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All Journal Jurnal Kedokteran Diponegoro Media Medika Muda
Dea Amarilisa Adespin
Department Of Public Health, Faculty Of Medicine, Diponegoro University
Medicine & Pharmacology

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EFFECT OF MOMORDICA CHARANTIA FRUIT ETHANOLIC EXTRACT ON MALONDIALDEHYDE (MDA) LEVEL IN BLOOD OF SPRAGUE-DAWLEY RATS INDUCED BY 7,12-DIMETHYLBENZ[A]ANTHRACENE Ongky Surya Wijaya Hendro; Eka Yudhanto; Ari Budi Himawan; Dea Amarilisa Adespin
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i1.31226

Abstract

Background: Cancer is a type of disease with a high rate of diagnostic cases. The real cause of cancer remains unknown. Free radicals can cause cancer by DNA’s gen mutation. 7, 12- Dimethylbenz[a]anthracene (DMBA) is often used for researching carcinogenesis. Many types of research have used natural substances as supportive cancer therapies including Momordica charantia (bitter melon). Malondialdehyde (MDA) is one of the oxidative damage biomarkers which can significantly increase, especially on breast cancer patients. The success of therapy on a breast cancer patient is shown by decreasing MDA levels in the blood. Aim: To investigate the effect of Momordica charantia fruit ethanolic extract on malondialdehyde levels in the blood of Sprague Dawley rats induced by 7,12- Dimethylbenz [a] anthracene. Methods: This study was a true experimental randomized post-test only with control group design on rats that divided into two groups: X1 given DMBA induction only and X2 given DMBA induction with Momordica charantia fruit ethanolic extract by feeding tube with  200mg/kgbw/day for 14 days. Results: The mean of MDA level in group X1 = 0,83±0,32 and in group  X2 = 0,30±0,19. The result of the normality test of data using the Shapiro-Wilk test obtained abnormal distribution data for one of the groups. The result of independent-samples T-Test showed a significant difference with P = 0,001. Conclusion: There was an effect of Momordica charantia fruit ethanolic extract on MDA level in the blood of Sprague-Dawley induced by 7,12- Dimethylbenz[a]anthracene.
BARRIERS TO THE IMPLEMENTATION OF ISONIAZID PREVENTIVE THERAPY AMONG CHILDREN UNDER FIVE YEARS OLD IN CLOSE CONTACT WITH SPUTUM SMEAR-POSITIVE TB PATIENTS Tirsa Hizkia Saverina Nugroho; Anindita Soetadji; Dea Amarilisa Adespin; Stefani Candra Firmanti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29456

Abstract

Background: The implementation of isoniazid preventive therapy (IPT) among children under five years old in close contact with sputum smear-positive TB patients is still low. Only 21,7% of children implemented the IPT in Central Java in 2017. Assessment of the barriers to IPT implementation needs to be carried out in the control of child TB cases.Objective: To analyze the barriers to IPT implementation among children under five years old in close contact with sputum smear-positive TB patients.Methods: A cross-sectional study was conducted among children (age <5 years) in close contact with sputum smear-positive TB patients. Data were collected from KRMT Wongsonegoro Hospital, Dr. Adhyatma, MPH Hospital, Puskesmas Kedungmundu, and Puskesmas Bandarharjo. Structured questionnaires were used to obtain sociodemographic information and to identify associated barriers to IPT implementation. The data were analyzed using Fisher’s exact test.Results: The majority (93,3%) of the total subject (75) of this study did not implement the IPT. The results of the bivariate analysis showed that distance to health facilities (p=0.024), perceived barriers (p=0.016), and cues to action (p=0.001) had a significant association as barriers to IPT implementation. Meanwhile age (p=0.622), gender (p=2.121), education level (p=0.073), economic level (p=0.521), knowledge level (p=0.166), and perceived threats (p=0.316) had no significant association as barriers to IPT implementation.Conclusion: IPT implementation rate is low. The barriers were distance to health facilities, perceived barriers, and cues to action.
ANALISIS KINERJA MAHASISWA DALAM PENDAMPINGAN IBU HAMIL RISTI DI KOTA SEMARANG TAHUN 2014 Dea Amarilisa Adespin; Sri Achadi Nugraheni; Cahya Tri Purnami
Media Medika Muda Vol 1, No 1 (2016)
Publisher : Faculty of Medicine Diponegoro University

