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All Journal The Indonesian Biomedical Journal Buletin Farmatera World Nutrition Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Dina Keumala Sari
Faculty Of Medicine, Universitas Sumatera Utara
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The use of 25(OH)D saliva test as a substitute for 25(OH)D serum test in healthy people Dina Keumala Sari; Liza Meutia Sari; Lidya Imelda Laksmi
World Nutrition Journal Vol. 4 No. S3 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.S3.0027

Abstract

Background and Objectives: Examination of serum 25(OH)D levels of vitamin D in the body circulation illustrates the level of circulating vitamin D, while serum 1.25(OH)D is used to describe vitamin D activity. Several studies have shown that there is a non-invasive test that can be done to check vitamin D levels, namely through salivary levels. This study aims to determine the ratio between serum 25(OH)D and 1.25(OH)D serum levels and to compare the levels in saliva.Methods: This study was a cross-sectional study that included 36 healthy people, male and female, aged 18-35 years old, living in Medan, North Sumatra. The tests performed were levels of 25(OH)D, 1.25(OH)D in serum and saliva.Results: The mean serum 25 (OH) D level was 17.22±4.37 ng/mL and the 25(OH)D saliva level was 3.46 ng/mL for the minimum value and 51.0 ng/mL for the maximum value (median: 6.01 ng/mL). The results showed a relationship between 25(OH)D saliva and serum 25(OH)D levels (p=0.04). There was no relationship between the levels of 1.25(OH)D in saliva and serum 1.25(OH)D.Conclusion: There was a relationship between 25(OH)D saliva and 25(OHD) serum levels in healthy people. Salivary 25(OH)D levels can be used as a non-invasive laboratory test compared to serum 25(OH)D levels.
High-fat Diet Increases Sprague-Dawley Corticosterone Blood Levels with Nominal Change in Adrenocorticotrophic hormone (ACTH) Level with Signs of Increased Mesenteric Adiposity Khairil Azwan; Resni Mona; Jannathul Firdous; Dina Keumala Sari; Pamela Rosie David; Noorzaid Muhamad
The Indonesian Biomedical Journal Vol 14, No 1 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i1.1727

Abstract

BACKGROUND: Corticosterone is a common hormone in research involving rodents as it is used to indicate and measure stress levels. It was widely reported that certain dietary habits and components induce Hypothalamic-Pituitary-Adrenal (HPA) axis activity, with corticosterone found in the bloodstream. Chronic corticosterone presence can portray signs and symptoms of certain endocrine. Certain food and chemicals were found to alter HPA axis activity leading to dysregulation of the HPA axis. Earlier studies have shown enhancement of the HPA axis to produce more glucocorticoids by an unbalanced diet. This study aims to shed more light on this subject.METHODS: Sprague Dawley rats were divided into five groups of seven each and were fed five respective diets (control, high-fat, high-protein, high-sugar, and high-starch), with tap water as drinking water ad libitum. After eight weeks, the rats were euthanized, blood was collected, and serum harvested and kept for analysis. Mesenteric fat was identified, harvested, and stained with hematoxylin and eosin (H&E) and set for viewing under light microscope. The hormones of interest which is adrenocorticotropic hormone (ACTH) and corticosterone was extracted from the blood, to be processed accordingly and quantified using the High-Performance Liquid Chromatography (HPLC) with photodiode array (PDA) analysis technique.RESULTS: The results showed an increase in Sprague-Dawley corticosterone blood levels with a nominal change in ACTH level. Advanced hypertrophy was observed in mesenteric adipose tissue in the high-fat diet group compared to the other diet groups.CONCLUSION: This study confirms the negative effect of a high-fat diet on health from a hormonal and adipocyte perspective. A high-fat diet was found to instigate the HPA axis and influence blood corticosterone level.KEYWORDS: adrenocorticotrophic hormone, ACTH, corticosterone, mesenteric fat, diet
Serumal and Salivary 25(OH)D and 1,25(OH)D Levels of Head and Neck Cancer Patients Dina Keumala Sari; Liza Meutia Sari; Lidya Imelda Laksmi; Farhat Farhat; Elvita Rahmi Daulay; Ferry Sandra; Zulfikar Lubis; Ratna Akbari Ganie
The Indonesian Biomedical Journal Vol 13, No 4 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i4.1726

