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Association of Growth Velocity with Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Children with a Vegan Diet Arie Purwana; Budiono Budiono; Jose RL Batubara; Muhammad Faizi
Journal of Biomedicine and Translational Research Vol 6, No 1 (2020): April 2020
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v6i1.5474

Background: The vegan diet in children provides the benefit of reducing the risk of being overweight and improving the fat profile. The risk that can occur in the provision of a vegan diet in children is anthropometric size below reference and low caloric intake. Growth hormone (GH) and Insulin like Growth Factors (IGFs) are powerful stimulators for longitudinal growth of bone and require insulin-like growth factor binding protein (IGFBPs) which acts as a transport protein for IGF-1. A vegan diet with lower calorie intake in children has lower IGF-I levels than children with an omnivorous diet.Objective: Examining the effect of vegan diets on IGF-1 levels, IGFBP-3 levels, and growth velocity.Methods: This study was done with a prospective cohort design. The study subjects were divided into two groups, namely the vegan group and the omnivorous group, then matched based on age and sex. During the study, anthropometric data collection, IGF-1 and IGFBP-3 levels measurements were done in both vegan children and omnivorous children.Results: During 6 months of observation, 22 subjects were divided into two groups, namely children with a vegan diet and children with an omnivorous diet. IGF-1 (ng / mL) in vegan children was 105.5 ± 47.3 compared to 102.7 ± 42.3 in omnivorous children with a value of p = 0.89. IGFBP-3 (ng / mL) in vegan children was 2146.4 ± 595.1 compared to 2142 ± 609.1 in omnivorous children with value of p = 0.99 and Growth Velocity (cm / 6 months) was 3.0 in vegan children (1.0-5.30), and 3.2 (2.6-6.5) in omnivorous children with value of p = 0.41.Conclusion:Children with vegan diet had IGF-1 level, IGFBP-3 level, and growth velocity that were the same as children with an omnivorous diet.

Case Report: Medical Aspect, Growth, and Quality of Life in Children with 46,XX Testicular Disorder of Sex Development (DSD) Nur Rochmah; Muhammad Faizi; Irwina Rahma Andriani; Soraya Salle Pasulu
Folia Medica Indonesiana Vol. 54 No. 3 (2018): September
Publisher : Faculty of Medicine, Universitas Airlangga

46,XX testicular disorder of sexual development (DSD) is characterized by male phenotype with 46,XX karyotype. The incidence rate is 1:25,000 in male newborn. Infants with ambiguous external genitals will be confronted with issue of gender assigment and may result in a stressful condition in the parents. Since gender assignment is inevitable, several factors should be considered in DSD management. The management approach for children born with DSD is individualized and multidisciplinary. Gender assignment aims to facilitate the patient to obtain the best quality of life. Adaptation of children with 46,XX testicular DSD as a determinant of quality of life is also influenced by psychological and family conditions. The purpose of this report was to observe medical growth and development aspects of the child with 46,XX terticular DSD as indicated by the aspects of growth and development, and health related quality of life, as well as the influential aspects. PA, 18 months, was diagnosed with 46,XX testicular DSD. The patient routinely visited to endocrinology clinic, urologic surgery, and child psychiatry clinic from the age of 6 months. The parents decided to raise patient as male. The patient had undergone surgery for hypospadias correction, hormone injections, child growth monitoring, and psychological monitoring (medical records of Dr. Soetomo Hospital, Surabaya in 2015). Management should consider individual and multidiciplinary accompaniment of the patient and parents, the importance of group support, and follow-up to adulthood, as well as possible longterm outcomes that will occur in the future so that the patients and the parents need to be prepared.

Risk Factor Related to Mortality of Diabetic Ketoacidosis Patients in Dr. Soetomo General Hospital Surabaya Alviano Satria Wibawa; Hermina Novida; Muhammad Faizi; Deasy Ardiany
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 11 No. 1 (2020): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V11I12020.36-40

