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All Journal Jurnal Kesehatan Folia Medica Indonesiana WMJ (Warmadewa Medical Journal) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) INDONESIAN JOURNAL OF PHARMACY Jurnal Sains dan Kesehatan
Bambang Subakti Zulkarnain
Department Of Clinical Pharmacy, Faculty Of Pharmacy, Airlangga University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Jurnal Sains dan Kesehatan

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Efektivitas Deferasirox pada Pasien Thalasemia Mayor: Artikel Review: Efficacy of Deferasirox for Thalassemia Mayor: Review Article Naksa Garnida Arfie; Bambang Subakti Zulkarnaen; Sudarmanto Sudarmanto
Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 3 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (407.429 KB) | DOI: 10.25026/jsk.v4i3.1159

Abstract

Thalassemia is a heterogeneous grouping of genetic disorders resulting from decreased synthesis of the alpha or beta chains of hemoglobin. Anemia and iron overload are the main causes of morbidity and mortality due to thalassemia disease. Iron chelation has improved the survival and quality of life of patients with thalassemia major. Deferasirox (DFX) was developed as monotherapy for the treatment of transfusion iron overload. Search data in this literature study using an electronic database, namely Science Direct, Pubmed with the keywords thalassemia, deferasirox and efficacy. The search results obtained 1015 articles and 5 articles that matched the inclusion and exclusion criteria. The total patients in this study were 410 people from 5 countries. The results of the review article found that deferasirox was effective in reducing iron in the body as seen from the LIC (Liver Iron Concentration), T2* heart and serum ferritin in patients with thalassemia major.
Co-Authors Alfian Nur Rosyid Arina Dery Puspitasari Arina Dery Puspitasari Brigitta Dhyah Kunthi Wardhani Budiatin, Aniek Setiya Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fauzul Meiliani Fauzul Meiliani Halla Hisan Hartoto Intan Kusuma Dewi Junaidi Khotib Lily Aina Lily Aina Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Muhammad Aminuddin Naksa Garnida Arfie Nanda Ardianto Nanda Ardianto Pharmasinta Putri Hapsari Pharmasinta Putri Hapsari Rahmawati, Yessi Asli Rosyid, Alfian Nur Rozalina Loebis Rozalina Loebis Sudarmanto Sudarmanto Tamara Nur Budiarti Tamara nUR Budiarti Toetik Aryani Yogiarto, Mohammad