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All Journal Jurnal Farmasi Klinik Indonesia JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Kefarmasian Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) Cerdika: Jurnal Ilmiah Indonesia

Retnosari Andrajati

Universitas Indonesia

Author-ID : 2857974

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Articles

Quality of Antibiotic Prescribing for Respiratory Tract Disease in Primary Healthcare Centers in the District of Tegal, Central Java, Indonesia Farida Fakhrunnisa; Retnosari Andrajati; Maksum Radji
Indonesian Journal of Clinical Pharmacy Vol 9, No 2 (2020)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2020.9.2.95

The prescription of antibiotics for diagnosed upper respiratory tract infections (URTIs) is frequently practiced. Furthermore, inappropriate use has been implicated in numerous problems, including the onset of resistance. This study is, therefore, aimed to evaluate the antibiotic prescribing quality for respiratory tract disease diagnosed at the outpatients of primary healthcare centers in Tegal District, Central Java, Indonesia. In addition, cross-sectional evaluation was employed, using data obtained within the period of June–August, 2018 in six locations, and subsequently subjected to qualitative analysis. The prescribing quality was evaluated by comparing the drug selected, dosage, frequency, and duration of administration stated in the prescriptions, with the terms in the Clinical Practice Guidelines for Primary Healthcare Facilities, 2014. A total of 1453 samples were selected through purposive sampling, where 632 were diagnosed with respiratory tract diseases, with common cold as the most frequent diagnosis (87.2%). In addition, exactly 621 (98.3%) failed to fulfill the rational antibiotic prescribing criteria, evidenced by irrational drug selection (22.0%), dosage (9.5%), frequency (1.7%), and duration of administration (65.0%). The physicians tend to comply more with the national treatment guidelines (OR: 1.828, 95%CI: 0.486–6.874, p-value 0.365), and the less experience of prescribers (<12 years of service) was identified as a negative contributing factor (OR: 0.536, 95%CI: 0.143–2.016, p-value 0.349). Furthermore, irrational prescription was observed in a much larger proportion, influenced by the prescribers’ qualification and experience. This association is currently not significant, due to deficiency of influencing samples.Keywords: Antibiotic, appropriateness prescribing, national treatment guidelines, qualification prescribers, rationality Kualitas Peresepan Antibiotik pada Penyakit Saluran Pernafasan di Beberapa Puskesmas di Kabupaten Tegal, Jawa Tengah, IndonesiaAbstrakPeresepan antibiotik untuk diagnosis infeksi saluran pernafasan atas sering dilakukan. Peresepan antibiotik yang tidak tepat dapat menyebabkan banyak masalah, salah satunya resistensi antibiotik. Tujuan dari penelitian ini adalah mengevaluasi kualitas peresepan antibiotik pada diagnosis penyakit saluran pernafasan pasien rawat jalan di Puskesmas Kabupaten Tegal, Jawa Tengah, Indonesia. Penelitian potong lintang menggunakan data peresepan pasien rawat jalan periode Juni–Agustus 2018 di enam puskesmas di Kabupaten Tegal. Resep dengan diagnosis penyakit saluran pernafasan digunakan untuk analisis kualitatif. Kualitas peresepan dinilai dengan membandingkan pemilihan obat, dosis pemberian, frekuensi pemberian dan durasi pemberian antara yang tertulis pada resep dengan Panduan Praktik Klinis Fasilitas Kesehatan Primer 2014. Sebanyak 1453 resep diambil secara purposive sampling, 632 resep di antaranya dengan diagnosis penyakit saluran pernafasan. Diagnosis yang paling sering yaitu salesma (87,2%). Sebanyak 621 (98,3%) resep tidak memenuhi kriteria peresepan antibiotik yang rasional, meliputi ketidakrasionalan pemilihan antibiotik (22,0%), dosis pemberian (9,5%), frekuensi penggunaan (1,7%), dan durasi pemberian (65,0%). Peresepan antibiotik oleh dokter lebih sesuai dengan panduan pengobatan nasional (OR 1,828, 95% CI: 0,486–6,874, p-value 0,365). Pengalaman penulis resep yang lebih singkat (<12 tahun) juga menjadi faktor persepan tidak rasional (OR 0,536, 95% CI: 0,143–2,016, p-value 0,349). Sebagian besar peresepan antibiotik pada penyakit saluran pernafasan tidak rasional. Baik kualifikasi maupun pengalaman penulis resep pada penelitian ini memiliki memengaruhi rasionalitas resep, meskipun tidak (belum) signifikan karena kurangnya sampel terhadap kerasionalan.Kata kunci: Antibiotik, kerasionalan, kesesuaian peresepan, kualifikasi penulis resep, panduan pengobatan nasional

