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Zulkifli Malik
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Medicine & Pharmacology

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HISTOPATOLOGI AORTA TORASIKA Rattus novergicus STRAIN WISTAR JANTAN SETELAH 8 MINGGU PEMBERIAN DIET ATEROGENIK Welinsa, Fatya; Asni, Enikarmila; Malik, Zulkifli
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 1 (2015): Wisuda Februari 2015
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ABSTRACTAtherosclerosis could be induced in animal model (Rattus novergicus) by feeding atherogenic diet consist of standart feed, cholesterol 2 % from yolk, 5 % goat fat, 0,2% cholic acid and induction with vitamin D3. The goal of this research was to analyze histopathological of thoracic aorta on male Rattus novergicus strain wistar after fed atherogenic diet for 8 weeks. This research was an experimental laboratory research with post test only with control design. Twelve male rats were segregated into two groups (n=6) labelled as control fed standart and atherogenic fed group. After 8 weeks thoracic aorta was taken and histological slides were made and colored with hematoxylin eosin and then measured with atherosclerosis score. The result showed that in atherogenic group there are macrophage, foam cell, and intracellular lipid accumulation with 100% percentage, extracellular lipid accumulation 33,33% (for a little extracellular lipid) and 66,67 (a lot of extracellular lipid) while control group there are macrophage, foam cell, and intracellular lipid accumulation with 33,33% percentage. The statistical test result show there is significant difference between control group and atherogenic group (p=0,003). As conclusion, there is significant difference between control group and atherogenic group.Keywords : Atherosclerosis, atherogenic diet, thoracic aorta
HUBUNGAN KORPORA AMILASEA DENGAN PROSTATITIS, BENIGN PROSTAT HIPERPLASIA, DAN KARSINOMA PROSTAT PADA TURP DI RSUD ARIFIN ACHMAD PROPINSI RIAU PERIODE 2008-2013 Alcan, Firdath Rubenzani; ", Zuhirman; Malik, Zulkifli
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 2 (2015): Wisuda Oktober 2015
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Corpora amylacea is a substance of protein secret produced by gland epithelial cell when the gland shape changed. Prostatitis is an inflammation of the prostate. Benign prostate hyperplasia is a benign enlargement of the prostate varied from gland hyperplasia or fibromuscular hyperplasia. Carcinoma of the prostate is an abnormal growth of the prostate cells. This study uses the medical record of pathological examination in the Anatomic Pathology Department Arifin Achmad Hospital of Riau Province. Based on correlation of prostatitis, benign prostate hyperplasia and carcinoma of the prostate with corpora amylacea, benign prostate hyperplasia has the strongest correlation (0.214) then prostatitis (-0.63) and carcinoma of the prostate (-0.233). The conclusion is corpora amylacea has the strongest relation with benign prostate hyperplasia, then followed by prostatitis and carcinoma of the prostateKeywords : Corpora amylacea, prostatitis, BPH and Ca prostate.
HISTOPATOLOGI ARTERI KORONARIA Rattus novergicus STRAIN WISTAR JANTAN SETELAH PEMBERIAN DIET ATEROGENIK SELAMA 5 MINGGU Annisa Ul Hasanah; Enikarmila Asni; Zulkifli Malik
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 1 (2015): Wisuda Februari 2015
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ABSTRACTAtherosclerosis is a complex chronic disease characterized by the accumulation of lipid, trombosits, neutrophils, monocytes, and macrophages within arterial walls. Atherosclerosis could be induced in animal model ( Rattus novergicus ) by feeding atherogenic diet. The goal of this research was to analyze histopathological of coronary artery on male Rattus novergicus strain wistar after fed atherogenic diet for 5 weeks. This research was an experimental laboratory research with post test only with control design. Twelve male rats were segregated into two groups ( n=6 ) labelled as control fed standart and atherogenic group fed atherogenic diet containing cholic acid 0,2%, fat 5%, egg yolk 2% and induction with vitamin D3. After 5 weeks coronary artery was taken and histological slides were made and colored with Hematoxylin Eosin. The measured parameter were atherosclerosis lession score. The result showed 66% sampels that given standart diet and 100% sampels that given atherogenic diet showed atherosclerosis lession.The statistical test result showed there is no significant difference between control group and atherogenic group. ( p=0,328 ). The conclusion, atherosclerosis occurred in 4 sampels ( 66% ) of control group and 6 sampels ( 100% ) of atherogenic group. There was no significant difference in coronary artery histopathology Rattus novergicus between the control group with atherogenic group.Keywords : Atherosclerosis, atherogenic diet, coronary artery.
HISTOPATOLOGI ARTERI KORONER Rattus novergicus STRAIN WISTAR JANTAN PADA MINGGU KE-12 SETELAH PEMBERIAN DIET ATEROGENIK Anwar Syaputra; Enikarmila Asni; Zulkifli Malik
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 2 (2015): Wisuda Oktober 2015
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ABSTRACTAtherosclerosis is a chronic inflammatory disease caused by endothelial dysfunction. Atherosclerosis can be induced in Rattus novergicus by feeding atherogenic diet and giving induction vitamin D3 to make the process of atherosclerosis happens earlier. The aim of this research is to know the difference of histopathologic atherosclerosis lesions of coronary artery of Rattus novergicus strain Wistar after being fed with atherogenic diet and standard diet after 12 weeks. This is an experimental laboratory research with post test only design. Twelve male rats were segregated into two groups (n=6) labelled as control fed standard diet and fed atherogenic diet (cholesterol 2% from yolk, goat fat 5% and cholic acid 0,2%) and induction of vitamin D3. The parameter which an analysis were score of atherosclerosis lesions. The result of atherosclerosis lesions of atherogenic group was found of all samples (100%) and of control group was found of four samples (66,67%). The statistic test result shows p=0,031. As the conclusion, the result shows significant difference of atherosclerosis lesions between atherogenic group and control group.Keywords: atherosclerosis, coronary artery, atherogenic diet, histopathology.
