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All Journal Folia Medica Indonesiana JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology
Dewi Wara Shinta
Department Of Pharmacy Practice, Faculty Of Pharmacy, Universitas Airlangga, Surabaya
Humanities Chemistry Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Medicine & Pharmacology Public Health Social Sciences Other

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Effect of Mannitol Hydration as Renoprotective on Cisplatin Induced Nephrotoxicity (CIN) in Head and Neck Cancer Patients Mareta Rindang, Andarsari; Yunita Dyah, Kusumaningrum; Rosy Nurlita, Hapsari; Dwi Hari, Susilo; Dewi Wara, Shinta
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16958

Abstract

Background: Cisplatin is a cytostatic agent used as treatments in head and neck cancer patients.Nephrotoxicity is one of cisplatin major side effects. This study aimed to evaluate the renoprotectiveeffect of mannitol-hydration administration in head and neck cancer patients who receive cisplatinchemotherapy. Methods: This was a cohort observational study to analyze the renal function of head andneck cancer patients who receives cisplatin before and after mannitol-hydration administration in IRNASurgery and Soekardja Room of Chemotherapy at RSUD Dr. Soetomo Surabaya during June – September2018. The data obtained were BUN, SCr, and eClCr Cockroft-Gault of each cycle. Result: A total of 52patients were evaluated. The average value of creatinine serum, creatinine clearance, and BUN at each cyclewere fluctuate. However, the average value of creatinine serum and BUN were within the normal limit.The result of statistical analysis using paired t-test in those parameters at each cycle were not statisticallysignificant (p > 0,05) after mannitol administration except during first cycle to second cycle the SCr increasedsignificantly and eClCr was decreased significantly (p-value 0,024; 0,006, CI 95% respectively ). At fourthcycle the eClCr also decreased significantly (p value 0,008, CI 95%). Conclusion: The renoprotective effectof mannitol in head and neck cancer patients who receive cisplatin chemotherapy is sufficiently adequatewhich can maintain the value of BUN and creatinine serum of patients at each cycle within the normal limit.
The Effect of Serotonin-Norepinephrine Reuptake Inhibitor Milnacipran on Anxiety-like Behaviors in Diabetic Mice Tuhfatul Ulya; Chrismawan Ardianto; Mahardian Rahmadi; Dewi Wara Shinta; Junaidi Khotib
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 3 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i32021.200-206

Abstract

Background: Diabetes mellitus is a chronic disease that causes neuronal plasticity and increased hypothalamic pituitary adrenal (HPA) axis of stress disorders. The change in metabolism is reportedly associated with inadequate response to antianxiety and antidepressant agents. Objective: This study aimed to determine the effect of milnacipran antidepressants on anxiety-like behavior in mice with diabetes mellitus. Methods: Male ICR mice were divided into naive, stress, diabetes mellitus (DM), DM + stress groups to measure anxiety-like behavior. Diabetes mellitus was induced using alloxan, and electric footshock stress was used as a stressor for 14 consecutive days. Anxiety-like behavior was measured using the light-dark box (LDB) and elevated plus maze (EPM) test at days 0, 7 and 14. The antidepressant milnacipran (MIL) was given for 7 days, on days 8 to 14. On day 14, evaluation of anxiety-like behavior after administration of MIL was carried out in all groups using LDB and EPM tests. Results: The results showed that administration of milnacipran effectively ameliorated anxiety-like behavior in the non-DM, but not in the DM group, using the LDB test. A similar result was demonstrated in the EPM test showing the non-DM group's attenuation after milnacipran administration. Conclusion: The present results indicate that there is an inadequate attenuation of the anxiety-like behavior after treatment with milnacipran in diabetes conditions.
EFFECT OF HYDROXYETHYL STARCH 200/0.5 ON VON WILLEBRAND FACTOR SERUM LEVEL AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) Sarah Puspita Atmaja; Junaidi Khotib; Eddy Rahardjo; Dewi Wara Shinta; Mahardian Rahmadi; Budi Suprapti
Folia Medica Indonesiana Vol. 51 No. 4 (2015): Oktober - December 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.596 KB) | DOI: 10.20473/fmi.v51i4.2848

