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All Journal Dental Journal (Majalah Kedokteran Gigi) Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Jurnal Material Kedokteran Gigi Denta: Jurnal Kedokteran Gigi
Sularsih Sularsih
Departemen Ilmu Material Dan Teknologi Kedokteran Gigi Fakultas Kedokteran Gigi Universitas Hang Tuah
Religion Humanities Dentistry Education Materials Science & Nanotechnology Public Health Social Sciences

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Journal : Jurnal Material Kedokteran Gigi

 1 
Pengaruh Viskositas Kitosan Gel Terhadap Penggunaannya di Proses Penyembuhan Luka Sularsih Sularsih
Jurnal Material Kedokteran Gigi Vol 2 No 1 (2013): JMKG Vol 2 No 1 Maret 2013
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

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Abstract

Chitosan powder when dissolved with acetat acid solution gives viscous solution. The accessibility of chitosan depends on viscosity of its solution. The viscosity determines the extent of penetration of chitosan. The aim of this study was to account the proliferation cells on wound healing process of dental extraction using different viscosity of chitosan gel. Rattus nornegicus strain wistar male, aged 8-16 weeks, divided into 2 treatment groups namely group 1 which given chitosan gel with high viscosity and group II which given chitosan with low viscosity. Chitosan were applied into the socket of dental extraction. Rat was decaputated 7 and 14 days after chitosan application and the jaw in the treated regions and control group were cut for histopatological to observe the proliferation cells. Data were analyzed using t test. The result showed significant differences of proliferation cells between groups with high and low viscosity of chitosan. The group with high viscosity of chitosan have more higher of proliferation cells.(p<0,05). The viscosity can influence the absorbtion of chitosan that accessibility to its application on proliferation cells of wound healing process.
Perbandingan Jumlah Sel Osteoblas pada Penyembuhan Luka Antara Penggunaan Kitosan Gel 1% dan 2% Sularsih Sularsih; Soeprijanto Soeprijanto
Jurnal Material Kedokteran Gigi Vol 1 No 2 (2012): JMKG Vol 1 No 2 September 2012
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

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Abstract

The use of chitosan in medical fields known as biomaterial nowdays can be used in dental clinical application. Chitosan is obtained by N-acetylating chitin and it is a biodegradable natural biopolymer that can enhance bone healing. The aim of this study was to compare account the rate of osteoblast cells on bone healing process of dental extraction in Rattus norvegicus for 7 and 14 days. Rattus nornegicus strain wistar male, aged 8-16 weeks, divided into 3 treatment groups namely group 1 which given chitosan gel 1%, group II which given chitosan gel 2 % and group III as control which were not given chitosan gel. Chitosan were applied into the socket of dental extraction. Rat was decaputated 7 and 14 days after chitosan application and the jaw in the treated regions and control group were cut for histopatological to observe the number of osteoblast cells. Data were analyzed using t test. The result showed no significant differences in osteoblast cells number between the use chitosan gel 1 and 2 % in 7 and 14 days observation (p<0,05). There was not different number of osteoblast cells with application between chitosan gel 1 % and 2 %. It can be concluded that chitosan gel 1 and 2 % has ability to enhance the bone healing process in post extraction socket of Rattus norvegicus.
Penggunaan Scaffold Kitosan-Aloe Vera Terhadap Proliferasi Sel Fibroblas pada Penyembuhan Luka Pasca Pencabutan Gigi Cavia Cobaya Sularsih Sularsih; Fitria Rahmitasari
Jurnal Material Kedokteran Gigi Vol 7 No 2 (2018): JMKG Vol 7 No 2 September 2018
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (583.702 KB) | DOI: 10.32793/jmkg.v7i2.370

