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Kadar 8-hydroxyl-2’-deoxyguanosine serum pasien glaukoma primer sudut terbuka lebih tinggi dibandingkan kontrol Prahesthy, Harumi Purwa; Kusumadjaja, Made Agus; Handayani, Ariesanti Tri
Medicina Vol 47 No 1 (2016): Januari 2016
Publisher : Medicina

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Glaukoma adalah penyebab kebutaan permanen di seluruh dunia. Data WHO tahun 2007 menyebutkan bahwa glaukoma merupakan penyebab sekitar 15% kebutaan di dunia. Penelitian ini bertujuan untuk mengetahui apakah kadar 8-hydroxyl-2’-deoxyguanosine (8-OHdG) serum pada pasien glaukoma primer sudut terbuka lebih tinggi dibandingkan kontrol. Penelitian ini merupakan penelitian potong-lintang yang dilaksanakan di Poliklinik Mata RSUP Sanglah dan RS Bali Mandara Denpasar Bali, pada bulan Agustus sampai November 2015. Setiap sampel dilakukan pemeriksaan menggunakan slit lamp, applanasi goldmann, dan funduskopi dengan lensa 78 untuk menegakkan diagnosis glaukoma primer dan presbiopia serta pengambilan sampel darah vena untuk pemeriksaan kadar 8-OHdG serum. Perbedaan kadar 8-OHdG serum dianalisis dengan uji t tidak berpasangan. Besar sampel yang memenuhi kriteria penelitian sebanyak 60 pasien yang terbagi menjadi 29 pasien glaukoma primer sudut terbuka dan 31 pasien kontrol. Rerata kadar 8-OHdG serum pada pasien glaukoma primer sudut terbuka didapatkan lebih besar dibanding kontrol [15,57 (SB 0,83) vs 8,87 (SB 0,87) ng/mL, beda rerata 6,70 (IK95% 6,25 sampai 7,13) ng/mL, P=<0,0001]. Berdasarkan hasil penelitian disimpulkan bahwa rerata kadar 8-OHdG serum pasien glaukoma primer sudut terbuka lebih tinggi daripada kontrol. Glaucoma is a leading cause of irreversible blindness throughout the world. WHO statistics, 2007, indicate glaucoma accounts for 15% of total global blindness. This study aimed to determine whether serum 8-hydroxyl-2’-deoxyguanosine (8-OHdG) level in primary open angle glaucoma patients higher than control. This was a cross-sectional study taking place in the Eye Outpatient Clinic of Sanglah Hospital and Bali Mandara Hospital Denpasar, Bali started from August to November 2015. Each samples underwent slit lamp examination, goldmann applanation, and funduscopy with 78 lens to determine glaucoma primer diagnosis and control, and venous blood sampling for examination of serum 8-OHdG levels. Analysis was conducted with independent t-test. The study included 60 patients collected as subjects, consist of 29 primary open angle glaucoma and 31 controll. Mean serum 8-OHdG levels in primary open angle glaucoma patients was higher than control [15.57 (SD 0.83) vs 8.87 (SD 0.87) ng/mL, mean difference 6.7 (%CI 6.25 to 7.13) ng/mL, P=<0.0001]. It was concluded that serum 8-OHdG levels in primary open angle glaucoma higher than control.

