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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Health Notions Journal of Aquaculture and Fish Health Jurnal Layanan Masyarakat (Journal of Public Service) Berkala Penelitian Hayati

Budiatin, Aniek Setiya

Department Of Pharmacy Practice, Faculty Of Pharmacy, Universitas Airlangga, Surabaya, Indonesia

Author-ID : 3094179

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 8 Documents Claim Missing Document

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Articles

Effectiveness of Injectable Alendronat for Bone Defect due to Osteoporosis Aniek Setiya Budiatin; Cantika Suci Adlina Lasandara; Junaidi Khotib; Samirah Samirah
Health Notions Vol 3, No 1 (2019): January
Publisher : Humanistic Network for Science and Technology (HNST)

Alendronate is a drug of the bisphosphonate group used for the treatment and prevention of osteoporosis in postmenopausal women. However, when given orally, alendronate can cause indigestion and osteonecrosis of the jaw. It also has a poor bioavailability. Taking these disadvantages into account, an injection formulation of alendronate was created in this study to act on the site locally. Beside alendronate, the injection also contains bovine hydroxyapatite and gelatin as alendronate carriers. Both, besides being able to act as carriers, are also able to reduce bone damage caused by osteoporosis. The aim of this study was to determine the effectiveness of alendronate injection for fractures caused by osteoporosis in mouse models that were ovariectomized. The parameters used in this study were ALP concentration in blood and bone radiology. The results of ALP concentration showed that there were no significant differences in each group. The average ALP concentration of the negative control group was 277.67 ± 46.090, in the positive control group 270.33 ± 189.716, in the BHA-Gel group 406.33 ± 212.547 and in the BHA-Gel Alendronate group 325.00 ± 73.750. Bone radiology results and macroscopic observations still showed bone defects in each group.Yet in the negative control group, the BHAGel-Alendronate group and the BHA-Gel group, bone defects were almost entirely ameliorated. On the contrary, bone defects were still present in the positive control group. Based on the results obtained, it was shown that the injection of alendronate has not been shown to significantly overcome osteoporosis fractures. Keywords: Osteoporosis, Alendronate, Ovariectomy, Bovine hydroxyapatite, Gelatin

The Effect of 20-20-20 Rule Dissemination and Artificial Tears Administration in High School Students Diagnosed with Computer Vision Syndrome Bambang Subakti Zulkarnain; Aniek Setiya Budiatin; Toetik Aryani; Rozalina Loebis
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 7, No 1 (2021): March
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Computers and gadgets are modern tools for assisting Senior High School students’ work. However, using gadgets more than 2 hours a day may cause computer vision syndrome (CVS), which can interfere with academic activities. CVS main symptom is dry eyes. CVS could be prevented by applying the 20-20-20 rule and artificial tears. A total of 100 students from two public high schools in Kediri with 50 students from each school were selected for this community service. All students diagnosed with CVS participated in the dissemination of 20-20-20 rule and artificial tear administration. The pre-test and post-test scores, the Tear Break Up Time Test (TBUT) and the Ocular Disease Surface Index (OSDI) were measured within two weeks. TBUT and OSDI are parameters for measuring dry eye. Likewise, interviews were conducted to assess the adherence to the 20-20-20 rule and artificial tea administration. The results showed the knowledge level increased (p <0.0001). Most students understood 20-20-20 rule and how to administer artificial tears correctly. However, the adherence to both methods was approximately 50%. There was an improvement in the TBUT (p <0.0001) for dry eyes but not for OSDI (p> 0.05). Applying the 20-20-20 rule and artificial tears could be used for CVS treatment.

