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All Journal Jurnal Kesehatan Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Media Kesehatan Politeknik Kesehatan Makassar Jurnal Riset Kefarmasian Indonesia Borneo Journal Of Pharmascientech Journal of Health Sciences and Medical Development

Nielma Auliah

Universitas Megarezky

Author-ID : 2681691

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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UJI EFEK ANALGETIK EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) TERHADAP MENCIT (Mus musculus) YANG DIINDUKSI ASAM ASETAT Auliah, Nielma; Lotuconsina, Ari Aprianto; Thalib, Muthmainnah
Jurnal Riset Kefarmasian Indonesia Vol 1 No 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Research has been carried out with the title "Test of the Analgetic Effect of Ethanol Extract of Jackfruit Leaves (Artocarpus heterophyllus Lam.) On Acetic Acid-induced Mice (mus musculus). Analgesics or painkillers are drugs that reduce or eliminate taste without losing consciousness. One of the traditional plants commonly used empirically is jackfruit leaves (Artocarpus heterophyllus Lam.). This study aims to determine the analgetic effect of ethanol extract of jackfruit leaves (Artocarpus heterophylus Lam.) At a dose of 100 mg / kgBB, 300 mg / kgBB and 600 mg / kgBW on acetic acid induced male mice (Mus musculus). This research is an experimental study and uses the chemical induction method. The results obtained in the form of% protection inhibition stretching ethanol extract of jackfruit leaves (Artocarpus heterophyllus Lam.) At a dose of 100mg / kgBB (28.79%); 300mg / kgBB (53.31%); 600mg / kgBB (60.70%). From the results of the research that has been done it can be concluded that the ethanol extract of jackfruit leaves (Artocarpus heterophyllus Lam.) Has the highest analgesic effect at a dose of 600mg / kgBW having a percentage of protection of 66.70%.

FORMULASI SEDIAAN MOUTHWASH EKSTRAK ETANOL BUNGAMAWAR MERAH (Rosa damascena Mill) SEBAGAI ANTIBAKTERI TERHADAP Streptococcus mutans Nurfitria Junita; Nielma Auliah; Wantry Diasny
BORNEO JOURNAL OF PHARMASCIENTECH Vol 4 No 2 (2020): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v4i2.341

It has been conducted a research about Formulation of Red Rose Ethanol Extract ofMouthwash (Rosa damascena Mill) as Antibacterial toward Streptococcus mutans. Thisresearch aim at knowing the activity of Red Rose Ethanol Extract of Mouthwash (Rosadamascena Mill) as Antibacterial toward Streptococcus mutans. In this study, usingexperimental research by formulating the ethanol extract of red rose (Rosa damascena Mill)mouthwash, then tested against Streptococcus mutans bacteria using the agar diffusionmethod. The ethanol extract of red rose (Rosa damascena Mill) mouthwash was prepared inthree concentrations, namely 1%, 3%, 5%, and control solution. The various concentrationswere tested for their antibacterial activity and an evaluation of the Mouthwash byorganoleptic observation, pH and cycling test. Meanwhile, the antibacterial activity test usedagar diffusion method using agar well diffusion. Results of the measurement of the largestaverage inhibition zone at a concentration of 5% of 21.4 mm. Result showed that physicalstability of mouthwash tended to stable on the low temperature storage (4°C) and had aninhibitory level in strong category in obstructing the growth of Streptococcusmutans

MOUTHWASH JUS BUAH NANAS (Ananas comosus L. Merr) TERHADAP BAKTERI Streptococcus mutans Sri Wahyuningsih; Nielma Auliah; Salwi Salwi
Jurnal Kesehatan Vol 13 No 2 (2020): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v13i2.16423

