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Fitria Rahmitasari
Department Of Dental Materials, Faculty Of Dentistry, Universitas Hang Tuah, Surabaya, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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The effect of spirulina gel on fibroblast cell number after wound healing Fitria Rahmitasari; Wisnu Setyari J; Ester Arijani Rachmat
Dental Journal (Majalah Kedokteran Gigi) Vol. 44 No. 4 (2011): December 2011
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (642.701 KB) | DOI: 10.20473/j.djmkg.v44.i4.p192-195

Abstract

Background: Wound healing treatment after tooth extraction should be an important consideration due to mouth discomfort and pain. Spirulina (blue green algae) consists of C-phycocyanin, b–carotenoids, vitamin E, zinc, some other trace elements and natural phytochemical which are believed to act as antioxidant and takes part in wound healing process. Purpose: The purpose of this study was to examine the effect of spirulina gel on fibroblast cell number after wound healing process. Methods: Twenty eight males guinea pig are devided into four group, 7 guinea pig each. They are control group and treatment group which is given 0%, 3%, 6%, and 12% spirulina gel. After tooth extraction, histopathological evaluation was done to count fibroblast cell. The data was analyzed by One-Way ANOVA and Tukey HSD. Results: The research has proven the relation between the increased growth of fibroblast cell and spirulina gel application. The higher the doses, the more cell growth. Hence, there has been significant different (p < 0.05) among groups. Conclusion: Spirulina gel increases the number of fibroblast in wound after tooth extraction and 12% spirulina gel has the most potential ability.Latar Belakang: Proses penyembuhan luka pasca pencabutan gigi merupakan salah satu hal yang penting karena akan menimbulkan rasa nyeri dan tidak nyaman dalam rongga mulut. Spirulina (Blue green Algae) mengandung C-phycocyanin, b-carotenoids, vitamin E, seng, beberapa trace elemen lainnya, dan phytochemical alami yang terbukti dapat berperan sebagai antioksidan dalam proses penyembuhan luka. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui efek pemberian gel spirulina terhadap jumlah sel fibroblas pada proses penyembuhan luka pasca pencabutan gigi. Metode: Dua puluh delapan ekor guinea pig jantan dibagi dalam 7 kelompok, masing-masing terdiri dari 4 ekor. Kelompok tersebut adalah kelompok kontrol dan kelompok perlakuan yang diberikan gel spirulina dengan konsentrasi 0%, 3%, 6%, dan 12%. Setelah pencabutan gigi, dilakukan penghitungan sel fibroblas dengan metode histopatologi. Hasil: Penelitian ini menunjukkan adanya hubungan antara pemberian gel spirulina terhadap peningkatan jumlah sel fibroblas. Semakin tinggi dosis gel spirulina akan semakin meningkatkan jumlah sel fibroblas pula. Didapatkan perbedaan yang signifikan antar kelompok (p < 0,05). Kesimpulan: Gel spirulina meningkatkan jumlah sel fibroblas pada luka bekas pencabutan dan gel spirulina dengan konsentrasi 12% mempunyai kemampuan yang paling potensial.
The potential of chitosan combined with chicken shank collagen as scaffold on bone defect regeneration process in Rattus norvegicus Fitria Rahmitasari; Retno Pudji Rahayu; Elly Munadziroh
Dental Journal (Majalah Kedokteran Gigi) Vol. 49 No. 1 (2016): March 2016
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.695 KB) | DOI: 10.20473/j.djmkg.v49.i1.p22-26