Introduction: Diabetic ketoacidosis (DKA) is a complication of diabetes mellitus which has a high risk of mortality. Mortality in DKA patients in developed countries is less than 5%, some other sources mention 5-10%, 2-10%, or 9-10%. Mortality events at clinics with simple facilities and elderly patients can reach 25-50%. The mortality rate of DKA patients is generally higher in infection conditions, especially in developing countries and in septic patients. Several factors such as age, sex, and high blood glucose can increase mortality risk of DKA patients. Other risk factors such as history of discontinued insulin therapy, impaired bicarbonate levels, pH, and increased leukocytes of DKA patients due to infection, abnormal albumin levels, electrolyte disturbances, and Serum Creatinine (SK) were thought to affect mortality of DKA patients. The purpose of this study was to determine the risk factors associated with mortality of DKA patients in Dr. Soetomo General Hospital Surabaya. Methods: The method used in this study was observational analytic involving 63 adult patients diagnosed with DKA with analysis using Chi-Square test. Results: From 63 patients included in this study, 37 patients diagnosed with DKA died and 26 patients lived. In a multivariate analysis, DKA severity with p = 0.001 (p < 0.005) was identified as having a relationship with mortality of DKA patients Dr. Soetomo General Hospital Surabaya. Conclusion: Severity is the only risk factor associated with mortality of DKA patients in Dr. Soetomo General Hospital Surabaya.

Diabetic ketoacidosis in children: an 11-year retrospective in Surabaya, Indonesia Nur Rochmah; Muhammad Faizi; Netty Harjantien
Paediatrica Indonesiana Vol 55 No 1 (2015): January 2015
Publisher : Indonesian Pediatric Society

Background Diabetic ketoacidosis (DKA) is a complication of type I diabetic mellitus (TIDM). Early recognition and prompt treatment can reduce mortality. Objective To evaluate the profiles of patients with diabetic ketoasidosis in Dr. Soetomo Hospital, Surabaya, Indonesia. Methods Retrospective medical records of patients admitted to the pediatric intensive care unit with DKA in Dr. Soetomo Hospital, Surabaya, Indonesia from January 2002 to June 2013 were reviewed. The data collected included clinical parameters, laboratory and imaging results, predisposing factors, complications and outcomes. Results During an 11 years period, there were 58 cases of DKA in children with T1DM. Eighteen subjects (31%) were boys. The severity of DKA was classified as follows: mild 13 (22.4%), moderate 23 (39.7%), and severe DKA 22 (37.9%). Recurrent DKA was diagnosed in 24 (41.4%) patients. Common clinical profiles recorded were dehydration 46 (79.3%), malaise 37 (63.8%), decreased consciousness 35 (60.3%), dyspnea 27 (46.6%), vomiting 26 (44.8%), fever 25 (43.1%), seizure 13 (22.4%), and decreased body weight 9 (15.5%). Laboratory results observed were as folllows: hyponatremia 19 (32.8%), hyperkalemia 12 (20.7%) and acute renal failure 3 (5.2%). Head CT scans showed that 2 (3.4%) patients suffered from cerebral edema. Infections, as triggers of DKA, were found in 12 (20.6%) patients: 4 caries and periodontitis, 3 urinary tract infections, 2 acute diarrhea, 2 acute pharyngitis, and 1 otitis externa. Four out of 24 patients with recurrent DKA failed to take their insulin dose prior to DKA. The average of length of patient stay in the PICU was 3.26 (SD 3.50) days. No patients died during the study. Conclusion Dehydration is the most common clinical profile of DKA in our study. More than half of the patients suffer from moderate to severe DKA.

Impact of growth hormone treatment on childrenâ€™s height Nur Rochmah; Muhammad Faizi
Paediatrica Indonesiana Vol 54 No 6 (2014): November 2014
Publisher : Indonesian Pediatric Society

Background The use of growth hormone (GH) is a routine treatment for growth hormone deficiency (GHD), small for gestational age (SGA), and Turner syndrome (TS). During the treatment, height measurement at regular intervals is a vital step to assess success. To date, there have been no previous studies on GH treatment in Dr. Soetomo Hospital, Surabaya, the referral hospital in East Indonesia. Objective To compare body height between pre- and post-growth hormone treatment in pediatric patients. Method This study was a non-randomized, pre-post clinical trial performed at Dr. Soetomo Hospital, Surabaya. The prospective cohort was accessed during January 2008-June 2013. The inclusion criteria was GH treatment for more than 3 months.Clinical data on GH treatment, including diagnosis, age, height pre-and post-treatment, height gain, duration of treatment, and parental satisfaction were collected. Two-tailed, paired T-test and Pearsonâ€™s test were used for statistical analyses. Result Nineteen patients underwent GH treatment during the study period, but only twelve patients had complete data and were included in the study. Eight subjects were female. Subjectsâ€™ meanage was 11 (range 8-15) years. Nine patients had GHD, 2 had TS, and 1 had SGA. Mean pre-treatment height was 121.05 cm, while mean post-treatment height was 130.5 cm. Mean duration of treatment was 10.5 (range 3-30) months. Mean height gain was 0.8 cm/month in GHD and SGA cases, and 0.78 cm/month for the TS cases. Eleven parents reported satisfaction with the results of GH treatment in their children. There is significant diffrent between pre- and post-treatment (P=0.001). Pearsonâ€™s correlation test (r=0.90) revealed a strong correlation between growth hormone treatment and height gain. Conclusion Growth hormone treatment has impact on heights in GH defficiency, Turner syndrome, and small for gestational age.