Comparison of Effects of The Hypoglycemia Management Protocol with 40% Dextrose Concentrated Solution to the Post-Correction Blood Sugar Response through Intravenous Infusion and Intravenous Bolus Yuriani Yuriani; Retnosari Andrajati; Laurentius A. Pramono
Indonesian Journal of Clinical Pharmacy Vol 8, No 2 (2019)
Publisher : Universitas Padjadjaran

Hypoglycemic patients who receive 40% dextrose (D40%) concentrated solution in the correction process need to avoid excessive blood glucose spikes. Administration of D40% was found in two different ways, through intravenous infusion (iv infusion) and intravenous bolus (iv bolus) and the effects of both types of administration were unknown. The purpose of this study was to compare the effect of a hypoglycemia treatment protocol using D40% concentrated solution to the post-correction blood sugar response through iv infusion and iv bolus at two different hospitals with two distinct protocols. This comparative analytical cross-sectional study was conducted retrospectively at St. Carolus Hospital (D40% iv infusion group) and Bella Hospital (D40% iv bolus group). Blood glucose responses, in form of coefficient of variation and degree of overcorrection, were compared between groups. The overall median blood glucose response was 69.5 (3–195) mg/dL for iv infusion group (n=60) and 77 (15–249) mg/dL for iv bolus group (n=62) (p=0.259). The coefficient of variation with iv infusion and iv bolus group were 47.18% and 52.75%, respectively. The median of degree of overcorrection in iv infusion group was lower compared with iv bolus group, 10% (0–138%) versus 23% (0–195%), respectively. Both D40% protocols did not have a significant correlation with the degree of overcorrection (Mann-Whitney test; p=0.099). D40% iv infusion and bolus administration had no effect to the post-correction blood sugar response.Keywords: Blood glucose, dextrose 40%, hypoglycemia, intravenous bolus, intravenous infusion Perbandingan Efek Protokol Manajemen Hipoglikemia dengan Larutan Pekat Dekstrosa 40% secara Intravena Infus dan Intravena Bolus terhadap Respon Gula Darah PascakoreksiAbstrakPasien hipoglikemia yang menerima larutan pekat dekstrosa 40% (D40%) dalam proses koreksinya perlu menghindari lonjakan gula darah yang berlebih. Cara pemberian D40% diberikan dengan dua cara yang berbeda yaitu melalui intravena infus (iv infus) dan intravena bolus (iv bolus), dan efek dari kedua jenis pemberian tersebut belum diketahui. Tujuan dari penelitian ini adalah membandingkan efek protokol manajemen hipoglikemia dengan larutan pekat D40% secara iv infus dan iv bolus terhadap respon gula darah pascakoreksi di dua rumah sakit dengan protokol yang berbeda. Penelitian analitik komparatif secara potong lintang ini dilakukan secara retrospektif di RS St. Carolus (kelompok iv infus D40%) dan RS Bella (kelompok iv bolus D40%). Respon gula darah, dalam bentuk koefisien variasi dan derajat overkoreksi, dibandingkan antara kedua kelompok. Median kenaikan gula darah pada kelompok iv infus D40% 69,5 (3–195) mg/dL (n=60 pasien) dan kelompok iv bolus D40% 77 (15–249) mg/dL (n=62 pasien) (p=0,259). Koefisien variasi dengan iv infus adalah 47,18% dan iv bolus 52,75%. Median derajat overkoreksi iv infus D40% lebih rendah dibandingkan iv bolus D40%, dengan masing-masing 10% (0–138%) dan 23% (0–195%). Kedua cara pemberian D40% tidak memiliki hubungan yang bermakna dengan derajat overkoreksi (uji Mann-Whitney; p=0,099). Pemberian iv infus dan bolus D40% tidak memiliki pengaruh terhadap respon gula darah pascakoreksi.Kata kunci: Dekstrosa 40%, gula darah, hipoglikemia, intravena bolus, intravena infus