Abstract

Background: In the field of dentistry, alveolar bone damage can be caused by periodontal disease, traumatic injury due to tooth extraction, cyst enucleation, and tumor surgery. One of the ways to regenerate the bone defect is using graft scaffold. Thus, combination of chitosan and collagen can stimulate osteogenesis. Purpose: The aim of this study was to examine the potential of chitosan combined with chicken shank collagen on bone defect regeneration process. Method: Twelve Rattus norvegicus were prepared as animal models in this research. A bone defect was intentionally created at both of the right and left femoral bones of the models. Next, 24 samples were divided into four groups, namely Group 1 using chitosan – collagen scaffold (50:50), Group 2 using chitosan collagen-scaffold (80:20), Group 3 using chitosan scaffold only, and Control Group using 3% CMC-Na. On 14th day, those animals were sacrificed, and histopathological anatomy examination was conducted to observe osteoclast cells. In addition, immunohistochemistry examination was also performed to observe RANKL expressions. Result: There was a significant difference in RANKL expressions among the groups, except between Group 3 using chitosan scaffold only and control group (p value > 0.05). The highest expression of RANKL was found in Group 1 with chitosan – collagen scaffold (50:50), followed by Group 2 with chitosan-collagen scaffold (80:20). Moreover, there was also a significant difference in osteoclast generation, except between Group 1 using chitosan – collagen scaffold (50:50) and Group 2 using chitosan-collagen scaffold (80:20), p value < 0.05; and between Group 3 using chitosan scaffold only and control group, p value > 0.05. Less osteoclast was found in the groups using chitosan – collagen scaffold (Group 1 and Group 2). Conclusion: Combination of chitosan and chicken shank collagen scaffold can improve regeneration process of bone defect in Rattus novergicus animals through increasing of RANKL expressions, and decreasing of osteoclast.
Penggunaan Scaffold Kitosan-Aloe Vera Terhadap Proliferasi Sel Fibroblas pada Penyembuhan Luka Pasca Pencabutan Gigi Cavia Cobaya Sularsih Sularsih; Fitria Rahmitasari
Jurnal Material Kedokteran Gigi Vol 7 No 2 (2018): JMKG Vol 7 No 2 September 2018
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (583.702 KB) | DOI: 10.32793/jmkg.v7i2.370

Abstract

Aloe vera has been investigated potential use in tissue engineering. Its bioactive compounds interact with growth factor receptor on the fibroblast and stimulate cells proliferation. The aim of this study was to investigate the proliferation of fibroblast cells on wound healing process of Cavia cobaya dental extraction using scaffold combination chitosan and Aloe vera. Cavia cobaya male with 300-350 grams of weight and in the age of 3 to 3.5 months. It divided into ten groups (n=5). For Treatment groups, Aloe vera scaffold(Av); Chitosan Scaffold (Ch); Scaffold combination chitosan-Aloe vera (Ch-Av) and scaffold combination chitosan- Aloe vera- hidroksiapatit(Ch-Av-HA) were applied into the socket of dental extraction. For control group, which were not given scaffold. Cavia cobaya were decaputated at 7 and 14 days and the jaw in the treated regions and control group were cut for Histopatology Anatomy examination to investigate the proliferation of fibroblast cells. Data were analyzed using One way Anova test. The proliferation of fibroblast cells were found higher in the group which given Av-Ch and Av-Ch-HA scaffold. The result showed significant differences in proliferation of fibroblast cells for 7 and 14 days observation compared to control group (p<0,05). The application of scaffold combination Chitosan and Aloe vera accelerate the wound healing process of Cavia cobaya dental extraction.
Agen Crosslink dalam Pembuatan Biomimetic Scaffold Sebagai Material Rekayasa Jaringan Tulang Fitria Rahmitasari; Sularsih Sularsih
Jurnal Material Kedokteran Gigi Vol 8 No 2 (2019): JMKG Vol 8 No 2 September 2019
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jmkg.v8i2.344

Abstract

Case of bone destruction such as socket of post-tooth extraction and periodontitis can cause pain and disrupt the function of mastication, so it takes a tissue engineering material in the form of biomimetic scaffold by mimicking the structure and the original function of bone. Material for bone tissue engineering that has grown widely include the use of collagen, gelatin, chitosan, and hydroxyapatite. These materials can be mutually combined using crosslink agents in the scaffold fabrication process. Determine the role of crosslink agents in the manufacture of biomimetic scaffolds as bone tissue engineering materials in the field of dentistry. Material in the scaffold fabrication is a polymer which can be modified by the incorporation of other polymers. Additionally, polysaccharides have abundant functional groups such as hydroxyl groups, amino groups and/or carboxylic acid groups, amenable to various types of chemical modifications. Modification with other polymers can be done by adding crosslink agents by irradiation or through chemical reactions. The role of a crosslink agent in a material modification can increase the material resistance to heat, light, other physical properties, and can increase the degree of dimensional stability and mechanical strength so these values are important to consider for the survival of cells in scaffolds at early time points. Different forms of crosslink agents can be utilized to obtain good biomimetic scaffold so that optimize the osteoconductivity properties of bone tissue engineering.
Scaffold 3D Kitosan dan Kolagen Sebagai Graft pada Kasus Kerusakan Tulang Fitria Rahmitasari
Jurnal Material Kedokteran Gigi Vol 5 No 2 (2016): JMKG Vol 5 No 2 September 2016
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jmkg.v5i2.246