Injektabel Komposit Hydroksiapatit-Gelatin sebagai Sistem Penghantaran Alendronat Aniek Setiya Budiatin; Junaidi Khotib; Didik Hasmono; Samirah Samirah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Background: Bisphosphonates, such as alendronate (ALE), have been known to be effective in the treatment of bone cancer and osteoporosis. However, it has been reported that the systemic administration of ALE causes a considerable side effect. Thus, the formulation injectable bone substitute (IBS) for local administration of ALE, which functions as drug delivery system (DDS) as well as filling agent in osteoporosis-induced bone fracture, is needed. Objective: To establish the biodegradable and biocompatible formulation for ALE in injectable form which supports the drug delivery system and acts as filling agent in bone fracture. Methods: Hydroxyapatite (HA) was added to the mixture of gelatin and hydroxypropyl methyl cellulose (GEL-HPMC). ALE was added to the mixture and semisolid form was prepared for granulation. The dried granule, as injectable matrix, was grinded and mixed with appropriate amount of Na2HPO4. Results: Porosity of injectable form was higher than those of granule form. Injectable semisolid form was produced by adding 0.8 mL Na2HPO4 on each gram of granule with 10-12 min setting time. MTT assay showed that matrix was biocompatible showed by more than 100% viability. In vitro dissolution study showed that ALE was slowly released in more than 20 days. Conclusions: The formula of IBS using HA-GEL-HPMC may act as an effective drug delivery system for local administration of ALE in bone fracture.

Molecular Docking of Active Compound of Lavandula angustifolia Mill Essential Oil against N-methyl-D-aspartate (NMDA) Receptor Baiq Risky Wahyu Lisnasari; Aniek Setiya Budiatin; Chrismawan Ardianto; Junaidi Khotib
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.75-81

Background: Lavender oil is widely known to possess a relaxant effect to relieve stress, anxiety, and depression. Linalyl acetate, linalool, geranyl acetate, and β-caryophyllene were the major constituents of lavender oil that potentially act on NMDAR (N-methyl-d-aspartate receptors), and emerging targets in the treatment of depression. Objective: This study aims to predict the binding of lavender compounds to NMDA receptors using an in silico model. Methods: The ligands of the docking study were four major chemical compounds of lavender oil, i.e., linalyl acetate, linalool, geranyl acetate, and β-caryophyllene. 5YE was defined as a native ligand, while memantine, an NMDAR antagonist, was used as a reference ligand. The NMDAR structure was taken from Protein Data Bank (ID 5H8Q), while the lavender compound was sketched in Chem3D. Autodock 4.2 was used to perform the docking analysis. Results: The result showed that beta-caryophyllene had the most potent interaction with NMDAR (free binding energy was -8.02 kcal/mol and inhibitory constant was 1.32 µM). Conclusion: The docking results suggest that beta-caryophyllene could be an NMDAR antagonist and be developed as a treatment for depression.

EFFECT OF DIABETES TRAINING PROGRAM ON KNOWLEDGE AND ASSESSMENT SKILL AMONG GERIATRIC WORKER COMMUNITY IN SURABAYA Zamrotul Izzah; Mahardian Rahmadi; Dewi Wara Shinta; Toetik Aryani; Aniek Setiya Budiatin
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 1 No. 2 (2017): Jurnal Layanan Masyarakat
Publisher : Universitas Airlangga

