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All Journal Jurnal Kesehatan Andalas INDONESIAN JOURNAL OF PHARMACY Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia
Dwitya Elvira
Allergy And Clinical Immunology Subdivision, Department Of Internal Medicine, Faculty Of Medicine, Universitas Andalas / M. Djamil Hospital, Padang, West Sumatera, Indonesia Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

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The Effect of Thionamide to TRH, TSH, IL-4, T-REG, and Anti-TPO in Graves’ Disease Eva Decroli; Dwitya Elvira; Dinda Aprilia
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (774.604 KB) | DOI: 10.14499/indonesianjpharm30iss2pp122-127

Abstract

The most common cause of hyperthyroidism is Graves' disease. TRH and TSH are hormonal factors that modulate and control thyroid function in Graves' disease. In the immunological aspect, Graves' disease is played by the role of T-reg, IL-4, and anti-TPO. Graves' disease treatment goal is to inhibit thyroid hormone secretion by administering thionamide. The evaluation of this treatment is its hormonal and immunological aspects. To describe the effect of thionamide on serum TRH, TSH, IL-4, T-reg, and anti-TPO levels in Graves' disease. This study is a clinical trial study in 25 study participants. All study participants were given thionamide, namely PTU 300mg for three months and blood samples were taken for laboratory tests. Serum TRH, TSH, IL-4, T-reg FOXP3, and anti-TPO levels were examined by ELISA. The mean levels at the beginning and after three months of therapy are: serum TRH 92.589pg/mL and 115.944pg/mL; serum TSH 0.041mU/L and 0.223mU/L; serum IL-4 19.759pg/mL and 23.040pg/mL; T-reg FOXP3 gene polymorphism 0.621ng/mL and 0.518 ng/mL; serum anti-TPO 2697.539pg/mL and 2604.710pg/mL. Increased levels of serum TRH and TSH levels were statistically significant. The change in serum IL-4, T-reg FOXP3 gene polymorphism, and anti-TPO levels were not statistically significant. The administration of thionamide in Graves' disease for three months will significantly decrease Wayne index and serum FT4 levels, increase serum TRH and TSH levels.
Co-Authors Adrial Adrial Alexander Kam Arina Widya Murni Azia Putri Al Jamil Dian Pertiwi Dinda Aprilia Efrida Efrida Elvia Fataya Eva Decroli Fadrian Fadrian Gustia Anugrahwati Hendriati, Hendriati Ilmiawati, Ilmiawati Muhamad Delfin Muhammad Iqbal Andreas Mustafa Noer Netti Suharti Raveinal Raveinal Raveinal RAVEINAL RAVEINAL Rido Wandrivel Rizka Nadia Rizqy Auliya Lubis Roza Kurniati Roza Kurniati Saptino Miro Siti Nurhajjah Suci Maulida Yuliarni Syafrita Yulistini, Yulistini