Abstract

Kerusakan tulang alveolar dalam kasus kedokteran gigi dapat disebabkan oleh penyakit periodontal, trauma pasca pencabutan gigi, post enukleasi kista, dan post operasi tumor. Kitosan merupakan bahan yang sering digunakan sebagai bahan graft namun penggunaannya sendiri kurang osteokonduktif apabila tidak dikombinasikan dengan bahan lain. Kitosan dapat dikombinasikan dengan kolagen dalam bentuk sediaan scaffold 3D untuk penyembuhan kasus kerusakan tulang. Untuk mengetahui sifat osteokonduktifitas bahan kitosan dan kolagen berupa sediaan scaffold 3D. Scaffold 3D kitosan dan kolagen dapat menirukan struktur dan fungsi alami dari protein ekstraseluler matriks, membentuk struktur unik yang dapat meningkatkan kekuatan mekanik, menurunkan tingkat biodegradasi, dan kombinasi keduanya dapat menghasilkan ion kompleks yang berperan untuk merangsang proliferasi dan diferensiasi sel sehingga dapat mempercepat proses penyembuhan tulang. Scaffold 3D kitosan dan kolagen berperan dalam proses penyembuhan tulang karena kedua bahan tersebut membentuk senyawa ion kompleks yang dapat meningkatkan sifat osteokonduktifitas.
Shear bond strength fissure sealant based on glass ionomer after topical fluor application: a comparison between sodium fluoride and acidulated phosphate fluoride Yulie Emilda Akwan; Annisa Listya Paramita; Fitria Rahmitasari
Odonto : Dental Journal Vol 9, No 2 (2022): December 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.2.222-230

Abstract

Background: Application of fissure sealants to young permanent teeth is one of the preventive measures for caries in the field of dentistry. Fissure sealants based on glass ionomer cement (GIC) have the advantage of releasing fluoride. Sodium fluoride and acidulated phosphate fluoride (APF) are remineralization agents because they can increase remineralization by altering hydroxyapatite to fluorapatite and this in turn makes fluorine able to increase pH. Fluoride can prevent caries by increasing remineralization of the enamel that has just been demineralized by acids produced by plaque bacteria. The aim of this study is to compare the shear bond strength fissure sealant based on glass ionomer between sodium fluoride and APF topical fluor applicationMethod: This research applied true experimental design with post test only control group design. The 21 maxillary permanent premolars were distributed into 3 groups, namely the control group (K1), the treatment group added 5% sodium fluoride (K2), and the treatment group added 1.23% APF (K3). Result: One Way ANOVA and post hoc LSD analysis test displayed no significant difference in each group. This could be due to the material used as a conditioner prior to the GIC application. The addition of fluoride ions will inhibit the demineralization process of the enamel produced by the application of conditioner. So it does not rule out that it will interfere with the attachment of the GIC material used as a fissure sealant in this research.Conclusion: There was no significant difference in shear bond strength of fissure sealant based on glass ionomer between sodium fluoride and acidulated phosphate fluoride topical application.
The effect of effervescent acanthus ilicifolius l. extract on antifungal properties and flexural strength acrylic Widyasri Prananingrum; Fitria Rahmitasari; Dwi Andriani; Arifzan Razak
Odonto : Dental Journal Vol 9, No 2 (2022): December 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (453.451 KB) | DOI: 10.30659/odj.9.2.310-318

Abstract

Background: Acanthus ilicifolius L. has antifungal potential and makes it possible to be a candidate for denture cleanser. This study aims to evaluate the effect of effervescent Acanthus ilicifolius L. extract on antifungal properties and flexural strength acrylic after immersion for three duration times.Method: Extracts were made by maceration method with ethanol. For the antifungal test, effervescent Acanthus ilicifolius L extract was prepared by combining the Acanthus ilicifolius L extract 4% and sodium perborate with two ratios, 1:7 and 1:14. The microdilution method was carried out. Effervescent Acanthus ilicifolius L extract 4% with ratio 1:7 was prepared for the flexural strength test. The fifty-four heat-cured acrylic resin (20x10x2.5mm) were fabricated and divided into 3 groups. Group 1 was immersed in aquadest (control); Group 2 was immersed in sodium perborate; Group 3 was immersed in effervescent Acanthous ilicifolius L. extract. Each group was immersed for 15 min, 8, and 56 hours (n=6). The flexural strength test was performed using Universal Testing Machine.Result: Effervescent Acanthus ilicifolius L. extract exhibited antifungal activity which increased in an effervescent Acanthus ilicifolius L extract-dependent manner significantly (0.57 to 0.50 OD). There were no significant differences between sodium perborate, effervescent_AI1 (1:7) and effervescent_AI2 (1:14). The flexural strength was found to be within the range of 66.1 - 68.3 MPa. There were no significant differences between groups (p < 0.05).Conclusion: Effervescent Acanthus ilicifolius L extract with the ratios 1:7 had a good antifungal effect and appropriate flexural strength after immersion for 15 min, 8, and 56 hours.
Tegillarca granosa shell combination with Vitis vinifera and fluoride in decreasing enamel microporosity Grace Caroline Setiawan; Adelia Tinisia; Muhammad Galang Adhinata Abdul Rahim; Fitria Rahmitasari; Widyasri Prananingrum
Dental Journal Vol. 57 No. 2 (2024): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i2.p131-138

