima puluh subyek yang terdiri atas 25 anak PJB pirau kiri ke kanan bukan sindrom Down dan 25 anak PJB pirau kiri kekanan dengan sindrom Down dilibatkan dalam penelitian. Tidak terdapat perbedaan kadar NT-proBNP anak PJB pirau kiri ke kananbukan sindrom Down dan dengan sindrom Down menurut klasifikasi fungsional (p=0,828).Kesimpulan. Tidak ada perbedaan kadar NT-proBNP antara anak sindrom Down yang menderita PJB pirau kiri ke kanan denganbukan sindrom Down.

Hubungan antara Besarnya Defek Septum Ventrikel dengan Fungsi Paru Nurlina Kumala Sari; Anindita Soetadji; M. Sholeh Kosim
Sari Pediatri Vol 16, No 3 (2014)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Latar belakang. Pada anak dengan defek septum ventrikel (DSV), terjadi peningkatan aliran darah ke paru. Semakin besar DSV, semakin meningkat aliran darah ke paru maka risiko infeksi saluran pernafasan akut dan gagal jantung meningkat dan menganggu fungsi paru. Fungsi paru yang baik penting untuk pemeliharaan suplai oksigen saat sebelum dan setelah dilakukan operasi. Spirometri merupakan alat yang penting dan praktis dalam menilai fungsi paru. Perbandingan FEV1/FVC digunakan untuk mendiagnosis dan membedakan antara penyakit paru obstruktif dan restriktif.Tujuan. Membuktikan adanya hubungan antara besarnya DSV, flow ratio, klasifikasi gagal jantung, frekuensi infeksi respiratori akut (IRA), dan status gizi dengan fungsi paru.Metode. Dilakukan penelitian observasional dengan pendekatan cross-sectional di RS dr. Kariadi dari bulan September 2011 sampai dengan Desember 2012. Subjek anak dengan DSV yang belum dilakukan operasi, umur 5-14 tahun yang mendapat terapi di instalasi rawat jalan RS dr. Kariadi. Dilakukan ekokardiografi untuk mengukur diameter DSV dan flow ratio (Qp/Qs) dan spirometri untuk menilai fungsi paru melalui pengukuran (FEV1/FVC). Analisis statistik dengan uji korelasi Spearman dan uji Fisherâ€™s Exact.Hasil. Subjek terdiri atas 20 anak dengan DSV (65% perempuan). Rerata diameter DSV 12,32 mm (SB 9,18), rerata dari flow ratio 2,63 (SB 0,92), rerata frekuensi IRA 4,60 kali (SB 2,98). Rerata FEV1/FVC adalah 94,1% (SB 9,82). Ukuran DSV besar, flow ratio yang tinggi, dan seringnya IRA mempunyai risiko tinggi untuk terjadinya gangguan fungsi paru restriktif, secara berturut-turut dengan RP=1,5 (p=0,038), RP=1,8 (p=0,009), RP=1,5 (p=0,038). Status gizi berhubungan sedang dengan fungsi paru (r=0,604, p=0,005).Kesimpulan. DSV besar, flow ratio, frekuensi IRA, dan status gizi berhubungan dengan fungsi paru.

The influence of intrauterine growth retardation on cardiac function, left ventricular mass and superior vena cava return in newborns Anindita Soetadji; Najib Advani; Asril Aminullah; Sudigdo Sastroasmoro
Paediatrica Indonesiana Vol 51 No 3 (2011): May 2011
Publisher : Indonesian Pediatric Society

Background Low birth weight (LBW) in neonates is a problemÂ leading to high morbidity and mortality. Barker hypothesized thatÂ fetal cardiac remodeling during hypoxic conditions or maternalÂ underô€nutrition is a risk factor for coronary heart disease in theyoung. Early vascular changes may influence cardiac function andÂ newborns' cerebral blood flow.Objective The aim of this study was to detennine the effectsÂ of being small for gestational age (SGA) on newborns' cardiacÂ function, left ventricular (LV) mass and superior vena cavaÂ (SYC) return.Methods This crossô€sectional study was conducted in CiptoÂ Mangunkusumo Hospital from February to June 2008. LBW andÂ nonnal newborns who fulfilled the inclusion criteria were recruitedÂ as subjects. Maternal history, infant physical examination, and echocardiography were obtained Mthin 48 hours oflife to excludeÂ those with congenital heart disease, and assess cardiac functionÂ and SYC flow.Results Subjects were 21 preterm appropriate for gestationalÂ age (AGA), 19 SGA and 19 normal newborns. SGA newbornsÂ showed lower LV mass, stroke volume and cardiac output thanÂ normal newborns. However, these SGA parameters were notÂ different from preterm AGA babies. In additio n, LV mass indexÂ was sig nificantly different but no difference ofSVC return betweenÂ the three groups.Conclusion SGA newborns' LV function was lower than that ofÂ nonnal newborns, as low as pretenn AGA newborns. N onnal SVCÂ return was observed in the three groups. This finding may be dueÂ to a brainô€sparing effect to maintain sufficient cerebral blood flowin the fetus.

