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All Journal Sari Pediatri Paediatrica Indonesiana eJournal Kedokteran Indonesia
Dina Muktiarti, Dina
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia-Rumah Sakit Cipto Mangunkusumo
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Paediatrica Indonesiana

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Soy protein sensitization in cow’s milk allergy patients Dina Muktiarti; Zakiudin Munasir; Alan R. Tumbelaka
Paediatrica Indonesiana Vol 47 No 2 (2007): March 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (400.004 KB) | DOI: 10.14238/pi47.2.2007.78-82

Abstract

Background The management of cow’s milk allergy (CMA) isavoidance of cow’s milk as strictly as possible. Extensive hydrolyzedprotein and amino acid based formulas are recommended dietaryproducts for treatment of CMA. However, they have somedisadvantages, such as bitter taste and high cost. Alternativeprotein sources from vegetable proteins, such as soy, can be usedas milk-substitute. Previous studies showed the prevalence of soyallergy in CMA patients in Western countries ranged between 0to 63%, but the prevalence in Asia was not greater than 20% andno data about this prevalence in Indonesia.Objectives To determine the proportion of soy proteinsensitization in CMA patients and characteristics of CMA patientswho were sensitized to soy protein.Methods Fifty seven CMA patients who consumed soy proteinwere taken their blood sample to examine the soy-specific IgE.Results From 57 CMA patients, we found only 18% of patientswho were sensitized to soy protein. Seven out of ten CMA patientswho were sensitized to soy protein were under 12 months old.Atopic dermatitis was the most frequent clinical manifestation(8/10) and all of them had family history of atopic diseases. Soysensitization in IgE-mediated and non-IgE mediated CMA were6/10 and 4/10, respectively.Conclusions Proportion of soy sensitization in CMA patients inthis study was 18%. Soy protein can be used as an alternative forcow’s milk substitute in CMA patients.
Outcomes of prevention of HIV mother-to-child transmission in Cipto Mangunkusumo Hospital Dina Muktiarti; Nia Kurniati; Arwin Akib; Zakiudin Munasir
Paediatrica Indonesiana Vol 52 No 5 (2012): September 2012
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.189 KB) | DOI: 10.14238/pi52.5.2012.294-9

Abstract

Background Human immunodeficiency virus (HIV) infectionis increasing worldwide. One foute of HIV transmission is frommother to child, during pregnancy, delivery or breastfeeding.Prevention of mother􀁂to􀁂child transmission may be an effectivestrategy to reduce the cases of new HIV infections.Objectives To investigate the incidence of HIV infection ininfants born to mothers with HIV and who received prophylactictherapy at birth, as well as to note the outcomes of HIVinfectedchildren in this program.Methods This retrospective study was carried out over a 9􀁂yearperiod, from January 20 03 to December 2011. The participantswere HIVexposed infants who attended the HIV clinic, at theDepartment of Child Health, Cipto Mangunkusumo Hospital,Jakarta. Infants were treated according to the prevention ofmother􀁂to􀁂child transmission (PMTCT) protocol at CMH.Parents' and infants' data was recorded. The end point of thisstudy was recording of HIVinfection status in the infants.Results There were 238 infants included in this study. HIVinfection was confirmed in 6 (2.5%) infants, while 170 (71.4%)subjects were uninfected, and 62 (26.1%) subjects were lostto follow􀁂up. No subjects who underwent complete PMTCTmanagement were infected. Most subjects were male, full􀁂tenn,and delivered by caesarean section in our hospital. The mostfrequently observed parental risk factor was intravenous druguse. Maternal antiretroviral therapy (ART) was given duringpregnancy in most cases. Morbidities in all subjects were low.Conclusion The PMTCT program at CMH was effective forreducing the number ofHIVinfected infants from mothers withHIY. [Paediatrlndanes. 2012;52:294-9]. 
Interleukin-6 and disease activity in childhood systemic lupus erythematosus Satria, Cahya Dewi; Kurniati, Nia; Muktiarti, Dina
Paediatrica Indonesiana Vol 63 No 6 (2023): November 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.6.2023.456-63

Abstract

Background Systemic lupus erythematosus (SLE) is a complex disease with various manifestations. Interleukin-6 (IL-6) is a pleiotropic cytokine with a wide range of biological activities which plays an important role in immune regulation and inflammation. Serum level of IL-6 may be used as a parameter of disease activity, especially in pediatric SLE patients with mild disease activity or total remission with conflicting clinical manifestations and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores. Objective To identify the characteristics of serum IL-6 concentration in pediatric SLE with mild disease activities and total remission. Methods This case-control study was performed at the allergy-immunology outpatient clinic, Department of Child Health Dr. Cipto Mangunkusumo Hospital, Jakarta and Dr. Sardjito Hospital, Yogyakarta. Serum IL-6 concentration and disease activity were assessed in all pediatric SLE patients aged 1-18 years old. Disease activity was assessed with SLEDAI scores and serum level of IL-6 was measured by enzyme-linked immunosorbent assay. Results Among 60 subjects included in this study, 30 subjects with mild activities were in the case group and 30 subjects with total remissions were in the control group. There was no difference in serum IL-6 concentration between the case and control group (OR 0.483; 95%CI 0.041to 5.628; P=0.500). In this study, 2 subjects with urinary tract infection had high serum IL-6 concentrations. Conclusion There is no difference in serum IL-6 concentration between pediatric SLE patients with mild disease activities compared to total remissions.
Co-Authors Alan R. Tumbelaka Anang Endaryanto Arini Setiawati Arwin Akib Arwin AP Akib Bambang Supriyatno Budi Setiabudiawan Cahya Dewi Satria, Cahya Dewi Dewi Kartika Suryani Dwi Lestari Pramesti Edy Novery Fransiska Kaligis Ismail, Raden Irawati Iswari Setianingsih Ita M. Nainggolan Johannes Hudyono Ketut Dewi Kumara Wati Melva Louisa Mulya Rahma Karyanti, Mulya Rahma Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Pustika Amalia Wahidiyat Rizqi Amalia Rizqi Amalia Safira A Tjandrasari Sudung O Pardede, Sudung O Sumadiono Sumadiono Tjhin Wiguna Zakiudin Munasir Zakiudin Munasir