Diabetes duration and thyroid stimulating hormone levels in children with type 1 diabetes mellitus Nur Rochmah; Muhammad Faizi
Paediatrica Indonesiana Vol 58 No 2 (2018): March 2018
Publisher : Indonesian Pediatric Society

Background Children with type 1 diabetes mellitus (T1DM) are at risk of thyroid dysfunction. An association between diabetes duration and thyroid stimulating hormone level remains inconclusive. Objective To assess for a possible association between diabetes duration and thyroid stimulating hormone levels in children with T1DM. Methods We conducted a cross-sectional study from January to June 2017 in the Pediatric Endocrine Outpatient Clinic at Dr. Soetomo Hospital. Subjects were children with T1DM aged 7 to <18 years. Exclusion criteria were children with diabetic ketoacidosis, previously diagnosed thyroid problems, and hospitalization in the pediatric intensive care unit (PICU).Â Results From the 55 regular patients in our outpatient clinic, 34 patients were included in the study. Nineteen (54.3%) subjects were male, and the overall mean age was 11.3 years. Subjects' mean duration of diabetes was 3 years and their mean thyroid stimulating hormone concentration was 3.76mIU/L. Pearson's correlation test revealed no significant association between duration of diabetes and thyroid stimulating hormone level (rs=-0.068; P=0.703). Conclusion There is no significant association between duration of diabetes and thyroid stimulating hormone levels in children with T1DM.

lmmunomodulatory Effects of Human Milk upon Immune Functions in Infants Ariyanto Harsono; Anang Endaryanto; Muhammad Faizi
Paediatrica Indonesiana Vol 39 No 9-10 (1999): September - October 1999
Publisher : Indonesian Pediatric Society

Human milk is capable to modulate the immune system in infants in several ways. lmmunorestoration is mostly dominated by immunoglobulins content of human milks especially secretory lgA, although lgG antibody also plays important role. Nucleotide content of human milk is among substances widely investigated all over the world, capable to potentiate immune response in infants by increasing NK cell activity and production of lL-2. lmmunopotentiation also the result of cell content activity of human milk, interferon, and complement. Special feature of anti-inflammatory propertyÂ of human milk is its capability to prevent of allergic disease in infants. This because ofprotein in breast milk is species specific, instead the role of secretotry lgA inÂ preventing absorption of foreign macromolecules. Other substances also play an important role in the antiinflammatory properties of human milk and interestingly the paucity of initiators and mediators in human milk.

Vitamin D, insulin-like growth factor-1, and stunting in children with transfusion-dependent thalassemia I Gusti Ayu Putu Eka Pratiwi; Roedi Irawan; I Dewa Gede Ugrasena; Muhammad Faizi
Paediatrica Indonesiana Vol 62 No 2 (2022): March 2022
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi62.2.2022.98-103

Background Transfusion-dependent thalassemia (TDT) has a major impact on a child's growth and is associated with stunting, risk of vitamin D deficiency, and decreased insulin-like growth factor-1 (IGF-1). To date, the relationship between vitamin D levels and stunting in TDT remains unclear. Futhermore, the role of vitamin D and IGF-1 in mediating stunting in TDT patients is still unknown. Objective To investigate the relationship between stunting and vitamin D as well as IGF-1 levels in children with TDT. Methods This cross-sectional study involved 50 TDT children aged 5 to 18 years, included consecutively from the Pediatric Hemato-oncology Outpatient Clinic, Dr. Soetomo Hospital, Surabaya, East Java. Subjects were divided into two groups: stunted (S) and not stunted (NS). Vitamin D and IGF-1 were evaluated by antibody competitive immunoassay and sandwich-enzyme-linked immunosorbent assay (ELISA), respectively. Age, sex, and duration of repeated transfusion were analyzed as confounding factors. Results Median IGF-1 levels were 91.43 (13.67-192.86) ng/mL and 161.53 (17.99-363.01) ng/mL in the S and NS groups, respectively (P=0.011). Mean vitamin D levels were 20 (+ 5.71) ng/mL and 20.46 (5.25) ng/mL in the S and NS groups, respectively (P=0.765). The correlation coefficient (r) of vitamin D and IGF-I levels was not significant. Multivariate analysis showed that low IGF-1 levels, male, and longer duration of repeated transfusions were associated with stunting in children with TDT. Conclusion Low IGF-1 level is associated with stunting in children with TDT. Vitamin D is not significantly associated with either stunting or IGF-1 in children with TDT.

