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ARIEF NURKANTO
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Antibacterial Activity and Mode of Action of (+)-2,2'-Epicytoskyrin A ANDRIA AGUSTA; DEWI WULANSARI; YULIASRI JAMAL; ARIEF NURKANTO; PRAPTIWI PRAPTIWI; AHMAD FATHONI
Microbiology Indonesia Vol. 9 No. 1 (2015): March 2015
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2156.354 KB) | DOI: 10.5454/mi.9.1.5

Abstract

Antibacterial activity of (+)-2,2'-epicytoskyrin A, a main metabolite from culture of fungal endophyte Diaporthe sp. GNBP-10, was investigated against several strains of Gram-positive, Gram-negative bacteria, and one strain of Mycobacterium smegmatis. (+)-2,2'-Epicytoskyrin A exhibited prominent activity against Staphylococcus aureus BCC 1452 with minimum inhibitory concentration (MIC) value of 0.06 μg mL-1. The effect of (+)-2,2'-epicytoskyrin A treatment to S. aureus, resulted in alteration of bacterial cell membrane with an increase of cation efflux, while the cytoplasmic content was not leaked out and finally resulted in cell damage.
Co-Authors AHMAD FATHONI ANDRIA AGUSTA Dewi Wulansari Praptiwi Praptiwi YULIASRI JAMAL