HISTOPATOLOGI AORTA TORASIKA TIKUS PUTIH (Rattus novergicus strain wistar) JANTAN SETELAH PEMBERIAN DIET ATEROGENIK SELAMA 12 MINGGU Sutrisno Tambunan; Enikarmila Asni; Zulkifli Malik
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 1 (2015): Wisuda Februari 2015
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ABSTRACTUnhealthy dietary pattern such as high fat diet and less of physical activity are the determinat of atherosclerosis. Atherosclerosis is a chronic inflammatory disease caused by lipid deposition in arterial wall. Beside the high fat consumption, addition of cholic acid and induction of vitamin D3 may also has role in atherosclerosis. Now, there has been many researches to know the process of the atherosclerosis using rat as animal model. The objective of this research is to know the differences of histopathologic image between thoracic aorta of male white rat (Rattus novergicus strain wistar) fed with standard diet and fed with atherogenic diet for 12 weeks. This research was an experimental laboratory with a post test only design. Twelve male rats were segregated into two groups (n=6) there were labelled as control group fed a standard diet and labelled as atherogenic group fed vitamin D3 and atherogenic diet which contain cholic acid 0,2%, fat 5% and yolk 2%. The experiment was designed for 12 weeks. The parameter used is atherosclerosis lesion score of all groups labelled. The result showed at control group found macrophage, foam cell and intracellular lipid accumulation with 33,33% percentage while atherogenic group found macrophage, foam cell and intracellular lipid accumulation with 100% percentage, extracellular lipid accumulation 33,33% (for a little extracellular lipid), 66,66 (a lot of extracellular lipid) and surface defect with 0,16%. The statistic test result showed the significant difference of atherosclerosis score between control group and atherogenic group (p=0,003). The conclusion of this study there is atherosclerosis process happen in 2 sampel (33,33%) in control group and 6 sampel (100%) in atherogenic group.Keywords : thoracic aorta, atherosclerosis, atherogenic diet, histopathology.
GAMBARAN HISTOPATOLOGI ARTERI KORONARIA TIKUS PUTIH JANTAN GALUR WISTAR SETELAH PEMBERIAN DIET ATEROGENIK SELAMA DELAPAN MINGGU Neneng Mutiara Sari; Enikarmila Asni; Zulkifli Malik
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 1 (2015): Wisuda Februari 2015
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ABSTRACTAtherosclerosis could be induced by feeding rats aterogenik dietcontaining high cholesterol and colic acid. For increasing atherosclerosis processvitamin D3 also given orally. Aim this research has an aims to analyze thedifference of coronary artery histopathologycal image between white rat strainwistar feeding by aterogenic diet and standard diet for 8 weeks. This is anexperimental laboratory research with post test only design. This research usedtwelve rats were segregated into two groups (n=6) labeled ads control; fedstandard diet and atherogenik fed diet ( containing colic acid 0,2%, fat 5%, andyolk 2%) and vitamin D3. The statistic test result do not show a significantdifference of atherogenic score of control group and atherogenic group. As theconclusion, feeding atherogenic diet for 8 weeks can induce the formation ofaccumulation of extracellular lipid in all samples of coronary artery of white rats,atheroma in 3 samples and thrombus 1 samples, while feeding standard diet justso atherosclerosis process on 4 samples, the formation of accumulation ofintracellular lipid in 1 samples and atheroma in 3 sample.Keywords : atherosclerosis, histopathology, atherogenic diet
HISTOPATOLOGI AORTA TORASIKA TIKUS PUTIH (Rattus norvegicus strain wistar) JANTAN SETELAH PEMBERIAN DIET ATEROGENIK SELAMA 12 MINGGU Sutrisno Tambunan; Zulkifli Malik; Ismawati "
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 1 (2015): Wisuda Februari 2015
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Abstract

Atherosclerosis is a chronic inflammatory disease caused by lipid deposition in arterial wall. Atherosclerosis could be induced in animal model (Rattus norvegicus) by feeding atherogenic diet. The objective of this research is to know the differences of histopathologic image between thoracic aorta of male white rat (Rattus norvegicus strain wistar) fed with standard diet and fed with atherogenic diet for 12 weeks. This research was an experimental laboratory with a post test only design. Twelve male rats were segregated into two groups (n=6) there were labelled as control group fed a standard diet and labelled as atherogenic group fed vitamin D3 and atherogenic diet which contain cholic acid 0,2%, fat 5% and yolk 2%. The experiment was designed for 12 weeks. The parameter used is atherosclerosis lesion score of all groups labelled. The result show that in atherogenic group there are macrophage, foam cell and intracellular lipid accumulation with 100% percentage, extracellular lipid accumulation 33,33% (for a little extracellular lipid), 66,66 (a lot of extracellular lipid) and surface defect with 0,16% while in control group there are macrophage, foam cell and intracellular lipid accumulation with 33,33% percentage. The statistic of Mann-Whitney test result shows (p=0,003). The conclusion that there is significant difference of histopathologic image between thoracic aorta of male white rat (Rattus norvegicus strain wistar) fed with atherogenic diet and fed with standard diet for 12 weeks.Keywords : thoracic aorta, atherosclerosis, atherogenic diet, histopathology.
Co-Authors Annisa Ul Hasanah Anwar Syaputra Enikarmila Asni Enikarmila Asni Fatya Welinsa Firdath Rubenzani Alcan Ismawati " Neneng Mutiara Sari Sutrisno Tambunan Zuhirman "