The prevalence of diabetes mellitus (DM) is higher among other degenerative diseases in Surabaya, Indonesia. Providing information is not suﬃcient to improve diabetic patients’ compliance and achieve goals of its therapy. Patients’ good awareness as well as emotional and social supports from community plays an important role to improve their compliance and clinical outcomes. Therefore, diabetes training program was delivered to geriatric worker community to improve their knowledge on DM and assessment skill to check the blood glucose level of geriatric diabetic patients. A total of 20 female workers were enrolled in the program. They received a series of lectures on diabetes and its management and gained practical skill on using the self-check blood glucose test. A validated questionnaire was administered to all workers at baseline and at final follow-up to assess knowledge and practice. The overall workers’ awareness increased over than 100%. After finishing the program, all workers joined a diabetic counseling program for geriatric patients in their community. Glucose levels were evaluated from their patients to assess the outcome of the counseling program. The random and fasting blood glucose levels decreased around 31% and 14%, consecutively. This study reveals that diabetes training program for geriatric community workers is beneficial to control blood glucose levels. AbstrakDiabetes melitus (DM) merupakan penyakit degeneratif yang memiliki prevalensi lebih tinggi di antara penyakit degeneratif lainnya di Surabaya, Indonesia. Pemberian informasi saja masih dirasakan belum cukup untuk memperbaiki tingkat kepatuhan pasien diabetes dan mencapai tujuan terapi. Kesadaran pasien serta dukungan emosional dan sosial dari masyarakat berperan penting untuk meningkatkan kepatuhan dan hasil terapi. Oleh karena itu, program pelatihan diabetes dilakukan kepada komunitas pekerja lanjut usia (lansia) untuk meningkatkan pengetahuan mereka tentang penyakit DM dan ketrampilan dalam pemeriksaan kadar glukosa darah. Sebanyak 20 orang pekerja perempuan ikut serta sebagai peserta dalam program ini. Mereka menerima serangkaian materi tentang penyakit DM dan pengelolaannya, serta mendapatkan praktek keterampilan untuk menggunakan tes glukosa darah secara mandiri. Sebagai evaluasi kegiatan, kuesioner diberikan kepada peserta pada awal dan akhir kegiatan. Kesadaran pekerja secara keseluruhan meningkat lebih dari 100%. Setelah akhir kegiatan, semua peserta bergabung dengan program konseling diabetes untuk pasien lansia di komunitas mereka. Tingkat glukosa dievaluasi dari pasien mereka untuk menilai hasil program konseling. Tingkat glukosa darah acak dan puasa menurun sekitar 31% dan 14%, berturut-turut. Studi ini mengungkapkan bahwa program pelatihan diabetes untuk pekerja komunitas lansia ini sangat bermanfaat untuk mengendalikan kadar glukosa darah di komunitas.

ELUSIDASI STRUKTUR ISOLAT SKUALENA DARI IKAN HIU CUCUT BOTOL (Centrophorus sp) Aniek Setiya Budiatin
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 11 No 1 (2005): December 2005
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/462

The main source of squalene was liver oil of shark. Producing of squalene this oil could be separated from other components inside. The research obtained that the value of squalene was 75.83 ± 1.14%. To discover the purification and safety to consume squalene which had been isolated from oil of the liver’s shark cucut botol ‘ was used a method which available in AOAC, therefore that could be done elucidation of the structure of isolate with any instruments such as KLT; FTIR; GC; GC-MS; and NMR. Structure elucidation of isolate compare with standard of squalene had result as follows: a. KLT: Rf isolate = 0.457; Rf standard = 0,457; b. FTIR = 2980– 2850 CH of methyl and methylene; 1668.58 & 1446.74 a double chain of carbon (C=C); 1381.16 & 835.25 = branch chain that all for isolate was the same with standard; GC tR = 9.065 minute of isolate and standard was 9.124 minutes; GC-MS the main fraction with mass 69 was one unit of isoprene (C5H9); the value of proton NMR (δ = ppm) were 1.601 & 1.674; 2.016; 5.150 & 5.155 for isolate; the standard were 1.599 & 1.670; 2.016; 5.155. The result of elucidation structure could be concluded that the isolate was the same with the squalene standard. Therefore, isolate could be able to consume safety as natural health food for all consumers because it had already pure and free from other compound such as cholesterol.

