Garuda - Garba Rujukan Digital

p-Index From 2019 - 2024

1.203

P-Index

This Author published in this journals

All Journal Jurnal Farmasi Klinik Indonesia JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Kefarmasian Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) Cerdika: Jurnal Ilmiah Indonesia

Retnosari Andrajati

Universitas Indonesia

Author-ID : 2857974

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

Published : 8 Documents Claim Missing Document

Claim Missing Document

Articles

Title

Quality of Antibiotic Prescribing for Respiratory Tract Disease in Primary Healthcare Centers in the District of Tegal, Central Java, Indonesia Farida Fakhrunnisa; Retnosari Andrajati; Maksum Radji
Indonesian Journal of Clinical Pharmacy Vol 9, No 2 (2020)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2020.9.2.95

The prescription of antibiotics for diagnosed upper respiratory tract infections (URTIs) is frequently practiced. Furthermore, inappropriate use has been implicated in numerous problems, including the onset of resistance. This study is, therefore, aimed to evaluate the antibiotic prescribing quality for respiratory tract disease diagnosed at the outpatients of primary healthcare centers in Tegal District, Central Java, Indonesia. In addition, cross-sectional evaluation was employed, using data obtained within the period of June–August, 2018 in six locations, and subsequently subjected to qualitative analysis. The prescribing quality was evaluated by comparing the drug selected, dosage, frequency, and duration of administration stated in the prescriptions, with the terms in the Clinical Practice Guidelines for Primary Healthcare Facilities, 2014. A total of 1453 samples were selected through purposive sampling, where 632 were diagnosed with respiratory tract diseases, with common cold as the most frequent diagnosis (87.2%). In addition, exactly 621 (98.3%) failed to fulfill the rational antibiotic prescribing criteria, evidenced by irrational drug selection (22.0%), dosage (9.5%), frequency (1.7%), and duration of administration (65.0%). The physicians tend to comply more with the national treatment guidelines (OR: 1.828, 95%CI: 0.486–6.874, p-value 0.365), and the less experience of prescribers (<12 years of service) was identified as a negative contributing factor (OR: 0.536, 95%CI: 0.143–2.016, p-value 0.349). Furthermore, irrational prescription was observed in a much larger proportion, influenced by the prescribers’ qualification and experience. This association is currently not significant, due to deficiency of influencing samples.Keywords: Antibiotic, appropriateness prescribing, national treatment guidelines, qualification prescribers, rationality Kualitas Peresepan Antibiotik pada Penyakit Saluran Pernafasan di Beberapa Puskesmas di Kabupaten Tegal, Jawa Tengah, IndonesiaAbstrakPeresepan antibiotik untuk diagnosis infeksi saluran pernafasan atas sering dilakukan. Peresepan antibiotik yang tidak tepat dapat menyebabkan banyak masalah, salah satunya resistensi antibiotik. Tujuan dari penelitian ini adalah mengevaluasi kualitas peresepan antibiotik pada diagnosis penyakit saluran pernafasan pasien rawat jalan di Puskesmas Kabupaten Tegal, Jawa Tengah, Indonesia. Penelitian potong lintang menggunakan data peresepan pasien rawat jalan periode Juni–Agustus 2018 di enam puskesmas di Kabupaten Tegal. Resep dengan diagnosis penyakit saluran pernafasan digunakan untuk analisis kualitatif. Kualitas peresepan dinilai dengan membandingkan pemilihan obat, dosis pemberian, frekuensi pemberian dan durasi pemberian antara yang tertulis pada resep dengan Panduan Praktik Klinis Fasilitas Kesehatan Primer 2014. Sebanyak 1453 resep diambil secara purposive sampling, 632 resep di antaranya dengan diagnosis penyakit saluran pernafasan. Diagnosis yang paling sering yaitu salesma (87,2%). Sebanyak 621 (98,3%) resep tidak memenuhi kriteria peresepan antibiotik yang rasional, meliputi ketidakrasionalan pemilihan antibiotik (22,0%), dosis pemberian (9,5%), frekuensi penggunaan (1,7%), dan durasi pemberian (65,0%). Peresepan antibiotik oleh dokter lebih sesuai dengan panduan pengobatan nasional (OR 1,828, 95% CI: 0,486–6,874, p-value 0,365). Pengalaman penulis resep yang lebih singkat (<12 tahun) juga menjadi faktor persepan tidak rasional (OR 0,536, 95% CI: 0,143–2,016, p-value 0,349). Sebagian besar peresepan antibiotik pada penyakit saluran pernafasan tidak rasional. Baik kualifikasi maupun pengalaman penulis resep pada penelitian ini memiliki memengaruhi rasionalitas resep, meskipun tidak (belum) signifikan karena kurangnya sampel terhadap kerasionalan.Kata kunci: Antibiotik, kerasionalan, kesesuaian peresepan, kualifikasi penulis resep, panduan pengobatan nasional