Abstract

Hydroxyethyl starch (HES) is a colloid administered frequently for intravascular volume expansion during perioperative period. Impairment of haemostasis have been reported during HES administration, but the volume of solution administered was usually higher than 20 ml.kg-1. The objective of this study was to evaluate the effect of Hydroxyethyl starch 200/0.5 dose less than 20 ml.kg-1 on von Willebrand factor serum level and activated partial thromboplastin time. A prospective, observational study was conducted to evaluate von Willebrand factor and activated partial thromboplastin time of patients receiving Hydroxyethyl starch 200/0.5. Inclusion criteria were patients undergoing elective surgery who were going to receive Hydroxyethyl starch 200/0.5 intraoperatively. Fourty six patients were divided into patients receiving crystalloid only group (n=23 patients) and hydroxyethyl starch (n=23 patients). Coagulation variables were assesed 30 minute after insicion and 60 minute after infusion of crystalloid or colloid. Measurement of von Willebrand within each group after crystalloid or HES 200 infusion showed significant decrease, from (mean±SE) 97.688±15.219 ng/ml to 31.611±10.058 ng/ml (p< 0.001) in crystalloid group and 92.884±15.208 ng/ml to 27.378±6.399 ng/ml (p<0.001) in HES 200 group. Activated partial thromboplastin time change was statistically significant (mean±SE) 31.27±1.39 to 35.61±1.62 in HES group only (p=0.007), but this change was not clinically significant. In conclusion, there was neither significant difference in von Willebrand serum level nor in activated partial thromboplastin time between the two groups. There was no coagulation influence with clinically significant effect in the use of HES 20 ml/kg BW in patients undergoing elective surgery.
THE USE OF HYDROXYETHYL STARCH 200/0,5 AS PLASMA SUBTITUTES IS SAFE IN HYPOVOLEMIC PATIENTS AS INDICATED IN CHANGES OF N-ACETYL--GLUCOSAMINIDASE AND CREATININ SERUM PARAMETERS Dewi Wara Shinta; Junaidi Khotib; Eddy Rahardjo; Mahardian Rahmadi; Budi Suprapti
Folia Medica Indonesiana Vol. 51 No. 4 (2015): Oktober - December 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (75.638 KB) | DOI: 10.20473/fmi.v51i4.2852

Abstract

Hydroxyethyl Starch (HES) is a compound that improves intravascular volume effectively and rapidly without causing tissue edema. However, HES also has renal safety profile which is still being debated. Based on clinical experience in Dr. Soetomo Hospital, the frequency of acute renal failure following HES 200/0.5 administration at a dose of less than 20 ml/kg (maximum dose) is very rare. The purpose of this study was to evaluate the effect of HES 200/0.5 at a dose of less than 20 ml/kg in patients undergoing surgery. N-acetyl-b-D-Glucosaminidase (NAG) per urine creatinine ratio and creatinine serum were used as main parameter to assess renal injury. This research was observational and prospective design in patients undergoing elective surgery at Gedung Bedah Pusat Terpadu, Dr. Soetomo Hospital, who requiring resuscitation therapy with HES 200/0.5 and met the inclusion and exclusion criteria. NAG was measured prior to surgery and 12 hours after administration of fluid therapy, while creatinine serum was observed before surgery and 48 hours after resuscitation. This study was conducted for three months, and obtained 50 subjects divided into 2 groups, crystalloid group and HES 200/0.5 group. Demographic and baseline characteristics did not differ between groups, except the total bleeding volume. Total bleeding in HES 200/0.5group was higher than crystalloid group (p <0.0001). The mean volume of fluid received in HES 200/0.5 group was 2042.0 ± 673.9 mL, higher when compared with that of crystalloid group (910.0 ± 592.0 ml). Doses of HES 200/0.5 received was 8.31 ± 4.86 ml/kg. Measurement of the of NAG/creatinine ratio and creatinine serum showed significant increase in both groups, but still within the normal range. In addition, the value of these two parameters did not differ between groups. In conclusion, HES 200/0.5 in a dose of less than 20 ml/kg is safe to use in patients who suffered from hypovolemic hemorrhage, without prior history of renal impairment.
PENINGKATAN KOMPETENSI DAN PENGETAHUAN APOTEKER TERHADAP OBAT OFF LABEL MELALUI WORKSHOP AND TRAINING Suharjono Suharjono; Mahardian Rahmadi; Chrismawan Ardianto; Arina Dery Puspitasari; Dewi Wara Shinta
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 2 No. 2 (2018): Jurnal Layanan Masyarakat
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (189.917 KB) | DOI: 10.20473/jlm.v2i2.2018.52-55

