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All Journal Jurnal Veteriner Biogenesis: Jurnal Ilmiah Biologi Journal of Livestock Science and Production
Yanuartono Yanuartono
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Veterinary

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Journal : Journal of Livestock Science and Production

 1 
Brief Review: The Negative Impact Of Mimosin in L. leucocephala in Ruminant Animals and Processing Methods to Reduce Poisoning Effects on Ruminant Livestock Yanuartono Yanuartono; Soedarmanto Indarjulianto; Alfarisa Nururrozi; Slamet Raharjo; Hary Purnamaningsih
Journal of Livestock Science and Production Vol 3, No 2 (2019): Journal of Livestock Science and Production
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jalspro.v3i2.2037

Abstract

Leucaena leucocephala, a high-quality ruminant feed, is essential for livestock production in the tropics, despite the presence of mimosine in the leaves. Mimosine, in high concentrations, can severely affect animal health and performance. Mimosine and its metabolites, 3-hydroxy-4-(1H)-piridon (DHP), are toxic to ruminants and caused hair loss, slow growth, and oral ulceration, whereas DHP is goitrogenic because it is analogous to tyrosine so resulting in goiter. Mimosine and its metabolites are the main hindrance blocks for the utilization of L.leucocephala as animal feed. Characteristic signs of L.leucocephala toxicity are alopecia, anorexia, reduced weight gain, and weight loss, excessive salivation, esophageal lesions, enlarged thyroid and low circulating concentrations of thyroid hormones. Therefore, the research workers had tried to develop different methods to eliminate the toxicological effects of mimosine and its metabolites. This paper aims to briefly review the negative effects of mimosine from L. leucocephala and its processing to reduce the toxic effects on ruminants. Keywords: Leucaena leucocephala, mimosine, toxicity, metabolites
Nematodes Resistance on Anthelmintics Group of Benzimidazole in Ruminants Yanuartono Yanuartono; Soedarmanto Indarjulianto; Alfarisa Nururrozi; Hary Purnamaningsih
Journal of Livestock Science and Production Vol 3, No 1 (2019): Journal of Livestock Science and Production
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jalspro.v3i1.1464

Abstract

One factor that inhibits the increase in ruminant productivity is nematode infection. It’s cause a decrease in feed intake, weight gain, milk production, disease, death, and expensive medical expenses The control of gastrointestinal nematode infections in livestock, over the past decades is primarily based on the preventive or curative use of chemotherapeutics and generally uses broad-spectrum anthelmintic such as benzimidazole, probenzimidazole, imidazothiazole, macrolide and ivermectin. The widespread use of several antelmintic groups now causes an increase in the incidence of gastrointestinal nematodes resistance against anthelmintics. Anthelmintics derived from various types of plants are expected to replace the benzimidazole so that it can reduce the level of resistance of the gastrointestinal nematodes in ruminants. However, for the future there is still a lot of research needed to further improve the ability of natural medicinal drugs to cope with gastrointestinal nematode infections in ruminants. Keywords : benzimidazole, nematode,resistance, ruminants
Co-Authors Afif Muhammad Akrom Alfarisa Nururrozi Hary Purnamaningsih Hizriah Alief Jainudin Laksono Trisnantoro Nurman Haribowo Puveanthan Nagappan Govendan Rief Ghulam Satria Permana Sitarina Widyarini Soedarmanto Indarjulianto Trini Susmiati