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Abstract

Background: Maternal Mortality Rate (MMR) in Semarang is one of the top five highest MMR in Central Java.As the effort to decrease MMR, Public Health Service (DKK) of Semarang had been colaborated with educational institution to envolved the midwifery student for mentoring high risk mother. Initial studies showed that the program did not work effectively. The objectives of this study was to analyze performance and to find out factors that related to midwivery student’s performance on mentoring high risk mother.Methods: This is a quantitative study used cross sectional design which envolved 115 respondents in Semarang.Data were collected by conducting interview using a structured questionnaire to analyze performance and related factors (knowledge, institution, location of duty, reward, supervision, facilities, attitude, and motivation).  Data were analyzed by using Rank spearman, Chi square and Logistic Regression.Results: This study showed that most of the respondents were good on knowledge (50.4%), perception of reward (60.9%), supervision (59.1%), facilities (58.3%), attitude (66.1%), motivation (89.6%) and performance (53.9%). The results of bivariate analysis showed that knowledge (0.001), reward (p=0.001), supervision (p=0.001), facilities (p=0.002), attitude (p=0.001) and motivation (p=0.001) had positive association with midwivery student’s performance on mentoring high risk mother. Meanwhile, institution (p=0.741) and location of duty (p=0.933) had no association with student performance. Furthermore, the result of multivariate analysis demonstrated that supervision, facilities and attitute jointly influenced midwivery student’s performances on mentoring high risk mother.Conclusion: There were positive relationship between performance with knowledge, reward, supervision, facilities, attitude and motivation.Keywords: Performances, Mentoring, High risk
Relationship of Hand Sanitizer Usage Frequency with the Incidence of Irritant Contact Dermatitis during COVID-19 Pandemic Almira Dwixie Dhara Desira; Puguh Riyanto; Liza Afriliana; Dea Amarilisa Adespin
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.32631

Abstract

Background: Irritant Contact Dermatitis (ICD) is an eruption of the skin caused by the non-immunologic inflammatory response of the skin to the irritant agents. The government urged to implement health protocols 3M, one of them is hand hygiene by used hand sanitizer to prevent the spread of COVID-19 infection. Repeated use of hand sanitizer can cause skin irritation and inflammatory response such as dryness, cracks, and other symptoms of ICD.Objective: To analyze the relationship between the frequency of use of hand sanitizer and the incidence of ICD.Methods: Observational analytics study cross-sectional design. The research subject were 260 medical faculty students of Diponegoro University who had to agree with informed consent, filled questionnaires and qualified by research criteria. Diagnostic of ICD based on questionnaires and physical examination of ICD. The statistical analysis data was used Chi-square test.Results: The results showed after analyze data use Chi-square test that there was not significantly related frequency use the hand sanitizer to the incidence irritant contact dermatitis during the COVID-19 pandemic with a p-value is 0,078 (p>0,05). The most frequent use of hand sanitizers is 5-10 times a day (56,5%), the most symptoms in ICD are dry, scaly, and peeling skin (30%), and the incidence of ICD due to the use of hand sanitizers are 33,5%.Conclusion: There was no significant relationship between frequency of use of hand sanitizer and irritant contact dermatitis during pandemic the COVID-19.
Factors Associated with the Non-Adherence of TB Screening in Children Aged Lidwina Vania Shaynaputri; Anindita Soetadji; Dea Amarilisa Adespin; Stefani Candra Firmanti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30184

Abstract

Background: TB screening in children having close contact with smear-positive TB patients is urgent to conduct to improve the case detection rate and to achieve the “End TB” target. In fact, the implementation of screening in Indonesia is still inadequate.Objective: To analyze the factors associated with the non-adherence of TB screening in children aged <15 years with smear-positive TB patients’ close contact.Methods: A cross-sectional study was conducted in Semarang between February and August 2020. Subjects were children <15 years old with smear-positive TB patient's close contact. Data were collected from interviewed parents or guardians of the child using a structured questionnaire. Chi-square or Fisher's exact test analysis was used to identify the factor associated with non-adherence to TB screening in children.Results: A total of 84 children were recruited into this study. The proportion of children who did not undergo the screening is still high (86,9%), and there was a significant association with children's age (OR 13,556, 95% CI=3.135-58,613), parents' age (OR 41,143, 95% CI=4,025-420,604), parents’ education level (OR 0,114, 95%CI=0.027–0.477), distance to health facilities, knowledge level, perceived barriers, and cues to action. There was no significant association between children’s gender, economic level, perceived threats with non-adherence of screening.Conclusion: Children and parents’ age, education level, distance to health facilities, knowledge level, perception of barriers, and cues to action associated with the non-adherence of TB screening in children aged <15 years with smear-positive TB patients’ close contact.
Co-Authors Almira Dwixie Dhara Desira Anindita Soetadji Anindita Soetadji Ari Budi Himawan Cahya Tri Purnami Eka Yudhanto Lidwina Vania Shaynaputri Liza Afriliana Ongky Surya Wijaya Hendro Puguh Riyanto Sri Achadi Nugraheni Stefani Candra Firmanti Stefani Candra Firmanti Tirsa Hizkia Saverina Nugroho