Abstract

Background: White spot lesion is a demineralization process indicated by the increased of enamel microporosity. A tegillarca granosa shell contains 98.7% calcium and Vitis vinifera contains phytochemical compounds with fluoride, which has a potential to stimulate remineralization. Purpose: To analyze the Tegillarca granosa shell combination with Vitis vinifera and fluoride in decreasing enamel microporosity. Methods: The cream was prepared by combining 10% and 20% Tegillarca granosa shell with 10 grams of Vitis vinifera extract and 100 mg of fluoride. The cream was tested beforehand for viscocity and pH. Furthermore, 16 premolars were etched and divided into four groups. Group 1 was smeared with placebo (negative control) and Group 2 was smeared with casein phosphopeptide-amorphous calcium phosphate (positive control). The other groups were smeared with cream 10% (Group 3) and 20% (Group 4) Tegillarca granosa shell combination with Vitis vinifera and fluoride. Teeth were treated three times a day for 30 minutes and soaked in artificial saliva. After 14 days, the enamel microporosity was carried out using a scanning electron microscope. The data was analyzed with one-way analysis of variance (ANOVA) test followed by post-hoc least significant difference (LSD). Results: The enamel microporosity showed significant difference between Group 1 and the other groups. There was no significant difference between Groups 2, 3, and 4 (p<0.05). Although there was no significant difference between Group 3 and 4, the lowest one was in Group 4 (p>0.05). Conclusion: The cream, prepared by combining Tegillarca granosa shell with Vitis vinifera and fluoride, is effective in decreasing the enamel microporosity.
UPAYA PENINGKATAN WAWASAN DALAM MENJAGA KESEHATAN GIGI DAN MULUT PADA GURU DAN ORANG TUA SISWA TK CAHAYA TAZKIA SURABAYA Fitria Rahmitasari; I.G.A.M Oka Lestari; Nina Nilawati; Dwi Setianingtyas; Novendy Yoyada; Ivan Tantra; Caecilia Indarti; Puguh Bayu Prabowo; Yulie Emilda; Mardiyanto Riski Hartono; Ari Rosita Irmawati; Shintya Rizki Ayu A
Jurnal Pengabdian Masyarakat Pesisir VOLUME 3 NOMOR 1
Publisher : Universitas Hang Tuah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/jpmp.v3i1.96

