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All Journal Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Indonesian Journal of Pharmaceutical Science and Technology
Maula Eka Sriyani
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Energy Environmental Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics

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KARAKTERISTIK FISIKOKIMIA SENYAWA BERTANDA 99mTc-KUERSETIN Eva Maria Widyasari; Maula Eka Sriyani; Isti Daruwati; Iim Halimah; Witri Nuraeni
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 20, No 1 (2019): Februari 2019
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.485 KB) | DOI: 10.17146/jstni.2019.1.1.4108

Abstract

Berkembangnya ilmu pengetahuan dan informasi di bidang kesehatan membuat masyarakat meyakini bahwa mengkonsumsi makanan yang kaya antioksidan penting untuk mencegah berbagai penyakit degeneratif seperti penyakit jantung dan kanker. Kuersetin merupakan senyawa flavonoid yang banyak ditemukan pada buah dan sayur yang memiliki aktivitas antioksidan yang sangat kuat. Banyak penelitian yang telah membuktikan efektivitas kuersetin sebagai senyawa antikanker secara in-vitro, namun data pengujiannya secara in-vivo masih terbatas. 99mTc-kuersetin diharapkan dapat dijadikan radiotracer untuk mengetahui efektivitas senyawa kuersetin sebagai senyawa antikanker pada pengujian in-vivo menggunakan hewan percobaan. Namun sebelum dilakukan pengujian in-vivo untuk menjamin aplikasinya perlu dilakukan pengujian karakteristik fisiko-kimia sediaan 99mTc-kuersetin. Oleh karena itu tujuan dari penelitian ini adalah untuk mengetahui karakteristik fisiko-kimia dari senyawa 99mTc-kuersetin. Hasil penelitian karakteristik fisiko-kimia 99mTc-kuersetin menunjukkan bahwa kemurnian radiokimia sediaan 99mTc-kuersetin adalah 98,94 ± 0,30%. Sediaan 99mTc-Kuersetin ini bermuatan netral, memiliki nilai lipofilisitas dengan log (P) = 0,62 ± 0,05 dan dapat berikatan kuat dengan plasma darah dengan persentase sebesar 95,06 ± 1,34%. Berdasarkan nilai lipofilisitas sebesar 0,62 ± 0,05 diharapkan senyawa ini akan mudah terdistribusi kedalam jaringan organ sehingga diharapkan akan efektif sebagai senyawa bertanda penyidik kanker.
Evaluation of 99mTc-Ethambutol Radiopharmaceutical Using High Performance Liquid Chromatography with Radioactive Detector (Radio-HPLC) Maula Eka Sriyani; Rizky Juwita Sugiharti; Eva Maria Widyasari; Iim Halimah
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.547 KB) | DOI: 10.24198/ijpst.v1i3.21033

Abstract

99mTc-ethambutol is a radiopharmaceuticals used to determine the location of Mycobacterium tuberculosisthat causes TB disease. To prepare this radiopharmaceuticals, several supporting compounds are required in addition to ethambutol and radionuclide compounds. These are mannitol as filler, SnCl2as a reducing agent and sodium pyrophosphate as co-ligand. The radiopharmaceuticals is made in the form of a lyophilized kit without 99mTc radionuclides. The aim of this study was to determined the effect of reducing agents on 99mTc-ethambutol preparation using the High Performance liquid chromatography (HPLC) equiped with radiodetector (radio-HPLC) to the quality of radiopharmaceuticals. In the previous study, the determination of radiochemical purity only used TLC by determining the amount of impurities TcO2and TcO4. This study was carried out more profoundly by using radio-HPLC to ensure the quality of radiopharmaceutical products that were made is actually 99mTc-ethambutol. The Test were performed using paper chromatography, electrophoresis, radio-HPLC, and stability test of 99mTc-ethambutol radiopharmaceuticals. The results showed that the radiopharmaceuticalkit of ethambutol is performing good physical characterictics and high radiochemical purity of 99mTc-ethambutol both in analysis using paper chromatography, electrophoresis and radio-HPLC. The 99mTc-ethambutol shown the peak at retention time (tr) 7,97 minutes using UV and radioactive detector, C18 column, isocratic system using phosphate buffer 0,2 M pH 7,4 and Acetonitrile (90 :10), flow rate 0,8 mL/min. The radiochemical purity of 99mTc-ethambutol is still remain high (91.44 ± 0.92%) after 27 days of kit were made.Key words: 99mTc-ethambutol, radio-HPLC, TB disease, Mycobacterium tuberculosis, radiopharmaceuticals. 
99mTc-Human Serum Albumin-Nanoparticle for Sentinel Lymph Node Identification Rizky Juwita Sugiharti; Iim Halimah; Iswahyudi Iswahyudi; Maula Eka Sriyani; Eva Maria Widyasari
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.053 KB) | DOI: 10.24198/ijpst.v1i3.21034

Abstract

The sentinel lymph node is the first lymph node in a lymph node basin to receive lymphatic drainage from a primary tumor. An accurate identification and characterization of sentinel lymph node is very important as it helps to decide the extension of surgery, the tumor staging, and establisment of the most adequate therapy. Technetium-99m labeled Human Serum Albumin nanoparticle (99mTc-HSA nanoparticle) was prepare as a radiopharmaceutical with particle size between 100 - 200 nmthat is used in lymphoscintigraphy technique for tracinglymphatic system and identifies the sentinel lymph node. Biodistribution study of 99mTc-HSA nanoparticle was conducted in mice to identify the accumulation of this agent in sentinel node and the other tissue. 99mTc-HSA nanoparticle showed good accumulation in sentinel node about1.29 +0.90 %ID with value of popliteal extraction 89.55 +8.52 at one hour post injection. This result was indicated that 99mTc-HSA nanoparticle is very promising compound to be further explored as sentinel lymph node imaging agent.Key words: Lymphoscintigraphy, 99mTc-HSA-nanoparticle, sentinel lymph node
Co-Authors Eva Maria Widyasari Eva Maria Widyasari Iim Halimah Isti Daruwati Iswahyudi Iswahyudi Rizky Juwita Sugiharti Witri Nuraeni