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All Journal Jurnal Kesehatan Folia Medica Indonesiana WMJ (Warmadewa Medical Journal) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) INDONESIAN JOURNAL OF PHARMACY Jurnal Sains dan Kesehatan
Bambang Subakti Zulkarnain
Department Of Clinical Pharmacy, Faculty Of Pharmacy, Airlangga University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

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The Effect of Dual Antiplatelet Post Percutaneous Coronary Intervention On Aggregation of Platelet In Myocardial Infarction Patients With Diabetes Mellitus and Non Diabetes Mellitus Rahmawati, Yessi Asli; Yogiarto, Mohammad; Zulkarnaen, Bambang Subakti
Indonesian Journal of Pharmacy Vol 29 No 1, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (896.699 KB) | DOI: 10.14499/indonesianjpharm29iss1pp44

Abstract

To analyze the differences in the effect of dual antiplatelet post PCI on the percentage of aggregation in myocardial infarction patients with DM and non DM. Percentage of aggregation were analyzed using light transmission aggregometry (LTA) before loading dose, after PCI, and after maintenance dose of dual antiplatelet (aspirin 100mg and clopidogrel 75mg). Total 22 patients were participated in this study divided into 10 and 12 patients in diabetic and non diabetic group. Percentage of aggregation after taking dual antiplatelet maintenace dose decrease significantly in both group (p=0.006 in diabetic group and p=0.002 in non diabetic group). Mean reduction of percentage of aggregation in diabetic group (3.30±2.91%) is less than non diabetic group (6.83±5.97%). Statistical analysis shows that the mean reduction of percentage of aggregation between two groups were not significantly different (p>0.05). Mean percentage of aggregation after dual antiplatelet maintenance dose was higher in diabetic group and mean reduction of percentage of aggregation was higher in non diabetic group, although statistically in both group it is not significantly different.
Pivotal role reelin signaling pathway in the development of tolerance to morphine-induced antinociception Bambang Subakti Zulkarnanin; Junaidi Khotib
Indonesian Journal of Pharmacy Vol 19 No 3, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.119 KB) | DOI: 10.14499/indonesianjpharm0iss0pp157-164

Abstract

The huge endogenous macromolecule protein responsible for controlling migration and dendritic growth of developing neurons, reelin, has recently been proposed that its signaling pathway modulates synaptic plasticity in the adult rodent brain. This study was carried out to investigate the pivotal role of the reelin signaling pathway in the development of tolerance to morphine induced antinociception. There was evidence that repeated intracerebroventricular administration of reelin’s monoclonal antibody, the competitive inhibitor to reelin – apolipoprotein receptor E2 recombinant, and disabled1 (Dab1) protein inhibitor – MG132, resulted in the inhibition to the development of antinociception tolerance to morphine administration. Furthermore, chronic in vivo administration with morphine caused significance increase of the immunoreactivity (IR) for phosphorylated-Dab1 in the thalamus. These data suggested that persistent activation of reelin signaling pathway due to chronic administration of morphine may be responsible for the development of tolerance to morphine-induced antinociception.Key words: Morphine tolerance, Neuronal plasticity, Opioid receptor, Reelin signalling pathway
Co-Authors Alfian Nur Rosyid Arina Dery Puspitasari Arina Dery Puspitasari Brigitta Dhyah Kunthi Wardhani Budiatin, Aniek Setiya Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fauzul Meiliani Fauzul Meiliani Halla Hisan Hartoto Intan Kusuma Dewi Junaidi Khotib Lily Aina Lily Aina Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Muhammad Aminuddin Naksa Garnida Arfie Nanda Ardianto Nanda Ardianto Pharmasinta Putri Hapsari Pharmasinta Putri Hapsari Rahmawati, Yessi Asli Rosyid, Alfian Nur Rozalina Loebis Rozalina Loebis Sudarmanto Sudarmanto Tamara nUR Budiarti Tamara Nur Budiarti Toetik Aryani Yogiarto, Mohammad