PROPORSI PASIEN KATARAK PADA RUMAH SAKIT MATA BALI MANDARA TAHUN 2015 I Gusti Ngurah Agung Trisnu Kamajaya; Putu Yuliawati; Ariesanti Tri Handayani
E-Jurnal Medika Udayana Vol 9 No 8 (2020): Vol 9 No 08(2020): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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ABSTRAK Katarak merupakan penyebab dominan kebutaan yang dapat dicegah didunia dan bertanggung jawab terhadap 75% dari seluruh kasus kebutaan dan 90% kasus tersebut berasal dari negara berkembang, terjadi pada seluruh umur dan insidennya meningkat pad,a umur 50 tahun ke atas. Tujuan dari penelitian ini adalah untuk mengetahui jumlah pasien katarak, faktor risiko terkait dan penanganan serta tajam penglihatan paska operasi. Penelitian ini merupakan penelitian observasional yang menggunakan desain cross sectional descriptive study secara consecutive sampling dari rekam medis pasien di RS Mata Bali Mandara pada periode Januari 2015-Desember 2015. Data disajikan dalam bentuk deskriptif. Berdasarkan data yang diperoleh, angka kejadian katarak tahun 2015 adalah 2.356 pasien dan 96 pasien dipilih dalam penelitian ini dengan hasil: (1) rentangan umur dominan adalah 60-69 tahun (2) jenis kelamin perempuan ditemukan terbanyak (3) distribusi asal pasien terbanyak dari Kabupaten Gianyar (4) dari 96 pasien dengan 192 mata, terdiagnosis katarak senilis imatur (KSI) sebanyak 96 mata, katarak senilis matur (KSM) sebanyak 24 mata, KSI dan KSM bilateral sebanyak 17 mata, dan katarak juvenile sebanyak 7 mata (5) tindakan small incision cataract surgery (SICS) sebanyak 58 kali dan 93 kali phacoemulsifikasi dan 10 mata tanpa tindakan (6) terdapat penurunan jumlah visus no light perception (NLP) dan counting finger (CF) light perception (LP) serta peningkatan jumlah visus 6/6-6/7.5 setelah tindakan (7) intra ocular lens (IOL) power dominan emetropia (18.00D-22.00D). Hasil penelitian ini dapat digunakan sebagai data dasar untuk penelitian selanjutnya untuk membahas mengenai faktor risiko, hubungan antar variable serta penyebab terjadinya katarak. Kata kunci: jenis katarak, SICS, phacoemulsifikasi, perbaikan tajam penglihatan

PROPORSI PASIEN KATARAK PADA RUMAH SAKIT MATA BALI MANDARA TAHUN 2015 I Gusti Ngurah Agung Trisnu Kamajaya; Putu Yuliawati; Ariesanti Tri Handayani
E-Jurnal Medika Udayana Vol 10 No 6 (2021): Vol 10 No 06(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i6.P13

Katarak merupakan penyebab dominan kebutaan yang dapat dicegah didunia dan bertanggung jawab terhadap 75% dari seluruh kasus kebutaan dan 90% kasus tersebut berasal dari negara berkembang, terjadi pada seluruh umur dan insidennya meningkat pad,a umur 50 tahun ke atas. Tujuan dari penelitian ini adalah untuk mengetahui jumlah pasien katarak, faktor risiko terkait dan penanganan serta tajam penglihatan paska operasi. Penelitian ini merupakan penelitian observasional yang menggunakan desain cross sectional descriptive study secara consecutive sampling dari rekam medis pasien di RS Mata Bali Mandara pada periode Januari 2015-Desember 2015. Data disajikan dalam bentuk deskriptif. Berdasarkan data yang diperoleh, angka kejadian katarak tahun 2015 adalah 2.356 pasien dan 96 pasien dipilih dalam penelitian ini dengan hasil: (1) rentangan umur dominan adalah 60-69 tahun (2) jenis kelamin perempuan ditemukan terbanyak (3) distribusi asal pasien terbanyak dari Kabupaten Gianyar (4) dari 96 pasien dengan 192 mata, terdiagnosis katarak senilis imatur (KSI) sebanyak 96 mata, katarak senilis matur (KSM) sebanyak 24 mata, KSI dan KSM bilateral sebanyak 17 mata, dan katarak juvenile sebanyak 7 mata (5) tindakan small incision cataract surgery (SICS) sebanyak 58 kali dan 93 kali phacoemulsifikasi dan 10 mata tanpa tindakan (6) terdapat penurunan jumlah visus no light perception (NLP) dan counting finger (CF) light perception (LP) serta peningkatan jumlah visus 6/6-6/7.5 setelah tindakan (7) intra ocular lens (IOL) power dominan emetropia (18.00D-22.00D). Hasil penelitian ini dapat digunakan sebagai data dasar untuk penelitian selanjutnya untuk membahas mengenai faktor risiko, hubungan antar variable serta penyebab terjadinya katarak. Kata kunci: jenis katarak, SICS, phacoemulsifikasi, perbaikan tajam penglihatan

