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All Journal e-Journal Pustaka Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Fifteen Aprilia Fajrin
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Health Professions Library & Information Science Materials Science & Nanotechnology

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Aktivitas Minyak Jahe Merah (Zingiber Officinale var. rubrum) Terhadap Nyeri Inflamasi pada Mencit Balb-C dengan Induksi CFA (Completed Freund’s Adjuvant) (Activity of Red Ginger Oil (Zingiber officinale var. rubrum) on Inflammatory Pain in Mice Balb-C Wi Fransiska Maria Christianty; Gati Dwi Sulistyaningrum; Fifteen Aprilia Fajrin; Diana Holidah
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Pain is a multidimentional experiences. Chronic pain is caused by inflammation. Nowdays, the treatment of chronic pain is still a challenge. Plants that known to have analgetic activity is red ginger (Zingiber officinale var. rubrum). This research observed the effect of red ginger oil on inflammatory pain. Inflammatory condition was induced by intraplantar injection of CFA (Completed Freund's Adjuvant). Twenty mice were divided into 4 groups i.e sham, negative control, red ginger oil in two different doses (100 and 200 mg/kg BW). Red ginger oil was administrated per oral once a day for seven consecutive days, a week after CFA injection. Latency time toward thermal stimulus was measured on days 0, 1, 3, 5, 7, 8, 10, 12, and 14 after CFA injection. Paw thickness at the ipsilateral site was also measured on days 0, 1, 3, 5, 7, 8, 10, 12 and 14 after CFA injection. The result showed that the administration of red ginger oil significantly increased latency time toward thermal stimulus compared to negative control. It also significantly reduced paw thickness especially at dose of 200 mg/kg BW. These findings suggested that administration of red ginger oil could treat the inflammatory pain, caused by CFA injection. Keywords: red ginger oil, inflammatory pain, CFA, hyperalgesia
POTENSI BIJI SAGA (Abrus precatorius) SEBAGAI KONTRASEPSI PRIA Siti Muslichah; Wiratmo Wiratmo; Diana Holidah; Fifteen Aprilia Fajrin
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 11 No. 02 Desember 2014
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v11i2.836

Abstract

ABSTRAK Saga (Abrus precatorius) merupakan salah satu tanaman yang dikenal mempunyai banyak aktivitas farmakologi. Biji saga digunakan oleh pengobat tradisional Ayurveda sebagai bahan kontrasepsi oral. Tujuan dari penelitian ini adalah untuk mengetahui potensi fraksi biji n-heksana, fraksi kloroform, dan fraksi biji saga sebagai bahan kontrasepsi pria. Fraksi-fraksi tersebut diberikan secara oral dengan dosis masing-masing 75 mg/kg bb selama 20 hari. Sebanyak 20 ekor tikus jantan dengan berat badan 200-250 g berumur 2-2,5 bulan dikelompokkan menggunakan Rancangan Acak Lengkap. Hasil penelitian menunjukkan terjadinya penurunan jumlah, motilitas, viabilitas serta peningkatan abnormalitas spermatozoa yang signifikan dibandingkan kontrol. Hasil tersebut menunjukkan bahwa ekstrak biji saga mempunyai efek terhadap reproduksi pria yang menunjukkan potensi tanaman ini sebagai pengatur kesuburan pria. Kata kunci: biji saga, kontrasepsi pria, kualitas sperma, jumlah sperma. ABSTRACT Saga (A. precatorius) is a medicinal plant having various pharmacological activities. A. precatorius seed was used by Ayurvedic practitioners as an oral contraceptive. The present study was aimed to evaluate the contraceptive potentials of hexane, chloroform and methanolic fractions of precatory seed as male contraceptive. The organic fractions were administered orally with the dose of 75 mg/kg body weight for 20 days. Twenty five male rats weight 200-250 g of 2-2.5 month old are grouped using Complete Random Design. A significant decline in sperm count and viability, total inhibition of sperm motility, and increased numbers of sperm abnormalities were observed after 20 days of treatment. The result showed that A. precatorius seed extract affected male reproduction, suggesting the potential role of this plant in the regulation of male fertility. Key words: Abrus precatorius, male contraceptive, sperm quality, sperm count.
Co-Authors Diana Holidah Fransiska Maria Christianty Gati Dwi Sulistyaningrum Siti Muslichah Wiratmo Wiratmo