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Penurunan Glukosa dan Perubahan Profil Lipida Serum Tikus Sprague- Dawley Hiperglikemia-Hiperkolesterolemia Akibat Asupan Sorbitol-Oleat Poliester (SOPE) Murdiati, Agnes; Wuryastuty, Hastari; Marsono, Y.; Harmayani, Eni
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 14, No 3 (2009): October 2009
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (343.509 KB) | DOI: 10.24002/biota.v14i3.2576

Abstract

Disorder of carbohydrate metabolism in the Diabetes Mellitus patients resulted in increasing of cholesterol synthesis. This condition increases the risk of heart attack or coronary heart disease, therefore it is recommended to lower fat intake. One of the alternatif to lower fat intake is by replacing fat with fat replacer in the diet. The aim of the present study is to evaluate the effect of replacing 75% of fat with SOPE on the glucose and lipid profile in diabetic-hipercholesterolemic rats. Eihgteen Sprague Dawley rats were devided into 2 groups of 9 rats. They were fed with hipercholesterol diet and were diabetic induced with alloxan IM injection. One group was fed with 75% SOPE substitute the fat in the standard diet and the other group was fed with standard diet. The result indicates that the oil substitution of standard diet of Sprague Dawley rats for sorbitol-oleic polyester as much as 75% gives an advantage to rats which suffer hiperglikemic-hypercholesterolemic because it decreased the glucose, total cholesterol, LDL cholesterol, and LDL/HDL cholesterol ratio, and did not decrease the HDL cholesterol, but increased triglyceride serum.
Potensi Tepung Pisang Uter (Musa Acuminata) Sebagai Pangan Fungsional Untuk Menurunkan Kolesterol Hastin Dyah Kusumawardani; Yustinus Marsono; Agnes Murdiati; Mohamad Samsudin
Buletin Penelitian Kesehatan Vol 47 No 4 (2019)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.851 KB) | DOI: 10.22435/bpk.v47i4.1589

Abstract

Abstract Cholesterol is needed in certain concentration as to avoid health effects. Efforts to handle hypercholesterolemia can be done by utilizing the content of resistant starch in Uter bananas flour. The aim of this study was to prove the hypocholesterolemic effect of Uter Banana flour in hypercholesterolemic Spraque-Dawlwy rats. Therefore, experimental research using animals to determine the hypocholesterolemic effect of Uter banana flour was carried out for 28 days, in Spraque Dawlwy male rats aged 2 months, weighing ± 200 grams. Rats were divided into 5 treatment groups. Group I was normal rats group, group II was hypercholesterol rats without treatment, group III was hypercholesterol rats with pulp fruit flour diet, group IV was hypercholesterol rats with whole fruit flour diet, group V was hypercholesterol rats with peel fruit flour diet. Each diet contained 100 mg / kgBB. Statistical analysis showed that a diet of pulp fruit flour and whole fruit flour can reduce levels of total cholesterol, triglycerides, and LDL significantly (p<0.05). Digesta characteristics differed among the treatment group and the hypercholesterolemia group without treatment (p <0.05). The whole fruit flour has ability to lower cholesterol better than pulp fruit flour, whereas, peel fruit flour has no hypocholesterolemic effects. Keywords: hypercholesterolemia, resistant starch, Uter Banana Flou Abstrak Kolesterol dibutuhkan oleh tubuh dalam jumlah tertentu agar tidak membahayakan kesehatan. Upaya penanganan hiperkolesterolemia dapat dilakukan dengan memanfaatkan kandungan pati resisten dalam pisang Uter. Tujuan dari penelitian ini adalah membuktikan efek hipokolesterolemik tepung Pisang Uter pada tikus Sprague Dawley hiperkolesterol. Untuk itu penelitian eksperimen dengan hewan coba untuk mengetahui efek hipokolesterolemik tepung pisang Uter dilakukan selama 28 hari, pada tikus Spraque Dawlwy jantan umur 2 bulan, dengan berat ± 200 gram. Tikus dibagi menjadi 5 kelompok perlakuan. Kelompok I adalah kelompok tikus normal, kelompok II adalah tikus hiperkolesterol tanpa perlakuan, kelompok III tikus hiperkolesterol dengan diet tepung daging buah, kelompok IV adalah tikus hiperkolesterol dengan diet tepung buah utuh, kelompok V adalah tikus hiperkolesterol dengan diet tepung kulit buah, masing-masing diberikan diet 100 mg/kgBB. Hasil uji statistik menunjukkan bahwa diet tepung daging buah dan tepung buah utuh dapat menurunkan kadar kolesterol total, trigliserida, dan LDL secara nyata (p<0,05). Karakteristik digesta berbeda antara perlakuan dan kelompok tikus hiperkolesterol tanpa perlakuan (p<0,05).Tepung buah utuh mempunyai kemampuan menurunkan kolesterol lebih baik dibandingkan tepung daging buah. Tepung kulit buah tidak mempunyai efek hipokolesterolemik. Kata kunci: Hiperkolesterol, pati resisten, tepung Pisang Uter
PENGGUNAAN MINYAK SAWIT UNTUK SUBSTITUSI LEMAK SUSU DALAM PRODUKSI SUSU KENTAL MANIS Naruki, Sri; Marsono, Yustinus; Murdiati, Agnes
Jurnal Teknologi Pangan dan Gizi Vol 5, No 1 (2004)
Publisher : Widya Mandala Surabaya Catholic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jtpg.v5i1.2379