In Vitro Cytotoxicity Test Reveals Non-toxic of Waste-based Scaffold on Human Hepatocyte Cells Oktantia Frenny Anggani; Aniek Setiya Budiatin; Laksmi Sulmartiwi; Muhammad Rahmad Royan
Journal of Aquaculture and Fish Health Vol. 10 No. 1 (2021): JAFH Vol 10 No. 1 February 2021
Publisher : Department of Aquaculture

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jafh.v10i1.23424

Scaffold, as one of the components for bone tissue engineering, requires formulated biomaterials that are both structurally and compositively similar to bone composition. Among others, chitosan, gelatin and chondroitin sulfate are known as potential candidates for scaffold composites that can be easily obtained from waste-based resources. This study aims to investigate the cytotoxicity of different scaffold composition and concentration regimes derived from waste-based chitosan, gelatine and chondroitin sulfate, in vitro. The composition regimes used were (Chitosan : Gelatin : Chondroitin Sulfate) 50 : 50 : 0 (A); 50 : 40 :10 (B); 50 : 35 : 15 (C); 50 : 30 : 20 (D); 50 : 25 : 25 (E). Meanwhile, the final concentrations of scaffold used were 2000, 1000, 500, 250, 100, 10 and 0,1 mg/ml. The different compositions and concentrations of scaffold was tested against Hepatocellular Carcinoma (Huh7it / Human Hepatocyte It). After 48-hour incubation in the scaffold solution, the percentage of cell viability was evaluated using 3-(4,5-dimethylthiazol-2yl)-5(3-carboxymethoxyphenyl)-2- (4-sulfophenyl)-2H-tetrazolium (MTT) assay. The result shows that there is no difference observed among different scaffold compositions on the cell viability (p > 0.05). However, different concentrations of scaffold show significant differences in cell viability in composition C and E (p < 0.01), suggesting possible dose- dependent effect of scaffold on cell viability. Overall, all the waste-based scaffold compositions show no toxicity against the Hepatocellular Carcinoma cells as exhibited by the cell viability that is above 70%, at least with the concentration up to 2000 mg/ml.

Acute and Subchronic Toxicity of Indonesian House Dust Mites (IHDM) Allergenic Extract for Asthma Allergy Immunotherapy Aniek Setiya Budiatin; Yusuf Alif Pratama; Winda Fatma Sari; Mahardian Rahmadi; Muhammad Taher; Zainul Amiruddin Zakaria; Junaidi Khotib
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.185-192

Background: In developing a pharmaceutical product, it is necessary to conduct pre-clinical and clinical trials to ensure its safety and effectiveness. The toxicity test is conducted to assess the safety of a substance to determine its toxic effect of the substance. Objective: This study aims to determine the acute and subchronic toxicity of administering IHDM allergenic extract using experimental animal models. Methods: Female BALB/c mice and female and male Wistar rats were used as experimental animal models. While the IHDM allergenic extract was used with the level of Der p1 is 11.3-26.6 ng/mL and was administered by intravenous route. The acute toxicity test was carried out for 14 days on four different dose groups of experimental animals. The subchronic toxicity test was carried out for 28 days using three other dose groups of experimental animals. Results: The administration of a single dose of IHDM allergenic extract at various doses did not cause mice behaviour changes, and no death was shown in each group. Likewise, there was no change in the principal organs by macroscopic observations. Meanwhile, administering IHDM allergenic extract at repeated doses for 28 days could show signs of toxicity. The symptoms were shown in the histopathological structure of the liver, kidney, and heart organs. Conclusion: It can be concluded that the IHDM allergenic extract is safe for single-dose administration but shows toxic signs when given in repeated doses. Further tests are needed for 90 days of subchronic toxicity and satellite testing.

Co-Authors Baiq Risky Wahyu Lisnasari Bambang Subakti Zulkarnain Cantika Suci Adlina Lasandara Chrismawan Ardianto Dewi Wara Shinta Didik Hasmono Junaidi Khotib Khoirotin Nisak Laksmi Sulmartiwi Mahardian Rahmadi Mahardian Rahmadi Muhammad Rahmad Royan Muhammad Taher Oktantia Frenny Anggani Rozalina Loebis Samirah Samirah Toetik Aryani Winda Fatma Sari Yusuf Alif Pratama Zainul Amiruddin Zakaria Zamrotul Izzah

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