ABSTRAKLeukosit adalah sel pertahanan tubuh yang berfungsi memfagosit seluruh benda yang dianggap asing oleh tubuh. Penelitian ini bertujuan untuk mengetahui jumlah total leukosit dan persentase diferensial leukosit kelinci setelah pemasangan implant plate material logam. Penelitian ini menggunakan 6 ekor kelinci yang dibagi menjadi 2 kelompok. Kelompok I (K-I) diimplan plate tantalum dan kelompok II (K-II) diimplan plate besi. Pengambilan darah melalui vena auricularis pada hari ke 0, 7, 14, 28, dan 56 setelah implan. Hasil penelitian menunjukkan implan plate tantalum dan plate besi tidak berpengaruh terhadap total leukosit dan diferensial leukosit. Total leukosit diantara hari pengamatan menunjukan perbedaan pada masing-masing kelompok, namun masih dalam nilai normal. Penggunaan implan plate tantalum dan plate besi tidak memiliki efek terhadap gambaran sel darah putih dan persentase diferensial leukosit.Kata kunci : leukosit, diferensial leukosit, plate besi, plate tantalumABSTRACTLeukocytes are the body's defense cells that function to phagocyte all objects considered as foreign by the body. This study aims to determine the total leukocytes and differential percentage of rabbit leukocytes that paired of plate implants with metal material. This study used 6 rabbits divided into 2 groups. Group I was implanted with tantalum plate and group II was implanted using an iron plate. Blood collection through the auricular vein on days 0, 7, 14, 28, and 56. Leukocyte and differential counts leukocytes are calculated using the Mindray hematology analyzer. The results of the study showed that tantalum implants and iron plates have no effect on total leukocytes and differentials leukocytes. The total leukocytes between observations show differences, but are still deep in normal range. The use of tantalum implants and iron plates has no effect against white blood cell images and differential leukocyte percentages.Keywords: leukocytes, differential leukocytes, iron plate, tantalum plate