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Marsudi Hutomo

Departemen/Staf Medik Fungsional Ilmu Kesehatan Kulit dan Kelamin Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya

Author-ID : 3287410

Immunology & microbiology Public Health

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1

Topical Therapy in Atopic Dermatitis Patient Wahyunita Desi Ratnaningtyas; Marsudi Hutomo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is an inflammation skin disorder characterized by itchy, chronic, residif, can occur in infant, child, and adult. The therapy for AD are divided into systemic and topical therapy. Topical therapy is the first line therapy for mild and moderate AD which are the most common type AD. Purpose: To evaluate the pattern of topical therapy in new AD patients. Methods: Retrospective study methods was performed by evaluating medical records of new AD patients who received topical therapy in Allergy Immunology Division, Department of Dermatology and Venereology, Dr. Soetomo General Hospital from 2013 until 2015. The evaluated data included the patient's visitation, age, gender, time visit, patient's complaint, periode of illness, history of atopy, physical examination, management, and follow up. Results: There were 272 patients (83.2%) of 327 new AD patients who received topical therapy. Topical therapies were provided in form of corticosteroid topical for 187 patients (23.6%), emolient for 183 patients (23.1%), and topical antibiotic for 40 patients (5.1%). Patients who did not return to the hospital after first visitation were 174 patients (53.2%). Conclusion: Corticosteroid topical is the first line therapy for atopic dermatitis, but emolient is important to improve skin barrier.

Severe Cutaneous Adverse Drug Reaction Damayanti Damayanti; Sylvia Anggraeni; Cita Rosita SP; Marsudi Hutomo; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Cutaneous adverse drug eruption (CADR) are frequently found. A systematic review showed, the incidence of severe CADR (SCADR) ranging from 0-8%. Few studies have assessed the severe form of CADR, which has high mortality rate. The epidemiological study was needed to show the profile of SCADR, especially in the setting of general hospital. Purpose: To evaluate clinical and epidemiological profile of SCADR in Dermatology and Venereology Ward Dr. Soetomo Hospital Surabaya. Methods: All SCADR patients in the period of January 2015–January 2016 was evaluated clinically and epidemiologically. Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic reaction (DRESS) cases were included in the study. Results: There were 14 patients in this study, consist of 10 SJS cases (71.4%), 2 TEN patients, and 2 AGEP patients. The highest frequency of age group was 25-29 years old (57.1%). Man to woman ratio was 3:4. The most common offending drug was paracetamol (50%), followed by amoxicillin (28.6%). Antibiotic was the highest frequent offending drug-group (64.3%), followed by antipiretics (50%). In this study, all patients got systemic corticosteroid and the mortality was 0%. Conclusion: The most common type of SCADR was SJS. The most common offending drug was paracetamol, and antibiotic was the highest frequent offending drug-group. Systemic corticosteroid therapy showed good result in severe CADR management.

Metal Patch Testing with Nickel, Chromium, and Cobalt in Atopic Dermatitis Patients Yuri Widia; Evy Ervianti; Marsudi Hutomo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a cutaneous inflammation characterized by skin hyperreactivity due to complex interplay between genetic susceptibility and environmental allergens. In AD, recurrences are frequent and cause problems. Although elevation of total immunoglobulin E (IgE) level; and positive specific IgE to environmental allergens and food are found in most cases, some AD patients with normal IgE level still recurred and raised the possibility of other factors as a trigger. Datas from some studies showed high frequency of positive results in metal patch testing and improvement in AD after allergen elimination and low metals diet. Based on these studies, metal is considered as a trigger of reccurrences in AD. Nickel, chromium and cobalt are the primary metals that gives high frequency of positive patch test results in patients with intrinsic AD. Purpose: To evaluate metal patch testing results with nickel, chromium and cobalt in atopic dermatitis patients at Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya. Methods: This study was observational cross-sectional descriptive study of patch testing to nickel, chromium, and cobalt at 23 AD patients who met the inclusion and exclusion criteria. Results: Patch testing to nickel sulphate metal gave positive result in 17.39% patients, potassium dichromate 8.7%, and cobalt chloride 4.35%. Four people (17.39%) showed positive patch test results; 3 people (13.04%) showed the value of the normal serum total IgE and 1 (4.35%) showed an increasing total serum IgE level. Conclusions: Metal patch testing against AD can be considered in AD patients with normal IgE values.

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