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All Journal Jurnal Tumbuhan Obat Indonesia Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY
Yosi Bayu Murti
Faculty Of Medicine Universitas Gadjah Mada, Jl. Farmako Skip 55281, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Public Health

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Journal : Majalah Obat Tradisional

 1   2 
PENGARUH HIDROLISIS ASAM-BASA TERHADAP AKTIVITAS PENANGKAPAN RADIKAL 2-2’ DIFENIL-1-PIKRIL HIDRAZIL (DPPH) FRAKSI AIR DARI EKSTRAK ETANOLIK BUAH TALOK (Muntingia calabura L.) Tatang Irianti; Yosi Bayu Murti; Damiana Nitya Kanistri; Desi Riza Pratiwi; Kuswandi Kuswandi; Ratih Anggar Kusumaningtyas
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1025.07 KB) | DOI: 10.22146/tradmedj.10724

Abstract

The investigation of talok fruits (Muntingia calabura L.) was shown the antioxidant activity of aqueous fraction of the ethanolic extract is relatively low. Hydrolysis treatment has increased the antioxidant activity by releasing the flavonoid aglycone from glycoside form. This study aims to determine the effect of acid and alkaline hydrolysis, and hydrolysis time on the antioxidant activity of aqueous fraction of calabura fruits ethanolic extract. The antioxidant activity of acid hydrolyzed aqueous fractions in 1 and 3h hydrolysis, respectively 9.5 and 1.5 times more potent than the aqueous fraction, while the alkaline in 1 and 3h hydro-lysis were 2.5 and 6.5 times. Flavonoid aglycone liberated on acid hydrolysis and alkaline had different anti-oxidant activity. The value of IC50 by acid hydrolyzed aqueous fraction in 1h and 3h hydrolysis of 20.55 and 97.88μg/mL, while the alkaline in 1h and 3h hydrolysis of 66.64 and 25.53μg/mL. One hour acid hydrolysis had antioxidant activity greater than 3h whereas in alkaline the greatest antioxidant activity is shown in 3h.
Screening of Extraction Process and The Estimation of Total Alkaloids in Carica papaya Linn. Leaf Sisca Devi; Meri Ropiqa; Yosi Bayu Murti; Akhmad Kharis Nugroho
Majalah Obat Tradisional Vol 25, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.52184

Abstract

The papaya leaf decoctions have been widely used as a traditional treatment for malaria. The alkaloid of papaya leaves, carpaine, is reported to have the antiplasmodial activity in vitro. The industrial-scale commercial product development requires the quantification of the carpaine, and total alkaloids in the papaya leave as the raw materials. This study aims to optimize the extraction process leading to the highest yield and total alkaloids. The extraction process was carried out using different methods and solvents. The first method was maceration with the water-miscible solvent of ethanol: distilled water: HCl 37% (89: 10: 1 v/v/v). The second method was maceration with the water-immiscible solvent of dichloromethane solvents in pH 8-9 with ammonium hydroxide. The third method was digestion with acid water solvent of 0.05 N HCl. The identification of alkaloids employed the analysis using Thin Layer Chromatography (TLC) and Dragendroff reagent. The quantification of carpaine used a densitometer, while the spectrophotometric method was used to estimate the total alkaloids. The results showed that despite the extraction methods used, the tested extracts confirm the alkaloids content with the highest yield of 3.09% (84.72% of total alkaloids).
Co-Authors Akhmad Kharis Nugroho Damiana Nitya Kanistri Damiana Nitya Kanistri Desi Riza Pratiwi Dewi Setyaningsih Dina Aryani Dina Aryani, Dina Enade Perdana Istyastono Hari Purnomo Indrawan Kurnia Dwinatari Indrawan Kurnia Dwinatari, Indrawan Kurnia Kuswandi Kuswandi Kuswandi Kuswandi Lalita Lisprayatna Lalita Lisprayatna, Lalita Mahfud Alkarim Mahfud Alkarim, Mahfud Mufrod Mufrod mufrod mufrod Muhammad Radifar Nugroho, Agung Endro Ratih Anggar Kusumaningtyas Ropiqa, Meri Santoso, Bilal Subchan Agus Sekararum Diah Kartikasari Sekararum Diah Kartikasari, Sekararum Diah Shanti Listyawati Sindu Nuranto Sisca Devi Sismindari Sismindari Sofa Farida Sofia Mubarika Sudarsono, Sudarsono T. Nanda Saifullah Sulaiman T. Nanda Saifullah Sulaiman, T. Nanda Saifullah Tatang Irianti TN. Saifullah Sulaiman TN. Saifullah Sulaiman, TN. Saifullah