Abstract

Drug information off label is not widely known and understood by health workers, both doctors and pharmacists. Prescribing drugs off label will also have an impact on ethical rules and drug costs, whether legal and can be covered by insurance. Therefore, there needs to be a continuing education activity for Pharmacists and health professionals to provide information and understanding of participants with the development of drugs off the label. This activity aims to improve the competencies of the participants, as well as understand the legal prescribing rules and as input for insurance and pharmaceutical regulations. The form of activities that will be carried out are workshops and training. The event was held for 2 days, 14-15 October 2018 at Graha Iptekdok, FKUA. There are 10 resource persons with 11 materials divided into 6 workshops, and 1 Micromedex training activity. This activity was attended by 383 participants and 5 invitations. Among the 383 participants, 55% were pharmacists working in hospitals, 30% were pharmacists working in pharmacies, and the rest were pharmacists working in industries, health centers, health services, and pharmacy students. Domicile participants come from various regions, with the largest percentage from Java. Based on the results of the questionnaire evaluation, the average material suitability assessment with participants’ needs was 8 out of 10. On the other hand, the material mastery by the speakers was also very good (8 out of 10). While in terms of the event, the average participant rated very well (7-9 of a scale of 10). A value of 7 is given to the parameters of room facilities. Seeing the enthusiasm of the participants of the Off Label Workshop andTraining in Community and Clinical Settings, the committee plans to follow up by holding a similar event to accommodate potential participants who cannot be accommodated in this event.AbstrakInformasi obat off label belum banyak diketahui dan dipahami oleh para tenaga kesehatan, baik dokter maupun apoteker. Peresepan obat off label juga akan berdampak pada aturan etik dan biaya obat, apakah legal dan bisakah ditanggung oleh asuransi. Oleh sebab itu, perlu adanya suatu kegiatan pendidikan berkelanjutan kepada para Apoteker dan profesi kesehatan untuk memberikan informasi dan pemahaman peserta dengan perkembangan obat off label. Kegiatan ini bertujuan untuk meningkatkan kompetensi para peserta, juga memahami aturan peresepan yang legal dan sebagai masukan untuk asuransi serta peraturan farmasi. Bentuk kegiatan yang akan dilakukan adalah workshop dan training. Acara dilakukan selama 2 hari, 14–15 Oktober 2018 di Graha Iptekdok, FKUA. Terdapat 10 narasumber dengan 11 materi yang dibagi dalam 6 workshop, dan 1 kegiatan pelatihan Micromedex. Kegiatan ini dihadiri oleh 383 peserta dan 5 undangan. Diantara 383 peserta, 55% merupakan apoteker yang bekerja di rumah sakit, 30% adalah apoteker yang bekerja di apotek, dan sisanya adalah apoteker yang bekerja di industri, puskesmas, dinas kesehatan, dan mahasiswa farmasi. Domisili peserta berasal dari berbagai daerah, dengan prosentase terbesar dari Jawa. Berdasarkan hasil evaluasi kuesioner, rata-rata penilaian kesesuaian materi dengan kebutuhan peserta adalah 8 dari skala 10. Selain itu, penguasaan materi oleh narasumber juga sangat baik (8 dari skala 10). Sedangkan dari segi acara, rata-rata peserta menilai sangat baik (7–9 dari skala 10). Nilai 7 diberikan pada parameter fasilitas ruangan. Melihat antusiasme dari peserta off Label Drugs Workshop and Training in Community and Clinical Settings, maka panitia berencana akan melakukan tindak lanjut dengan mengadakan acara yang serupa untuk mengakomodir calon peserta yang tidak dapat tertampung pada acara ini.
EFFECT OF DIABETES TRAINING PROGRAM ON KNOWLEDGE AND ASSESSMENT SKILL AMONG GERIATRIC WORKER COMMUNITY IN SURABAYA Zamrotul Izzah; Mahardian Rahmadi; Dewi Wara Shinta; Toetik Aryani; Aniek Setiya Budiatin
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 1 No. 2 (2017): Jurnal Layanan Masyarakat
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.808 KB) | DOI: 10.20473/jlm.v1i2.2017.56-60