Comparison of Effects of The Hypoglycemia Management Protocol with 40% Dextrose Concentrated Solution to the Post-Correction Blood Sugar Response through Intravenous Infusion and Intravenous Bolus Yuriani Yuriani; Retnosari Andrajati; Laurentius A. Pramono
Indonesian Journal of Clinical Pharmacy Vol 8, No 2 (2019)
Publisher : Universitas Padjadjaran

Hypoglycemic patients who receive 40% dextrose (D40%) concentrated solution in the correction process need to avoid excessive blood glucose spikes. Administration of D40% was found in two different ways, through intravenous infusion (iv infusion) and intravenous bolus (iv bolus) and the effects of both types of administration were unknown. The purpose of this study was to compare the effect of a hypoglycemia treatment protocol using D40% concentrated solution to the post-correction blood sugar response through iv infusion and iv bolus at two different hospitals with two distinct protocols. This comparative analytical cross-sectional study was conducted retrospectively at St. Carolus Hospital (D40% iv infusion group) and Bella Hospital (D40% iv bolus group). Blood glucose responses, in form of coefficient of variation and degree of overcorrection, were compared between groups. The overall median blood glucose response was 69.5 (3–195) mg/dL for iv infusion group (n=60) and 77 (15–249) mg/dL for iv bolus group (n=62) (p=0.259). The coefficient of variation with iv infusion and iv bolus group were 47.18% and 52.75%, respectively. The median of degree of overcorrection in iv infusion group was lower compared with iv bolus group, 10% (0–138%) versus 23% (0–195%), respectively. Both D40% protocols did not have a significant correlation with the degree of overcorrection (Mann-Whitney test; p=0.099). D40% iv infusion and bolus administration had no effect to the post-correction blood sugar response.Keywords: Blood glucose, dextrose 40%, hypoglycemia, intravenous bolus, intravenous infusion Perbandingan Efek Protokol Manajemen Hipoglikemia dengan Larutan Pekat Dekstrosa 40% secara Intravena Infus dan Intravena Bolus terhadap Respon Gula Darah PascakoreksiAbstrakPasien hipoglikemia yang menerima larutan pekat dekstrosa 40% (D40%) dalam proses koreksinya perlu menghindari lonjakan gula darah yang berlebih. Cara pemberian D40% diberikan dengan dua cara yang berbeda yaitu melalui intravena infus (iv infus) dan intravena bolus (iv bolus), dan efek dari kedua jenis pemberian tersebut belum diketahui. Tujuan dari penelitian ini adalah membandingkan efek protokol manajemen hipoglikemia dengan larutan pekat D40% secara iv infus dan iv bolus terhadap respon gula darah pascakoreksi di dua rumah sakit dengan protokol yang berbeda. Penelitian analitik komparatif secara potong lintang ini dilakukan secara retrospektif di RS St. Carolus (kelompok iv infus D40%) dan RS Bella (kelompok iv bolus D40%). Respon gula darah, dalam bentuk koefisien variasi dan derajat overkoreksi, dibandingkan antara kedua kelompok. Median kenaikan gula darah pada kelompok iv infus D40% 69,5 (3–195) mg/dL (n=60 pasien) dan kelompok iv bolus D40% 77 (15–249) mg/dL (n=62 pasien) (p=0,259). Koefisien variasi dengan iv infus adalah 47,18% dan iv bolus 52,75%. Median derajat overkoreksi iv infus D40% lebih rendah dibandingkan iv bolus D40%, dengan masing-masing 10% (0–138%) dan 23% (0–195%). Kedua cara pemberian D40% tidak memiliki hubungan yang bermakna dengan derajat overkoreksi (uji Mann-Whitney; p=0,099). Pemberian iv infus dan bolus D40% tidak memiliki pengaruh terhadap respon gula darah pascakoreksi.Kata kunci: Dekstrosa 40%, gula darah, hipoglikemia, intravena bolus, intravena infus

Co-Authors ANTON BAHTIAR Erni Rustiani Farida Fakhrunnisa Fuad Zainudin Irsalina Nurul Putri Laurentius A. Pramono LIANA ARSYANTI Mahdi Jufri Makhdalena Makhdalena Maksum Radji Rahmi Safyanty Ratu Ayu Dewi Sartika Risani Andalasia Putri Rurynta Ferly Shavira Sudibyo Supardi Sudibyo Supardi Yuriani Yuriani

Title Search

Found 2 Documents Search Journal : Jurnal Farmasi Klinik Indonesia

Abstract

Abstract

Title

Found 2 Documents
Search
Journal : Jurnal Farmasi Klinik Indonesia