Abstract

Angka proporsi perilaku menyikat gigi secara benar sebanyak dua kali sehari yaitu setelah sarapan pagi dan sebelum tidur malam hanya sebesar 2,8% pada masyarakat Indonesia. Sejumlah 93% anak-anak usia sekolah mengalami masalah gigi dan mulut, dimana angka ini merupakan angka prevalensi yang sangat tinggi. Upaya Kementerian Kesehatan Republik Indonesia dalam menurunkan angka prevalensi karies gigi yaitu dengan melaksanakan program “Indonesia Bebas Karies 2030”. PT. Unilever Tbk. melakukan kerjasama dengan Asosiasi Fakultas Kedokteran Gigi Indonesia (AFDOKGI), Asosiasi Rumah Sakit Gigi dan Mulut Pendidikan Indonesia (ARSGMPI), Persatuan Dokter Gigi Indonesia (PDGI), dan Fakultas Kedokteran Gigi Universitas Hang Tuah akan melakukan program “School Health Program” (SHP) dalam rangkaian kegiatan Bulan Kesehatan Gigi Nasional (BKGN) 2022. Program Training of Trainer (ToT) pada guru dan orang tua untuk kegiatan sikat gigi pagi dan malam 21 hari mengajarkan anak-anak dan orang dewasa tentang manfaat kebersihan mulut yang baik dan menunjukkan kepada mereka cara menyikat gigi dua kali sehari dengan pasta gigi berfluoride untuk mewujudkan Indonesia bebas karies di tahun 2030. Kegiatan ini mengunakan sistem digital / online melalui aplikasi zoom. Peserta kegiatan ini adalah 5  orang tua dan 5 guru di TK Cahaya Tazkia. Dalam memberikan edukasi, para dokter gigi menggunakan media power point dan video edukasi. Bentuk materi edukasi yang diberikan meliputi video animasi sikat gigi, kalender digital sikat gigi 21 hari, poster/ flyer digital, flipchart. Sebelum memulai edukasi para peserta dilakukan pre test terlebih dahulu tentang pengetahuan seputar gigi dan kebersihannya sesuai materi yang akan disampaikan, setelah diakhir sesi zoom tersebut juga dilakukan post test dengan materi yang sama untuk mengetahui tingkat pengetahuan dan pemahaman peserta terhadap materi tersebut. Kegiatan penyuluhan kesehatan gigi dan mulut melalui ToT pada guru dan orang tua siswa/siswi di TK Cahaya Tazkia Surabaya memberikan hasil peningkatan tingkat pengetahuan guru dan orang tua dalam menjaga kesehatan gigi dan mulut. Hasil analisis statistik menggunakan paired sample t-test untuk membandingkan nilai rata-rata pre test dan post test siswa/siswi menunjukkan nilai signifikansi p=0.001 (p<0.05) yang berarti bahwa terdapat perbedaan yang signifikan pada tingkat pengetahuan guru dan orang tua siswa/siswi di TK Cahaya Tazkia dalam menjaga kesehatan gigi dan mulut sebelum dan sesudah diberi materi Dental Health Education (DHE) melalui “Training of Trainer”.  
The effect of incorporating hydroxyapatite into Type II glass ionomer cement on flexural strength and the examination of fractured surfaces using scanning electron microscopy Fitria Rahmitasari; Twi Agnita Cevanti; Puguh Bayu Prabowo; Sularsih Sularsih; Widyasri Prananingrum
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.152-161

Abstract

Background: Glass ionomer cement (GIC) is widely recognized as the prevailing direct esthetic restorative material. In order for a restoration material to be considered effective, possess favorable physical and mechanical properties. Incorporating with hydroxyapatite (HA) can provide these properties. This research is to investigate the impact of integrating HA into GIC on the flexural strength and scanning electron microscopy (SEM) of the fractured surfaces. Methods: The study consisted of 28 samples of GIC, which are fabricated in the shape of rectangular prisms (25x2x2mm). The samples were divided into four groups n=7. Group 1 is a control group (GIC), Group 2 GIC+2%HA, group 3 GIC+2%HA, and GIC+4%HA. The flexural strength of the sample was evaluated by a Universal testing machine, followed by an examination of the fracture surface using SEM. Result: The Brown-Forsythe was used as data analysis to examine the flexural strength values across all groups, resulting in a statistically significant p-value of less than 0.05. The addition of HA does not result in a significant increase in the flexural strength value of the glass ionomer cement (GIC). The integration of microstructure based on scanning electron microscopy (SEM) pictures demonstrates improved visual quality following the incorporation of HA. Conclusion: The addition of HA to GIC did not result in a significant change in flexural strength compared to the control group. However, GIC group with 2% HA exhibited the highest average flexural strength value among all the groups
Co-Authors Adelia Tinisia Andriani, Dwi Annisa Listya Paramita Ari Rosita Irmawati Arifzan Razak Caecilia Indarti Chaterina Diyah Nanik K. Destya Arizha Fatryana Dwi Setianingtyas Elly Munadziroh Ester Arijani Rachmat Grace Caroline Setiawan I.G.A.M Oka Lestari Ivan Tantra Kartika Zefanya Mardiyanto Riski Hartono Moh. Basroni Rizal Muhammad Galang Adhinata Abdul Rahim Nina Nilawati Novendy Yoyada Puguh Bayu Prabowo Puguh Bayu Prabowo Retno Pudji Rahayu Saka Winias Shintya Rizki Ayu A Sularsih Sularsih Sularsih Sularsih Twi Agnita Cevanti Widaningsih Widaningsih Widyasri Prananingrum Widyasri Prananingrum Widyasri Prananingrum Wisnu Setyari J Yulie Emilda