Analisis Pelayanan Kefarmasian Berdasarkan Indikator Pelayanan Pasien WHO pada Puskesmas Kecamatan yang Belum dan Sudah Terakreditasi di Kota Depok Makhdalena Makhdalena; Mahdi Jufri; Retnosari Andrajati
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Pharmaceutical care based on WHO patient care indicators in various developing countries, including Indonesia, have not met the requirements. Puskesmas accreditation is expected to improve pharmaceutical care that has an impact on rational drug use. The purpose of the study was to analyze pharmacy care based on WHO patient care indicators in all sub-district health centers (9 health centers not yet accredited and 2 health centers already accredited) in Depok City. This study used a cross-sectional design and was carried out in December 2016-February 2017. The sample was adult patients from general poly and accompanying patients from integrated management of sick toddlers who met the inclusion criteria, as well as all prescription drugs taken. There were 30 respondents and 30 prescriptions for each sub-district health center. Data collection was done through interviews and observation of respondents and analysis of the recipe sheets. Data analysis used Mann-Whitney and Chi-square tests. The results show that the sub-district health centers have not been accredited which meets WHO recommendations for preparation time and delivery of drugs (> 3 minutes) of 77.8% and those who are 100% accredited. None of the sub-district health centers in Depok City meet WHO recommendations for the suitability of drug delivery, adequate drug labeling and patients with correct drug knowledge (= 100%). The time of preparation and delivery of drugs at the subdistrict health centers has been accredited significantly longer than those not yet accredited (p

Analisis Penggunaan Obat Antihipertensi di Poliklinik Rawat Jalan Rumah Sakit PMI Bogor: Perbandingan Cost Effectiveness dan Kualitas Hidup Pasien ERNI RUSTIANI; RETNOSARI ANDRAJATI; LIANA ARSYANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 2 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (415.036 KB)

Hypertension is the main problem in Indonesia and all of the world. The primary goal of hypertension treatment is reduce the total risk of cardiovascular morbidity and mortality. The high prevalence of hypertension and the requirement of medications for prolonged periods, caused the drug- treatment cost represents a major issue in health economics. The aim of this study was to describe patients characteristic when using antihypertensive drugs in polyclinic PMI hospital Bogor, determine the most cost effective drugs for blood pressure reduced output and asses the influence of hypertensive treatments to quality of life, analyzed the relationship between cost effectiveness and quality of life. This research conducted a cross-sectional descriptive study. Analytical study was Cost Effectiveness Analysis (CEA). Data were collected from primary data (using SF-12 questionnaire) and secondary data (receipt, medical record and laboratory financial data). All data analyzed using SPSS for windows version 17. Of the 137 patient, most of them women (52.6%), average age 58.6 ± 11.4 years, range 28 – 87 year, most of the patients (51.1%) with comorbid conditions and combination therapy (50.4%) was used more commonly. Results of this study indicating that the most cost effective drugs for blood pressure reduced output was combination of Beta Blocker (BB) + diuretic. The outcome measures of cost effectiveness and patient quality of life are correlated with one another.