The Association between Serum Malondialdehyde and Nitric Oxide Level of Children Living In Area of Chronic Pesticide Exposure Astra Parahita; Galuh Hardaningsih; Anindita Soetadji
Diponegoro International Medical Journal Vol 1, No 1 (2020): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i1.7897

Background: Chronic exposure of organophosphate pesticides is an oxidative stress that causes liver and aortic damage. Malondialdehyde (MDA) is a biological marker of oxidative damage to cell lipids membrane. The liver produces insulin growth factor-1 (IGF-1) which stimulates the enzyme nitric oxide synthase (eNOS) to produce vascular nitric oxide (NO). Children who are living in those area may be exposed to pesticide chronically. Objective: The study aims is to determine the relationship between serum MDA and NO level of children living in an area of chronic pesticide exposure.Method: Cross sectional study was conducted to 50 children aged between 8 – 10 years in agriculture areas of Brebes. Serum MDA and NO level was measured at the same time using ELISA method, data were shown on numerical scale. Statistical analysisby Pearson correlation.Result: Fifty children met the criteria, consisting of 30 males (60%) and 20 females (40%). The mean of serum MDA level in males, females, and total subjects were normal 6.03 (3.86) µg/ mL, 5.18 (2.11) µg/ mL, and 5.69 (2.60) µg/ mL, respectively. The mean of serum NO level in males, females, and total subjects were increased 79.42 (50.78) µmol/ L, 68.11 (50.81) µmol/ L, and 74.90 (50.58) µmol/ L, respectively. There was no association between serum MDA and NO level found.Conclusion: Serum NO level of children living in an area of chronic pesticide exposure was higher than normal value. However, there was no association between serum MDA and NO level found.

Clinical Characteristics of Down Syndrome with Congenital Heart Disease Safira Azzahra; Agustini Utari; Anindita Soetadji
eJournal Kedokteran Indonesia Vol 10, No. 1 - April 2022
Publisher : Faculty of Medicine Universitas Indonesia

Down syndrome (DS) or trisomy 21, causes overexpression of genes in most affected organs, including congenital heart disease (CHD). CHD is found in 40-60% of people with DS, with a high mortality rate in early life.Clinical signs and symptoms often found are essential indicators of early diagnosis of CHD. This study aimed todetermine the clinical characteristics of DS children with and without CHD. This study was a retrospective study.The study was conducted on August until October 2019. We took data from the inpatient and outpatient medicalrecords database for the years 2017-2019 in Dr. Kariadi Hospital, Semarang, Indonesia. Some informationincludes clinical signs and symptoms, nutritional status, comorbidities, and frequency of hospitalization in amonth were collected. A total of 66 patients were diagnosed with DS, consisting of 44 DS patients with CHDand 22 DS patients without CHD. There were no differences in nutritional status, interrupted breastfeeding, chestretraction, respiratory rate, thyroid disorder, hearing abnormalities, acute otitis media, and obstructive sleepapnea in both groups (p> 0.05). There were significant differences in the clinical characteristics of cyanosis(p=0.005), heart murmur (p=<0.001), and frequency of acute respiratory tract infection in a year (p=<0.001), andfrequency of hospitalization per month (p=0.039) in DS children with and without CHD. In conclusion, we foundsignificant difference in clinical characteristic in DS children with and without CHD.

Co-Authors Agustini Utari Arif Faiza Asril Aminullah Astra Parahita Dana Sumanti Dea Amarilisa Adespin Galuh Hardaningsih M. Sholeh Kosim Maria Mexitalia Mohammad Syarofil Anam Najib Advani Nanik Tri Mulyani Nisa Alifia Rahmi Nurlina Kumala Sari Safira Azzahra Stefani Candra Firmanti Sudigdo Sastroasmoro Tirsa Hizkia Saverina Nugroho Wardati Rahma

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