Abstract

Aloe vera has been investigated potential use in tissue engineering. Its bioactive compounds interact with growth factor receptor on the fibroblast and stimulate cells proliferation. The aim of this study was to investigate the proliferation of fibroblast cells on wound healing process of Cavia cobaya dental extraction using scaffold combination chitosan and Aloe vera. Cavia cobaya male with 300-350 grams of weight and in the age of 3 to 3.5 months. It divided into ten groups (n=5). For Treatment groups, Aloe vera scaffold(Av); Chitosan Scaffold (Ch); Scaffold combination chitosan-Aloe vera (Ch-Av) and scaffold combination chitosan- Aloe vera- hidroksiapatit(Ch-Av-HA) were applied into the socket of dental extraction. For control group, which were not given scaffold. Cavia cobaya were decaputated at 7 and 14 days and the jaw in the treated regions and control group were cut for Histopatology Anatomy examination to investigate the proliferation of fibroblast cells. Data were analyzed using One way Anova test. The proliferation of fibroblast cells were found higher in the group which given Av-Ch and Av-Ch-HA scaffold. The result showed significant differences in proliferation of fibroblast cells for 7 and 14 days observation compared to control group (p<0,05). The application of scaffold combination Chitosan and Aloe vera accelerate the wound healing process of Cavia cobaya dental extraction.
Pengaruh Penggunaan Kitosan Dengan Berat Molekul Yang Berbeda Terhadap Ekspresi Tumor Necrosis Factor Alpha (Tnf Α) Pada Penyembuhan Luka Pencabutan Gigi Tikus Rattus Norvegicus Sularsih Sularsih; Soeprijanto Soeprijanto
Jurnal Material Kedokteran Gigi Vol 5 No 1 (2016): JMKG Vol 5 No 1 Maret 2016
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

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Abstract

Chitosan which is composed glucosamine and acetlyglucosamine has been proven to be biologically, renewable,biodegradable, biocompatible and biofunctional. Tumor necrosis factor alpha (TNF a) is inflammatory factors that have important role in wound healing process of dental extraction. The aim of this study was to compare the expression of Tumor Necroting Factor Alpha (TNF a) on wound healing process of dental extraction using different molecular weight of chitosan gel. Rattus nornegicus strain wistar male, aged 8-16 weeks, divided into 3 treatment groups namely group 1 which given chitosan gel with high molecular weight. Group II which given chitosan with low molecular weight and group III which given’t chitosan gel. Chitosan gel were applied into the socket of dental extraction. Rat was decaputated 3 and 4 days after chitosan application and the jaw in the treated regions and control group were cut for imunohistochemical examination to observe the expression of Tumor Necroting Factor Alpha (TNF a). Data were analyzed using One way Anova test. The result showed significant differences of expression of Tumor Necroting Factor Alpha (TNF a) between groups with different molecular weight (p<0,05). The expression of TNF using chitosan with high and low molecular weight were 11,83±2,137 and 9,60±0,894 on 3 days examination and 17,00±1,871 and 12,17±1,722 on 4 days examination. The application of Chitosan gel with high molecular weight on wound healing process of dental extraction could stimulate the expression of TNF a.
Agen Crosslink dalam Pembuatan Biomimetic Scaffold Sebagai Material Rekayasa Jaringan Tulang Fitria Rahmitasari; Sularsih Sularsih
Jurnal Material Kedokteran Gigi Vol 8 No 2 (2019): JMKG Vol 8 No 2 September 2019
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jmkg.v8i2.344

Abstract

Case of bone destruction such as socket of post-tooth extraction and periodontitis can cause pain and disrupt the function of mastication, so it takes a tissue engineering material in the form of biomimetic scaffold by mimicking the structure and the original function of bone. Material for bone tissue engineering that has grown widely include the use of collagen, gelatin, chitosan, and hydroxyapatite. These materials can be mutually combined using crosslink agents in the scaffold fabrication process. Determine the role of crosslink agents in the manufacture of biomimetic scaffolds as bone tissue engineering materials in the field of dentistry. Material in the scaffold fabrication is a polymer which can be modified by the incorporation of other polymers. Additionally, polysaccharides have abundant functional groups such as hydroxyl groups, amino groups and/or carboxylic acid groups, amenable to various types of chemical modifications. Modification with other polymers can be done by adding crosslink agents by irradiation or through chemical reactions. The role of a crosslink agent in a material modification can increase the material resistance to heat, light, other physical properties, and can increase the degree of dimensional stability and mechanical strength so these values are important to consider for the survival of cells in scaffolds at early time points. Different forms of crosslink agents can be utilized to obtain good biomimetic scaffold so that optimize the osteoconductivity properties of bone tissue engineering.
Co-Authors Amelia Elizabeth Pranoto Anita Yuliati Bella Sagita Puspita Budi Santoso Dian W. Damaiyanti Dwi Ayu Trisnawati Dyah Ayu R Endah Wahjuningsih Felinda Gunawan Fitria Rahmitasari Kharinna Widowati Lita Agustia Michelle Suhartono Nafi’ah Nur Tsurayya Priambodo Pambudi Rahardjo RM Coen Pramono D Soemartono Soeprijanto Soeprijanto Soeprijanto Soeprijanto Widaningsih Widyasri Prananingrum Yessy Andriani Fauziah Yongki Hadinata