Abstract

BACKGROUND: Saliva has been suggested as a substitute of serum for the detection of 25 Dihydroxyvitamin D (25(OH)D) in healthy people. However, investigation of salivary 1,25(OH)D has not been clearly reported. Vitamin plays important roles in inhibiting cancer progression. Current study was conducted to investigate serumal and salivary 25(OH)D) and 1,25(OH)D levels of healthy and head and neck cancer (HNC) subjects.METHODS: Research were conducted at Haji Adam Malik Hospital, Medan, Indonesia. Forty HNC and 40 healthy subjects were recruited and selected based on inclusion and exclusion criteria. Medical records were documented, followed by anthropometric evaluation and serum and saliva collection. Laboratory investigation for 25(OH)D and 1,25(OH) was performed using Enzyme-linked immunosorbent assay (ELISA) methods.RESULTS: Significant serumal (p=0.002) and salivary (p=0.016) 25(OH)D mean level differences of HNC and normal groups were obtained. More serumal or salivary 25(OH)D deficient subjects were found in control group than those in HNC group. Meanwhile, serumal and salivary 1,25(OH)D mean levels of HNC group were not significantly different with the ones of control group. There were significant correlations of serumal-salivary 25(OH)D as well as serumal-salivary 1,25(OH)D levels in normal group.CONCLUSION: Serumal and salivary 25(OH)D and 1,25(OH)D levels of HNC group were relatively normal. Salivary 25(OH)D and 1,25(OH)D could be suggested as substitutes for serumal ones.KEYWORDS: vitamin D, 25(OH)D, 1,25(OH)D, head and neck cancer
Daily Soy–Catfish–Anchovy–Rice (SCAR) Porridge Increases 25(OH)D Serum Levels in Tuberculosis Patients with Vitamin D Receptor Gene Polymorphisms Dina Keumala Sari; Ridha Dharmajaya; Mutiara Indah Sari; Dewi Masyithah Darlan
The Indonesian Biomedical Journal Vol 13, No 4 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i4.1725

Abstract

BACKGROUND: The presence of vitamin D receptor (VDR) polymorphism and high levels of inflammatory markers are predisposing factors indicating disease progression and malnutrition. To meet nutritional needs in maintaining nutritional status in tuberculosis patients with VDR gene polymorphisms (TaqI or FokI), food that is easily absorbed and high in vitamin D, calcium, and protein is needed. This study was conducted to determine whether high vitamin D and calcium porridge called soy–catfish–anchovy–rice (SCAR) porridge would increase 25(OH)D serum levels and other parameters, including calcium, albumin, high-sensivity C-reactive protein (hs-CRP), and blood glucose serum levels.METHODS: The study was a parallel, open, clinical trial. There were 22 subjects in the intervention (I) group who received 50 g of SCAR porridge once per day along with dietary counseling, and 21 subjects in the control (C) group who only received dietary counseling. All subjects with TC and CC (TaqI) or TC and CC (FokI) genotype were included in this study. The intervention lasted for 14 days, and the parameters such as 25(OH)D, calcium, albumin, hs-CRP, and blood glucose serum levels were assessed before and after intervention between groups.RESULTS: All subjects in both groups completed the study. After 14 days of intervention, there was a significant increase in 25(OH)D (p=0.01) and decrease in hs-CRP (p=0.02) serum levels in the I group, and no change was observed in the C group. There was no significant difference in albumin and blood glucose serum levels.CONCLUSION: The results show that 50 g of SCAR porridge per day for 14 days is an effective supplementation that can increase 25(OH)D and decrease hs-CRP serum levels in tuberculosis patients with VDR gene polymorphism.KEYWORDS: vitamin D, hs-CRP, polymorphism, porridge
The Correlation between Body Mass Index and Albumin Level with Sputum Conversion in AFB-Positive Pulmonary TB Patients in Primary Health Center in Medan, Indonesia Juli Yosa Mega; Dina Keumala Sari; Juliandi Harahap
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 1 No. 1 (2019): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.973 KB) | DOI: 10.32734/jetromi.v1i1.1264