Abstract

A research on substitution of milk fat with palm oil in Sweet Condense Milk (SCM) production has been conducted. The aim of this research was to investigate the effects of milk fat substitution with palm oil on physical, chemical and nutritional properties of the Palm Oil SCM (POSCM) POSCM were prepared by substitution of corn oil (0, 25, 50, 75 and 100%) with palm oil (R-vita) of the commercial recombined SCM formula. Chemical and physical properties of the POSCMs were determined. The POSCMs were then reconstituted and sensory character as well as nutritional properties was examined. The result showed that substitution of 50% corn oil with red palm oil (R-vita)resulted in a good quality of POSCM similar to the control SCM (0% red palm oil). This POSCM have viscosity and chemical composition similar to SCM and the emulsion stability 98%. POSCM production decreased 10% of carotene content but the tocoferol content were not affected bu the process. Substitution of milk fat with red palm oil decrease the cholesterol but have no effects on TAG concentration in rats.
KADAR SERAT PANGAN DAN DAYA CERNA PATI NASI MERAH YANG DIPERKAYA KAPPA-KARAGENAN DAN EKSTRAK ANTOSIANIN DENGAN VARIASI METODE PENGOLAHAN Nurhidajah -; Mary Astuti; Sardjono -; Agnes Murdiati; Yustinus Marsono
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2015: Prosiding Bidang MIPA dan Kesehatan The 2nd University Research Colloquium
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Brown rice is one of the varieties of rice that are less popular because of the texture cooked more hard than white rice. Brown rice contain anthocyanins on the epidermis and is hypoglycemia. The nature of hypoglycemia brown rice also affected by the low digestibility of starch and dietary fiber contained in brown rice. Two things are influenced by the processing method when forming the rice into the rice. The purpose of this study was to evaluate the digestibility of starch and dietary fiber content of brown rice with a variety of processing. This research method is the enrichment of red rice with kappa-carrageenan 2% which aims to improve the organoleptic properties of texture and flavor, especially brown rice and anthocyanin extract 5ml / 100 grams of brown rice. The processing of brown rice into the rice is done with four processing method that is steamed, boiled, rice cooker and a control is raw rice. The results showed the highest levels of dietary fiber in brown rice processing method using a rice cooker, but statistically there was no effect of food processing methods with fiber. The highest starch digestibility on red rice by the method of the boiled and showed no effect of treatment with starch digestibility.Keywords: Brown rice, dietary fiber, starch digestibility and processing
Penurunan Glukosa dan Perubahan Profil Lipida Serum Tikus Sprague- Dawley Hiperglikemia-Hiperkolesterolemia Akibat Asupan Sorbitol-Oleat Poliester (SOPE) Agnes Murdiati; Hastari Wuryastuty; Y. Marsono; Eni Harmayani
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 14, No 3 (2009): October 2009
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v14i3.2576

Abstract

Disorder of carbohydrate metabolism in the Diabetes Mellitus patients resulted in increasing of cholesterol synthesis. This condition increases the risk of heart attack or coronary heart disease, therefore it is recommended to lower fat intake. One of the alternatif to lower fat intake is by replacing fat with fat replacer in the diet. The aim of the present study is to evaluate the effect of replacing 75% of fat with SOPE on the glucose and lipid profile in diabetic-hipercholesterolemic rats. Eihgteen Sprague Dawley rats were devided into 2 groups of 9 rats. They were fed with hipercholesterol diet and were diabetic induced with alloxan IM injection. One group was fed with 75% SOPE substitute the fat in the standard diet and the other group was fed with standard diet. The result indicates that the oil substitution of standard diet of Sprague Dawley rats for sorbitol-oleic polyester as much as 75% gives an advantage to rats which suffer hiperglikemic-hypercholesterolemic because it decreased the glucose, total cholesterol, LDL cholesterol, and LDL/HDL cholesterol ratio, and did not decrease the HDL cholesterol, but increased triglyceride serum.
Policy Analysis Reducing Under Five Stunting Children in Special Region Yogyakarta, Indonesia TRi Siswati; Agnes Murdiati
Jurnal Kebijakan Kesehatan Indonesia Vol 11, No 2 (2022)
Publisher : Center for Health Policy and Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkki.71795

Abstract

 Yogyakarta Special Region is a provinces with a low prevalence of stunting children in Indonesia as many as 21%. Many policies support reducing stunting children effort. This study aims to analysis of policies related to reduce stunting. The method was desk review using secondary data, literature review, policy/regulation tracing related to stunting children and discussions, presentations, Focus Group Discussion (FGD), and Round Table Discussion (RTD). Causes of stunting include distal factors such as the economy, poverty, education, and well-being. Proximate factors were baby low birth weight and adolescent pregnancy. Interventions conducted with a focus target on 1000 early day life include sensitive and specific nutritional interventions. All regional organization have taken a role in combating stunting. Also regulations both internationally, nationally and regionally support the acceleration of the decline of stunting. But the specific regulations on stunting is not available. Effort to reducing stunting have been implemented but need more synergitic and integrated intervention between regional organization with Bappeda as the leading sector.