Outdoor Activities and Myopia on Junior High School Student in Rural Area of Bali Ni Made Ari Suryathi; I Putu Budhiastra; Ariesanti Tri Handayani
Majalah Oftalmologi Indonesia Vol 44 No 1 (2018): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Introduction and Aims. Refractive errors such as miopia, hyperopia and astigmatism in teenagers are common in Asian country nowadays. Gadget usage also influence the prevalence and incidence of refractive errors specially for miopia and astigmatism. Outdoor activities have positive impact to prevent miopia. The aim of this study is to report the role of outdoor activities as unique school program that could prevent refractive errors in Junior High School in rural area of Bali Method. This is analytic descriptive study with cross sectional approach of 231 Pekutatan II Junior High School students taken in December 2016. This school located in rural area; 35,3 km from Jembarana and 60,5 km from Denpasar, the capital city of Bali. The area of the school is about 1500 m2, where 70% of the land are still vacant to natural habitat and this school had their own garden area that being organized by the students themselves after school hours. This school do not have computer extra curriculum as well. Result. From 231 students there were only 14 students that have refractive errors consist of 5 boys and 9 girls, mostly aged 15 years. Six students (2%) were diagnosed as myopia and 8 students (3.4%) were diagnosed as compound astigmatism myopia. The length of gadget usage in this school were 1.66 hours and outdoor activities time were 4.78 hours per day. The hereditary factors of refractive errors were noted in 12 students (5 %). Outdoor activities associated with refractive errors in this study (p = 0.03). While time using gadget does not have an association with the refractive errors (p = 0.38). Conclusion. Rural area where the outdoor activities are still common have protective effect to prevalence of refractive errors in teenager.

Karakteristik amplitudo akomodasi mata pada anak sekolah dasar dengan kelainan refraksi di Kabupaten Badung, Bali, Indonesia Luh Gede Anggasari Dewi; Ariesanti Tri Handayani; Ida Bagus Putra Manuaba; Anak Agung Mas Putrawati Triningrat
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Background: Amplitude of Accommodation (AA) is the maximum amount of accommodation of a person's response when looking closely. Decreased accommodation capability indicates functional abnormalities, including refractive disorders. This study aims to determine the characteristics of accommodative amplitude in elementary school children with refractive abnormalities in Badung Regency, Bali.Methods: This study was an analytic cross-sectional observational research. Data were collected prospectively based on the results of examinations and observational records of students in four elementary schools. Data were presented in frequency, percentage, and bivariate tests. Data were analyzed by SPSS version 20 for Windows.Results: Most of the study respondents were 7 years old (25.7%), female (52.7%), not wearing glasses (91.2%), bilateral myopia correction (43.2%), and having sharp vision before correction of 0.3 (0.2-0.5) diopters. There was a significant difference in binocular eye accommodation based on the comparison of Subject AA with the Expected Value (p = 0.001). However, there was no significant difference in the comparison of students' refractive errors with the amplitude of monocular accommodation (p> 0.05).Conclusion: The measurement of monocular AA decreased with age and in this study, there was no AA result that was lower than the expected value or the minimum value according to the Hofstetteer formula. AA measurement results are not affected by refractive errors. It is necessary to screen for refractive errors early in children to reduce the number of amblyopia. Latar Belakang: Amplitudo akomodasi (AA) adalah jumlah maksimum akomodasi dari respon seseorang saat melihat dekat. Penurunan kemampuan akomodasi menunjukkan adanya kelainan fungsional antara lain berupa kelainan refraksi. Tujuan penelitian ini untuk mengetahui karakteristik amplitudo akomodatif pada anak sekolah dasar dengan kelainan refraksi di Kabupaten Badung, Bali.Metode: Penelitian ini merupakan observasional dengan pendekatan studi potong lintang analitik. Data dikumpulkan secara prospektif berdasarkan hasil pemeriksaan dan pencatatan hasil observasi pada anak-anak di empat sekolah dasar. Data ditampilkan dalam bentuk frekuensi, persentase, dan analisis bivariat. Data dianalisis dengan SPSS versi 20 untuk Windows.Hasil: Sebagian besar responden penelitian berusia 7 tahun (25,7%), berjenis kelamin perempuan (52,7%), tidak menggunakan kacamata (91,2%), koreksi kacamata myopia bilateral (43,2%), dan memiliki tajam pengelihatan sebelum koreksi sebesar 0,3 (0,2-0,5) dioptri. Terdapat perbedaan yang bermakna akomodasi mata binokular berdasarkan perbandingan AA Subjek dengan Expected Value (p=0,001). Akan tetapi tidak terdapat perbedaan bermakna pada perbandingan kelainan refraksi siswa dengan amplitudo akomodasi monokular (p>0,05).Kesimpulan: Pengukuran AA monokular menurun sesuai usia dan pada penelitian ini, tidak terdapat hasil AA yang lebih rendah dibandingkan dengan expected value maupun nilai minimal menurut formula Hofstetteer. Hasil pengukuran AA tidak dipengaruhi oleh kelainan refraksi. Perlu dilakukan skrining kelainan refraksi lebih awal pada anak-anak untuk mengurangi jumlah ambliopia.

