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Yuharmen '
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SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA ANALOG PIRAZOLIN TURUNAN 3’BROMOKALKON INTI NAFTALEN Sriatun Sadiah; Yuharmen '; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Analog compound  of  3'bromochalcone  pyrazoline  derivative  5-  (3-bromofenil)  -3-(naphthalene-2-yl)  -1-fenill-4.5-dihydro-1H pirazol (PP2) was  synthesized through nucleophilic addition reactions using glacial acetic acid catalyst under microwave radiation. PP2  compound  was obtained as yellow crystal  with yield  of  77.73%.  The purity of pyrazoline analog coumpound has been tested using TLC  observation, determination of melting point,  HPLC  analysis  and characterized by UV spectroscopy, IR spectroscopy, Mass spectroscopy and NMR spectroscopy. Antibacterial test conducted by the agar diffusion method with concentration of 10 μg/disk dan 30 μg/disk against Gram-positive bacteria, B. subtilis and S. aureus, and Gram-negative bacteria, E. coli and S. typhi. PP2  compound  showed that there was a low antibacterial activity. However, the inhibition of PP2 against Gram-positive bacteria is greater than  that of Gram-negative bacteria.
SINTESIS 3-(4-BROMOFENIL)-1-(NAFTALEN-1-IL)PROP-2-EN-1-ON DARI 1-ASETILNAFTALEN DENGAN 4-BROMOBENZALDEHID R. I. P. Sari; Yuharmen '; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Chalcone of 3-(4-Bromo-phenyl)-1-naphthalen-1-yl-propenone was synthesizedby the stirring method in Claisen-Schmidt Condensation with NaOH as the catalyst. Thestructure of the compound was confirmed by 1 H-NMR, 13 C-NMR, IR, MS, and UVspectroscopy method. The compound produced was in 81.9% yields. Datacharacterization showed that the compound obtained was the targetted compound.
UJI AKTIVITAS ANTIFUNGAL KULIT MANGGIS (Garcinia mangostana) DAN SEMANGKA (Citrullus vulgaris)TERHADAP Trichophyton mentagrophytes PENYEBAB DERMATOMYCOSIS Tengku Putri Sholihah; Atria Martina; Yuharmen '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 2, No 1 (2015): Wisuda Februari 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Dermatomycosis is the most common infection diseasesuffered by inhabitants of tropical countries and caused by  Trichophyton mentagrophytes. Mangosteen and watermelon epicarp have high phytochemical compounds which is potential as antibacterial, antifungal and antioxidant. This study aimed to determine antifungal activity of mangosteen and watermelon epicarp against  Trichophyton mentagrophytes. The study was conducted using completely randomizedfactorial design. Epicarp of mangosteen and watermelon were processed to fresh and dry extracts with concentration 40% and 80% (fresh extract) and 5%, 10% and 20% (dry extract). Dry extract were dissolved using 3 different solvent, e.g: aquabides, heated aquabides and etyl alcohol. Antifungal activity was tested using paper disc method. The results showed that almost all of watermelon and mangosteen epicarp dry extract had antifungal activity againts  Trichophyton mentagrophytes,  while fresh extract did not showed antifungal activity againts  Trichophyton mentagrophytes.  The highest antifungal activity of watermelon was showed in 20% extract in heated aquabides with inhibition zone diameter is 36,8 mm. The highest antifungal activity of mangosteen was showed in 10% extract in heated aquabides with inhibition zone diameter is 28,5 mm.
ISOLASI DAN UJI TOKSISITAS METABOLIT SEKUNDER EKSTRAK n-HEKSANA KULIT BATANG TUMBUHAN Polyalthia pulchra var. angustifolia King (ANNONACEAE) Yuhendri '; Jasril '; Yuharmen '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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The secondary metabolites of the stem bark of Polyalthia pulchra were isolated andthan their toxicity activity assayed using Brine Shrimp Lethality Test (BSLT) method.The sample was extracted by maceration method using n-hexane solvent. Structures ofthe isolated compounds were conducted using Gas Chromatography and MassSpectrometry (GC-MS). The dried sample produced 3.21 g n-hexane extract (0.25%)and 0.032 g 2 nd fraction of n-hexane (FH2) (0.0025%). The toxicity assay showed thatn-hexane extract and FH2 fraction was toxic with LC 50 5.9 and 7.1 ppm. From theresults of GC–MS analysis, it is shown that FH2 fraction contains campesterol,stigmasterol, and γ-sitosterol compounds with retention times 75.605, 76.568 and,78.172 minutes, respectively.