Efek Ekstrak Kulit Manggis (Garcinia mangostana) Terhadap Murine Sepsis Score (MSS) Mencit Sepsis yang Diinduksi Shigella dysenteriae Pradipta Reza Syahruna; Arifa Mustika; Muhammad Faizi
Jurnal Medik Veteriner Vol. 3 No. 1 (2020): April
Publisher : Faculty of Veterinary Medicine, Universitas Airlangga

Penelitian ini untuk mengetahui efek terapi ekstrak kulit manggis (Garcinia mangostana) terhadap sepsis yang diinduksi Shigella dysenteriae. Penelitian ini merupakan penelitian eksperimental, menggunakan 30 mencit dibagi menjadi 5 kelompok. Masing-masing mencit diinjeksi S. dysenteriae secara intraperitoneal. Perlakuan hari pertama post injeksi kontrol positif diberi Azithromycin 246 mg/kgBB, kontrol negatif diberi akuades, kelompok perlakuan diberi ekstra kulit manggis dengan dosis sebagai berikut: K1= 100 mg/kgBB, K2= 200 mg/kgBB, dan K3= 400 mg/kgBB. Perlakuan hari kedua post injeksi sesuai masa inkubasi bakteri skor MSS tiap mencit dihitung. Terdapat korelasi antara pemberian ekstrak kulit manggis dengan skor MSS mencit (p<0.05), tidak terdapat perbedaan signifikan antara pemberian ekstrak 200 mg/KgBB dan 400 mg/kgBB dengan Azithromycin.

Hubungan antara Kadar HBA1C dengan Hasil Sural Radial Amplitude Ratio (SRAR) pada Pasien DM Tipe 1 dengan Neuropati Diabetik Perifer Anny Hanifah; Mudjiani Basuki; Muhammad Faizi
AKSONA Vol. 1 No. 1 (2021): JANUARY 2021
Publisher : Universitas Airlangga

Pendahuluan: Neuropati diabetik perifer merupakan salah satu komplikasi mikroangiopati pada penderita diabetes mellitus. Manifestasi neuropati diabetik perifer paling banyak adalah polineuropati simetris distal, yang menunjukkan gangguan sensorik, motorik, serta penurunan refleks tendon dengan pola length-dependent. Diabetes Mellitus tipe 1 terbanyak diderita pada penderita usia muda, dimana saraf tepi memiliki amplitudo yang relatif masih tinggi, sehingga penurunan amplitudo yang relatif kecil, masih dianggap normal. Perbandingan amplitudo saraf sural dan radial dapat mendeteksi adanya neuropati subklinis. Penderita diabetes mellitus tipe 1 dengan kadar glukosa darah yang tidak teregulasi dengan baik mempunyai risiko 25.6% terkena neuropati diabetik perifer. Tujuan: untuk mengetahui hubungan antara kadar HbA1C dengan kejadian neuropati diabetik perifer pada penderita Diabetes Mellitus tipe 1. Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan cross sectional dengan teknik pengambilan subjek penelitian menggunakan consecutive sampling admission yang memenuhi kriteria inklusi dan eksklusi. Subjek penelitian dilakukan pengukuran terhadap kadar HbA1C, amplitudo saraf sural dan radial dan dihitung perbandingan diantara keduanya. Hasil: Pada 38 subjek penelitian didapatkan 31 subjek penelitian dengan Sural Radial Amplitude Ratio (SRAR) rendah dan 7 subjek penelitian dengan nilai SRAR normal. Hasil analisis penelitian didapatkan bahwa pada subjek dengan nilai SRAR rendah lebih besar pada kelompok HbA1C tinggi yaitu 26 subjek (83.87%) dibandingkan dengan kelompok HbA1C normal yaitu 5 subjek (16.13%). Perbedaan tersebut bermakna secara statistik dengan p= 0.021, rasio odd 6.933 (IK 95% 1.173-40.981). Kesimpulan: Terdapat hubungan negatif antara kadar HbA1C dengan kejadian neuropati diabetik perifer pada penderita Diabetes Mellitus Tipe 1.

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