This research aimed to determine the formulation of pineapple juice into mouthwash and to investigate antibacterial activity against Streptococcus mutans. This was an experimental design method, it started by formulating pineapple juice (Ananas comosus L.Merr) into mouthwash and testing the activity of bacteria using the agar diffusion method to determine the inhibition zone. The research result showed that pineapple juice (Ananas comosus L.Merr) can be formulated into mouthwash with a concentration of 5%; 10%; and 15% and there was no significant difference after the stability test. The mouthwash also has antibacterial activity against Streptococcus mutans with a zone of inhibition for a concentration of 5%; 10% and 15%, respectively 8.6 mm; 9.4 mm; and 9.7 mm. Antibacterial activity of pineapple juice mouthwash against Streptococcus mutans showed a moderate inhibition zone category.ABSTRAKPenelitian ini bertujuan untuk mengetahui jus buah nanas dapat diformulasi dalam bentuk sediaan mouthwash dan aktivitas antibakteri mouthwash terhadap bakteri Streptococcus mutans. Penelitian ini termasuk penelitian eksperimental laboratorium dengan memformulasi sediaan dan menguji aktivitas bakteri menggunakan metode difusi agar untuk mengetahui zona hambat sediaan mouthwash jus buah nanas (Ananas comosus L.Merr). Hasil penelitian menunjukkan bahwa jus buah nanas (Ananas comosus L.Merr) dapat diformulasi menjadi sediaan mouthwash dengan konsentrasi 5%; 10%; dan 15% dan tidak terjadi perbedaan signifikan setelah uji kestabilan. Mouthwash juga memiliki aktivitas antibakteri terhadap Streptococcus mutans dengan rata-rata zona hambat untuk konsentrasi 5%; 10% dan 15% masing-masing 8,6 mm; 9,4 mm dan 9,7 mm. Aktivitas antibakteri mouthwash jus buah nanas terhadap bakteri Streptococcus mutans menunjukkan kategori zona hambat sedang.

FORMULASI DAN UJI STABILITAS FISIKA DAN KIMIA SEDIAAN SHAMPO ANTIKETOMBE EKSTRAK KULIT BUAH JERUK PURUT (Citrus hystrix Dc) Nielma Auliah; Muhammad Asri; Sri Wahyuningsih
Media Kesehatan Politeknik Kesehatan Makassar Vol 15, No 2 (2020): Media Kesehatan
Publisher : Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v15i2.1696

Penelitian ini bertujuan untuk memformulasikan ekstrak kulit buah jeruk purut (Citrus hystrix Dc.) menjadi sediaan Shampo Antiketombe dengan variasi konsentrasi F1 tanpa ekstrak, F2 5%, F3 10% dan F4 15%. Jenis penelitian ini berupa eksperimen laboratorium dengan pengujian shampo antiketombe meliputi uji stabilitas, Organleptik, Ph, Viskositas dan uji antijamur terhadap jamur Candida albicans. Hasil yang diperoleh yaitu shampo antiketombe dengan konsentrasi 5%, 10%, dan 15% menunjukkan Ph 5,2 – 6,8 dimana memenuhi syarat sediaan shampo yaitu antara 5,0-9,0. Secara organoleptis sediaan shampo antiketombe ekstrak kulit buah jeruk purut menunjukkan tidak ada perubahan bau, warna dan bentuk sebelum dan setelah penyimpanan dipercepat yakni sediaan shampo tetap memiliki bau yang khas, warna coklat hingga coklat tua dan bentuk yang agak kental. Hasil penelitian uji aktivitas antijamur menunjukkan Formulasi shampo antiketombe ekstrak kulit buah jeruk purut dengan konsentrasi 5%, 10%, dan 15% dapat menghambat pertumbuhan jamur Candida albicans dengan respon zona hambat (Kuat-sangat kuat). Dari hasil penelitian yang telah dilakukan, disimpulkan bahwa shampo antiketombe ekstrak kulit buah jeruk purut stabil secara fisika dan kimia untuk penujian organoleptis, Ph, viskositas dan efektif sebagai antiketombe terhadap jamur Candida albicans.

PENGUJIAN ANTI AGING SEDIAAN KRIM CANGKANG BEKICOT (ACHATINA FUNICA) PADA KELINCI (ORYCTOLAGUS CUNICULUS) YANG DIPAPAR SINAR UV Muhammad Asri; Nielma Auliah
Media Kesehatan Politeknik Kesehatan Makassar Vol 14, No 2 (2019): Media Kesehatan
Publisher : Politeknik Kesehatan Makassar

Snail shells is one of the mollusk phyla that contains protein and chitin function as protector from wind. The protector of wind is a process to prevent premature of the skin. This research aimed to find the formulation and efficacy test of snail shel cream (Achatina fulica) on rabbits (Oryctolagus cuniculus) as protector from the wind .The type of this research used experimental method with UV exposure method using Philips light intensity 10 Mw/cm2 where the back skin of animals try to be wrinkled. The samples of snail shells (Achatina fulica) used the powdered shell is then used as the active compound in the cream dosage formulation. Cracked cream shell powder formulas are formulated in four formulas with concentration 0% (without cracked cream shell powder) 5%, 10%, 15%, and testing the skin of the rabbit’s back (Oryctolagus cuniculus). Treatment is divided into 5 treatments namely treatment 1 as positive control used cream without active compound, treatment 2 concentration cream 5%, treatment 3 concentration cream 10%, treatment 4 concentration cream 15%, and treatment 5 as negative control used cream patent as the protector of x wind. The result of this research showed the effectivitas of concentration cream 5% which had 16,4 mm, and the positive control had 5,7 mm. It can conclude that with concentration 5% had the most powerful effectiveness than variation in the concentration of other creamsKeywords : Snail shells (Achatina fulica), Formulation, The protector of wind

