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All Journal Jurnal Kesehatan Andalas INDONESIAN JOURNAL OF PHARMACY Universa Medicina Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Dwitya Elvira
Allergy And Clinical Immunology Subdivision, Department Of Internal Medicine, Faculty Of Medicine, Universitas Andalas / M. Djamil Hospital, Padang, West Sumatera, Indonesia Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : Universa Medicina

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HIV-1 drug resistance-associated mutations in relation to viral load among HIV/AIDS patients at Dr. M. Djamil-Hospital Padang Rizka Nadia; Dwitya Elvira; Raveinal Raveinal
Universa Medicina Vol. 43 No. 1 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.38-43

Abstract

BackgroundAccording to the WHO, 38 million people suffer from HIV worldwide and according to the HIV Drug Resistance Report, the prevalence of antiretroviral therapy (ART) resistance is 3-29%. Drug resistance-associated mutations (DRAMs) are the presence of one or more HIV mutations that reduce the ability of certain drugs to inhibit viral replication and that will increase viral replication and HIV RNA, which can lead to therapeutic failure. The objective of this study was to determine the prevalence of HIV-1 DRAMs among patients with chronic HIV-1 infections and to compare HIV RNA viral load between M184V and K103N mutations. Methods A cross-sectional was conducted involving 80 patients with HIV who met the inclusion criteria. The study subjects were examined for genotype and HIV RNA viral load, both using the polymerase chain reaction (PCR). Data were analyzed with the Kruskal-Wallis test. Results The overall drug resistance mutation prevalence was 10.0%. The most common mutations were M184V and K103N. There was a significant difference between the median HIV RNA viral load counts in patients with either M184V or K103N, and with both M184V and K103N mutations, the values being 45.420, 13.207, and 97.517 copies/mL, respectively (p<0.001). Conclusion The HIV RNA viral load count was higher in the mutation group than in the group without mutation. Long-term and ongoing surveillance of HIV DRAMs among these patients is necessary, which will help us to adjust the treatment regimen.
Co-Authors Adrial Adrial Alexander Kam Arina Widya Murni Azia Putri Al Jamil Dian Pertiwi Dinda Aprilia Efrida Efrida Elvia Fataya Eva Decroli Fadrian Fadrian Gustia Anugrahwati Hendriati, Hendriati Ilmiawati, Ilmiawati Muhamad Delfin Muhammad Iqbal Andreas Mustafa Noer Netti Suharti Raveinal Raveinal Raveinal RAVEINAL RAVEINAL Raveinal Raveinal Rido Wandrivel Rizka Nadia Rizka Nadia Rizqy Auliya Lubis Roza Kurniati Roza Kurniati Saptino Miro Siti Nurhajjah Suci Maulida Yuliarni Syafrita Yulistini, Yulistini