Abstract

Tuberculosis (TB) remains a major public issue in Indonesia including in North Sumatra province. Despite reported good efficacy of TB treatment in the region, the success of treatment depends on many factors including nutritional status. This study aims to determine the relationship between Body Mass Index and Albumin level with sputum conversion in AFB-positive pulmonary TB patients.The study was done in two primary health centres in Medan between October and November 2018. A total of 39 newly diagnosed TB patients with confirmed AFB-positve were included in the study.Participants received TB treatment according to the national guidelines. The proportion of participants with below normal, normal and above normal BMI status were 13 (33.3%), 21 (53.9%) and 5 (12.8%), respectively. Level of albumin was determined as normal in 25 participants (64.1%), and the remaining as low. Normal BMI status was significantly associated with increased albumin level (P<0.05). At 2 months follow-up, the sputum conversion was observed in 24 individuals (61.5%), and the conversion was significantly associated with normal BMI and/or normal albumin level (P<0.05). We concluded that nutritional status is an important factor in the success of TB treatment.
Vitamin D Supplementation in Tuberculosis Patients: A Cross Sectional Study Dina Keumala Sari; Nurfida Khairina Arrasyid; Y. S. Harahap
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 1 No. 1 (2019): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.929 KB) | DOI: 10.32734/jetromi.v1i1.1265

Abstract

Previous studies have not been able to show with certainty the effect of vitamin D supplementation in tuberculosis patients. The objective of this study is to determine whether vitamin D supplementation to patients with tuberculosis could influence 25-hydroxyvitamin D (25(OH)D) and calcium serum levels. The results, after 28 days, the vitamin D supplementation showed significant increase of 25(OH)D serum level at the end point (p=0.001), but not for the calcium serum level (p=0.3). The Conclusions is supplementation with 1,000 IU vitamin D per day increased the 25(OH)D serum level but there was no association with the calcium serum level.
Hubungan asupan diet dengan penanda inflamasi pada penyandang obesitas Meriza Martineta; Dina Keumala Sari; Zaimah Z Tala; Nenni Dwi Aprianti Lubis
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.6460

Abstract

Latar belakang: Obesitas merupakan keadaan tubuh yang disebabkan oleh keseimbangan energi positif yang erat hubungannya dengan pola diet. Penyandang obesitas mengalami inflamasi low-grade kronik dalam tubuh akibat produksi sitokin inflamasi dari jarinagan adiposa.  Tujuan penelitian ini adalah mengetahui adanya hubungan antara asupan diet dengan penanda inflamasi (high sensitivity C-reactive protein, Hs-CRP) penyandang obesitas. Methods:sebanyak 34 orang laki-laki dan wanita berusia 19-59 tahun dengan IMT ≥25,0 kg/m2dilakukan pemeriksaan darah Hs-CRP dan penilaian asupan diet menggunakan metode food frequency questionnaires (FFQ).  Hubungan antara asupan diet dengan Hs-CRP dinilai dengan menggunakan korelasi Spearman. Hasil: asupan kalori, protein, lemak, karbohidrat, serat, PUFA dan kolesterol tidak memiliki hubungan yang signifikan dengan Hs-CRP (p >0.05). Kesimpulan:Asupan diet tidak berhubungan dengan hs-CRP. 
Co-Authors Dewi Masyithah Darlan Elvita Rahmi Daulay Farhat Farhat Ferry Sandra Jannathul Firdous Juli Yosa Mega Juliandi Harahap Khairil Azwan Lidya Imelda Laksmi Lidya Imelda Laksmi Liza Meutia Sari Liza Meutia Sari Lubis, Nenni Dwi Aprianti Meriza Martineta Mutiara Indah Sari Noorzaid Muhamad Pamela Rosie David Ratna Akbari Ganie Resni Mona Ridha Dharmajaya Y. S. Harahap Zaimah Z Tala Zulfikar Lubis