UJI AKTIVITAS SEDIAAN TEH BIJI MAHONI ( Swietenia mahagoni ) UNTUK MENURUNKAN KADAR GLUKKOSA DAN AKTIVITAS PEROKSIDASI LIPID PADA TIKUS DIABETES MILLITUS TIPE 2 Nielma Auliah; Muhammad Asri
Media Kesehatan Politeknik Kesehatan Makassar Vol 14, No 2 (2019): Media Kesehatan
Publisher : Politeknik Kesehatan Makassar

This research aimed to know the effect of mahagony seeds ( Swieteniamahagoni ) tea of MDA levels induced type 2 diabetes mellitus alloxan. By using the control group design method, post-test and by using 15 rats divided into 5 groups, namely group I negative group, group II control Alloxan induction, group III tea mahagony seeds 5 gram/kgBB, group IV tea mahagony seeds 10 gram/kgBB and group V mahagony seeds 15 gram/kgBB. The treatment was carried out for 14 days. In this research showed that the level of blood glucose affects increase of MDA levels. At 15 gram/kgBBof tea dosage presentasionshowed a significant value on decreasing blood glucose levels P = 0,000 < (α 0,05) and blood MDA levels P = 0,000 < (α 0,05) and it can be concluded that mahogany seed tea (Swieteniamahagoni) had an effect on decreasing levels of rat MDA type 2 diabetes mellitus induced by alloxan, with a dose of 15 grams /kgBB which is the optimal dose in reducing blood Glucose and MDA levels. Keywords : Type 2 Diabetes Mellitus, MDA, Mahogany Seeds Tea, Alloxan

EVALUASI PENGGUNAAN ANTIBIOTIK DENGAN METODE GYSSENS PADA PASIEN PNEUMONIA DI RUMAH SAKIT BHAYANGKARA KUPANG PERIODE JULI – DESEMBER 2019 Muhammad Yusuf; Nielma Auliah; Hana Evangelista Sarambu
Jurnal Riset Kefarmasian Indonesia Vol 4 No 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.243

Pneumonia is a disease in Indonesia that has a high mortality rate in 2018. Pneumonia is an inflammation of the lungs caused by microorganisms (bacteria, viruses, fungi, parasites). Pneumonia caused by Mycobacterium tuberculosis is not included. While lung inflammation caused by non-microorganisms (chemicals, radiation, aspiration of toxic substances, drugs, etc.) is called pneumonitis. One of the treatment for pneumonia is antibiotics where the incidence of resistance in patients often occurs due to irrational use, therefore it needs to be monitored and evaluated by health workers. The purpose of this study was to determine the use of antibiotics in pneumonia patients at Bhayangkara Hospital Kupang with the Gyssens method according to the Minister of Health of the Republic of Indonesia No. 8 of 2015. The Gyssens method is an evaluation of the use of antibiotics to assess the accuracy of the use of antibiotics which includes the accuracy of indications, the accuracy of selection based on effectiveness, toxicity, price and spectrum, duration of administration, dose, interval, route and time of administration. The method used is non-experimental with a descriptive research design, the sample taken is 25 medical record data. The results of the research category 0 (precise and rational) were 84% or in other words the use of antibiotics was rational, category IVb (there were antibiotics that were less toxic) was 12% and in category IIb (inappropriate interval antibiotics) was 4%.

SINTESIS NANOPARTIKEL PERAK DENGAN AIR REBUSAN DAUN PEGAGAN (Centella asiatica L.) DAN UJI AKTIVITAS DALAM MENGHAMBAT PERTUMBUHAN BAKTERI Pseudomonas aeruginosa DAN Staphylococcus aureus Indah; Muhammad Asri; Nielma Auliah; Andi Triraparti Ashari
Majalah Farmasi dan Farmakologi Vol. 26 No. 2 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i2.19903

