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All Journal Jurnal Kimia Riset Chimica et Natura Acta Jurnal Abdi: Media Pengabdian Kepada Masyarakat Unesa Journal of Chemistry
Tukiran Tukiran
Universitas Negeri Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Social Sciences Other

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Journal : Chimica et Natura Acta

 1 
Phytochemical Screening and Total Phenolic Compounds of Red Ginger (Zingiber officinale) and Secang Wood (Caesalpinia sappan) As Preliminary Test of Antiarthritis Rizka Tazky Amalia; Tukiran Tukiran; Fauzia Indah Sabila; Suyatno Suyatno
Chimica et Natura Acta Vol 9, No 1 (2021)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v9.n1.34230

Abstract

Rheumatoid arthritis is an auto-immune disease that causes chronic inflammation occurs of the joints. Rheumatoid arthritis is characterized by the the overproduction of proinflammation cytokines such as TNF-α and IL-1. The phenolic compounds mainly anthocyanin and elagitanin have TNF-α inhibition activity that induces cyclooxygenase-2 expressions that cause inflammation. Phytochemical screening showed that ethanol extract of red ginger contains alkaloids, phenolics, flavonoids, tannins, terpenoid, and steroids while ethanol extract of secang wood contains alkaloids, phenolics, flavonoids, tannins, and terpenoid. This research aims to identify the secondary metabolite qualitatively and total phenolic compunds on red ginger and secang wood with Folin-Ciocalteu method. Total phenolic compounds are defined as the Gallic Acid Equivalent (GAE). The results showed that the total phenolic compunds of red ginger and sappan wood were 21.90 mg GAE/g extract and 27.65 mg GAE/g extract, respectively. The phenolic compounds in red ginger and secang wood have the potential as antiarthritic.
Co-Authors Andryan Dwisaksana Biyan Yesi Wilujeng Danny Adi Kurniawan Fauzia Indah Sabila I GUST MADE SANJAYA Irene Cornelia Constanty Kusumawati Dwiningsih . Leny Yuanita Norviria Tsalasatin Apriliani Nurul Hidajati Rizka Tazky Amalia Suyatno Sutoyo Woro Setyarsih