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All Journal Indonesia Chimica Acta
Firdaus Firdaus
Hasanuddin University
Chemical Engineering, Chemistry & Bioengineering

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STUDY OF COMPOUNDS FROM EXTRACT OF Melochia umbellata (Houtt.) Stapf var. Degrabrata K. (PALIASA) LEAVES THAT HAS POTENTIAL AS ANTIBACTERIAL Selfi Wullur; Firdaus Firdaus; Hasnah Natsir; Nunuk Hariani Soekamto
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 8 No 1 - June 2015
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v8i1.2472

Abstract

Determination of antibacterial activity of each extract of M. umbellata (Houtt.) Stapf var. K. degrabrata leaves has been conducted against three strains bacteria Escherichia coli, Staphylococcus aureus, and Shigella dysenteriae by using amoxicillin as a positive control and DMSO as a negative control. Agar diffusion method has been used with MHA medium (Muller Hinton Agar) on variation concentrations of each extract were 2500 ppm, 5000 ppm, 10,000 ppm, and 20,000 ppm N-hexane extract was the most active extract against S. aureus with zone of inhibitions were 10.50 mm, 10.80 mm, 11.00 mm and 11.45 mm, respectively. The most active extract against S. dysenteriae was ethyl acetate extracts with zone of inhibitions were 9.36 mm, 11.55 mm, 11.58 mm and 17.70 mm, respectively. Isolated compound from n-hexane extract was first compound as white powder with a melting point of 75-77 °C which was identified as 1-Tetracosanol and second compound was obtained in the form of a yellow paste which was identified as steroid compound that had long conjugated substituent. These compounds were elucidated based on the data of IR, UV-Vis, 1H-NMR, and 13C-NMR.
A Caffeic Acid Derivative Potential for Anticancer Drug: Synthesis of N-(piperidinyl)caffeamide and Its Activity against P388 Leukemia Murine Cells Firdaus Firdaus; Nunuk Hariani Soekamto; Syadza Firdausiah; Musrifah Tahar
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.10962

Abstract

Some esters and amide derivatives of p-hydroxycinnamic acid have anticancer activity. However, the amide compound is more stable to metabolic reactions compared to its ester derivative. In this research, the synthesis of a new compound, namely N-(piperidinyl)caffeamide (M5) and its anticancer activity assay, has been conducted. The compound M5 was synthesized using p-hydroxycinnamic acid and piperidine as starting materials, and the activity assay was carried out against P388 Leukemia Murine Cells by the MTT method. By these methods, the compound M5 was obtained a yellowish crystalline with a melting point of 212-214°C, and it was very active as an anticancer with an IC50 value of 0.861 μg/mL. This compound was more active than the analog compounds previously synthesized.
Co-Authors Hasnah Natsir Musrifah Tahar Nunuk Hariani Soekamto Selfi Wullur Syadza Firdausiah