Daun pegagan (Centella asiatica L.) mengandung bahan aktif seperti saponin, tanin, flavonoid, steroid serta triterpenoid yang dapat mereduksi ion perak. Penelitian ini bertujuan untuk mengetahui apakah air rebusan daun pegagan dapat digunakan sebagai bioreduktor dalam mensintesis nanopartikel perak serta untuk mengetahui apakah hasil biosintesis daun pegagan memiliki aktivitas daya hambat terhadap bakteri Pseudomonas aeruginosa dan Staphylococcus aureus. Penelitian ini merupakan penelitian eksperimental. Penentuan aktivitas daya hambat terhadap bakteri Pseudomonas aeruginosa dan Staphylococcus aureus dengan metode difusi cakram. Hasil penelitian menunjukan air rebusan daun pegagan segar dapat digunakan sebagai bioreduktor dalam mensintesis nanopartikel perak yang ditandai dengan adanya puncak serapan pada panjang gelombang 400-500 nm. Ukuran nanopartikel perak yang dihasilkan berkisar 50 s/d 90 nm. Aktivitas antibakteri dari hasil biosintesis memiliki rata-rata zona hambat 25 mm (sangat kuat) untuk bakteri Pseudomonas aeruginosa dan 22,6 mm (sangat kuat) untuk Staphylococcus aureus. Disimpulkan bahwa daun pegagan dapat mereduksi dan memiliki aktivitas antibakteri terhadap Pseudomonas aeruginosa dan Staphylococcus aureus.

Antioxidant Evaluation of Facial Toner Formulations Containing Ethyl Acetate Fraction from Garcinia Mangostana L. Fruit using ABTS 2,2'-Azinobis 3-ethyl benzothiazoline 6-sulphonic Acid Method Sriyanty Sadsyam; Nielma Auliah; Wa Ode Wisna Anto Uko; Nasrawati Basir; Andi Ulfiana Utari
Journal of Health Sciences and Medical Development Vol. 2 No. 02 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i02.266

The mangosteen fruit is rich in polyphenols, particularly xanthones, which have potent antioxidant effects. Given the various effects of facial toners and the growing demand for natural skincare products, mangosteen rind may serve as an alternative ingredient in facial toner formulations. This laboratory experimental study aimed to assess the antioxidant activity of facial toner preparations containing the ethyl acetate fraction of mangosteen rind (Garcinia mangostana L.) using the ABTS method at different concentrations (0.2%, 0.4%, and 0.6%). Four facial toner formulas were formulated, with Formula 1 being the control formula without any active substance and Formulas 2-4 containing the ethyl acetate fraction of mangosteen rind at different concentrations. The prepared formulas underwent physical and chemical stability tests, including organoleptic, homogeneity, pH, viscosity, and humidity tests, before and after six cycles of cycling. The antioxidant activity of the formulas was also evaluated using the ABTS method. The results showed no significant difference (p>0.05) in the organoleptic, viscosity, pH, and humidity tests before and after cycling. Formula 3 showed significant (p<0.05) antioxidant activity compared to the other formulas. Therefore, it can be concluded that the ethyl acetate fraction of mangosteen rind (Garcinia mangostana L.) can be formulated into a facial toner with potent antioxidant activity.

UJI AKTIVITAS ANTIBAKTERI SEDIAAN SABUN CAIR MINYAK ATSIRI KULIT BUAH JERUK BALI (Citrus maxima) Andi Juaella Yustisi; Sri Wahyuningsih; Nielma Auliah
Jurnal Riset Kefarmasian Indonesia Vol 5 No 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.355

Pomelofruit (Citrus maxima) has several chemical compounds, one of which is essential oil, 6.68g of essential oil was found in the peel of the pomelofruit (Citrus maxima) which has an active compound, namely limonene (94.96%). The essential oil provided strong antibacterial activity against S. aureus isolates. The purpose of the study was to formulate the essential oil of pomelofruit peel (Citrus maxima) into liquid soap preparations that met physical stability and to test the antibacterial activity of liquid soap preparations of pomelofruit (Citrus maxima) peel essential oil against S. aureus bacteria. The method used in testing the stability of liquid soap preparations is cycling test and in the antibacterial activity test using the Disk diffusion method. The results obtained that the essential oil of pomelofruit peel (Citrus maxima) can be formulated in the form of liquid soap because it meets the physical stability test, namely before and after the cycling test and activity tests. antibacterial against S. aureus. at 1% concentration of 18.9mm (strong), 3% of 20.4mm (very strong), and 5% of 21.1mm (very strong). Based on this, the essential oil of pomelofruit peel (Citrus maxima) can be made into liquid soap preparations that meet the physical stability test and have antibacterial activity in very strong category at a concentration of 5% in inhibiting the growth of S. aureus bacteria.

Co-Authors Andi Juaella Yustisi Andi Triraparti Ashari Andi Ulfiana Utari Hana Evangelista Sarambu Indah Lotuconsina, Ari Aprianto Muhammad Asri SR Muhammad Yusuf Nasrawati Basir Nurfitria Junita Salwi Salwi Sri Wahyuningsih Sriyanty Sadsyam Thalib, Muthmainnah Wa Ode Wisna Anto Uko Wantry Diasny

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