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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Online Mahasiswa (JOM) Bidang Kedokteran
Desby Juananda
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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Ethanol Extracts of Centella asiatica (L.) Urb. Leaf Increase Superoxide Dismutase-2 (SOD-2) Expression on Rat Cerebellar Purkinje Cells After Chronic Stress Desby Juananda; Dwi Cahyani Ratna Sari; Mawaddah Ar-Rochmah; Nur Arfian; Muhammad Mansyur Romi
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.455 KB) | DOI: 10.26891/JIK.v11i2.2017.24-29

Abstract

Beberapa penelitian menunjukkan bahwa stres kronis meningkatkan produksi reactive oxygen species (ROS), dan /atau menekan mekanisme pertahanan antioksidan. Efek neuroprotektif dari Centella asiatica (L.). Urb telah dilaporkandapat melindungi neuron dari kerusakan oksidatif. Tujuan dari penelitian ini adalah untuk mengetahui efek ekstraketanol C. asiatica leaf terhadap ekspresi superoxide dismutase-2 sel (SOD- 2) pada sel Purkinje serebelum tikussetelah diberikan kejutan kronis di kaki. Sebanyak 25 tikus Sprague Dawley jantan dewasa muda diacak ke dalam limakelompok. Kelompok kontrol negatif terdiri dari tikus yang tidak stres; kelompok kontrol stres menerima aquadest; dankelompok lain diobati dengan dosis yang berbeda (mg / kg berat badan / hari, p.o.) ekstrak etanol daun C. asiatica: 150,300 dan 600, masing-masing diikuti oleh pemberian kejutan kronis di kaki selama dua puluh delapan hari. Ekspresi SOD-2 dari lapisan sel Purkinje diukur menggunakan metode imunohistokimia. Data dianalisis dengan one-way ANOVA (p<0,05). Kami menemukan bahwa ekspresi SOD-2 (%) dari lapisan sel Purkinje untuk kelompok kontrol negatif, kelompokkontrol stres, CeA150, CeA300 dan CeA600 kelompok adalah 22,38 ± 9,73, 9,81 ± 2,21, 10,29 ± 3,60, 14,72 ± 6,65, dan22,75 ± 10,93, masing-masing (p <0,05). Analisis post-hoc menunjukkan perbedaan yang signifikan antara kelompokkontrol negatif dan kelompok kontrol stres (p <0,05). Ada juga perbedaan yang signifikan antara kelompok kontrolstres dan kelompok CeA600 (p <0,05), tetapi tidak ada perbedaan yang signifikan antara kelompok perlakuan (p> 0,05).Penelitian ini menunjukkan bahwa ekstrak etanol daun C. asiatica meningkatkan ekspresi SOD-2 pada sel Purkinjecerebellar tikus setelah stres kronis.
Gambaran Komplikasi Transurethral Resection of the Prostate pada Pasien Benign Prostatic Hyperplasia Zuhirman Zuhirman; Desby Juananda; Putry Lestari
Jurnal Ilmu Kedokteran Vol 10, No 1 (2016): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (74.798 KB) | DOI: 10.26891/JIK.v10i1.2016.44-53

Abstract

Benign prostatic hyperplasia (BPH) is a benign tumor that most common, a serious problem and may affect thequality of life. Transurethral resection of the prostate (TURP) is the gold standard for BPH management. The aim ofthis study was to describe the complications of TURP in patients with BPH. This was a descriptive study by reviewingthe medical records of BPH patients underwent TURPs at RSUD Arifin Achmad, Riau Province in 2011-2015. Therewere 280 medical records fulfilled the inclusion criteria in which showed 93 patients who experienced complicationsof TURP. The most age range was 60-69 years old (12,9%), the mean of the resection duration was 30(10-80) minutesand the mean of weight of the resected prostatic tissue was 30 (10-50)grams. The most common complications wasbleeding (42,9%), urinary retention (27,6%).In the research, we conclude the complications were higher than theones in the literatures.
Pengaruh Stres Kronik terhadap Otak: Kajian Biomolekuler Hormon Glukokortikoid dan Regulasi Brain-Derived Neurotrophic Factor (BDNF) Pascastres di Cerebellum Desby Juananda; Dwi Cahyani Ratna Sari; Djoko Prakosa2,; Nur Arfian; Mansyur Romi
Jurnal Ilmu Kedokteran Vol 9, No 2 (2015): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.93 KB) | DOI: 10.26891/JIK.v9i2.2015.65-70

Abstract

The brain is the central organ of stress adaptation, and is also a target of stress. Chronic stress may result in abnormalchanges in brain plasticity; include dendritic retraction, neuronal toxicity, and suppression of neurogenesis andaxospinous synaptic plasticity. Repetitive stress exposure will gradually change the electrical characteristic, morphologyand proliferative capacity of neurons. Among brain region, the cerebellum is known to be severely affected by oxidativedamage associated with glucocorticoids level. It is believed due to the highest levels of glucocorticoid receptorslocalized in the external granular layer. BDNF, a member of neurotrophin family, is known to be a strong survivalpromoting factor, and plays a critical role in cell proliferation and differentiation, neuronal protection, and the regulationof synaptic function in the central nervous system. BDNF is highly expressed in the cerebellum, mainly in granulecells. Both acute and chronic stress change BDNF expression in the brain. Although the impact of stress on BDNFlevels showed the different results, BDNF is believed to protect neurons from injuries caused by stress.
PENERAPAN NILAI KODE ETIK KEDOKTERAN INDONESIA PADA ERA JAMINAN KESEHATAN NASIONAL DI KABUPATEN INDRAGIRI HULU Sunki Yulia Dwi P; Dedi Afandi; Desby Juananda
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 4, No 2 (2017): Wisuda Oktober Tahun 2017
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTThe Indonesian Medical Codes of Ethics or Kode Etik Kedokteran Indonesia (KODEKI) is a set of ethical profession which used by the doctor in Indonesia as their basic guidelines to behave. In 1st January 2014, Jaminan Kesehatan Nasional or National Health Coverage (NHC) officially applied in Indonesia including Indragiri Hulu Regency. Therefore, to handle the increasing amount of patients in NHC’s era, a general practitioner as a gatekeeper had to still apply the KODEKI. The aim of this research is to know how is the implementation of KODEKI in NHC’s era in Indragiri Hulu Regency. This research uses the design of exploration method with qualitative approach on four general practitioners. The informants of this research were selected by using snowball sampling method which suitable with inclusion criteria. This research was done by interview method with question’s lists and recorded with an audio recorder. The result showed that all of the informants possess altruism, responsibility, professional idealism, accountability, scientific integrity, and social integrity. It showed that general practitioners in NHC’s era in Indragiri Hulu Regency are still applying KODEKI.Keywords : KODEKI values, NHC, Indragiri Hulu
Co-Authors Dedi Afandi Djoko Prakosa2, Dwi Cahyani Ratna Sari Mansyur Romi Mawaddah Ar-Rochmah Muhammad Mansyur Romi Nur Arfian Putry Lestari Sunki Yulia Dwi P Zuhirman Zuhirman