Abstract

The prevalence of diabetes mellitus (DM) is higher among other degenerative diseases in Surabaya, Indonesia. Providing information is not sufficient to improve diabetic patients’ compliance and achieve goals of its therapy. Patients’ good awareness as well as emotional and social supports from community plays an important role to improve their compliance and clinical outcomes. Therefore, diabetes training program was delivered to geriatric worker community to improve their knowledge on DM and assessment skill to check the blood glucose level of geriatric diabetic patients. A total of 20 female workers were enrolled in the program. They received a series of lectures on diabetes and its management and gained practical skill on using the self-check blood glucose test. A validated questionnaire was administered to all workers at baseline and at final follow-up to assess knowledge and practice. The overall workers’ awareness increased over than 100%. After finishing the program, all workers joined a diabetic counseling program for geriatric patients in their community. Glucose levels were evaluated from their patients to assess the outcome of the counseling program. The random and fasting blood glucose levels decreased around 31% and 14%, consecutively. This study reveals that diabetes training program for geriatric community workers is beneficial to control blood glucose levels. AbstrakDiabetes melitus (DM) merupakan penyakit degeneratif yang memiliki prevalensi lebih tinggi di antara penyakit degeneratif lainnya di Surabaya, Indonesia. Pemberian informasi saja masih dirasakan belum cukup untuk memperbaiki tingkat kepatuhan pasien diabetes dan mencapai tujuan terapi. Kesadaran pasien serta dukungan emosional dan sosial dari masyarakat berperan penting untuk meningkatkan kepatuhan dan hasil terapi. Oleh karena itu, program pelatihan diabetes dilakukan kepada komunitas pekerja lanjut usia (lansia) untuk meningkatkan pengetahuan mereka tentang penyakit DM dan ketrampilan dalam pemeriksaan kadar glukosa darah. Sebanyak 20 orang pekerja perempuan ikut serta sebagai peserta dalam program ini. Mereka menerima serangkaian materi tentang penyakit DM dan pengelolaannya, serta mendapatkan praktek keterampilan untuk menggunakan tes glukosa darah secara mandiri. Sebagai evaluasi kegiatan, kuesioner diberikan kepada peserta pada awal dan akhir kegiatan. Kesadaran pekerja secara keseluruhan meningkat lebih dari 100%. Setelah akhir kegiatan, semua peserta bergabung dengan program konseling diabetes untuk pasien lansia di komunitas mereka. Tingkat glukosa dievaluasi dari pasien mereka untuk menilai hasil program konseling. Tingkat glukosa darah acak dan puasa menurun sekitar 31% dan 14%, berturut-turut. Studi ini mengungkapkan bahwa program pelatihan diabetes untuk pekerja komunitas lansia ini sangat bermanfaat untuk mengendalikan kadar glukosa darah di komunitas.
Co-Authors Arina Dery Puspitasari Budi Suprapti Budiatin, Aniek Setiya Chrismawan Ardianto Dwi Hari Susilo Eddy Rahardjo Junaidi Khotib Mahardian Rahmadi Mareta Rindang Andarsari Rosy Nurlita, Hapsari Sarah Puspita Atmaja Suharjono Suharjono Toetik Aryani Tuhfatul Ulya Yunita Dyah, Kusumaningrum Zamrotul Izzah