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All Journal Majalah Obat Tradisional
Agung Endro Nugroho
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada
Health Professions Medicine & Pharmacology Public Health

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INTERAKSI SENYAWA AKTIF DARI Aegle marmelos CORREA SEBAGAI ANTI INFLAMASI DENGAN RESEPTOR COX-1 DAN COX-2 Dani Dwi Agistia; Hari Purnomo; Maulana Tegar; Agung Endro Nugroho
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (719.411 KB) | DOI: 10.22146/tradmedj.7983

Abstract

The compounds in Aegle marmelos have an activity as anti inflammation. The objective of this study is to evaluate six active compounds in Aegle marmelos Correa, (E,R)- Marmin, skimmianine, (S)-aegeline, aurapten, zeorin, and dustanin as anti inflammation to the COX-1 and COX-2 as target receptors. Method: Molecular docking was done with PLANTS. Ligand preparation used MarvinSketch, and protein preparation was done by using YASARA. The result was marmin, skimmianine, aegeline, aurapten, zeorin, and dustanin have interaction with Arg120, tyr 355, and Ile 523 in COX-1 and Ser353, Arg 513, and Ser 530 in COX-2. Based on the result of molecular docking, active compounds in Aegle marmelos Correa have potency as anti inflammation agent.
Wound Healing Activity of Ethanolic Extract Gel of Tawas Ut Tuber (Ampelocissus rubiginosa L.) in Incisional Model Wistar Rats Khoerul Anwar; Dewita Fitri Widodo; Nurlely Nurlely; Liling Triyasmono; Sudarsono Sudarsono; Agung Endro Nugroho
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1414.125 KB) | DOI: 10.22146/mot.29063

Abstract

Tawas ut tuber (Ampelocissus rubiginosa Lauterb.) is empirically used in wound healing by Dayak community. The present study was undertaken to assess wound healing activity of gel from ethanol extract of A. rubiginosa tuber using parameters of the closure of wound length, tensile strength, and histopathological observations. This study used twenty-five male Wistar rats divided into five groups: positive control (Bioplacenton®), negative control (placebo gel), and three of testing groups with gel extract (concentrations of 1.5%, 2.0%, and 2.5%). Wound healing activity was evaluated to 4 cm length and ± 2 mm depth incision wound model on the back skin of rats. The measurement of wound length was observed on the day of 4th, 8th, 12th, 16th, and 20th used quantitative analyze. On the day of 20th, animal was anaesthetized and the skin has been taken for tensile strength evaluation and histopathological observations. This study showed that group treated with gel extract at the concentration of 2.5% experienced higher wound healing activity with average percentage of wound closure of 99.00% ± 0.16, tensile strength 3.8541 gram/mm2, and proved with the re-epithelization, neocapillarization, and increase collagen density appeared in histopathological observations. Based on this study, gel from ethanol extract of A. rubiginosa tuber possesses wound healing activity.
Co-Authors Dani Dwi Agistia Dewita Fitri Widodo Hari Purnomo Khoerul Anwar Liling Triyasmono Maulana Tegar Nurlely, Nurlely Sudarsono Sudarsono