ISOLASI METABOLIT SEKUNDER DAN UJI TOKSISITAS EKSTRAK METANOL DAUN TANAMAN Cerbera odollam Gaertn. (APOCYNACEAE) Rissan Ramaesy Tobing; Hilwan Yuda Teruna; Yuharmen '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Cerbera odollam Gaertn is a plant found in Indonesia and used as a medicine. Isolationof its secondary metabolites and toxicity assay on leaves of this plant have been doneby macerating method with methanol solvent. The separation was carried out by vacuum liquid chromatography (VLC) and column chromatography, respectively. Characterization of the fractions was established using UV-Vis, FT-IR, and NMR. Toxicity assay was conducted by Brine Shrimp Lethality Test (BSLT) method. The LC 50 of 2 th , 4 th to 11 th fractions of the methanol extract were 874.78; 1076.71; 7.88; 0.85; 3.02; 0.23; 8.62; 3.94; 223.46; and 168.23 ppm respectively. The 3 th fraction was not toxic, where as other fractions were toxic and potential as anticancer.
IDENTIFIKASI DAN UJI TOKSISITAS EKSTRAK METANOL DARI DAUN TANAMAN SIRSAK (Annona muricata L) R. Juliani; Yuharmen '; H. Y. Teruna
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Soursoup (Annona muricata L) was used in herbal medicine. This Annonaceae familymember contains alkaloids, tannins, and several other chemical constituents, includingasetogenin that allegedly to have cytotoxic potential. The n-hexane and methanolmacerating method was applied to isolate the secondary metabolites from the stem barkof this plant. The separation was carried out by vacuum liquid chromatography (VLC),column chromatography, and gel chromatography respectively. Characterization of thefractions was established using UV-Vis and FTIR spectrophotometry. Toxicity assaywas conducted by Brine Shrimp Lethality Test (BSLT) method. The LC 50 of 3 rd to 11 thfractionts of the methanol extract wer 4481.25; 37; 11.46; 0.85; 3.02; 0.23; 10.97; 8.53and 4093 ppm, respectively. The 3 rd and 11 th fractionts were not toxic, whereas otherfractions were toxic and potential to be used as an anticancer.
PERBANDINGAN ISOLASI MINYAK ATSIRI DARI BUNGA KENANGA (Cananga odorata (Lam.) Hook.f & Thoms) CARA KONVENSIONAL DAN MICROWAVE SERTA UJI AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN Fela Tri Anggia; Yuharmen '; Nur Balatif
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Cananga odorata (Lam.) Hook.f & Thoms plants were one of essential oil sources wich has an antibacterial and antioxidant activity. In the research, isolation of essential oil from Cananga odorata (Lam.) Hook.f & Thoms was carried out with traditional hydrodistillation method and microwave method. The optimalcondition in the traditional method was 4 hours, while the optimal condition in the microwave method were 100o C, 40 minutes and 600 W. Isolation of the essential oil from Cananga odorata (Lam.) Hook.f & Thoms using microwave method produced higher yield (1,08%) compared to the traditional method (0,62%). The essential oil from Cananga odorata (Lam.) Hook.f & Thoms was indentified by GC-MS and resulted 35 compounds for traditional method and 53 compounds formicrowave method. Antibacterial activity assay showed equal result for both methods, that the Gram-negative bacteria (Salmonella enteritidis, Staphylococcus aureus) were more active in inhibiting the growth of bacteria compared to Grampositivebacteria (Escherichia coli, Bacillus subtilis). The antioxidant activity assay of the essential oil from Cananga odorata in the microwave method (884,31 µg/mL) was better than that of the traditional method (883,78 µg/mL).
Co-Authors Atria Martina Fela Tri Anggia H. Y. Teruna Hilwan Yuda Teruna Jasril ' Nur Balatif R. I. P. Sari R. Juliani Rissan Ramaesy Tobing Sriatun Sadiah Tengku Putri Sholihah Yuhendri '