Implementasi Penyesuaian Obat Diabetes pada Saat Puasa Ramadan dan Pengaruhnya Terhadap Nilai HbA1c Rahmi Safyanty; Retnosari Andrajati; Sudibyo Supardi; Ratu Ayu Dewi Sartika
Jurnal Sains Farmasi & Klinis Vol 7, No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

This study aimed to evaluate the effect of diabetes medication adjustment during Ramadan fasting according to the recommendation of International Diabetes Federation-Diabetes and Ramadan International Alliance (IDF-DAR) to HbA1c values in type-2 diabetes mellitus patients. The study was conducted at a hospital in Jakarta, Indonesia with a cross-sectional study design involving 80 ambulatory patients with type-2 DM who fasted during Ramadan in 2016. About 60% of patients used oral antidiabetes drug (OAD), mostly the combination of biguanide + sulfonylurea drugs (27.5%). The adjustments were made in which 56.2% was in accordance with IDF-DAR recommendations. The study showed that the HbA1c values decreased insignificantly (p = 0.082) from 8.75 ± 1.90 to 8.63 ± 1.82 after the adjustment. The appropriate drug adjustment based on IDF-DAR had a significant effect on the HbA1c value of DM patient with p-value 0.030 (p < 0.05).The discrepancy of drug use based on IDF-DAR 3.222 times greater caused uncontrolled HbA1c. The most influential variable to HbA1c value was drug type with p-value 0.006 (p < 0.05). Improper adjustment of Insulin or combination insulin-OAD caused HbA1c value 5 times greater to be uncontrolled than OAD.

Pengaruh Penggunaan Obat On-Label dan Off-Label dengan Munculnya Reaksi Obat Tidak Dikehendaki pada Pasien Pediatrik Irsalina Nurul Putri; Anton Bahtiar; Retnosari Andrajati
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.9105

Reaksi obat tidak dikehendaki (ROTD) adalah salah satu masalah kesehatan di masyarakat yang terjadi terutama pada populasi anak. ROTD pada anak dapat memiliki efek yang relatif lebih parah bila dibandingkan dengan orang dewasa. Penggunaan obat off-label merupakan faktor risiko terjadinya ROTD pada anak. Penelitian tentang penggunaan obat off-label sudah dilakukan di beberapa tempat di Indonesia tetapi sebagian besar hanya sebatas persentase penggunaan obat off-label tetapi tidak diketahui lebih lanjut tentang pengaruhnya terhadap munculnya ROTD. Tujuan dari penelitian ini adalah mengevaluasi penggunaan obat off-label dan on-label sebagai faktor risiko terjadinya reaksi obat tidak dikehendaki pada pasien pediatri. Penelitian ini merupakan penelitian studi kohor yang membandingkan reaksi obat tidak dikehendaki antara peresepan secara on-label dan off-label selama masa rawat pasien. Studi ini meneliti 130 pasien dengan jumlah penggunaan obat sebanyak 549 obat selama 4 bulan masa penelitian. Sebanyak 141 obat digunakan secara off-label dan 408 obat digunakan secara on-label. Pemberian obat off-label memiliki risiko untuk terjadinya ROTD 5,787 (Relative Risk=5,787; 95% Confidence Interval 1,072- 31,256) atau 5 kali lebih besar dibandingkan dengan pemberian obat on-label. Peneitian ini mengindikasikan bahwa pemberian obat off-label merupakan faktor risiko terjadinya reaksi obat tidak dikehendaki. Variabel perancu yang berhubungan bermakna dengan kejadian ROTD adalah variabel umur (p< 0,05).

