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All Journal Majalah Obat Tradisional JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)

Marchaban Marchaban

Faculty of Pharmacy, Universitas Gadjah Mada

Author-ID : 3038093

Health Professions Medicine & Pharmacology Public Health

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Articles

PENETAPAN KADAR ALKALOID DARI EKSTRAK ETANOLIK BUNGA KEMBANG SEPATU (Hibiscus rosa-sinensis L.) Mimiek Murrukmihadi; Subagus Wahyuono; Marchaban Marchaban; Sudibyo Martono
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Kembang sepatu flower (Hibiscus rosa-sinensis L.) was fractionally used as expectorant. Based on Bioassay Guided fractionation, an active fraction was separated, and the fraction was identified is Alkaloid was the major compound based on TLC analysis. Viscosity value measured by viscometer was used as a Bioassay model of expectorant activity in vitro and asetyl cysteine was used as positive control. Alkaloid content determination of the ethanolic extract was measured by TLC-Densitometric compared with standard curve of isolated alkaloid as the selected marker (Y=12.1360X+2901.4474). The alkaloid content in the ethanolic extract was determined as 2.35 ± 0.67 %.

OPTIMASI FORMULASI SIRUP FRAKSI TIDAK LARUT ETIL ASETAT YANG MENGANDUNG ALKALOID DARI BUNGA KEMBANG SEPATU (Hibiscus rosa-sinensis L.) Mimiek Murrukmihadi; Subagus Wahyuono; Marchaban Marchaban; Sudibyo Martono
Majalah Obat Tradisional Vol 16, No 2 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Ethylacetate insoluble fraction containing alkaloids from the hibiscus flower (Hibiscus rosa-sinensis L.) with a concentration of 0.6% w/v has mucolityc activity which is equivalent to 0.1% acetylcysteine based on the capasity to decrease viscosity of the mucus. The use of hibiscus as a new cough medicine done traditionally. Syrup of ethylacetate insoluble fraction containing alkaloids was the appropiate liquid dosage form that has some advantages for examples easy to use and fast absorption of the active substance. The study aims to determine the optimum formulation syrup ethanolic fractions containing alkaloids from hibiscus flowers using the method of Simplex Lattice Design. Ethylacetate insoluble fraction containing alkaloids from the hibiscus flower is obtained by using the Vacuum Liquid Chromatography (VLC). Simplex Lattice Design Methods used to optimize the formulation syrup ethylacetate insoluble fraction containing alkaloids from hibiscus flower with seven formulas with variations in the amount of glycerin, sorbitol solution 70%, and mucilago 0.5% CMC-Na. Physical stability was analized to find higher total response value (R total) as parameter of the optimum formula by Simplex Lattice Design Methods with Design Expert ® software version 8.0.2. Optimum formula syrup ethylacetate insoluble fraction containing alkaloids from the hibiscus flower obtained with the proportion of 25.376% glycerine, 51.985% of 70% sorbitol solution, and 22.639% of 0.5% CMC Na mucilago. Data obtained physical characteristics test compared with prediction value using Design Expert ® software version 8.0.2. Physical characteristics of optimum syrup ad the zero week compared with physical characteristics on the forth week using paired t-test. The result showed that physical properties of syrup formula optimum didn’t different significantly for easy for pouring and tasted response except for viscosity and acidity. Ethylacetate fraction syrup containing alkaloids from hibiscus flower optimization results are less stable during the four weeks of storage.

Topical Anti-inflammatory Activity of Bangle (Zingiber cassumunar Roxb). Ethanolic Extract in Mice Induced By Carrageenan Endang Dwi Wulansari; Subagus Wahyuono; Marchaban Marchaban; Sitarina Widyarini
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Rhizome of bangle (Zingiber cassumunar Roxb.) is one of the materials that are traditionally used in the traditional preparation to maintain skin from redness. The content of chemical compound in bangle rhizomes has many benefits, including inhibition of the inflammatory processes. This study aims to determine the topical anti-inflammatory activity of ethanolic extract of bangle rhizomes in mice induced by carrageenan. Thirty five female Swiss mice were used in this study. Animals were divided into 7 group of five: normal group, carrageenan 2% group, carrageenan 2% group plus control of basis (Biocream®), carrageenan 2% group plus 2.5% hydrocortisone cream, and carrageenan 2% group plus cream of ethanolic extract of bangle rhizomes with the concentration of 1%, 2.5% and 5% w/w. Carrageenan 2% was injected subcutaneously in all treatment group except normal group. The skinfold thickness of mice was measured every 1 hour for 6 hours after carrageenan injection. Results of this study shows that there is a significant differences between treatment groups (p <0.05) compared to carrageenan 2% treated group. To conclude, ethanolic extract of bangle rhizomes has topical anti-inflammatory in mice induced by carrageenan.

Correspondence Analysis between Me Too Drugs Formulation with Patent Information and the Analytical Method (Case Study: Amlodipine Tablets - PT Indofarma (PERSERO) Tbk.) Fetrikani Andartaji; Gede Bayu Suparta; Marchaban Marchaban
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 7, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.33260

One of the blockbuster drugs that has been off-patent and attract domestic pharmaceutical industry to produce a lot of version of me too is anti-hypertensive drugs Norvask®, in which the active ingredient is the salt form of amlodipine besylate. The goal of this study is to verify the conformity between me too drugs formulation and patent information (Case study: Amlodipine Tablets – PT Indofarma (Persero) Tbk). The results are expected to change the views of people who often doubt that me too drugs quality are smaller than patent drugs. The analysis method used in this study is performed descriptively. Information about amlodipine formulation obtained from PT Indofarma (Persero) Tbk is verified with the active substance test results obtained from amlodipine drugs on the market. After that, the total results can be compared with the proprietary patent information obtained from United States Patent and Trademark Office (USPTO) website. The result showed that there is a compatibilty between formulation of me too drugs and patent information (Case Study: Amlodipine – PT Indofarma (Persero) Tbk) in major issues such as compotition, active ingredient, level of active ingredient, dosage form and production process. Profile dissolution which is owned by amlodipine tablet from PT Indofarma (Persero) Tbk remains equivalent to the innovator product (Norvask®), although there was a modification by adding an excipient X. Amlodipine tablet generic produced by PT Indofarma (Persero) Tbk is me too 100% (identical).

Co-Authors Endang Dwi Wulansari Fetrikani Andartaji Gede Bayu Suparta Mimiek Murrukmihadi Sitarina Widyarini Subagus Wahyuono Sudibyo Martono

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