Refractive lens exchange on keratoconus patient: a case report Ivane Jessica Buddyman; Cokorda Istri Dewiyani Pemayun; Ariesanti Tri Handayani
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Introduction. Keratoconus is a vision disorder that occurs when the cornea becomes thin and irregularly (cone) shaped. Instead of being focused correctly on the retina, this abnormal shape causes the light entering the eye to improperly refracted and manifested as a distortion of vision. Refractive Lens Exchange is one type of Invasive therapy in Keratoconus. Here we describe a case of Keratoconus managed by the Refractive Lens Exchange procedure in our Center.Case Description. A male, 25 years old, visited the clinic due to blurry vision since ten years ago. Every six months or a year, he needs to adjust his lens power. Ophthalmology examination found visual acuity in the right eye was 2/60 PH 6/60, and if using S-9.00, visual acuity improved to 6/30. Meanwhile, visual acuity in the left eye was 1/60 PH 6/60 and if using S–11.75, visual acuity improved to 6/48. Corneal topography supports the finding of Keratoconus. Management for this patient was Refractive Lens Exchange + Intraocular Lens + Capsular Tension Ring. Initially, This advised was differ from the patient expectation, as he wanted a LASIK procedure. An important reminder was given, that Keratoconus is contraindicated for LASIK and any corneal surface ablation procedure. After series of procedure, the VA of the right eye was 6/15 PH 6/6, with C - 4.00 x 1800 VA became 6/6. VA left eye was 6/18 PH 6/9, with C - 4,00 x 1800 VA became 6/9. Binocular vision was 6/6. For near vision, S +3.00 was added for both eyes.Conclusions. Refractive Lens Exchange + Intraocular lens implantation is effective and safe procedures to treat high myopia in keratoconus cornea.

Visual Acuity Improvement of Cataract Patients After Cataract Surgery at Sumbawa Hospital in 2018 Siska Takarai; I Wayan Gede Jayanegara; Anak Agung Mas Putrawati Triningrat; Ni Made Ari Suryathi; Ariesanti Tri Handayani; Anak Agung Ayu Sukartini Djelantik; Angelo Doniho; Anthea Casey; Giovani Faustine
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 8, No 4 (2022)
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.72478

A cataract is the most common cause of vision impairment and blindness worldwide. The Rapid Assessment of Avoidable Blindness survey held in 2014 - 2016 showed that the prevalence of blindness in West Nusa Tenggara was the second highest in Indonesia. This prevalence was expected to be higher in rural areas due to cultural barriers, patient education, and accessibility to eye-care facilities. This study aims to evaluate visual acuity improvement after cataract surgery and observe the sight restoration rate. The participants of this study were cataract patients who underwent surgery at Sumbawa Hospital West Nusa Tenggara between 27 - 30 August 2018 in a social service program held by the Sanglah General Hospital team. Surgery was not performed on patients who did not desire surgery, in cases where the surgery would not improve visual function, and on patients who were known to be medically unfit for safe surgical intervention. Demographic data and visual acuity at admission and postoperative day one were recorded and analyzed. The output of this program was qualitatively measured by analyzing the SRR. A total of 86 patients were included in this study. Visual acuity postoperative day one showed improvement, and the blindness percentage dropped to 51.16%. The sight restoration rate observed in this study was 58.14%. Although the benefits of cost-effective cataract surgery are straightforward, challenges to executing the procedure remain high, such as unaffordability surgery costs and accessibility to eye-care facilities and infrastructures. Equitable growth in other fields can automatically increase healthcare services in rural areas and encourage healthcare workers to spread evenly.