Pengaruh Intervensi terhadap Kepatuhan Penggunaan Analgesik Opioid dan Skala Nyeri Pasien Kanker Rurynta Ferly Shavira; Retnosari Andrajati; Risani Andalasia Putri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 2 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v3i2.23682

Cancer pain patients who receive opioid analgesics need to be given educational interventions to increase patient knowledge that can have a positive impact on patient adherence, especially in outpatients who will take opioid analgesics without being accompanied by professional. To maximize the effectiveness of the intervention, it is necessary to know the relationship between the intervention to adherence and the intervention to the pain scale. This study aimed to analyze the effect of the intervention and other factors on patient adherence in using opioid analgesics and the cancer pain scale. This study was conducted at Dharmais Cancer Hospital from March-April 2021 using a quasi-experimental design in the form of nonequivalent control group. In this study, the method used are pill count to measure adherence and NRS (Numerical Rating Scale) to measure the pain scale. Measurement of adherence using pill count was conducted after the intervention, but the measurement of the pain scale was conducted before and after the intervention. A total of 134 respondents were divided into 2 intervention groups, namely the counseling group and the digital booklet group. The results of the multivariate analysis showed that there was no variable that interfered with the relationship between the intervention and respondent's adherence. The adherence of respondents who received counseling was 4 times higher than the respondents who received digital booklet. From the results of this study, it can also be concluded that the more obedient the respondent is, the lower the pain scale.

Pengaruh Penyuluhan Dan Pemberian Leaflet Pada Ibu Terhadap Pengetahuan, Persepsi Dan Penyimpanan Antibiotik Di Kelurahan Beji Dan Pancoran Mas Kota Depok Fuad Zainudin; Retnosari Andrajati; Sudibyo Supardi
Cerdika: Jurnal Ilmiah Indonesia Vol. 3 No. 4 (2023): Cerdika : Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Swamedikasi antibiotik dapat meningkatkan terjadinya resistensi dan risiko penggunaan antibiotik yang tidak tepat. Salah satunya disebabkan kurangnya pengetahuan masyarakat terhadap bahaya menyimpan antibiotik dirumah. Penelitian ini bertujuan untuk menilai pengaruh penyuluhan dan pemberian leaflet pada ibu terhadap pengetahuan, persepsi dan penyimpanan antibiotik. Penelitian ini menggunakan rancangan penelitian Quasi Experiment non randomized pre post control group. Intervensi berupa penyuluhan dan pembagian leaflet pada ibu. Penelitian dilakukan di Kota Depok pada bulan Januari-Oktober 2014. Wilayah kerja kelurahan Pancoran Mas sebagai lokasi intervensi dan kelurahan Beji sebagai kontrol. Subjek penelitian adalah ibu rumah tangga usia 18-65 tahun. Jumlah subjek untuk kelompok intervensi 52 dan kontrol 52 ibu rumah tangga. Analisis data dilakukan dengan menggunakan uji beda dan analisis multivariat. Hasil penelitian menunjukkan pengetahuan awal ibu didapatkan informasi sebesar 81,7% tidak tahu bahwa membeli antibiotik harus menggunakan resep, persepsi awal ibu didapatkan informasi sebesar 42,3 % menganggap antibiotik bukan obat keras dan sebesar 51% diketahui ibu menyimpan antibiotik dirumah. Perbedaan bermakna pengetahuan dan persepsi ibu pada kelompok penyuluhan dan pemberian leaflet lebih tinggi dibanding sebelum penyuluhan. Sedangkan pada kelompok kontrol tidak bermakna (p>0,05). Penyuluhan dan pemberian leaflet memberikan pengaruh secara bermakna terhadap peningkatan pengetahuan dan persepsi. Ada hubungan yang bermakna antara pengetahuan, persepsi dan penyimpanan antibiotik ditunjukan dengan nilai p < 0,05

Co-Authors ANTON BAHTIAR Erni Rustiani Farida Fakhrunnisa Fuad Zainudin Irsalina Nurul Putri Laurentius A. Pramono LIANA ARSYANTI Mahdi Jufri Makhdalena Makhdalena Maksum Radji Rahmi Safyanty Ratu Ayu Dewi Sartika Risani Andalasia Putri Rurynta Ferly Shavira Sudibyo Supardi Sudibyo Supardi Yuriani Yuriani

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