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All Journal Jurnal Kedokteran Diponegoro Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kedokteran Raflesia
Enny Nugraheni
Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Bengkulu
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Jurnal Kedokteran Diponegoro

 1 
THE RELATIONSHIP BETWEEN RAINFALL, AIR TEMPERATURE AND WIND SPEED EFFECTS DENGUE HEMORRHAGIC FEVER CASE IN BENGKULU CITY AT 2009-2014 Chandra Gunawan Sihombing; Enny Nugraheni; Wahyu Sudarsono
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 1 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (420.797 KB) | DOI: 10.14710/dmj.v7i1.19395

Abstract

Background: The disease dengue hemorrhagic fever (DHF) was infectious disease caused by dengue virus (DENV 1,2,3, and 4) which transmitted through the bite of Aedes mosquito. The incident of DHF in the transmission affected by climate factors such as rainfall, air temperature and wind speed which influenced dengue vector. Bengkulu city was area of dengue disease endemic. The research was looking for a relation of dengue cases to climatic variables, which was still not available yet. Therefore, it was necessary to know the relation of climate factors with dengue cases in Bengkulu city for preventation and warning of dengue fever.Methods: This research was analytic observational research by using a design study  ecological according to time. Type of data collected was secondary data. The data derived from Health Departement of  Bengkulu city for dengue cases data in Bengkulu city and BMKG station at Pulau Baii for climate data in Bengkulu city at 2009-2014. The data analyzed by using univariate and bivariate analysis correlation and simple linear regression.Result:The result showed pattern tedency of increasing and decreasing of DHF cases and conditions of climate in Bengkulu city at 2009-2014 were same every year generally. The result of bivariate analysis not showed the strength of the relation of climate variables toward dengue cases. rainfall (r = -0,107; p = 0,372), air temperature (r = 0,041; p = 0,733), wind speed (r = 0,087; p = 0,470).Conclusion: It concluded that there were no correlation between rainfall, air temperature and wind speed toward DHF cases in Bengkulu city at 2009-2014
Insilico Analysis of Codon 131 Polymorphism in FcγRIIA Gene and it is Association with Clinical Symptoms Persistence of Dengue Patients Enny Nugraheni; Dwi Ramadhani; Mardhatillah Sariyanti; Ety Febrianti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.31010

Abstract

Background. Dengue Hemorrhagic Fever (DHF) is infection caused by Dengue Virus. Failure of vascularization is a main symptom of Dengue Hemorrhagic Fever inducing mediator secretion by an immune cell. FcgRIIA  and CCL2 have a significant role in dengue pathogenesis and possibility in having a chance to cause dengue with a worse manifestation. Objective. Analysis of bio-informatic structure, function and expression of FcgRIIA  gene. Methods. Insilico analysis used NCBI database to find position and sequences. Analysis mutant use SNO and OMIM. Protein prediction withUniprot.  Result. FcgRIIA   human with access number of NM_001136219 by a length of 2429 bp has its full name as Fc Fragment of IgG receptor IIa, located in 1q23.3 chromosom. analyzed mutation was rs1801274 with type of missense protein residue function experiencing a change from Histidin (H) turning into Arginin (R) with allele of wild-type A and becoming G amino acid position of 166. there was structural difference of FcgRIIA   gene in wild type and mutant. Conclusion. Gene FcγRIIA  is a play a role of pathogenesis of dengue infection. Mutation in FcγRIIA  have polymorfisme at Dengue Hemorrage Fever
Co-Authors ACENG RUYANI Annelin Kurniati Chandra Gunawan Sihombing Debbie Rizqoh Dwi Ramadhani Etty Febrianti Ety Febrianti Ike Sulistyowati Jusup Endang Lusiana Astuti Madonna Fitri Pasaribu Mardhatillah Sariyanti Marlia Novelia Mulya Sundari Mulyadi Mulyadi Taufiq Ramadhan Tendri Ayu Putri Utari Hartati Suryani Wahyu Sudarsono Zayadi Zainuddin