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Journal : Jurnal Katalisator

Daya Antihiperglikemia Yoghurt Pada Mencit Putih Jantan Irene Puspa Dewi; Roza Septriani; Verawaty Verawaty; Dwi Mulyani
Jurnal Katalisator Vol 4, No 2 (2019): KATALISATOR
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22216/jk.v4i2.4607

Abstract

Research has been conducted on the antihyperglycemic of yogurt in male white mice. Yogurt contains probiotics that have a positive effect on both type 1 and types 2 diabetes mellitus. Yogurt is given for 3 weeks at a dose of 200 grams / Kg BW / day and 400 grams / Kg BW / day to mice that have been alloxan-induced. As a comparison, a positive control group was created, the alloxan-induced mice group, but not given yogurt and a negative control group, the mice group without any treatment. After 3 weeks of treatment with yogurt, it was found that there was a significant difference between the average blood glucose levels in the mice of the 200 grams/ Kg BW group and the 400 grams / Kg BW dose with the positive control group. From the data on the percentage increase in blood glucose levels of mice, it is known that by giving yogurt for 3 weeks, reducing the high percentage of increase in blood glucose levels in mice. From these data, it can be concluded that the administration of yogurt with a dose of 200 grams / Kg / day and 400 grams / Kg / day can help reduce blood glucose levels in alloxan-induced mice. Telah dilakukan penelitian mengenai daya antihiperglikemia yogurt pada mencit putih jantan. Yogurt mengandung probiotik  yang memberikan pengaruh positif terhadap diabetes mellitus baik tipe 1 maupun tipe 2. Yogurt diberikan selama 3 minggu dengan dosis 200/Kg BB/hari dan 400 gram/Kg BB/hari kepada mencit yang telah diinduksi aloksan. Sebagai pembanding dibuat kelompok kontrol positif yaitu kelompok mencit yang diinduksi aloksan, namun tidak diberi yogurt dan kelompok kontrol negatif, yaitu kelompok mencit tanpa perlakuan apapun. Setelah 3 minggu perlakuan dengan yogurt, didapatkan hasil bahwa terdapat perbedaan bermakna antara rata-rata kadar glukosa darah mencit kelompok dosis 200 gram/Kg BB dan dosis 400 gram/Kg BB dengan kelompok kontrol postif. Dari data persentase kenaikan kadar glukosa darah mencit, diketahui bahwa dengan pemberian yogurt selama 3 minggu, mengurangi tingginya persentase kenaikan kadar glukosa darah mencit.dari data-data tersebut, dapat disimpulkan bahwa pemberian yogurt dengan dosis 200 gram/Kg BB/hari dan 400 gram/Kg BB/hari dapat membantu menurunkan kadar glukosa darah mencit yang diinduksi aloksan.
AKTIFITAS ANTIBAKTERI EKSTRAK SIRIH MERAH DAN LIDAH MERTUA TERHADAP BAKTERI ESCHERICHIA COLI Irene Puspa Dewi; Verawaty Verawaty; Tuty Taslim; Rusvaira Khairunnisa
Jurnal Katalisator Vol 5, No 2 (2020): KATALISATOR
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22216/jk.v5i2.5346

Abstract

Based on previous studies note that the red betel leaf and lidah mertua leaf has a pharmacological activity as an antibacterial against Escherichia coli. This research aims to compare the antibacterial activity between ethanol extract of red betel leaf and lidah mertua leaf  againts bacterium Escherichia coli. The research used the agar diffusion method to measure the diameter of the inhibition area formed around the paper disc. Each extract ethanol is prepared with a concentration of 10% and 20%. As a positive control used ciprofloxacin. The result shown that inhibition area diameter of ethanol extract of red betel leaf with a concentration 10% is 0,97cm and 20% is 1.23 cm. Inhibition area diameter of ethanol extract of lidah mertua leaf with a concentration 10% is 1.20 cm and 20% is 1.53 cm. One Way Anova statistical analysis concluded that the average of inhibition area diameter between the ethanol extract of red betel leaf and lidah mertua leaf did not differ significantly both at concentrations of 10% and 20%. From these results we concluded that there was no significant difference in antibacterial activity of ethanol extract of red betel leaf and lidah mertua leaf againts the bacterium Escherichia coli.