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All Journal Jurnal Kedokteran Diponegoro Journal of the Medical Sciences (Berkala Ilmu Kedokteran) The Indonesian Biomedical Journal
Stefani Candra Firmanti
Department Of Microbiology, Faculty Of Medicine, Universitas Diponegoro, Jl. Prof. Soedarto, Semarang 50275
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Child tuberculosis in Respira Lung Hospital, Yogyakarta: demographic and clinical profiles Stefani Candra Firmanti; Rina Triasih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.838 KB) | DOI: 10.19106/JMedScieSup0050012018010

Abstract

Tuberculosis (TB) remains a significant source of morbidity and mortality among children in endemic settings. Demografic and clinical profiles of children with TB in Yogyakarta have not been well documented. A total of 80 children with TB were diagnosed with TB during the study period. There were 41 (51.2%) females and 39 (48.8%) males. The case findings of child TB cases has been increasing from 20 cases in 2014, 28 cases in 2015, and 32 cases in 2016. The majority of the children (89.3%) aged less than 5 years. The most common symptoms were cough 50 (62.5%), followed by weight loss 45 (56.3%), and fever 28 (35%). Contact with a TB case was identified in 46 (57.5%) children. Mantoux test was  done  in  76  (95%)  children  with  positive  result  documented  in  61(76.3%) children. Chest X-ray was done in 54 (67.5%) children, of which 52 (65%) chest X- rays showed suggestive of TB. Confirmed diagnosis (bacteriology) was only documented in one child (1.25%).
BARRIERS TO THE IMPLEMENTATION OF ISONIAZID PREVENTIVE THERAPY AMONG CHILDREN UNDER FIVE YEARS OLD IN CLOSE CONTACT WITH SPUTUM SMEAR-POSITIVE TB PATIENTS Tirsa Hizkia Saverina Nugroho; Anindita Soetadji; Dea Amarilisa Adespin; Stefani Candra Firmanti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29456

Abstract

Background: The implementation of isoniazid preventive therapy (IPT) among children under five years old in close contact with sputum smear-positive TB patients is still low. Only 21,7% of children implemented the IPT in Central Java in 2017. Assessment of the barriers to IPT implementation needs to be carried out in the control of child TB cases.Objective: To analyze the barriers to IPT implementation among children under five years old in close contact with sputum smear-positive TB patients.Methods: A cross-sectional study was conducted among children (age <5 years) in close contact with sputum smear-positive TB patients. Data were collected from KRMT Wongsonegoro Hospital, Dr. Adhyatma, MPH Hospital, Puskesmas Kedungmundu, and Puskesmas Bandarharjo. Structured questionnaires were used to obtain sociodemographic information and to identify associated barriers to IPT implementation. The data were analyzed using Fisher’s exact test.Results: The majority (93,3%) of the total subject (75) of this study did not implement the IPT. The results of the bivariate analysis showed that distance to health facilities (p=0.024), perceived barriers (p=0.016), and cues to action (p=0.001) had a significant association as barriers to IPT implementation. Meanwhile age (p=0.622), gender (p=2.121), education level (p=0.073), economic level (p=0.521), knowledge level (p=0.166), and perceived threats (p=0.316) had no significant association as barriers to IPT implementation.Conclusion: IPT implementation rate is low. The barriers were distance to health facilities, perceived barriers, and cues to action.
Interferon-g-Inducible Protein 10 for Diagnosis of Tuberculosis in Children Stefani Candra Firmanti; Rina Triasih; Tri Wibawa; Sofia Mubarika Haryana
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.973

Abstract

BACKGROUND: The diagnosis of tuberculosis (TB) in children is challenging by the absence of a practical gold standard. Interferon (IFN)-ginducible protein 10 (IP-10) is a chemokine that may serve as the leading candidate marker in child TB diagnosis. The aim of this study is to assess the diagnostic value of IP-10 in the diagnosis of TB in children.METHODS: We recruited eligible symptomatic and asymptomatic children aged <15 years actively by contact investigation and passively from inpatient and outpatient clinics in two hospitals, in Yogyakarta, Indonesia. We conducted clinical examination and chest X-ray in all eligible children. Sputum smear and the rapid molecular TB test were performed in children with TB symptoms. All participants underwent blood sampling for IFN-g Release Assay and IP-10 test.RESULTS: A total of 79 children were recruited to this study. Twelve children were with TB disease, 16 with latent TB infection (LTBI), 40 were TB-exposed only and 11 were non-TB. Children with evidence of TB infection either with TB disease or LTBI had higher levels of antigen-stimulated IP-10 compared to non-infected children, both TB exposed only and non-TB (p=0.000). A cut-off 408.74 pg/mL for antigen-stimulated IP-10 showed high diagnostic accuracy for diagnosis of TB infection (AUC: 0.97, 95% CI: 0.92-1.00, sensitivity: 92.3%, and specificity: 91.9%). However, the stimulated levels of IP-10 between children with TB disease and LTBI were not significantly different (p=0.268).CONCLUSION: IP-10 performed well to diagnose TB infection in children. However, it cannot be used to differentiate TB infection from TB disease.KEYWORDS: IFN-g, IP-10, latent TB, active TB, children
Co-Authors Anindita Soetadji Dea Amarilisa Adespin Rina Triasih Sofia Mubarika Haryana Tirsa Hizkia Saverina Nugroho Tri Wibawa