Prevalence and Risk Factors of Senile Cataract in Balinese Population Age 50 Years Old or Older Anak Agung Mas Putrawati Triningrat; Putu Adhi Surya Pradana; Ariesanti Tri Handayani; Gde Ngurah Indraguna Pinatih; Made Agus Kusumadjaja; Wayan Gede Jayanegara
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

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Objective: Cataract is the leading cause of blindness in the world with increasing trend both in prevalence and incidence. Surgery is the only definitive treatment for cataract but often unaffordable for society in developing countries. The incidence of cataract could be prevented by understanding its risk factors and formulate health programs according to them. The purpose of this study was to assess the prevalence and risk factors of senile cataract among 50 years old or older Balinese population. Method: The population-based cross-sectional study was conducted from September 2015 until July 2016 in Bali province. The variable’s data were obtained through direct examination and interview. Poisson regression analysis was used to assess the definitive correlation between risk factors and cataract. A p-value <0.05 or value which falls within 95% confidence interval were considered significant. Result: 550 subjects were enrolled during the study. The number of cataracts found in this study was 231 (42%). According to the analyses, cataract was significantly associated with older age (PR: 3.05; p=0.001), low educational level (PR: 2.18; p=0.04), diabetes (PR: 2.96; p=0.001), and the rate of ultraviolet exposure (PR: 1.92; p=0,002). Conclusion: The prevalence of cataract among 50 years old or older in Balinese population was 42%. Older age, low education, diabetes mellitus, and ultraviolet exposure were found to be significant and independent risk factors for cataract in 50 years old or older Balinese population.Keywords: Cataract, Prevalence, Risk factor.

Outdoor Activities and Myopia on Junior High School Student in Rural Area of Bali Ni Made Ari Suryathi; I Putu Budhiastra; Ariesanti Tri Handayani
Majalah Oftalmologi Indonesia Vol 44 No 1 (2018): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v44i1.159

Introduction and Aims. Refractive errors such as miopia, hyperopia and astigmatism in teenagers are common in Asian country nowadays. Gadget usage also influence the prevalence and incidence of refractive errors specially for miopia and astigmatism. Outdoor activities have positive impact to prevent miopia. The aim of this study is to report the role of outdoor activities as unique school program that could prevent refractive errors in Junior High School in rural area of Bali Method. This is analytic descriptive study with cross sectional approach of 231 Pekutatan II Junior High School students taken in December 2016. This school located in rural area; 35,3 km from Jembarana and 60,5 km from Denpasar, the capital city of Bali. The area of the school is about 1500 m2, where 70% of the land are still vacant to natural habitat and this school had their own garden area that being organized by the students themselves after school hours. This school do not have computer extra curriculum as well. Result. From 231 students there were only 14 students that have refractive errors consist of 5 boys and 9 girls, mostly aged 15 years. Six students (2%) were diagnosed as myopia and 8 students (3.4%) were diagnosed as compound astigmatism myopia. The length of gadget usage in this school were 1.66 hours and outdoor activities time were 4.78 hours per day. The hereditary factors of refractive errors were noted in 12 students (5 %). Outdoor activities associated with refractive errors in this study (p = 0.03). While time using gadget does not have an association with the refractive errors (p = 0.38). Conclusion. Rural area where the outdoor activities are still common have protective effect to prevalence of refractive errors in teenager.

Tear Break Up Time Pattern in Medical Students After COVID-19 Pandemic NI KADEK PUSPA MEGA PUTRI SUDIBIA; Ariesanti Tri Handayani
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/ep09d087

Introduction & ObjectivesCOVID-19 pandemic makes most activities are carried out online with using the VDT. Tear Break UpTime (TBUT) examination is a short and fast examination and is able to determine damage to thetear film and subjective examination using the OSDI Questionnaire. This study aimed to assess TBUTpattern in medical students after COVID-19 pandemic regarding VDT used for online learningactivities. MethodsThis study is an observational analytic study with a cross-sectional approach. The difference inproportion between TBUT results based on gender was analyzed using chi-square test. Statisticalanalysis was carried out using a multivariate test based on the results of data normality. The onewayANOVA test is used for normally distributed data, while Kruskall-Wallis is used if the data is notnormally distributed. ResultsA total of 75 subjects were included in the study, consisting of 53 females (70,7%) and 22 males(29.3%). Average use of VDT 8 hours per day. The average TBUT in both eyes were < 10 secondsand random breaks was the most common pattern seen in this study (61,3% OD and 62,7% OS).There was no significant difference between TBUT and gender but there was statistically significantdifference between OSDI score and TBUT. ConclusionLongterm use of VDT may be affect TBUT and subjective symptoms shown by OSDI score. Randombreak was the most common pattern seen in young adults in relation with VDT use.

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