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Hiromitsu Takayama
Faculty of Pharmaceutical Sciences, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan
Astronomy Chemistry Earth & Planetary Sciences Mathematics Physics

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Suatu Senyawa Stilbene Terprenilasi dari Kayu Akar Tumbuhan Artocarpus Altilis Euis Holisotan Hakim; Valentina Adimurti; Lukman Makmur; Sjamsul Arifin Achmad; Didin Mujahidin; Yana Maolana Syah; Norio Aimi; Mariko Kitajima; Hiromitsu Takayama
Journal of Mathematical and Fundamental Sciences Vol. 33 No. 3 (2001)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Suatu stilben terprenilasi, trans-4-(3-metil-E-but-l-enil)-3,5,2',4'-tetrahidroksistilben telah ditemukan untuk pertama kalinya dari ekstrak kloroform kayu akar tumbuhan Artocarpus altilis (Moraceae), yang dikenal dengan nama Sukun. Struktur molekul senyawa ini telah ditetapkan berdasarkan data fisika dan spektroskopi UV, IR, MS, 1H dan 13C NMR. Senyawa ini bersifat toksik (LC50 = 45,7 µg/mL) terhadap benur udang Artemia salina Leach. A prenylated stilbene from the root trunk of Artocarpus altilisA prenylated stilbene, trans-4-(3-methyl-E-but-l-enyl)-3,5,2',4'-tetrahydroxystilbene had been isolated for the first time from the chloroform extract of the root trunk of Artocarpus altilis (Moraceae), locally known as Sukun. The structure of this compound was Elucidated based on physical and spectroscopic data UV, IR, MS, 1H and 13C NMR. It showed strong toxicity (LC50 = 45,7 µg/mL) agains Atrtemia salina Leach shrimp.*Bagian ke-25 dari seri "llmu Kimia Tumbuhan Moraceae lndonesia". Untuk Bagian ke-24 lihat pustaka (5)
Artonol B and Sikloartobilosanton dari Artocarpus teysmanii MIQ Lukman Makmur; Syamsurizal Syamsurizal; Tukiran Tukiran; Yoharmus Syamsu; Sjamsul Arifin Achmad; Euis Holisotan Hakim; Didin Mujahidin; Norio Aimi; Mariko Kitajima; Hiromitsu Takayama
Journal of Mathematical and Fundamental Sciences Vol. 31 No. 2 (1999)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Dua senyawa masing-masing turunan santon lakton, yaitu artonol B (1) dan turunan furanodihidrobenzosanton, yakni Sikloartobilosanton (2), telah ditemukan pada tumbuhan Artocarpus teysmanii Miq. (Moraceae), suatu tumbuhan langka yang endemik untuk Indonesia dan dikenal dengan nama Tipulu. Struktur molekul kedua senyawa tersebut telah ditetapkan berdasarkan data fisika dan spektroskopi (MS, 1H dan 13C NMR). Artonol B (1) dan sikloartobilosanton (2) memperlihatkan toksisitas yang tinggi terhadap udang Artemia salina, dan senyawa 2 juga memperlihatkan aktivitas antimitotik yang rendah terhadap target cdc2 kinase dan cdc25 fosfatase. Artonol B and Cycloartobiloxanthone from Artocarpus teysmanii MIQTwo compounds, a xanthone lactone derivative, namely artonol B (1) and a furanodihydrobenzoxanthone derivative, namely cycloartobiloxanthone (2) had been isolated from Artocarpus teysmanii Miq. (Moraceae), locally known as Tipulu. The structures of both compounds were elucidated based on physical and spectroscopic data (MS, 1H and 13C NMR). Both artonol B (1) and cycloartobiloxanthone (2) showed strong toxicity against Artemia salina in the shrimp bioassay, and compound 2 also showed weak antimitotic activity against cdc2 kinase and cdc25 phosphatase as the targets. Bagian ke-8 dari seri Ilmu Kimia Tumbuhan Moraceae Indonesia, untuk bagian ke-6 lihat pustaka [10].
Co-Authors Didin Mujahidin Didin Mujahidin Euis Holisotan Hakim Lukman Makmur Lukman Makmur Mariko Kitajima Norio Aimi Sjamsul Arifin Achmad Sjamsul Arifin Achmad Syamsurizal Syamsurizal Tukiran Tukiran Valentina Adimurti Yana Maolana Syah Yoharmus Syamsu