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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Mansyur Romi
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Pengaruh Stres Kronik terhadap Otak: Kajian Biomolekuler Hormon Glukokortikoid dan Regulasi Brain-Derived Neurotrophic Factor (BDNF) Pascastres di Cerebellum Desby Juananda; Dwi Cahyani Ratna Sari; Djoko Prakosa2,; Nur Arfian; Mansyur Romi
Jurnal Ilmu Kedokteran Vol 9, No 2 (2015): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.93 KB) | DOI: 10.26891/JIK.v9i2.2015.65-70

Abstract

The brain is the central organ of stress adaptation, and is also a target of stress. Chronic stress may result in abnormalchanges in brain plasticity; include dendritic retraction, neuronal toxicity, and suppression of neurogenesis andaxospinous synaptic plasticity. Repetitive stress exposure will gradually change the electrical characteristic, morphologyand proliferative capacity of neurons. Among brain region, the cerebellum is known to be severely affected by oxidativedamage associated with glucocorticoids level. It is believed due to the highest levels of glucocorticoid receptorslocalized in the external granular layer. BDNF, a member of neurotrophin family, is known to be a strong survivalpromoting factor, and plays a critical role in cell proliferation and differentiation, neuronal protection, and the regulationof synaptic function in the central nervous system. BDNF is highly expressed in the cerebellum, mainly in granulecells. Both acute and chronic stress change BDNF expression in the brain. Although the impact of stress on BDNFlevels showed the different results, BDNF is believed to protect neurons from injuries caused by stress.
Kajian kefalometrik (Studi perbandingan antara suku Jawa dan suku Naulu di pulau Seram, Maluku Tengah Neni Trilusiana Rahmawati; M Hirai; E Suryadi; Mansyur Romi; T Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 35, No 4 (2003)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (8371.931 KB)

Abstract

Background: Regional variation in anthropometric measurements and anthroposcopic always found, even in one population or subrace. Therefore, it is interesting to study these composite physical traits in rural population of Indonesia with different environment. Objectives: To examine the characteristics of the cephalometry of Javanese population in Yogyakarta, and to compare with Naulunese population in Seram Island of Middle Maluku. Methods: 100 people of Java in Yogyakarta consists of 50 males and 50 females, aged 20 - 75 years, were studied and compared with Naulu people (62 males and 110 females). Stature, weight, maximum head breadth and length, minimal frontal breadth, bizygomatic breadth, face height, breadth and height of nasal were measured. Analysis of variance and t-test were used to study the difference of cephalometric between males and females of Javanese population, and to study the difference between Javanese and Naulunese populations. Results: The results showed that Javanese population has mesocephalic head, wide forehead, narrow face and mesorhine nasal type. There were significant differences between Javanese males and females in regard to their height, weight, bizygomatic breadth, face height, nasal breadth and nasal index. There were significant differences between Javanese and Naulunese populations in terms of their height, head breadth, minimal frontal breadth, face height, frontoparietalis and facial index. In addition, there were similarities of head shape, width forehead and nasal shape among both populations. Conclusions: The finding indicated that Javanese and Naulunese populations have mesocephalic head, wide forehead and mesorhine nasal type.Key words: cephalometric - Javanese - Naulunese - cephalic index - anthropometric
Co-Authors Desby Juananda Djoko Prakosa2, Dwi Cahyani Ratna Sari E Suryadi M Hirai Neni Trilusiana Rahmawati Neni Trilusiana Rahmawati Nur Arfian T Jacob