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All Journal Biomolecular and Health Science Journal JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Indonesian Andrology and Biomedical Journal
R.Haryanto Aswin
Department Of Medical Biology, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Effect of Antioxidant Vitamin C and E Administration on Spermatozoa Quality of White Rat (Rattus Norvegicus) Strain Wistar Male Against Allethrin Exposure Faisal Yusuf Ashari; Rina Yudiwati; R.Haryanto Aswin
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (379.846 KB) | DOI: 10.20473/bhsj.v1i2.9282

Abstract

Introduction: Allethrin is an active ingredient used in anti-mosquito drugs. Allethrin enters the body through inhalation, allegedly can disrupt the quality of spermatozoa by decreasing its amount, motility, viability and morphology. Many studies suggested that with sufficient intake of vitamin C and E would be able to minimize free radicals caused by allethrin. This study aims to investigate the effect of giving antioxidant vitamin C and E on spermatozoa quality of white rat (Rattus norvegicus) strain Wistar male with allethrin exposure.Methods: This research was a post-test design randomized control group design using Rattus novergicus male strains Wistar exposed to allethrin (LPB IPB veterinary stem cell). A total of 16 white rat strains Wistar male divided into 4 groups, one control group (without any treatment) and 3 treatment groups (given antioxidant vitamin C, vitamin E and both). The exposure of mosquito coils was performed 8 hours per day for 45 days and on the 46th day, spermatozoa was observed. The data were analyzed using ANOVA one way and BNT.Results: The results showed that treatment with vitamins affected the amount, motility and viability of rat spermatozoa exposed to allethrin. The mean amount of control group spermatozoa and treatment was 14,93, the mean spermatozoa motility control and treatment groups were 45,13 and the mean spermatozoa viability of control and treatment groups was 58,88. This is shown by the real difference between the control group and the treatment (p <0,05). Similarly, in the control group found morphological abnormalities.Conclusion: Exposure of mosquito coils 8 hours/day for 45 days decreased the spermatozoa quality. Overall, the admission of antioxidant vitamin C and E are able to maintain the quality of spermatozoa instead of one type of vitamin.
Quality of Life of Chronic Hepatitis B Patients Consuming Nucleoside Analog: A Case-Control Clinical Study in Indonesia Natasya Ariesta Selyardi Putri; R. Haryanto Aswin; Izzatul Fithriyah; Ummi Maimunah; Muhammad Miftahussurur; Yoshio Yamaoka
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.31409

Abstract

Introduction: Chronic hepatitis B raises serious concern due to its high morbidity, such as cirrhosis and hepatocellular carcinoma, and mortality from 267 per 100,000 person-years. Up to now, medical therapy that successfully eradicates the hepatitis B virus is not available. Therapy is given in the long term for suppressing viral replication and disease progression. Nucleoside analog (NA) is a medication that is consumed orally once a day for years. Previous studies showed that patients who were treated with NA had a different quality of life (QoL) compared to naïve patients. This research aimed to analyze the QoL of chronic hepatitis B patients who consumed NA by comparing it with naïve patients at Dr. Soetomo General Academic Hospital Surabaya. Methods: Subjects were recruited consecutively from chronic hepatitis B patients at Dr. Soetomo General Academic Hospital Surabaya during 9 February – 31 May 2021. Data about sociodemographic characteristics, hepatitis B therapy history, and QoL were gained by using the SF-36 questionnaire and medical records. Subjects were divided into NA and naïve groups which responses underwent an analytical comparison. Results: NA group had significantly higher QoL in a physical component score (PCS) and mental component score (MCS), with physical functioning (PF), role limitations due to physical health (RP), role limitations due to emotional problems (RM), energy/fatigue (VT), emotional well-being (MH), social functioning (SF), and general health perception (GH) subscales having p<0.05Conclusion: The QoL of patients who were treated with NA was significantly higher than that of naïve patients in terms of physical and mental components.
Effect of Acute Exposure of Cigarette Smoke on Endometrium Thickness and Number of Ovarian Follicles in Rats Izdihar Ramadhanty Abiyasa Putri; R Haryanto Aswin; Tri Hartini Yuliawati
Indonesian Andrology and Biomedical Journal Vol. 2 No. 1 (2021): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (793.857 KB) | DOI: 10.20473/iabj.v2i1.36

Abstract

Background: Cigarrete smoke has been ascociated with many health-related problems especially in long time use. One of many health problems that are affected is the reproductive system that give negative impact in fertility. However, there are limited studies about this in acute exposure of cigarette smoke. Objective: The aim of this study is to investigate the effect of acute exposure of cigarette smoke on endometrial thickness and number of ovarian follicles in rats. Methods: Thirty adult female rats were randomly divided into 3 groups: P0, P1 and P2. The P1 and P2 groups were exposed to cigarette smoke for 15 days with dose of 2 and 4 cigarettes daily, respectively. Vaginal swab was done twice, before and after the last treatment, to determine the proestrus phase of the animals. Histological slide of uterus and ovarium using Haematoxylin Eosin staining were observed under light microscop. Number of ovarian follicles were measured, and the thickness of endometrium was meassured using CellSens software version 2.3 (Olympus Life Science). Statistical analysis of data was performed using MANOVA in SPSS software version 23 for Windows.   Results: There were no significant differences in both endometrial thickness and number of ovarian follicles between 3 groups (p>0.05). However, we found that there were a downward trend of some variables (endometrial thickness, number of primary follicles, de Graff follicles, and corpus luteum) from P0 to P2. Conclusion: We concluded that acute exposure of cigarette smoke not yet influenced the female reproductive organ, based on histological appearance of endemotrium and ovarium.
PERBEDAAN PROFIL ANALISIS SEMEN PADA PRIA DI POLI ANDROLOGI RUMAH SAKIT UMUM DAERAH DR. SOETOMO BERDASARKAN KRITERIA INDEKS MASSA TUBUH Williana Suwirman; Zakiyatul Faizah; Relly yanuari Primariawan; Judie Hartono; R Haryanto Aswin
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 6 No 1 (2018): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 6.1 Edisi April - Sep
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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Abstract

Latar belakang : Hubungan antara indeks massa tubuh dengan kualitas semen masih kontroversial. Tujuan penelitian ini adalah menilai hubungan antara indeks massa tubuh dengan kualitas sperma di RSUD Dr. Soetomo, Surabaya, Indonesia. Metode : Penelitian ini adalah penelitian observasional yang menggunakan desain penelitian retrospektif-cross sectional. Sampel penelitian yang digunakan adalah 502 pria yang dibagi kedalam 4 kelompok berdasarkan indeks massa tubuhnya, yaitu kurus (<18.5), normal (18.5-25), kelebihan berat badan (25.1-27), and obesitas (>27). Data dianalisis menggunakan Fisher’s exact test. Hasil : Tidak ada perbedaan signifikan di antara tiap kelompok berdasarkan seluruh parameter analisis semen yang meliputi konsentrasi, motilitas, dan morfologi sperma. Kesimpulan : Tidak ada perbedaan profil analisis semen yang signifikan di antara setiap kelompok indeks massa tubuh.
Co-Authors Faisal Yusuf Ashari Faizah, Zakiyatul Izdihar Ramadhanty Abiyasa Putri Izzatul Fithriyah Judie Hartono Muhammad Miftahussurur Natasya Ariesta Selyardi Putri Relly Yanuari Primariawan Rina Yudiwati Tri Hartini Yuliawati Ummi Maimunah Williana Suwirman Yoshio Yamaoka